References to primary literature
- References of special interest have been highlighted as: of interest of considerable interest
- SC HMATZ D, ABRUZZO G, POWLES M et al.: Pneumocand- ins from Zaleria arboricola. 1V. Biological Evaluationof Natural and Semisynthetic Pneumocandins for Activ-ity against Pneumocystis carinii and Candida Species. J. Antibiotics. (1992) 45(12):1886–1891.
- Good account of the SAR of a number of compounds including enzyme inhibitory activity; and in vitro and in vivo activity.
- BALKOVEC J, BLACK R, HAMMOND M et al.: Synthesis, Stability, and Biological Evaluation of Water-Soluble Prodrugs of a New Echinocandin Lipopeptide. Discov-ery of a Potential Clinical Agent for the Treatment of Systemic Candidiasis and Pneumocystis carinii Pneu-monia (PCP). J. Med. Chem. (1992) 35:194–198.
- Includes both chemistry, and biology of cilofungin, echinocandin and the pneumocandins.
- SCHMATZ D, POWLES M, MCFADDEN D et al.: Antipneu- mocystis Activity of Water-Soluble Lipopeptide L-693,989 in Rats. Antimicro. Agents Chem°. (1992) 36(9):1964–1970.
- Excellent description of the rat model of Pneumocystis pneumonia.
- BARTIZAL K, ABRUZZO G, TRAINOR C et al.: Antifungal Activity of L-693,989 a New Water-Soluble Prodrug De-rivative of an Echinocandin Analog L-688,786. 31st ICAAC (1992) Abstract No 206.
- BALKOVEC J, BLACK R, HAMMOND M, et al.: Echino-candin Anologues: Synthesis and In Vivo Efficacy of L-693,989 and Other Water-Soluble Echinocandins in Candida and Pneumocystis Rodent Models. 31st ICAAC (1992) Abstract No 204.
- PERFECT J, PICKARD W, HUNT D et al.: The Use of Amphotericin B inNosocomial Infection. Rev. Infect. Dis. (1991) 13:474–479.
- HUNTER P, CARTER E, MURDOCK P et al.: Comparative Activity of a New Polyene, BRL 49594A and Am-photericin B Against Fungal and Mammalian Cells. 32nd ICAAC(1992) Abstract No 1042.
- HUNTER P, MLTRDOCK P, RANDALL G et al.: Comparative Activity In Vivo and Toxicity of a New Polyene, BRL 49594A and Amphoteridn B. 32nd ICAAC(1992) Abstract No 1043.
- These two abstracts detail the comparative activities of the derivative, and amphotericin B in a range of test systems including haemolysis tests using human and rat RBC's and 14 day toxicity studies in rats as well as the more conventional antifungal tests.
- SArFOH K, SUZUKI K, HIRANO M et al.: PradimIcins FS and FB, New Pradimicin Analogs: Directed Production, Structures and Biological Activities.]. Antibiotics (1993) 46:398–405.
- Good account of the serine analogues of pradirnicin. Includes the structures and in vitro and in vivo activities.
- INOSO K, NAGATSU J, KAWASHIMA Y, SUZUKI S: Studies on Polyoxins, antifungal antibiotics. L Isolation and Characterization of Polyoxin A and B. Agric. Biol. Chem. (1965) 29:848–854.
- FURTER R, RAST D: A Comparison of the Chitin Synthase- Inhibitory and Antifungal Efficacy of Nudeoside-Pep-tide Antibiotics: Structure-Activity Relationships. PENIS Micro .Let. (1985) 28:205–211.
- A useful description of the correlation between antifungal and chitin synthase inhibitory activities of a number of polyoxins and nikkomy-cins. Also includes details of the antagonism of their activity by di-and tri-peptides.
- ZASLOFF M: Magainins, a class of antimicrobial peptides from Zenopus skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Nat. Acad. Set. USA. (1987) 84:5449–5453.