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Key Paper Evaluation

PDE5 inhibitors for cystic fibrosis: can they also enhance chloride transport?

Evaluation of: Lubamba B, Lecourt H, Lebacq J, et al. Preclinical evidence that sildenafi l and vardenafi l activate chloride transport in cystic fi brosis. Am J Respir Crit Care Med 2008;177(5):506–15

, MD
Pages 965-968 | Published online: 21 May 2008

Bibliography

  • Rowe SM, Miller S, Sorscher EJ. Cystic fibrosis. N Engl J Med 2005;352(19):1992-2001
  • Galietta L. Cystic fibrosis transmembrane conductance regulator pharmacotherapy. In: Larsson K, editor, Cystic fibrosis. European Respiratory Monograph; 2006. p. 88-104
  • Boucher RC. New concepts of the pathogenesis of cystic fibrosis lung disease. Eur Respir J 2004;23(1):146-58
  • Lubamba B, Lecourt H, Lebacq J, et al. Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis. Am J Respir Crit Care Med 2008;177(5):506-15
  • Kelley TJ, Al-Nakkash L, Drumm ML. CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells. Am J Respir Cell Mol Biol 1995;13(6):657-64
  • Kelley TJ, Al-Nakkash L, Cotton CU, Drumm ML. Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition. J Clin Invest 1996;98(2):513-20
  • Al-Nakkash L, Hwang TC. Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms. Pflugers Arch 1999;437(4):553-61
  • Dormer RL, Harris CM, Clark Z, et al. Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis. Thorax 2005;60(1):55-9
  • Poschet JF, Timmins GS, Taylor-Cousar JL, et al. Pharmacological modulation of cGMP levels by phosphodiesterase 5 inhibitors as a therapeutic strategy for treatment of respiratory pathology in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 2007;293(3):L712-9

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