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Review

Inhibitors of the enzyme purine nucleoside phosphorylase

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Pages 283-299 | Published online: 25 Feb 2005

Bibliography

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  • ••Detailed account of the structure-based design of PNPinhibitors.
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  • •Acyclovir diphosphate was found to be a very potent PNP inhibitor. The mono- and triphosphates were less active.
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  • HALAZY S, EHRHARD A, DANZIN C: 9-(Difluorophos-phonoalkyOguanines as a new class of multisubstrate analogue inhibitors of purine nucleoside phosphory-lase. J. Am. Chem. Soc. (1991) 113:315–317.
  • MAMONT PS, WEIBEL M, DANZIN C, HALAZY S: Effects of9-(difluorophosphonoalkyOguanines, a new class of multisubstrate analogue inhibitors of purine nucleo-side phosphorylase in cultured human leukemic lym-phoblast Molt-4-cells. Intern. J. Purine Pyrim. Res. (1991) 2:62. © Ashley Publications Ltd. All rights reserved.Exp. Opin. Ther. Patents (1998) 8(3)
  • SEDIVA K, ANANEY AV, VOTRUBAI, HOLY A, ROSEN-BERG I: Inhibition of purine nucleoside phosphory-lase by phosphonomethoxyalkyl analogues of nucleotides. Intern J. Purine Pyrim. Res. (1991) 2:35. Description of acyclic phosphonate inhibitors.
  • SECRIST III JA, NIWAS S, ROSE JD et al: Structure-based design of inhibitors of purine nucleoside phosphory-lase. 2. 9-Alicylic and 2-heteroalicylcic derivatives of 9-deazaguanine. J. Med. Chem. (1993) 36:1847–1854.
  • ••Detailed account of the structure-based design of PNPinhibitors.
  • ERION MD, NIEAS S, ROSE JD et al: Structure-based de- sign of inhibitors of purine nucleoside phosphory-lase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted in the methylene group. J. Med. Chem. (1993) 36:3771–3783.
  • ••Detailed account of the structure-based design of PNPinhibitors.
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  • ••Preliminary account of the clinical activity of BCX-34 (peld-esine).
  • HALAZY S, EGGENSPILLER A, EHARD A, DANCIN C: Phos- phonate derivative of N9-benzylguanine: a new class of potent purine nucleoside phosphorylase inhibitor. Bioorg. Med. Chem. Lett. (1992) 2:407–410.
  • •Phosphonate derivatives of 9-benzylguanine.
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  • •Phosphonate derivatives of 9-benzylguanine.
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  • •Description of the activity of PD 141955 (CI–1000).
  • GILBERTSEN RB, JOSYULA U, SIRCAR JC et al.: Compara- tive in vitro and in vivo activities of two 9-deazaguanine analogue inhibitors of purine nucleo-side phosphorylase CI-972 and PD 141955. Biochem. Pharmacol (1992) 44:996–999.
  • •Description of the activity of PD 141955 (CI–1000).
  • WILBURN DJ, CONG MK, GILBERTSON RB: PD 141955 and CI-972: 9-deaza guanine analogue purine nucleo-side phosphorylase inhibitors. I. Suppression of the human mixed lymphocyte reaction (MLR). Agents Ac-tions (1993) 39.
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  • •Description of the activity of PD 141955 (CI–1000).
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  • DONG MK, SCOTT ME, SCHRIER DJ et al.: The biochemis-try ad pharmacology of PD 116124 (8-amino-2'-nord-eoxyguanosine), an inhibitor of purine nucleoside phosphorylase (PNP). J. Pharm. Exp. Ther. (1992) 260:319–325.
  • •Description of the activity of PD 116124.
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  • •Description of the activity of PD 119229 (CI–950).
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  • •Description of the activity of PD 119229 (CI–950).
  • SIRCAR JC, KOSTLAN CR, PINTER GW et al.: 8-Amino-9- substituted guanines: potent purine nucleoside phos-phorylase (PNP) inhibitors. Agents Action (1987) 21:253–256.
  • •Description of the activity of PD 119229 (CI–950).
  • GILBERTSON RB, DONG MK, KOSSAREK LM, SIRCAR JC,KOSTLAN CR, CONROY MC: Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972. Biochem. Biophys. Res. Comm. (1991) 178:1351–1358.
  • ELLIOTT AJ, KOTIAN PL, MONTGOMERY JA, WALSH DA:Synthesis of pyrrolo[3,2-d]pyrimidines (9-deazaguanines) by reductive cyclodeamination reac-tions. Tetrahedron Lett. (1996) 37:5829-5830. BioCryst's preparation of 9- (3-thienylmethyl)- 9-deazaguanine.
  • BENNETT LL, ALLAN PW, NOKER PE eta].: Purine nucleo-side phosphorylase inhibitors: biochemical and phar-macological studies with 9-benzy1-9-deazaguanine and related compounds. J. Exp. Pharmacol. Ther. (1993) 266:707–714.
  • •9-Benzy1-9-deazaguanine raises inosine levels and increases the half-life of ddI in rats.
  • BANTIA S, MONTGOMERY JA, JOHNSON HG, WALSH GM: In vivo and in vitro pharmacologic activity of the pu-rine nucleoside phosphorylase inhibitor BCX-34: the role of GTP and dGTP. Immunopharmacology (1996) 35:53–63.
  • ••dGTP does not accumulate in rodents and T-cell prolifera-tion is not inhibited when rats are treated with BCX-34 (peldesine). © Ashley Publications Ltd. All rights reserved.Exp. Opin. Ther. Patents (1998) 8(3)

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