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Research

Review: Central & Peripheral Nervous System: Cholecystokinin-B receptor antagonists

Pages 231-237 | Published online: 29 Feb 2008

References

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  • EVANS BE, BOCK MG: Promiscuity in Receptor ligand research: Benzodiazepine-based cholecystokinin an-tagonists. Adv. Med. Chem. (1993) 2: 111–152.
  • This is an excellent review of the original discovery of the ben-zodiazepine CCK antagonists and their role in characterisation of CCK pharmacology.
  • HARRO J, VASAR E, BRADWEJN J: CCK in animal and human research on anxiety. Tr. Pharmacol. Sci. (1993) 112: 452–454
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  • RASMUSSEN K, CZACHURA JF, STOCKTON ME, HOWBERT n Electrophysiological effects of diphenylpyrazolidine cholecystokinin-A antagonists on m1dbrain dopamine neurons. J. Pharmacol. Exp. Ther. (1993) 264: 480–488.
  • NOBLE F, DERRIEN M, ROQUES BP: Modulation of opioid antinociception by CCK at the supraspinal level: evi-dence of regulatory mechanisms between CCK and enkephalin systems in the control of pain. Br. J. Phar-macol (1993) 109: 1064–1070.
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  • Excellent reviews of the CCK-B area.
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  • A description of the SAR of new C-5 substituted benzodiazepine CCK-B antagonists.
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  • NISHIDA A, TAKINAMI Y, YUKI H, KOBAYASHI A, AKUZAWA S, ICAMATO T, ITO H, YAMANO M, NAGAKURA Y, MIYATA K: YM022 aR)-1-(2,3-dihydro-1-(2"methyl-phenacy1)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-y1)-3-(3-methylphenyOurea), a potent and selective gastrin- lesions in rats. J. Pharmacol, Exp. Ther. (1994) 270(3): 1256–1261.
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  • The primary disclosure of the discovery of the "dipeptoid" CCK receptor antagonists.
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