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Role of microRNAs in gliomagenesis: targeting miRNAs in glioblastoma multiforme therapy

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Pages 1475-1488 | Published online: 19 Jul 2012

Bibliography

  • Louis D, Ohgaki H, Wiestler OD, The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97-109
  • Masui K, Cloughesy TF, Mischel PS, Molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies. Neuropathol Appl Neurobiol 2012;38:271-91
  • Jansen M, Yip S, Louis DN. Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers. Lancet Neurol 2010;9:717-26
  • Cheng L, Bao S, Rich JN. Potential therapeutic implications of cancer stem cells in glioblastoma. Biochem Pharmacol 2010;80:654-65
  • Krex D, Klink B, Hartmann C. Long-term survival with glioblastoma multiforme. Brain 2007;130:2596-606
  • Riddick G, Fine HA. Integration and analysis of genome-scale data from gliomas. Neurology 2011;7:439-50
  • Cadieux B Ching Genome-wide hypomethylation in human glioblastomas increased proliferation methylenetetrahydrofolate reductase allele status, and associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res 2006;66:8469-76
  • Nagarajan RP, Costello JF. Epigenetic mechanisms in glioblastoma multiforme. Semin Cancer Biol 2009;19:188-97
  • Lujambio A, Esteller M. CpG island hypermethylation of tumor suppressor microRNAs in human cancer. Cell Cycle 2007;6:1455-9
  • Kim VN. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 2005;6:376-85
  • MiRBase 18 Released November 2011. Available from: http://mirnablog.com/mirbase-18-released
  • Wuchty S, Arjona D, Li A. Prediction of associations between microRNAs and gene expression in glioma biology. PLoS One 2011;6(2):e14681
  • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-97
  • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993;75:843-54
  • Kozomara A, Griffiths-Jones S. MiRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 2011;39:D152-7
  • Han J, Lee Y, Yeom KH, The Drosha–DGCR8 complex in primary microRNA processing. Genes Dev 2004;18:3016-27
  • Hummel R, Maurer J, Haier J. MicroRNAs in brain tumors a new diagnostic and therapeutic perspective? Mol Neurobiol 2011;44:223-34
  • Kawahara H, Imai T, Okano H. MicroRNAs in neural stem cells and neurogenesis. Front Neurosci 2012;6:30
  • Grund S, Polycarpou-Schwarz M, Luo Ch. Rare drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells. Neoplasia 2012;14:238-48
  • Gonzalez-Gomez P, Sanchez P, Mira H. MicroRNAs as regulators of neural stem cell- related pathways in glioblastoma multiforme. Mol Neurobiol 2011;44:235-49
  • Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005;120:15-20
  • Calin GA, Sevignani C, Dumitru CD, Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004;101:2999-3004
  • Garzon R, Fabbri M, Cimmino A, MicroRNA expression and function in cancer. Trends Mol Med 2006;12:580-7
  • Cowland JB, Hother C, Grønbaek K. MicroRNAs and cancer. APMIS 2007;115:1090-106
  • Lawler S, Chioca EA. Emerging functions of microRNAs in glioblastoma. J Neurooncol 2009;92:297-306
  • Zhang B, Pan X, Cobb GP, Anderson TA. MicroRNAs as oncogenes and tumor suppressors. Dev Biol 2007;302:1-12
  • Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-11
  • Huang Z, Cheng L, Guryanova A, Cancer stem cells in glioblastoma- molecular signaling and therapeutic targeting. Protein Cell 2010;1:638-55
  • Singh SK, Hawkins C, Clarke ID, Identification of human brain tumour initiating cells. Nature 2004;432:396-401
  • Fernandez-L A, Northcott PA, Taylor MD, Kenney AM. Normal and oncogenic roles for microRNAs in the developing brain. Cell Cycle 2009;8:4049-54
  • Sana J, Hajduch M, Michalek J, MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications. J Cell Mol Med 2011;15:1636-44
  • Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol 2005;5:375-86
  • Kefas B, Comeau L, Floyd DH, The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. J Neurosci 2009;29:15161-8
  • Garcia A, Kandel JJ. Notch: a key regulator of tumor angiogenesis and metastasis. Histol Histopathol 2012;27:151-6
  • Wang Z, Li Y, Ahmad A, Targeting notch signaling pathway to overcome drug resistance for cancer therapy. Biochim Biophys Acta 2010;1806:258-67
  • Li J, Wang K, Chen X, Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells. BMC Mol Biol 2012;13:4
  • Jiang L, Lin C, Song L, MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-kB/IkBa negative feedback loop. J Clin Invest 2012;122:33-47
  • Ma X, Becker Buscaglia LE, Barker JR, Li Y. MicroRNAs in NF-kB signaling. J Mol Cell Biol 2011;3:159-66
  • Phillips HS, Kharbanda S, Chen R, Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006;9:157-73
  • Zinn PO, Majadan B, Sathyan P, Radiogenomic mapping of edema/cellular invasion MRI-phenotypes in glioblastoma multiforme. PLoS One 2011;6(10):e25451
  • Srinivasan S, Patric IR, Somasundaram K. A ten-microRNA expression signature predicts survival in glioblastoma. PLoS One 2011;6(3):e17438
  • Lages E, Guttin A, El Atifi M, MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes. PLoS One 2011;6(5):e20600
  • Kim TM, Huang W, Park R, A developmental taxonomy of glioblastoma defined and maintained by microRNAs. Cancer Res 2011;71:3387-99
  • Rao SA, Santosh V, Somasundaram K. Genome-wide expression profiling identifies deregulated miRNAs in malignant astrocytoma. Mod Pathol 2010;23:1404-17
  • Malzkorn B, Wolter M, Liesenberg F, Identification and functional characterization of microRNAs involved in the malignant progression of gliomas. Brain Pathol 2010;20:539-50
  • Kim H, Huang W, Jiang X, Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proc Natl Acad Sci USA 2010;107:2183-8
  • Lacomy R, Sana J, Hankeova S, MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients. Cancer Sci 2011;102:2186-90
  • Dou T, Wu Q, Chen X, A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population. J Cancer Res Clin Oncol 2010;136:1853-9
  • Permuth- Wey J, Thompson RC, Nabors LB, A functional polymorphism in the pre-miR-146 gene is associated with risk and prognosis in adult glioma. J Neurooncol 2011;105:639-46
  • Skalsky RL, Cullen BR. Reduced expression of brain enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene. PLoS ONE 2011;6(9):e24248
  • Roth P, Wischhusen J, Happold C, A specific miRNA signature in the peripheral blood of glioblastoma patients. J Neurochemistry 2011;118:449-57
  • Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005;65:6029-33
  • Conti A, Aguennouz M, La Torre D, MiR-21 and 221 upregulation and miR-181b downregulation in human grade II–IV astrocytic tumors. J Neurooncol 2009;93:325-32
  • Chen Y, Liu W, Chao T, MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G. Cancer Lett 2008;272:197-205
  • Papagiannakopoulos T, Shapiro A, Kosik KS. MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res 2008;68:8164-72
  • Gabriely G, Wurdinger T, Kesari S, MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol 2008;28:5369-80
  • Zhou X, Ren Y, Moore L, Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status. Lab Invest 2010;90:144-55
  • Li Y, Li W, Yang Y, MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme. Brain Res 2009;1286:13-18
  • Ohno M, Natsume A, Kondo Y, The modulation of microRNAs by type I IFN through the activation of signal transducers and activators of transcription 3 in human glioma. Mol Cancer Res 2009;7:2022-30
  • Gillies JK, Lorimer IA. Regulation of p27Kip1 by miRNA 221/222 in glioblastoma. Cell Cycle 2007;6:2005-9
  • le Sage C, Nagel R, Egan DA, Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J 2007;26:3699-708
  • Zhang J, Han L, Ge Y, miR-221/222 promote malignant progression of glioma through activation of the Akt pathway. Int J Oncol 2010;36:913-20
  • Lukiw WJ, Cui JG, Li YY, Culicchia F. Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM). J Neurooncol 2009;91:27-32
  • Zhang CZ, Zhang JX, Zhang AL, Mir-221 and mir-222 target PUMA to induce cell survival in glioblastoma. Mol Cancer 2010;9:229
  • Shi L, Cheng Z. Zhang J, et al. hsa-mir-181a and hsa-mir- 181b function as tumor suppressors in human glioma cells. Brain Res 2008;1236:185-93
  • Chen G, Zhu W, Shi D, MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2. Oncol Rep 2010;23:997-1003
  • Godlewski J, Nowicki MO, Bronisz A, Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and selfrenewal. Cancer Res 2008;68:9125-30
  • Cui JG, Zhao Y, Sethi P, Micro-RNA-128 (miRNA-128) down-regulation in glioblastoma targets ARP5 (ANGPTL6), Bmi-1 and E2F-3a, key regulators of brain cell proliferation. J Neurooncol 2010;98:297-304
  • Zhang Y, Chao T, Li R, MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a. J Mol Med 2009;87:43-51
  • Nan WU, Guo-cai WU, Rong HU. Ginsenoside Rh2 inhibits glioma cell proliferation by targeting microRNA-128. Acta Pharmacol Sin 2011;32:345-53
  • Nan Y, Han L, Zhang A, MiRNA-451 plays a role as tumor suppressor in human glioma cells. Brain Res 2010;1359:14-21
  • Godlewski J, Bronisz A, Nowicki MO, MicroRNA-451: a conditional switch controlling glioma cell proliferation and migration. Cell Cycle 2010;14:2742-8
  • Kefas B, Godlewski J, Comeau L, MicroRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res 2008;68:3566-72
  • Webster RJ, Giles KM, Price KJ, Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7. J Biol Chem 2009;284:5731-41
  • Silber J, Lim DA, Petritsch C, miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med 2008;6:14
  • Makeyev EV, Zhang J, Carrasco MA, Maniatis T. The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative premRNA splicing. Mol Cell 2007;27:435-48
  • Fowler A, Thomson D, Giles K, MiR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion. Eur J Cancer 2011;47:953-63
  • Kefas B, Comeau L, Erdle N, Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells. Neuro Oncol 2010;12:1102-12
  • Sasayama T, Nishihara M, Kondoh T, MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC. Int J Cancer 2009;125:1407-13
  • Huse JT, Brennan C, Hambardzumyan D, The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev 2009;23:1327-37
  • Song L, Huang Q, Chen K, MiR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-b. Biochem Biophys Res Commun 2010;402:135-40
  • Guan Y, Mizoguchi M, Yoshimoto K, MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance. Clin Cancer Res 2010;16:4289-97
  • Ciafrè SA, Galardi S, Mangiola A, Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun 2005;334:1351-8
  • Li Y, Guessous F, Zhang Y, MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res 2009;69:7569-76
  • Xia H, Qi Y, Ng SS, MicroRNA-146b inhibits glioma cell migration and invasion by targeting MMPs. Brain Res 2009;1269:158-65
  • Nass D, Rosenwald S, Meiri E, Mir-92b and Mir-9/9* are specifically expressed in brain primary tumors and can be used to differentiate primary from metastatic brain tumors. Brain Pathol 2009;19:375-83
  • Krichevsky AM, Gabriely G. MiR-21: a small multi-faceted RNA. J Cell Mol Med 2009;13:39-53
  • Novakova J, Slaby O, Vyzula R, Michalek J. MicroRNA involvement in glioblastoma pathogenesis. Biochem Biophys Res Commun 2009;386:1-5
  • Gao F, Zhang P, Zhou C, Frequent loss of PDCD4 expression in human glioma: possible role in the tumorigenesis of glioma. Oncol Rep 2007;17:123-8
  • Gal H, Pandi G, Kanner AA, MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells. Biochem Biophys Res Commun 2008;376:86-90
  • Friedman HS, Prados MD, Wen PY, Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 2009;27:4733-40
  • Ningaraj NS, Salimath BP, Sankpal UT, Targeted brain tumor treatment-current perspectives. Drug Target Insights 2007;2:197-207
  • Mocellin S, Pasquali S, Pilati P. Oncomirs: from tumor biology to molecularly targeted anticancer strategies mini-reviews. Med Chem 2009;9:70-80
  • Anesti AM, Simpson GR, Price T, Expression of RNA interference triggers from an oncolytic herpes simplex virus results in specific silencing in tumour cells in vitro and tumours in vivo. BMC Cancer 2010;10:486
  • Ren Y, Zhou X, Mei M, MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol. BMC Cancer 2010;10:27
  • Ren Y, Kang CS, Yuan XB, Co-delivery of as-miR-21 and 5-FU by poly(amidoamine) dendrimer attenuates human glioma cell growth in vitro. J Biomater Sci Polym Ed 2010;21:303-14
  • Shi L, Chen J, Yang J, MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity. Brain Res 2010;1352:255-64
  • Breier G, Blum S, Peli J, Transforming growth factor-b and ras regulate the vegf/vegf-receptor system during tumor angiogenesis. Int J Cancer 2002;97:142-8
  • Wurdinger T, Tannous BA, Saydam O, MiR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell 2008;14:382-93
  • Ujifuku K, Mitsutake N, Takakura S, miR-195, miR-455-3p and miR-10a(*) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells. Cancer Lett 2010;296:241-8
  • Xu J, Liao X, Lu N, Chromatin-modifying drugs induce miRNA-153 expression to suppress Irs-2 in glioblastoma cell lines. Int J Cancer 2011;129:2527-31
  • Slaby O, Lakomy R, Fadrus P, MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients. Neoplasma 2010;57:264-9
  • Ujifuku K, Mitsutake N, Takakura S, miR-195, miR-455-3p and miR-10a(*) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells. Cancer Lett 2010;296:241-8
  • Niemoeller OM, Niyazi M, Corradini S, MicroRNA expression profiles in human cancer cells after ionizing radiation. Radiat Oncol 2011;6:29
  • Li Y, Zhao S, Zhen Y, miR-21 inhibitor enhances apoptosis and reduces G2-M accumulation induced by ionizing radiation in human glioblastoma U251 cells. Brain Tumor Pathol 2011;28:209-14
  • Chaudhry MA, Sachdeva H, Omaruddin RA. Radiation-induced micro-RNA modulation in glioblastoma cells differing in DNA-repair pathways. DNA Cell Biol 2010;29:553-61
  • Verissimo CS, Molenaar JJ, Fitzsimons CP, Vreugdenhil E. Neuroblastoma therapy: what is in the pipeline? Endocr Relat Cancer 2011;18:R213-31
  • Cole KA, Attiyeh EF, Mosse YP, A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. Mol Cancer Res 2008;6:735-42
  • Weeraratne SD, Amani V, Neiss A, miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma. Neuro Oncol 2011;13:165-75
  • Garzia L, Andolfo I, Cusanelli E. MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. PLoS One 2009;4(3):e4998
  • Costa FF, Bischof JM, Vanin EF, Identification of MicroRNAs as potential prognostic markers in ependymoma. PLoS One 2011;6(10):e25114
  • Mao ZG, He DS, Zhou J. Differential expression of microRNAs in GH-secreting pituitary adenomas. Diagn Pathol 2010;5:79
  • Colbari Amaral F, Torres N, Saggioro F. MicroRNAs differentially expressed in ACTH-secreting pituitary tumors. J Clin Endocrinol Metab 2009;94:320-3
  • Mueler WC, Spector Y, Edmonston T, Accurate classification of metastatic brain tumors using a novel micro-RNA-based test. Oncologist 2011;16:165-74
  • Yang YP, Chien Y, Chiou GY, Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma. Biomaterials 2012;33:1462-76
  • Wu C, Lin J, Hong M, Combinatorial control of suicide gene expression by tissue specific promoter and microRNA regulation for cancer therapy. Mol Ther 2009;17:2058-66

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