5-HT and the brain–gut axis: opportunities for pharmacologic intervention

Bibliography

• DROSSMAN DA, THOMPSON WG, TALLEY NJ, FUNCH-JENSEN P, JANSSENS J, WHITEHEAD WE: Identification of sub-groups of functional gastrointestinal disorders. Gastroenterol. Int. (1990) 3:159-172.
   Google Scholar
• DROSSMAN DA: Review article: an integrated approach to the irritable bowel syndrome. Aliment. Pharmacol. Ther. (1999) 13(Suppl. 2):3-14.
   PubMedGoogle Scholar
• THOMPSON WG, LONGSTRETH GF, DROSSMAN DA, HEATON KW, IRVINE EJ, MULLER-LISSNER SA: Functional bowel disorders and functional abdominal pain. Gut (1999) 45(Suppl. 2):II43-II47.
   PubMed Web of Science ®Google Scholar
• HAHN BA, YAN S, STRASSELS S: Impact of irritable bowel syndrome on quality of life and resource use in the United States and United Kingdom. Digestion (1999) 60:77-81.
   PubMed Web of Science ®Google Scholar
• WELLS NE, HAHN BA, WHORWELL PJ: Clinical economics review: irritable bowel syndrome. Aliment. Pharmacol. Ther. (1997) 11:1019-1030.
   PubMed Web of Science ®Google Scholar
• KERN F Jr, ALMY TP, ABBOT FK, BOGDONOFF MD: The motility of the distal colon in nonspecific ulcerative colitis. Gastroenterology (1951) 19:492-503.
   PubMed Web of Science ®Google Scholar
• ROGERS J, HENRY MM, MISIEWICZ JJ: Increased segmental activity and intraluminal pressures in the sigmoid colon of patients with the irritable bowel syndrome. Gut (1989) 30:634-641.
   PubMed Web of Science ®Google Scholar
• SULLIVAN MA, COHEN S, SNAPE WJ Jr: Colonic myoelectrical activity in irritable-bowel syndrome: effect of eating and anticholinergics. N. Engl. J. Med. (1978) 298:878-883.
   PubMed Web of Science ®Google Scholar
• KUMAR D, WINGATE DL: The irritable bowel syndrome: a paroxysmal motor disorder. Lancet (1985) 2:973-977.
   PubMed Web of Science ®Google Scholar
• RITCHIE J: Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut (1973) 14:125-132.
   PubMed Web of Science ®Google Scholar
• WHITEHEAD WE, ENGEL BT, SCHUSTER MM: Irritable bowel syndrome: physiological and psychological differences between diarrhea-predominant and constipation-predominant patients. Dig. Dis. Sci. (1980) 25:404-413.
   PubMed Web of Science ®Google Scholar
• MERTZ H, NALIBOFF B, MUNAKATA J, NIAZI N, MAYER EA: Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology (1995) 109:40-52 [Erratum in: Gastroenterology (1997) 113:1054].
   PubMed Web of Science ®Google Scholar
• MAYER EA, GEBHART GF: Basic and clinical aspects of visceral hyperalgesia. Gastroenterology (1994) 107:271-293.
   PubMed Web of Science ®Google Scholar
• PRIOR A, READ NW: Reduction of rectal sensitivity and post-prandial motility by granisetron, a 5 HT3-receptor antagonist, in patients with irritable bowel syndrome. Aliment. Pharmacol. Ther. (1993) 7:175-180.
   PubMed Web of Science ®Google Scholar
• COULIE B, CAMILLERI M: Irritable bowel syndrome. Clin. Persp. Gastroenterol. (1999) 2:329-338.
   Google Scholar
• GERSHON MD: Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel. Aliment. Pharmacol. Ther. (1999) 13(Suppl. 2):15-30.
   PubMed Web of Science ®Google Scholar
• ORR WC, CROWELL MD, LIN B, HARNISH MJ, CHEN JD: Sleep and gastric function in irritable bowel syndrome: derailing the brain–gut axis. Gut (1997) 41:390-393.
   PubMed Web of Science ®Google Scholar
• CREMONINI F, TALLEY NJ: Diagnostic and therapeutic strategies in the irritable bowel syndrome. Minerva Med. (2004) 95:427-441.
   PubMedGoogle Scholar
• BEARCROFT CP, PERRETT D, FARTHING MJ: Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Gut (1998) 42:42-46.
   PubMed Web of Science ®Google Scholar
• HEITKEMPER M, BURR RL, JARRETT M, HERTIG V, LUSTYK MK, BOND EF: Evidence for autonomic nervous system imbalance in women with irritable bowel syndrome. Dig. Dis. Sci. (1998) 43:2093-2098.
   PubMed Web of Science ®Google Scholar
• FORD MJ, CAMILLERI MJ, HANSON RB, WISTE JA, JOYNER MJ: Hyperventilation, central autonomic control, and colonic tone in humans. Gut (1995) 37:499-504.
   PubMed Web of Science ®Google Scholar
• TOUGAS G: The autonomic nervous system in functional bowel disorders. Can. J. Gastroenterol. (1999) 13(Suppl. A):15A-17A.
   PubMedGoogle Scholar
• BUENO L, FIORAMONTI J, DELVAUX M, FREXINOS J: Mediators and pharmacology of visceral sensitivity: from basic to clinical investigations. Gastroenterology (1997) 112:1714-1743.
   PubMed Web of Science ®Google Scholar
• GOYAL RK, HIRANO I: The enteric nervous system. N. Engl. J. Med. (1996) 334:1106-1115 [Erratum in: N. Engl. J. Med. (1996) 335:215].
   PubMed Web of Science ®Google Scholar
• GERSHON MD: The enteric nervous system: a second brain. Hosp. Pract. (Off Ed.) (1999) 34:31-2, 35-8, 41-2 passim.
   Web of Science ®Google Scholar
• TALLEY NJ: Review article: 5-hydroxytryptamine agonists and antagonists in the modulation of gastrointestinal motility and sensation: clinical implications. Aliment. Pharmacol. Ther. (1992) 6:273-289.
   PubMed Web of Science ®Google Scholar
• GRIDER JR, FOXX-ORENSTEIN AE, JIN JG: 5-Hydroxytryptamine 4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine. Gastroenterology (1998) 115:370-380.
   PubMed Web of Science ®Google Scholar
• WHITEHEAD WE, HOLTKOTTER B, ENCK P et al.: Tolerance for rectosigmoid distention in irritable bowel syndrome. Gastroenterology (1990) 98(5 Part 1):1187-1192.
   PubMed Web of Science ®Google Scholar
• COOK IJ, VAN EEDEN A, COLLINS SM: Patients with irritable bowel syndrome have greater pain tolerance than normal subjects. Gastroenterology (1987) 93:727-733.
   PubMed Web of Science ®Google Scholar
• KOZLOWSKI CM, GREEN A, GRUNDY D, BOISSONADE FM, BOUNTRA C: The 5-HT3 receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised rat. Gut (2000) 46:474-480.
   PubMed Web of Science ®Google Scholar
• MATHIS C, SCHIKOWSKI A, THEWISSEN M, ROSS H-G, PAK MA, ENCK P: Modulation of rectal spinal afferent sensitivity via 5-HT4 receptors. Neurogastroenterol. Motil. (1998) 10:459.
   Google Scholar
• SCHIKOWSKI A, MATHIS C, THEWISSEN M, ROSS H-G, PAK MA, ENCK P: Dose-dependent modulation of rectal spinal afferent sensitivity with a 5-HT4 receptor agonist. Gastroenterology (1999) 16:A643 (Abstract).
   Google Scholar
• GREENWOOD-VAN MEERVELD B, VENKOVA K, HICKS G, DENNIS E, CROWELL MD: Activation of peripheral 5-HT receptors attenuates colonic sensitivity to intraluminal distension. Neurogastroenterol. Motil. (2006) 18:76-86.
   PubMed Web of Science ®Google Scholar
• COATES MD, JOHNSON AC, GREENWOOD VAN-MEERVELD B, MAWE GM: Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse. Neurogastroenterol. Motil. (2006) 18(6):464-471.
   PubMed Web of Science ®Google Scholar
• COATES MD, MAHONEY CR, LINDEN DR et al.: Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology (2004) 126(7):1657-1664.
   PubMed Web of Science ®Google Scholar
• ARIAS B, CATALAN R, GASTO C, GUTIERREZ B, FANANAS L: 5-HTTLPR polymorphism of the serotonin transporter gene predicts non-remission in major depression patients treated with citalopram in a 12-weeks follow up study. J. Clin. Psychopharmacol. (2003) 23(6):563-567.
   PubMed Web of Science ®Google Scholar
• CHEN JJ, LI Z, PAN H et al.: Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: abnormal intestinal motility and the expression of cation transporters. J. Neurosci. (2001) 21(16):6348-6361.
   PubMed Web of Science ®Google Scholar
• YEO A, BOYD P, LUMSDEN S et al.: Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut (2004) 53(10):1452-1458.
   PubMed Web of Science ®Google Scholar