440
Views
6
CrossRef citations to date
0
Altmetric
Reviews

Novel therapies, including enzastaurin, in the treatment of ovarian cancer

, MD PhD

Bibliography

  • Ovarian cancer statistics. Centers for Disease Control and Prevention. 2012. Available from: http://www.cdc.gov/cancer/ovarian/statistics/index.htm [Last accessed 4 February 2014]
  • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012;62(1):10-29
  • Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127(12):2893-917
  • Ovarian Cancer. National Cancer Institute. 2013. Available from: http://www.cancer.gov/cancertopics/types/ovarian [Last accessed 4 February 2014]
  • Vergote I, Tropé CG, Amant F, et al. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Group; NCIC Clinical Trials Group. Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer. N Engl J Med 2010;363(10):943-53
  • du Bois A, Luck HJ, Meier W, et al. Arbeitsgemeinschaft Gynäkologische Onkologie Ovarian Cancer Study Group. A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer. J Natl Cancer Inst 2003;95(17):1320-9
  • Ozols RF, Bundy BN, Greer BE, et al. Gynecologic Oncology Group. Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. J Clin Oncol 2003;21(17):3194-200
  • McGuire WP, Hoskins WJ, Brady MF, et al. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N Engl J Med 1996;334(1):1-6
  • Piccart MJ, Bertelsen K, James K, et al. Randomized intergroup trial of cisplatin-paclitaxel versus cisplatin-cyclophosphamide in women with advanced epithelial ovarian cancer: three-year results. J Natl Cancer Inst 2000;92(9):699-708
  • Diaz-Montes TP, Bristow RE. Secondary cytoreduction for patients with recurrent ovarian cancer. Curr Oncol Rep 2005;7(6):451-8
  • Stuart GC, Kitchener E, Bacon H, et al. 2010 Gynecologic Cancer InterGroup (GCIG) consensus statement on clinical trials in ovarian cancer: report from the Fourth Ovarian Cancer Consensus Conference. Int J Gynecol Cancer 2011;21(4):750-5
  • Herzog TJ, Armstrong DK, Brady MF, et al. Ovarian cancer clinical trial endpoints: society of Gynecologic Oncology white paper. Gynecol Oncol 2014;132(1):8-17
  • Katsumata N, Yasuda M, Isonishi S, et al. Japanese Gynecologic Oncology Group. Long-term results of dose-dense paclitaxel and carboplatin versus conventional paclitaxel and carboplatin for treatment of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (JGOG 3016): a randomised, controlled open-label trial. Lancet Oncol 2013;14(10):1020-6
  • Katsumata N, Yasuda M, Takahashi F, et al. Japanese Gynecologic Oncology Group. Dose-dense paclitaxel once a week in combination with carboplatin every 3 weeks or advanced ovarian cancer: a phase 3, open-label, randomised controlled trial. Lancet 2009;374(9698):1331-8
  • Burg ME, Janssen JT, Ottevanger PB, et al. Multicenter randomized phase III trial of 3-weekly paclitaxel/platinum (PC3w) versus weekly paclitaxel/platinum (PCw) induction therapy followed by PC3w maintenance therapy in advanced epithelial ovarian cancer (EOC) [abstract 5538]. J Clin Oncol 2009;27(Suppl):15s
  • Pignata S, Scambia G, Lauria R, et al. A randomized multicenter phase III study comparing weekly versus every 3 weeks carboplatin (C) plus paclitaxel (P) in patients with advanced ovarian cancer (AOC): Multicenter Italian Trials in Ovarian Cancer (MITO-7)—European Network of Gynaecological Oncological Trial Groups (ENGOT-ov-10) and Gynecologic Cancer Intergroup (GCIG) trial. J Clin Oncol 2013;31(Suppl):abstract LBA5501
  • du Bois A, Reuss A, Pujade-Lauraine E, et al. Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: a combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials: by the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d’Investigateurs Nationaux Pour les Etudes des Cancers de l’Ovaire (GINECO). Cancer 2009;115(6):1234-44
  • Bookman MA, Brady MF, McGuire WP, et al. Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: a phase III trial of the Gynecologic Cancer InterGroup. J Clin Oncol 2009;27(4):1419-25
  • Gore M, du Bois A, Vergote I. Intraperitoneal chemotherapy in ovarian cancer remains experimental. J Clin Oncol 2006;24(28):4528-30
  • Oliner J, Min H, Leal J, et al. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell 2004;6(5):507-16
  • Herbst RS, Hong D, Chap L, et al. Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors. J Clin Oncol 2009;27(21):3557-65
  • Mita AC, Takimoto CH, Mita M, et al. Phase 1 study of AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, in combination with chemotherapy in adults with advanced solid tumors. Clin Cancer Res 2010;16(11):3044-56
  • Doi T, Ohtsu A, Fuse N, et al. Phase 1 study of trebananib (AMG 386), an angiogenesis targeting angiopoietin-1/2 antagonist, in Japanese patients with advanced solid tumors. Cancer Chemother Pharmacol 2013;71(1):227-35
  • Karlan BY, Oza AM, Richardson GE, et al. Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer. J Clin Oncol 2012;30(4):362-71
  • Monk BJ, Poveda A, Vergote I, et al. LATE BREAKING ABSTRACT: A phase III, randomized, double-blind trial of weekly paclitaxel plus the angiopoietin 1 and 2 inhibitor, trebananib, or placebo in women with recurrent ovarian cancer: TRINOVA-1. Eur J Cancer 2013;49(Suppl):abstract 41
  • TRI-NOVA-2: trebananib in ovarian cancer-2. ClinicalTrials.gov. 2013. Available from: http://clinicaltrial.gov/ct2/show/NCT01281254 [Last accessed 27 January 2014]
  • TRI-NOVA-3: a study of AMG 386 or AMG 386 placebo in combination with paclitaxel and carboplatin to treat ovarian cancer. ClinicalTrials.gov. 2013. Available from: http://clinicaltrial.gov/ct2/show/NCT01493505 [Last accessed 17 February 2014]
  • Burger RA, Brady MF, Bookman MA, et al. Gynecologic Oncology Group. Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med 2011;365(26):2473-83
  • Perren TJ, Swart AM, Pfisterer J, et al. ICON7 Investigators. A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med 2011;365(26):2484-96
  • Oza AM, Perren TJ, Swart AM, et al. Late breaking abstract: ICON7: final overall survival results in the GCIG phase III randomized trial of bevacizumab in women with newly diagnosed ovarian cancer. Eur J Cancer 2013;49(Suppl):abstract 6
  • Pujade-Lauraine E, Hipert F, Weber P, et al. AURELIA: A randomized phase III trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum (PT)-resistant recurrent ovarian cancer (OC). J Clin Oncol 2012;30(Suppl):abstract LBA5002
  • Witteveen P, Lortholary A, Fehm T, et al. LATE BREAKING ABSTRACT: Final overall survival (OS) results from AURELIA, an open-label randomised phase III trial of chemotherapy (CT) with or without bevacizumab (BEV) for platinum-resistant recurrent ovarian cancer (OC). Eur J Cancer 2013;49(Suppl):abstract 5
  • Aghajanian C, Blank SV, Goff BA, et al. OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol 2012;30(17):2039-45
  • Eskander RN, Randall LM. Bevacizumab in the treatment of ovarian cancer. Biologics 2011;5:1-5
  • Sloan B, Scheinfeld NS. Pazopanib, a VEGF receptor tyrosine kinase inhibitor for cancer therapy. Curr Opin Investig Drugs 2008;9(12):1324-35
  • Friedlander M, Hancock KC, Rischin D, et al. A Phase II, open-label study evaluating pazopanib in patients with recurrent ovarian cancer. Gynecol Oncol 2010;119(1):32-7
  • Oaknin A, Gonzalez-Martin A, García Y, et al. A phase II study of pazopanib in recurrent or persistent ovarian (EOC), peritoneal (PPC), or fallopian tube cancer (FTC): a Spanish Ovarian Cancer Group (GEICO) study. J Clin Oncol 2012;30(Suppl):abstract 5068
  • Du Bois A, Floquet A, Kim JW, et al. Randomized, double-blind, phase III trial of pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (AEOC): results of an international Intergroup trial (AGO-OVAR16). J Clin Oncol 2013;13(Suppl):abstract LBA5503
  • Pazopanib hydrochloride, paclitaxel, and carboplatin in treating patients with refractory or resistant ovarian epithelial cancer, fallopian tube cancer, or peritoneal cancer. ClinicalTrials.gov. 2013. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01402271 [Last accessed 4 September 2013]
  • Hilberg F, Roth GJ, Krssak M, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 2008;68(12):4774-82
  • Ledermann JA, Hackshaw A, Kaye S, et al. Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer. J Clin Oncol 2011;29(28):3798-804
  • du Bois A, Kristensen G, Ray-Coquard I, et al. AGO-OVAR 12: A randomized placebo-controlled GCIG/ENGOT-INTERGROUP phase III trial of standard frontline chemotherapy +/- nintedanib for advanced ovarian cancer. Int J Gynecol Cancer 2013;23(8):abstract
  • ENGOT Trials. European Society of Gynaecological Oncology. 2013. Available from: http://www.esgo.org/engot/Pages/ENGOTTrials.aspx [Last accessed 4 September 2013]
  • Dantzer F, de La Rubia G, Menissier-De Murcia J, et al. Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1. Biochemistry 2000;39(25):7559-69
  • Ramus SJ, Gayther SA. The contribution of BRCA1 and BRCA2 to ovarian cancer. Mol Oncol 2009;3(2):138-50
  • Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009;361(2):123-34
  • Audeh MW, Carmichael J, Penson RT, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 2010;376(9737):245-51
  • Kaye SB, Lubinski J, Matulonis U, et al. Phase II open label, randomized, multicentre study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor to pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer. J Clin Oncol 2012;30(4):372-9
  • Ledermann JA, Harter P, Gourley C, et al. Phase II randomized placebo-controlled study of olaparib (AZD2281) in patients with platinum-sensitive relapsed serous ovarian cancer (PSR SOC). J Clin Oncol 2011;29(Suppl 15):abstract 5003
  • Ledermann JA, Harter P, Gourley C, et al. Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer (SOC) and a BRCA mutation (BRCAm). J Clin Oncol 2013;31(Suppl 15):abstract 5505
  • Gelmon KA, Tischkowitz M, Mackay H, et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol 2011;12(9):852-61
  • Donawho CK, Luo Y, Luo Y, et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res 2007;13(9):2728-37
  • A trial of ABT-888 in combination with temozolomide versus pegylated liposomal doxorubicin alone in ovarian cancer. ClinicalTrials.gov. 2013. Available from: http://clinicaltrials.gov/ct2/show/NCT01113957 [Last accessed 4 September 2013]
  • ABT-888 with cyclophosphamide in refractory BRCA-positive ovarian, primary peritoneal or ovarian high-grade serous carcinoma, fallopian tube cancer, triple-negative breast cancer, and low-grade non-Hodgkin’s lymphoma. ClinicalTrials.gov. 2013. Available from: http://clinicaltrials.gov/ct2/show/NCT01306032 [Last accessed 4 September 2013]
  • Veliparib in treating patients with persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer. ClinicalTrials.gov. 2013. Available from: http://clinicaltrials.gov/ct2/show/NCT01540565 [Last accessed 15 May 2013]
  • Jones P, Altamura S, Boueres J, et al. Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem 2009;52(22):7170-85
  • Sandhu SK, Schelman WR, Wilding G, et al. The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial. Lancet Oncol 2013;14(9):882-92
  • A maintenance study with niraparib versus placebo in patients with platinum sensitive ovarian cancer. ClinicalTrials.gov. 2013. Available from: http://clinicaltrial.gov/ct2/show/NCT01847274 [Last accessed 4 September 2013]
  • Shen Y, Feng Y, Wang B, et al. LT-00673, a highly potent PARPIs, shows antitumor activity against tumor cells with DNA repair deficiencies. [Poster:4098] Presented at the American Association for Cancer Research Annual Meeting; 17-21 April 2010; Washington, DC
  • Study of BMN 673, a PARP inhibitor, in patients with advanced or recurrent solid tumors. ClinicalTrials.gov. 2013. Available from: http://clinicaltrial.gov/ct2/show/NCT01286987 [Last accessed 4 September 2013]
  • Wang DD, Kern KA, Carpentieri M, et al. Absolute bioavailability of PF-01367338 tablets following oral administration in cancer patients. J Clin Oncol 2011;29(Suppl):abstract e13615
  • Molife LR, Roxburgh P, Wilson RH, et al. A phase I study of oral rucaparib in combination with carboplatin. J Clin Oncol 2013;31(Suppl):abstract 2586
  • Kristeleit RS, Shapiro G, LoRusso P, et al. A phase I dose-escalation and PK study of continuous oral rucaparib in patients with advanced solid tumors. J Clin Oncol 2013;31(Suppl):abstract 2585
  • Parker N, Turk MJ, Westrick E, et al. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem 2005;338(2):284-93
  • Miotti S, Bagnoli M, Ottone F, et al. Simultaneous activity of two different mechanisms of folate transport in ovarian carcinoma cell lines. J Cell Biochem 1997;65(4):479-91
  • Ebel W, Routhier EL, Foley B, et al. Preclinical evaluation of MORAb-003, a humanized monoclonal antibody antagonizing folate receptor-alpha. Cancer Immun 2007;7:6
  • Dosio F, Milla P, Cattel L. EC-145, a folate-targeted Vinca alkaloid conjugate for the potential treatment of folate receptor-expressing cancers. Curr Opin Investig Drugs 2010;11(12):1424-33
  • Konner JA, Bell-McGuinn KM, Sabbatini P, et al. Farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer: a phase I study. Clin Cancer Res 2010;16(21):5288-95
  • White AJ, Coleman RL, Armstrong DK, et al. Efficacy and safety of farletuzumab, a humanized monoclonal antibody to folate receptor alpha, in platinum-sensitive relapsed ovarian cancer subjects: Final data from a multicenter phase II study. J Clin Oncol 2010;28(Suppl 15):abstract 5001
  • An efficacy and safety study of MORAb-003 in platinum-resistant or refractory relapsed ovarian cancer (FAR-122). ClinicalTrials.gov. 2012. Available from: http://clinicaltrial.gov/ct2/show/NCT00738699 [Last accessed 4 September 2013]
  • Efficacy and safety of MORAb-003 in subjects with platinum-sensitive ovarian cancer in first relapse. ClinicalTrials.gov. 2013. Available from: http://clinicaltrial.gov/ct2/show/NCT00849667 [Last accessed 4 September 2013]
  • Reddy JA, Bloomfield A, Nelson M, et al. Combination studies of EC145 with approved anti-cancer drugs for ovarian cancer. Cancer Res 2011;71(Suppl 8):abstract 2570
  • Naumann RW, Coleman RL, Burger RA. PRECEDENT: A randomized phase II trial comparing EC145 and pegylated liposomal doxorubicin (PLD) in combination, versus PLD alone, in subjects with platinum-resistant ovarian cancer. J Clin Oncol 2011;29(Suppl 15):abstract 5045
  • Study for women with Platinum Resistant Ovarian Cancer Evaluating EC145 in combination with Doxil® (PROCEED). ClinicalTrials.gov. Available from: http://clinicaltrial.gov/ct2/show/NCT01170650 [Last accessed 5 February 2014]
  • Miller CR, Oliver KE, Farley JH. MEK 1/2 inhibitors in the treatment of gynecologic malignancies. Gyn Oncol 2014. [ Epub ahead of print]
  • Farley J, Brady WE, Vathipadiekal V, et al. Selumetinib in women with recurrent low-grade serous carcinoma of the ovary or peritoneum: an open-label, single-arm phase 2 study. Lancet Oncol 2013;14:134-40
  • A study of MEK162 vs. physician’s choice chemotherapy in patients with low-grade serous ovarian, fallopian tube or peritoneal cancer. ClinicalTrials.gov. 2014. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01849874?term=NCT01849874 [Last accessed 28 January 2014]
  • Study of MEK162 and paclitaxel in patients with epithelial ovarian, fallopian tube or peritoneal cancer. ClinicalTrials.gov. 2014. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01649336?term=NCT+01649336 [Last accessed 28 January 2014]
  • Trial of pimasertib with SAR245409 or Placebo in ovarian cancer. ClinicalTrials.gov. 2014. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01936363?term=NCT01936363 [Last accessed 28 January 2014]
  • Faul MM, Gillig JR, Jirousek MR, et al. Acyclic N-(azacycloalkyl) bisindolylmaleimides: isozyme selective inhibitors of PKCbeta. Bioorg Med Chem Lett 2003;13(11):1857-9
  • Suzuma K, Takahara N, Suzuma I, et al. Characterization of protein kinase C beta isoform’s action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci USA 2002;99(2):721-6
  • Xia P, Aiello LP, Ishii H, et al. Characterization of vascular endothelial growth factor’s effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest 1996;98(9):2018-26
  • Aeder SE, Martin PM, Soh JW, et al. PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways. Oncogene 2004;23(56):9062-9
  • Kawakami Y, Nishimoto H, Kitaura J, et al. Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion. J Biol Chem 279:47720-5.2004
  • Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 22:2954-63.2004
  • Carnero A, Blanco-Aparicio C, Renner O, et al. The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 2008;8(3):187-98
  • Graff JR, McNulty AM, Hanna KR, et al. The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 2005;65(16):7462-9
  • Bräutigam K, Bauerschlag DO, Weigel MT, et al. Combination of enzastaurin and pemetrexed inhibits cell growth and induces apoptosis of chemoresistant ovarian cancer cells regulating extracellular signal-regulated kinase 1/2 phosphorylation. Transl Oncol 2009;2(3):164-73
  • Keyes KA, Mann L, Sherman M, et al. LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice. Cancer Chemother Pharmacol 2004;53(2):133-40
  • Cadron I, Van Gorp T, Mihalyi A, et al. The impact of enzastaurin (LY317615.HCl) on CA125 biosynthesis and shedding in ovarian cancer cells. Gynecol Oncol 2010;118(1):64-8
  • Camidge DR, Gail Eckhardt S, Gore L, et al. A phase I safety, tolerability, and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced solid tumors. Anticancer Drugs 2008;19(1):77-84
  • Welch P, Musib L, Darstein C, et al. Effects of a proton pump inhibitor (lansoprazole) and food on the bioavailability of enzastaurin administered as single oral doses to healthy subjects. J Clin Oncol 2007;25(Suppl 18):abstract 14076
  • Welch PA, Sinha VP, Cleverly AL, et al. Safety, tolerability, QTc evaluation, and pharmacokinetics of single and multiple doses of enzastaurin HCl (LY317615), a protein kinase C-beta inhibitor, in healthy subjects. J Clin Pharmacol 2007;47(9):1138-51
  • Carducci MA, Musib L, Kies MS, et al. Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer. J Clin Oncol 2006;24(25):4092-9
  • Robertson MJ, Kahl BS, Vose JM, et al. Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma. J Clin Oncol 2007;25(13):1741-6
  • Rademaker-Lakhai JM, Beerepoot LV, Mehra N, et al. Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer. Clin Cancer Res 2007;13(15 Pt 1):4474-81
  • Hanauske AR, Lahn M, Musib LC, et al. Phase Ib safety and pharmacokinetic evaluation of daily and twice daily oral enzastaurin in combination with pemetrexed in advanced/metastatic cancer. Ann Oncol 2009;20(9):1565-75
  • Vergote I, Amant F, Oskay-Oezcelik G, et al. Carboplatin and paclitaxel in combination with oral enzastaurin in advanced ovarian or primary peritoneal cancer: results from a safety lead-in study. Int J Gynecol Cancer 2009;19(9):1505-10
  • Usha L, Sill MW, Darcy KM, et al. A Gynecologic Oncology Group phase II trial of the protein kinase C-beta inhibitor, enzastaurin and evaluation of markers with potential predictive and prognostic value in persistent or recurrent epithelial ovarian and primary peritoneal malignancies. Gynecol Oncol 2011;121(3):455-61
  • Vergote I, Chekerov R, Amant F, et al. Randomized, phase 2, placebo-controlled, double-blind study with and without enzastaurin in combination with paclitaxel and carboplatin as first-line treatment, followed by maintenance treatment in advanced ovarian cancer. J Clin Oncol 2013;31(25):3127-32
  • Nwankwo N, Zhang Z, Wang T, et al. Phase I study of enzastaurin and bevacizumab in patients with advanced cancer: safety, efficacy and pharmacokinetics. Invest New Drugs 2013;31(3):653-60
  • Evaluation of enzastaurin in the treatment of persistent or recurrent ovarian or primary peritoneal cancer. ClinicalTrials.gov. 2013. Available from: http://clinicaltrial.gov/ct2/show/NCT00420381 [Last accessed 27 January 2014]
  • Dreicer R, Garcia J, Rini B, et al. A randomized, double-blind, placebo-controlled, Phase II study with and without enzastaurin in combination with docetaxel-based chemotherapy in patients with castration-resistant metastatic prostate cancer. Invest New Drugs 2013;31(4):1044-50
  • Padda SK, Krupitskaya Y, Chhatwani L, et al. A phase I dose-escalation and pharmacokinetic study of enzastaurin and erlotinib in patients with advanced solid tumors. Cancer Chemother Pharmacol 2012;69(4):1013-20
  • Chiappori A, Bepler G, Barlesi F, et al. Phase II, double-blinded, randomized study of enzastaurin plus pemetrexed as second line therapy in patients with advanced non-small cell lung cancer. J Thorac Oncol 2010;5(3):369-75
  • Hainsworth JD, Arrowsmith ER, McCleod M, et al. Randomized phase II study of R-CHOP plus enzastaurin versus R-CHOP in the first-line treatment of patients with intermediate- and high-risk diffuse large B-cell lymphoma (DLBCL): preliminary analysis. J Clin Oncol 2011;29(Suppl):abstract 8016
  • Querfeld C, Kuzel TM, Kim YH, et al. Multicenter phase II trial of enzastaurin in patients with relapsed or refractory advanced cutaneous T-cell lymphoma. Leuk Lymphoma 2011;52(8):1474-80
  • Fine HA, Kim L, Royce C, et al. Results from phase II trial of enzastaurin (LY317615) in patients with recurrent high grade gliomas. J Clin Oncol 2005;23(Suppl):abstract 1504
  • Wick W, Puduvalli VK, Chamberlain MC, et al. Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J Clin Oncol 2010;28(7):1168-74
  • Crump M, Leppä S, Fayad LE, et al. Phase III study of enzastaurin in patients with high-risk diffuse large B cell lymphoma following response to primary treatment: the Prelude trial [abstract]. Blood 2013;122(21):371

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.