Melatonin receptor ligands

Bibliography

• VANECEK J: Cellular mechanisms of melatonin action. Pharmacol. Rev. (1998) 78:687–721.
   Google Scholar
• ••Excellent review on cellular melatonin action and signaltransduction.
   Google Scholar
• FINOCCHIARO LM, ARZT ES, FERNANDEZ-CASTELO S et al. Serotonin and melatonin synthesis in peripheral blood mononuclear cells: stimulation by interferon-y as part of an immunomodulatory pathway. J. Interferon Res. (1988) 8:705–716.
   PubMedGoogle Scholar
• LAUNAY JM, LAMAITRE BJ, HUSSON HP et al.: Melatonin synthesis by rabbit platelets. Life Sci. (1982) 31:1487–1494.
   PubMed Web of Science ®Google Scholar
• LIEBMANN PM, WOLFLER A, FELSNER P, HOFER D, SCHAUENSTEIN K: Melatonin and the immune system. Int. Arch. Allergy Immunol. (1997) 112:203–211.
   PubMed Web of Science ®Google Scholar
• HILL SM, BLASK DE: Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Res. (1988) 48:6121–6126.
   PubMed Web of Science ®Google Scholar
• REPPERT SM, WEAVER DR, EBISAWA T: Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron (1994) 13:1177–1185.
   PubMed Web of Science ®Google Scholar
• •Cloning of the human mti receptor.
   Google Scholar
• REPPERT SM, GODSON C, MAHLE CD et al.: Molecular characterization of a second melatonin receptor ex-pressed in human retina and brain: the Mel(lb) mela-tonin receptor. Proc. Natl. Acad. Sci. USA (1995) 92:8734–8738.
   PubMed Web of Science ®Google Scholar
• ••This report describes the cloning of the human MT2 receptorcDNA and its functional expression in COS cells. Also, the expression profile of the MT2 mRNA in various tissues was investigated.
   Google Scholar
• DUBOCOVICH ML, MASANA MI, JACOB S, SAURI DM: Melatonin receptor antagonists that differentiate be-tween the human Melia and Melib recombinant sub-types are used to assess the pharmacologic profile of the rabbit retina ML1 presynaptic heteroreceptor. cancer Naunyn-Schmiedeberg's Arch. Pharmacol. (1997) 355:365–375.
   PubMed Web of Science ®Google Scholar
• ••First report describing selectivity of melatonin receptorantagonists.
   Google Scholar
• DUBOCOVICH ML: Melatonin receptors: are there mul- tiple subtypes? Trends Pharmacol. Sci. (1995) 16:50–56.
   Google Scholar
• ••Review of the data suggesting the existence of an MT3receptor.
   Google Scholar
• NONNO R, LUCINI V, PANNACCI M et al.: Pharmacologi-cal characterization of the human melatonin Melia re-ceptor following stable transfection into NI113T3 cells. Br. J. Pharmacol. (1998) 124:485–492.
   PubMed Web of Science ®Google Scholar
• GODSON C, REPPERT SM: The Melia melatonin receptoris coupled to parallel signal transduction pathways. Endocrinology (1997) 138:397–404.
   PubMed Web of Science ®Google Scholar
• LIU C, WEAVER DR, JIN X et al.: Molecular dissection of two distinct actions of melatonin on the suprachias-matic circadian clock. Neuron (1997) 19:91–102.
   PubMed Web of Science ®Google Scholar
• ••Demonstration that the mti and MT2 receptors mediate dif-ferent effects of melatonin on the suprachiasmatic nucleus.
   Google Scholar
• DUBOCOVICH ML, YUN K, AL-GHOUL WM, BENLOUCIF S, MASANA MI: Selective MT2 melatonin receptor an-tagonists block melatonin-mediated phase advances of circadian rhythms. FASEB J. (1998) 12:1211–1220.
   PubMed Web of Science ®Google Scholar
• ••Experimental proof using MT2-selective melatonin receptorantagonists that the MT2 receptor is involved in the regula-tion of circadian rhythms.
   Google Scholar
• CARLBERG C, WIESENBERG I: The orphan receptor fam- ily RZR/ROR, melatonin and 5-lipoxygenase: An unex-pected relationship. J. Pineal Res. (1995) 18:171–178.
   PubMed Web of Science ®Google Scholar
• ANDRÉ E, CONQUET F, STEINMAYR M et al: Disruption of retinoid-related orphan receptor 6 changes cir-cadian behavior, causes retinal degeneration and leads to vacillans phenoType In mice. EMBO J (1998) 17:3867–3877.
   PubMed Web of Science ®Google Scholar
• BECKER-ANDRÉ M, ANDRÉ E, DELAMARTER JF: Identifi-cation of nuclear receptor mRNAs by RT-PCR amplifi-cation of conserved zinc-finger motif sequences. Biochem. Biophys. Res. Commun. (1993) 194:1371–1379.
   PubMed Web of Science ®Google Scholar
• STEINMAYR M, ANDRÉ E, CONQUET F et al: Staggerer phenotype in retinoid-related orphan receptor a-def-icient mice. Proc. Natl. Acad. Sci. USA (1998) 95:3960–3965.
   PubMed Web of Science ®Google Scholar
• DUSSAULT I, FAWCETT D, MATTHYSSEN A, BADER JA, GIGUÈRE V: Orphan nuclear receptor RORa-deficient mice display the cerebellar defects of staggerer. Mech. Develop. (1998) 70:147–153.
   PubMed Web of Science ®Google Scholar
• STEINHILBER D, BRUNGS M, WERZ 0 et al.: The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes. J. Biol. Chem. (1995) 270:7037–7040.
   Google Scholar
• SCHRADER M, DANIELSSON C, WIESENBERG I, CARL-BERG C: Identification of natural monomeric response elements of the nuclear receptor RZR/ROR. They also bind COUP-TF homodimers. J. Biol. Chem. (1996) 271:19732–19736.
   PubMed Web of Science ®Google Scholar
• DUSSAULT I, GIGUÈRE V: Differential regulation of the N-myc proto-oncogene by R011a and RVR, two orphan members of the superfamily of nuclear hormone re-ceptors. Mol. Cell. Biol. (1997) 17:1860–1867.
   PubMed Web of Science ®Google Scholar
• CARLBERG C, VAN HUIJSDUIJNEN RH, STAPLE JK, DELA-MARTER JF, BECKER-ANDRÉ M: RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. Mol. Endocrin. (1994) 8:757–770.
   PubMed Web of Science ®Google Scholar
• WITT-ENDERBY PA, CHU G-H, GILLEN ML, LI P-K: Devel-opment of a high-affinity ligand that irreversibly binds to Mehb melatonin receptors. J. Med. Chem. (1997) 40:4195–4198.
   PubMed Web of Science ®Google Scholar
• BERESFORD IJM, BROWNING C, STARKEY SJ et al.: GR196429: a nonindolic agonist at high-affinity mela-tonin receptors. J. Pharmacol Exp. Ther. (1998) 285:1239–1245.
   PubMed Web of Science ®Google Scholar
• DAVIES DJ, GARRATT PJ, TOCHER DA et al.: Mapping the melatonin receptor. 5. Melatonin agonists and antago-nists derived from tetrahydrocyclopent[b] indoles, tet-r ahydr ocarb az ole s and hexa-hydrocyclo hept[b]indoles. J. Med. Chem. (1998) 41:451–467.
   Google Scholar
• SUGDEN D, PICKERING H, TEH M-T, GARRATT PJ: Mela-tonin receptor pharmacology: toward subtype speci-ficity. Biol. Cell (1997) 89:531–537.
   PubMed Web of Science ®Google Scholar
• BECKER-ANDRÉ M, WIESENBERG I, SCHAEREN-WIEMERS N et al.: Pineal gland hormone melatonin binds and ac-tivates an orphan of the nuclear receptor superfamily. J. Biol. Chem. (1994) 269:28531–28534.
   PubMed Web of Science ®Google Scholar
• WIESENBERG I, MISSBACH M, KAHLEN J-P, SCHRADER M, CARLBERG C: Transcriptional activation of the nuclear receptor RZRa by the pineal gland hormone mela-tonin and identification of CGP 52608 as a synthetic ligand. Nucleic Acids Res. (1995) 23:327–333.
   PubMed Web of Science ®Google Scholar
• ••Identification of melatonin and CGP 52608 as RZR/RORaligands.
   Google Scholar
• MISSBACH M, JAGHER B, SIGG I et al.: Thiazolidine dio- nes, specific ligands of the nuclear receptor retinoid Z receptor / retinoid acid receptor-related orphan re-ceptor a with potent antiarthritic activity. J. Biol. Chem. (1996) 271:13515–13522.
   PubMed Web of Science ®Google Scholar
• •Characterisation of potent thiazolidinedione derivative on arthritis and receptor activation.
   Google Scholar
• STEINHILBER D, BRUNGS M, WERZ 0 et al.: The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes. J. Biol. Chem (1995) 270:7037–7040.
   Google Scholar
• GREINER EF, KIRFEL J, GRESCHIK H et al.: Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor. Proc. Natl. Acad. Sci. USA (1996) 93:10105–10110
   PubMed Web of Science ®Google Scholar
• WIESENBERG I, CHIESI M, MISSBACH M et al.: Specific ac-tivation of the nuclear receptors PPARy and RORA by the antidiabetic thiazolidinedione BRL 49653 and the antiarthritic thiazolidinedione derivative CGP 52608. Mol. Pharmacol. (1998) 53:1131–1138.
   PubMed Web of Science ®Google Scholar
• •Definition of the pharmacological profile of thiazolidinediones.
   Google Scholar
• KARASEK M, WINCZYK K, KUNERT-RADEK J, WIESEN-BERG I, PAWLIKOWSKI, M: Antiproliferative effects of melatonin and CGP52608 on the murine colon 38 ade-nocarcinoma in vitro and in vivo. Neuroendocrin. Lett. (1998) 19:71–78.
   Google Scholar
• SICSIC S, SERRAZ I, ANDRIEUX J et al.: Three-dimensional quantitative structure-activity relation-ship of melatonin receptor ligands: a comparative mo-lecular field analysis study. J. Med. Chem. (1997) 40:739–748.
   PubMed Web of Science ®Google Scholar
• MOR M, RIVARA S, SILVA C et al.: Melatonin receptorligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. J. Med. Chem. (1998) 41:3831-3844. Patents
   Google Scholar