Glutamine as a supplemental treatment in pediatric and adult oncology patients

Bibliography

• Mok E, Hankard R. Glutamine supplementation in sick children: is it beneficial? J Nutr Metab 2011;2011:617597
   PubMedGoogle Scholar
• Neu J, DeMarco V, Li N. Glutamine: clinical applications and mechanisms of action. Curr Opin Clin Nutr Metab Care 2002;5:69-75
   Google Scholar
• Wernerman J. Clinical use of glutamine supplementation. J Nutr 2008;138:2040-4
   PubMed Web of Science ®Google Scholar
• Wischmeyer PE. Clinical applications of L-glutamine: past, present, and future. Nutr Clin Pract 2003;18:377-85
   PubMedGoogle Scholar
• Ligthart-Melis GC, Van De Poll MCG, Boelens PG, Glutamine is an important precursor for de novo synthesis of arginine in humans. Am J Clin Nutr 2008;87:1282-9
   PubMed Web of Science ®Google Scholar
• Duggan C, Gannon J, Allan Walker W. Protective nutrients and functional foods for the gastrointestinal tract. Am J Clin Nutr 2002;75:789-808
   PubMed Web of Science ®Google Scholar
• Kuhn KS, Stehle P, Furst P. Glutamine content of protein and peptide-based enteral products. J Parenter Enteral Nutr 1996;20:292-5
   PubMed Web of Science ®Google Scholar
• Haberle J, Gorg B, Rutsch F, Congenital glutamine deficiency with glutamine synthetase mutations. N Engl J Med 2005;353:1926-33
   PubMed Web of Science ®Google Scholar
• Chen MK, Salloum RM, Austgen TR, Tumor regulation of hepatic glutamine metabolism. J Parenter Enteral Nutr 1999;15:159-64
   Web of Science ®Google Scholar
• Windmueller HW, Spaeth AE. Respiratory fuels and nitrogen metabolism in vivo in small intestine of fed rats. Quantitative importance of glutamine, glutamate, and aspartate. J Biol Chem 1980;2551:07-12
   Google Scholar
• Neu J, Shenoy V, Chakrabarti R. Glutamine nutrition and metabolism: where do we go from here? FASEB J 1996;10:829-37
   PubMed Web of Science ®Google Scholar
• Kuhn KS, Muscaritoli M, Wischmeyer P, Stehle P. Glutamine as indispensable nutrient in oncology: experimental and clinical evidence. Eur J Nutr 2010;49:197-210
   PubMed Web of Science ®Google Scholar
• Circu MI, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 2010;48:749-62
   PubMed Web of Science ®Google Scholar
• Wu G, Fang YZ, Yang S, Glutathione metabolism and its implications for health. J Nutr 2004;134:489-92
   PubMed Web of Science ®Google Scholar
• Kefaloyianni E, Gaitanaki C, Beis I. ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-κB transactivation during oxidative stress in skeletal myoblasts. Cell Signal 2006;18:2238-51
   PubMed Web of Science ®Google Scholar
• Mok E, Constantin B, Favreau F, L-glutamine administration reduces oxidized glutathione andMAP kinase signaling in dystrophic muscle of mdx mice. Pediatr Res 2008;63:268-73
   PubMed Web of Science ®Google Scholar
• Babu R, Eaton S, Drake DP, Glutamine and glutathione counteract the inhibitory effects of mediators of sepsis in neonatal hepatocytes. J Pediatr Surg 2001;36:282-6
   PubMed Web of Science ®Google Scholar
• Wischmeyer PE, Riehm J, Singleton KD, Glutamine attenuates tumor necrosis factor-α release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. Nutrition 2003;19:1-6
   PubMed Web of Science ®Google Scholar
• Singleton KD, Wischmeyer PE. Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. Am J Physiol 2007;292:1839-45
   Google Scholar
• Hayashi Y, Sawa Y, Fukuyama N, Preoperative glutamine administration induces heatshock protein 70 expression and attenuates cardiopulmonary bypass-induced inflammatory response by regulating nitric oxide synthase activity. Circulation 2002;106:2601-7
   PubMed Web of Science ®Google Scholar
• Coeffier M, Dechelotte P. Combined infusion of glutamine and arginine: does it make sense? Curr Opin Clin Nutr Metab Care 2010;13:70-4
   PubMed Web of Science ®Google Scholar
• Melis GC, Wengel NT, Boelens PG, Van Leeuwen PAM. Glutamine: recent developments in research on the clinical significance of glutamine. Curr Opin Clin Nutr Metab Care 2004;7:59-70
   PubMed Web of Science ®Google Scholar
• Dilsiz A, Ciftci I, Aktan TM, Enteral glutamine supplementation and dexamethasone attenuate the local intestinal damage in rats with experimental necrotizing enterocolitis. Pediatr Surg Int 2003;19:578-82
   PubMed Web of Science ®Google Scholar
• Wang J, Chen L, Li P, Gene expression is altered in piglet small intestine by weaning and dietary glutamine supplementation. J Nutr 2008;138:1025-32
   PubMed Web of Science ®Google Scholar
• Kessel A, Toubi E, Pavlotzky E, Treatment with glutamine is associated with down-regulation of Toll-like receptor-4 and myeloid differentiation factor 88 expression and decrease in intestinal mucosal injury caused by lipopolysaccharide endotoxaemia in a rat. Clin Exp Immunol 2008;151:341-7
   PubMed Web of Science ®Google Scholar
• Bosaeus I. Nutritional support in multimodal therapy for cancer cachexia. Support Care Cancer 2008;16:447-51
   PubMed Web of Science ®Google Scholar
• Muscaritoli M, Anker SD, Argilè J, Consensus definition of sarcopenia, cachexia and precachexia: joint document elaborated by Special Interest Groups (SIG) ‘cachexia-anorexia in chronic wasting disease' and ‘nutrition in geriatrics'. Clin Nutr 2010;29:154-9
   PubMed Web of Science ®Google Scholar
• Tishdale MJ. With a promising new treatment pathogenesis of cancer cachexia. J Support Oncol 2003;1:159-68
   PubMedGoogle Scholar
• Muscaritoli M, Molfino A, Gioia G, The ‘parallel pathway': a novel nutritional and metabolic approach to cancer patients. Intern Emerg Med 2010;6:105-12
   PubMed Web of Science ®Google Scholar
• Inui A. Cancer anorexia-cachexia syndrome. Current issues in research and management. CA Cancer J Clin 2002;52:72-91
   PubMed Web of Science ®Google Scholar
• Rossi Fanelli F, Cangiano C, Muscaritoli M, Tumour-induced changes in host metabolism: a possible marker of neoplastic disease. Nutrition 1995;11:595-600
   PubMed Web of Science ®Google Scholar
• Argilés JM, Busquets S, López-Soriano FJ. Anti-inflammatory therapies in cancer cachexia. Eur J Pharmacol 2011;668(Suppl 1):S81-6
   PubMed Web of Science ®Google Scholar
• Wheeler MT, Snyder EC, Patterson MN, An E-box within the MHC IIB gene is bound by MyoD and is required for gene expression in fast muscle. Am J Physiol 1999;276:1069-78
   PubMedGoogle Scholar
• Davis MP, Dreicer R, Walsh D, Appetite and cancer-associated anorexia: a review. J Clin Oncol 2004;22:1510-17
   PubMed Web of Science ®Google Scholar
• Melis GC, TerWengel N, Boelens PG, Van Leeuwen PAM. Glutamine: recent developments in research on the clinical significance of glutamine. Curr Opin Clin Nutr Metab Care 2004;7:59-70
   PubMed Web of Science ®Google Scholar
• Pastore A, Federici G, Bertini E, Piemonte F. Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta 2003;333:19-39
   PubMed Web of Science ®Google Scholar
• Brasse-Lagnel CG, Lavoinne AM, Husson AS. Amino acid regulation of mammalian gene expression in the intestine. Biochimie 2010;92:729-35
   PubMed Web of Science ®Google Scholar
• Collins CL, Wasa M, Souba WW, Abcouwer SF. Determinants of glutamine dependence and utilization by normal and tumor-derived breast cell lines. J Cell Physiol 1998;176:166-78
   PubMed Web of Science ®Google Scholar
• Laviano A, Renvyle T, Yang ZJ. From laboratory to bedside: new strategies in the treatment of malnutrition in cancer patients. Nutrition 1996;12:112-22
   PubMed Web of Science ®Google Scholar
• Erbil Y, Oztezcan S, Giris M, The effect of glutamine on radiation-induced organ damage. Life Sci 2005;78:376-82
   PubMed Web of Science ®Google Scholar
• Fahr MJ, Kornbluth J, Blossom S, Harry M. Vars Research Award. Glutamine enhances immunoregulation of tumor growth. J Parenter Enteral Nutr 1994;18:471-6
   PubMed Web of Science ®Google Scholar
• Learn DB, Thomas EL. Inhibition of tumor cell glutamine uptake by isolated neutrophils. J Clin Invest 1988;82:789-96
   PubMed Web of Science ®Google Scholar
• Savarese DM, Savy G, Vahdat L, Prevention of chemotherapy and radiation toxicity with glutamine. Cancer Treat Rev 2003;29:501-13
   PubMed Web of Science ®Google Scholar
• Carretero J, Obrador E, Pellicer J, Mitochondrial glutathione depletion by glutamine in growing tumor cells. Free Radic Biol Med 2000;29:913-23
   PubMed Web of Science ®Google Scholar
• Klimberg VS, Organ CH Jr. Honorary Lectureship. Glutamine, cancer, and its therapy. Am J Surg 1996;172:418-24
   PubMed Web of Science ®Google Scholar
• Rouse K, Nwokedi E, Woodliff JE, Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism. Ann Surg 1995;221:420-6
   PubMed Web of Science ®Google Scholar
• Diestel CF, Marques RG, Lopes-Paulo F, Role of L-glutamine and glycine supplementation on irradiated colonic wall. Int J Colorectal Dis 2007;22:1523-9
   PubMed Web of Science ®Google Scholar
• El Malt M, Ceelen W, Boterberg T, Does the addition of glutamine to total parenteral nutrition have beneficial effect on the healing of colon anastomosis and bacterial translocation after preoperative radiotherapy? Am J Clin Oncol 2003;26:54-9
   Google Scholar
• Salman B, Oguz M, Akmansu M, Effect of timing of glutamine- enriched enteral nutrition on intestinal damage caused by irradiation. Adv Ther 2007;24:648-61
   PubMed Web of Science ®Google Scholar
• van den Berg A, Fetter WP, Westerbeek EA, The effect of glutamine-enriched enteral nutrition on intestinal permeability in very-low-birth-weight infants: a randomized controlled trial. JPEN J Parenter Enteral Nutr 2006;30:408-14
   PubMed Web of Science ®Google Scholar
• Kaufmann Y, Todorova VK, Luo S, Klimberg VS. Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model. Nutr Cancer 2008;60:518-25
   PubMed Web of Science ®Google Scholar
• Marks SL, Cook AK, Reader R, Effects of glutamine supplementation of an amino acid-based purified diet on intestinal mucosal integrity in cats with methotrexate-induced enteritis. Am J Vet Res 1999;60:755-63
   PubMed Web of Science ®Google Scholar
• Ward E, Picton S, Reid U, Oral glutamine in paediatric oncology patients: a dose finding study. Eur J Clin Nutr 2003;57:31-6
   PubMed Web of Science ®Google Scholar
• Okur A, Ezgu FS, Tumer L, Effects of oral glutamine supplementation on children with solid tumors receiving chemotherapy. Pediatr Hematol Oncol 2006;23:277-85
   PubMed Web of Science ®Google Scholar
• Anderson PM, Schroeder G, Skubitz KM. Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy. Cancer 1998;83:1433-9
   PubMed Web of Science ®Google Scholar
• Xue H, Sawyer MB, Field CJ, Bolus oral glutamine protects rats against CPT-11-induced diarrhea and differentially activates cytoprotective mechanisms in host intestine but not tumor. J Nutr 2008;138:740-6
   PubMed Web of Science ®Google Scholar
• Xue H, Sawyer MB, Field CJ, Nutritional modulation of antitumor efficacy and diarrhea toxicity related to irinotecan chemotherapy in rats bearing the ward colon tumor. Clin Cancer Res 2007;13:7146-54
   PubMed Web of Science ®Google Scholar
• Daniele B, Perrone F, Gallo C, Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Gut 2001;48:28-33
   PubMed Web of Science ®Google Scholar
• Li Y, Yu Z, Liu F, Oral glutamine ameliorates chemotherapy-induced changes of intestinal permeability and does not interfere with the antitumor effect of chemotherapy in patients with breast cancer: a prospective randomized trial. Tumori 2006;92:396-401
   PubMed Web of Science ®Google Scholar
• Kozelsky TF, Meyers GE, Sloan JA, Phase III double-blind study of glutamine versus placebo for the prevention of acute diarrhea in patients receiving pelvic radiation therapy. J Clin Oncol 2003;21:1669-74
   PubMed Web of Science ®Google Scholar
• Uderzo C, Rebora P, Marrocco E, Glutamine-enriched nutrition does not reduce mucosal morbidity or complications after stem-cell transplantation for childhood malignancies: a prospective randomized study. Transplantation 2011;27:1321-5
   Web of Science ®Google Scholar
• Wang WS, Lin JK, Lin TC, Oral glutamine is effective for preventing oxaliplatin-induced neuropathy in colorectal cancer patients. Oncologist 2007;12:312-19
   PubMed Web of Science ®Google Scholar
• Amara S. Oral glutamine for the prevention of chemotherapy-induced peripheral neuropathy. Ann Pharmacother 2008;42:1481-5
   PubMed Web of Science ®Google Scholar
• Wernerman J, Kirketeig T, Andersson B, Scandinavian Glutamine trial: a pragmatic clinical multi-centre RCT of ICU patients. Acta Anaesthesiol Scand 2011;55:812-12
   PubMed Web of Science ®Google Scholar
• Doig GS, Heighes PT, Simpson F, Early enteral nutrition, provided within 24 h of injury or intensive care unit admission, significantly reduces mortality in critically ill patients: a metaanalysis of randomised controlled trials. Intensive Care Med 2009;35:2018-27
   PubMed Web of Science ®Google Scholar
• Vanek VW, Matarese LE, Robinson M, Novel Nutrient Task Force, Parenteral Glutamine Workgroup; American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors. A.S.P.E.N. position paper: parenteral nutrition glutamine supplementation. Nutr Clin Pract 2011;26:479-94
   PubMed Web of Science ®Google Scholar
• Marik PE, Zaloga GP. Early enteral nutrition in acutely ill patients: a systematic review. Crit Care Med 2001;29:2264-70
   PubMed Web of Science ®Google Scholar
• August DA, Huhmann MB; American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors. A.S.P.E.N. clinical guidelines: nutrition support therapy during adult anticancer treatment and in hematopoietic cell transplantation. JPEN J Parenter Enteral Nutr 2009;33:472-500
   PubMed Web of Science ®Google Scholar
• Berg A, Rooyackers O, Norberg A, Wernerman J. Elimination kinetics of L-alanyl-L-glutamine in ICU patients. Amino Acids 2005;29:221-8
   PubMed Web of Science ®Google Scholar
• Berg A, Forsberg E, Wernerman J. The local vascular tolerance to an intravenous infusion of a concentrated glutamine solution in ICU patients. Clin Nutr 2002;21:135-9
   PubMed Web of Science ®Google Scholar
• Wernerman J. Glutamine supplementation. Ann Intensive Care 2011;18:25
   Web of Science ®Google Scholar
• Roth E. Nonnutritive effects of glutamine. J Nutr 2008;138:2025-31
   PubMed Web of Science ®Google Scholar
• Moe-Byrne T, Wagner JV, McGuire W. Glutamine supplementation to prevent morbidity and mortality in preterm infants. Cochrane Database Syst Rev 2012;3:CD001457
   PubMedGoogle Scholar
• Wang Y, Jiang Z-M, Nolan MT, The impact of glutamine dipeptide-supplemented parenteral nutrition on outcomes of surgical patients: a meta-analysis of randomized clinical trials. JPEN J Parenter Enteral Nutr 2010;34:521-9
   PubMed Web of Science ®Google Scholar
• Petit J, Kaeffer N, Déchelotte P, Oksenhendler G. Respective indications of enteral or parenteral nutrition during pre- and post-downloaded operative periods. Ann Fr Anesth Reanim 1995;14:127-36
   PubMed Web of Science ®Google Scholar
• Oliveira GP, Dias CM, Pelosi P, Rocco PR. Understanding the mechanisms of glutamine action in critically ill patients. An Acad Bras Cienc 2010;82:417-30
   PubMed Web of Science ®Google Scholar
• Murray SM, Pindoria S. Nutrition support for bone marrow transplant patients. Cochrane Database Syst Rev 2009(1):CD002920
   Google Scholar
• Furst P, Pogan K, Stehle P. Glutamine dipeptides in clinical nutrition. Nutrition 1997;13:731-7
   PubMed Web of Science ®Google Scholar
• Paccagnella A, Morassutti I, Rosti G. Nutritional intervention for improving treatment tolerance in cancer patients. Curr Opin Oncol 2011;23:322-30
   PubMed Web of Science ®Google Scholar
• Furst P. New strategies in clinical nutrition. Perit Dial Int 1996;16:28-35
   Google Scholar
• De-Souza DA, Greene LJ. Pharmacological nutrition after burn injury. J Nutr 1998;1285:797-803
   Google Scholar
• Elia M. Glutamine in parenteral nutrition: more food for thought. Gut 1999;45:6-7
   PubMed Web of Science ®Google Scholar
• Strasser F, Demmer R, Bohme C, Prevention of docetaxel- or paclitaxel-associated taste alterations in cancer patients with oral glutamine: a randomized, placebo-controlled, double-blind study. Oncologist 2008;13:337-46
   PubMed Web of Science ®Google Scholar
• Wang WS, Lin JK, Lin TC, Oral glutamine is effective for preventing oxaliplatin-induced neuropathy in colorectal cancer patients. Oncologist 2007;12:312-19
   PubMed Web of Science ®Google Scholar
• Choi K, Lee SS, Oh SJ, The effect of oral glutamine on 5-fluorouracil/leucovorin-induced mucositis/stomatitis assessed by intestinal permeability test. Clin Nutr 2007;26:57-62
   PubMed Web of Science ®Google Scholar
• Aquino VM, Harvey AR, Garvin JH, A double-blind randomized placebo-controlled study of oral glutamine in the prevention of mucositis in children undergoing hematopoietic stem cell transplantation: a pediatric blood and marrow transplant consortium study. Bone Marrow Transplant 2005;36:611-16
   PubMed Web of Science ®Google Scholar