Tocolytic therapies in development for preterm labour

References

• VVISCHNEK A: Risk-benefit assessment of tocolytic drugs. Drug Safety (1991) 6(5):371–380.
   PubMed Web of Science ®Google Scholar
• Survey about current therapeutical procedures, critical consideration of indications in view of modem neonatologic concepts
   Google Scholar
• ICEIRSE M, GRANT A, KING J: Preterrn labour. In: Effective Care in Pregnancy and Childbirth Chalmers I, Enkin M,Keirse M (Eds), Oxford University Press, Oxford, 1989, p694–745.
   Google Scholar
• Evaluation of all randomised and controlled studies concerning management of pregnancy and childbirth
   Google Scholar
• ZAHN V: Physiologie der Uteruskontraktionen. Z. Ge- burts. Perinat (1978) 182:263–267.
   Google Scholar
• First publication dealing with physiologic uterine motility during pregnancy
   Google Scholar
• ZIMMER A: Einmalapplikation, Mehrfachapplikation und Metabolitenmuster von Clenbuterol bei Menschen. Arzn. Forsch /Drug Res. (1976) 26:1446–1450.
   PubMedGoogle Scholar
• WISCHNIK A, HERMER M, ALBERTI W: Clenbuterol als neues Tokolytikum zur oralen Anwendung - Klinische Ergebnisse. In: Neueste Ergebnisse fiber Betamimetika Jung H, Fendel H, Karl C (Eds) Steinkopff Verlag Darmstadt, 1986, p88–99.
   Google Scholar
• WISCHNIK A, HOTZINGER H, SCHROLL A, TRENKWALDER U, WISCHNIK B, HEIMISCH W, WEIDENBACH A: Clen-buterol und Fenoterol - Tierexperimenteller Vergleich zweier Tokolytika. Z. Geburtsb. u. Perinat (1984) 188:228–233.
   PubMedGoogle Scholar
• BERG G, ANDERSSON RGG, RYDEN G: Effects of selective beta-adrenergic agonists on spontaneous contractions, cAMP levels and phosphodiesterase activity in myometrial strips from pregnant women treated with terbutaline. Gynecol. Obstet. Invest. (1982) 14:56–64
   PubMed Web of Science ®Google Scholar
• RYDEN G, ANDERSSON RGG, BERG G: Is the relaxing effect of betaadrenergic agonists on human myometrhun only transitory? Acta Obstet. Gynecol. Scan. (1982) 108(Suppl.):47–51.
   Google Scholar
• BERG G, ANDERSSON RGG, RYDEN G: Beta-adrenergic receptors in human myometriuna during pregnancy: Changes in the number after beta-mimetic treatment. Am. J. Obstet. Gynecol. (1985) 151:392–396.
   PubMed Web of Science ®Google Scholar
• Important publication for the understanding of the `downregulation' during tocolytic treatment.
   Google Scholar
• SPÄTLING L, FALLENSTEIN F, SCHNEIDER H, DANCIS J: Bolus tocolysis: Treatment of preterm labour with pul-satile administration of a beta-adrenergic agonist Am. J. Obstet. Gynecol. (1989) 160:713–717.
   Google Scholar
• New concept for administration of tocolytics considering uterine contraction physiology and release charasteristics of adrenergic substances.
   Google Scholar
• FALLENSTEIN F, SPATLING L, BEHRENS C, ABDALLAH A: Wehengesteuerte Bolustokolyse. In: Bolustokolyse in Tbeorie und Praxis Spaling L, Fallenstein F (Eds), Steinkopff Verlag Darmstadt, 1993, P135–139.
   Google Scholar
• First concept of 'intelligent' administration of tocolytics, triggered by uterine contractions.
   Google Scholar
• ALLBERT JR, WISE CA, LOU CH, GOOKIN KS, PARMENTER MA, MORRISON JC: Subcutaneous tocolytic infusion therapy for patients at very high risk for preterm birth. PerinatoL (1992) 12:28–31.
   PubMedGoogle Scholar
• Study about the possibility of parenteral tocolytic therapy on an ambulatory basis.
   Google Scholar
• KULLANDER S, SVANBERG L: On resorption and the effects of vaginally administered terbutaline in women with premature labor. Acta Obstet Gynecol. Scand. (1985) 64:613–616.
   PubMed Web of Science ®Google Scholar
• One of the few studies dealing with the possibility of local (vaginal) adnünsitration of a tocolytic.
   Google Scholar
• STRIGL R, PEER. tt,R U, ERHARDT W, BLHMEL G: Bietet der Kalziumantagonist Verapamil bei der Tokolyse mit Beta-Sympathikomimetika den erwarteten Schutz vor Myokardschäden. Geburtsb. u. Frauenbeilk. (1980) 40:500–506.
   PubMedGoogle Scholar
• This paper was essential for the disproval of useless comedications with verapamil, meant to act as cardioprotection.
   Google Scholar
• ROBERTS JM: Current understanding of pharmacologic mechanisms in the prevention of pre-term birth. Clin. Obstet. Gynecol. (1984) 27:592–605.
   PubMed Web of Science ®Google Scholar
• VEILLE JC, BISSONNETTE JM, HOHIMER AR: The effect of a calcium channel blocker (nifedipine) on uterine blood flow in the pregnant goat Am. J. Obstet. Gynecol. (1986) 1160–1163.
   Google Scholar
• Important experimental study for the understanding of possible foetal side effects of calcium channel blockers.
   Google Scholar
• ULMSTEN U, ANDERSSON ICE, WINGERUP L: Treatment of premature labour with the calcium antagonist nffedip-ine. Arch. Gynecol. (1980) 229:1–5.
   PubMedGoogle Scholar
• Important clinical study about the clinical use of calcium channel blockers.
   Google Scholar
• ULMSTEN U: Treatment of normotensive and hyperten-sive patients with preterm labour using oral nifedipine, a calcium antagonist Arch. Gynecol. (1984) 236:69–72.
   Google Scholar
• GOLICHOWSICI AM, HATHAWAY DR, FINEBERG N, PELEG D: Tocolytic and hemodynamic effects of nifedipine In the ewe. Am. J. Obstet. Gynecol. (1985) 151:1134-1140. As [16].
   Google Scholar
• HILTMANN W D, WISCHNIK A: Magnesium und foetaler BlutfluP. In: Medizin, Management, Magnesium. Weidinger H (Ed) Blackwell Ueberreuther, Berlin, 1990 n321-324. First study about the acute foetal haemodynamic effect of bolus administration of magnesium sulphate as physiologic calcium an-tagonist
   Google Scholar
• MURRAY C, HAVERICAMP AD, ORLEANS M, BERGA S, PECHT D: Nifedipine for treatment of preterm labour a historic prospective study. Am.J. Obstet. Gynecol. (1992) 167(1):52–36.
   PubMed Web of Science ®Google Scholar
• HAAS HG, MEYER R, STEGEMANN M: Calcium-Magne- sium-Interaktion am Herztnuskel: Reaktionen an derZelloberfläche. In: Medizin, Managment, Magnesium. Weidinger H (Ed) Blackwell Uebereuter, Berlin, 1990, p184–198.
   Google Scholar
• Very important in vitro study for the understanding of the calcium antagonistic mechanism of magnesium at the cell membrane
   Google Scholar
• MELIN P, TROJNAR J, JOHANSSON B, VILHARDT H, AKER- LUND M: Synthetic antagonists of the myometrial re-sponse to vasopressin and oxytocin. J. Endocrinol. (1986) 111:125–131.
   PubMed Web of Science ®Google Scholar
• MANNING M, SAWYER WTI: Discovery, development and some uses of vasopressin and oxytocin antagonists. J. Lab. Clin. Med. (1989) 114:617–632.
   PubMedGoogle Scholar
• PM I IBONE DJ, CLINESCHMIDT BV, ANDERSON PS: A structurally unique, potent and selective oxytocin an-tagonist derived from Streptontyces silvensis. Endocri-nology (1989) 125:217–222.
   PubMed Web of Science ®Google Scholar
• -25] present the first clinical applicable oxytocin antagonists with peptidyl structure.
   Google Scholar
• PHIIIBONE DJ, CLINESCHMIDT By, KISHEL MT, US EV, REISS DR, WOYDEN CJ, EVANS BE, FREIDINGER RM,VEBER OF, COOK MJ, HALUSKA GJ, NOVY MJ, LOWEN-SOHN RI: Identification of an orally active, nonpeptidyl oxytocin antagonist. J. PharmacoL Exp. Ther. (1993) 264.
   Google Scholar
• First publication of an orally active oxytocin antagonist.
   Google Scholar
• AKERLUND M, STROMBERG P, HAU1CSSON A: Inhibition of uterine contractions of premature labour with an oxytocin analogue. Results from a pilot study. Br. J. Obstet. Gynaecol. (1987) 94:1040–1044.
   PubMed Web of Science ®Google Scholar
• ANDERSEN LF, LYNDRUP J, AKERLUND M, MELIN P: Oxy- tocin receptor blockade: A new principle in the treat-ment of pretermlabour. Am.J.PerinatoL (1989) 6:196-199. 1271 and 1281 are reports of clinical use of oxytocin antagonists.
   Google Scholar
• MELIN, P. Oxytocin antagonists and their therapeutic use. Regulatory Peptides (1993) 45:285–288.
   PubMed Web of Science ®Google Scholar
• EVANS BE, LEIGHTON JL, RITTLE ICE, GILBERT KF, LUN-DELL GF, GOULD NP, HOBBS DW, DIPARDO RM, VEBER DF, PEI TIBONE DJ: Orally active, nonpeptide oxytocine antagonists. J. Med. Chem. (1992) 35(21):3919–27.
   PubMed Web of Science ®Google Scholar
• GUZICK DS, WINN K: The association of preterm labour with preterm delivery. Obstet. Gynecol. (1985) 65:11–15.
   PubMed Web of Science ®Google Scholar
• GOYERT G, WOLFE H, BHATIA R, NORMAN G, FARAG AM, MAMMEN E: Evaluation of potential early markers of chorioamnionitis associated with preterm premature ruptured membranes. Am. J. Perinatol. (1990) 7:33-35. Evaluation of serum infection parameters for early detection of chorioamnionitis.
   Google Scholar
• LOCKWOOD JL, SENYEI AE, DISCHE MR, CASAL D, SHAH KD, THUNG SN, JONES L, DELIGDISCH L, GARITE TJ: Foetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery. New Engl. J. Med. (1991) 325:669–674.
   PubMed Web of Science ®Google Scholar
• Evaluation of local fibronectin concentrations as an early detection parameter for chorioamnionitis.
   Google Scholar
• SALING E, BRAND-NIEBELSCHÜTZ S, SCHMITZ C: Ver- meidung von Spätaborten und risikoreichen Frühge-burten - ftir die Routine geeignete MaDnahmen. Z. Geburtsh. u. Perinat. (1991) 195:209–221.
   PubMedGoogle Scholar
• System for the prevention and early detection of ascending genital infections adapted to the possibilities in ambulatory routine.
   Google Scholar
• DUFF P, KOPELMAN JN: SubclinirAl intra-amniotic infec-tion in asymptomatic patients with refractory preterm labor. Obstet. Gynecol. (1987) 69:756–759.
   PubMed Web of Science ®Google Scholar
• HAMEED C, TEJANI N, VERMA LTL: Silent chorioanutioni-tis as a cause of preterm labour refractory to tocolytic therapy. Am. J. Obstet. Gynecol. (1984) 149:726–730.
   PubMed Web of Science ®Google Scholar
• HATJIS CG, SWAIN M: Systemic tocolysis for premature labor is associated with an increased incidence of pulmonary edema in the presence of maternal infec-tion. Am. J. Obstet. Gynecol. (1988) 159:723–728.
   PubMed Web of Science ®Google Scholar
• WEIDINGER H, PASSLOER HJ, KOVACS L, BERLE P: Nutzen der prophylaktischen Vagina inntiseptik mit Hexetidin In Geburtshilfe und Gynäkologie. Geburts. u. Frauen-heilk. (1991) 51:929–935.
   PubMedGoogle Scholar
• Synopsis of the bacteriocidaVbacteriostatic properties of a new vaginal antiseptic.
   Google Scholar
• MCGREGOR JA, FRENCH JI, RELLER LB: Adjunctive erythromycine treatment for idiopathic preterm labor: Results of a prospective, double-blind, placebo control-led trial. Am. J. Obstet. Gynecol. (1986) 154:98–103.
   PubMed Web of Science ®Google Scholar
• MCGREGOR JA, FRENCH JI, KYUNG SEO: Antimicrobial therapy in preterm premature rupture of membranes:
   Google Scholar
• Results of a prospective, double blind placebo control-led trial of erythromycin. Am. J. Obstet. Gynecol. (1991) 165:632–640 [39]and [40] are studies dealing with the possibilities of systemic antibiotic therapy in preterm labour/premature rupture of mem-branes.
   Google Scholar
• WIQVIST N: The use of inhibitors of prostaglandin synthesis in obstetrics. In: Human Parturition. Keirse MJNC, Anderson ABM, Berinebroek Gravenhorst J (Eds), Martinus Nijhoff, The Hague, 1979, p189–200.
   Google Scholar
• ZUCICERMAN H, SHALEV E, GILAD G, KATZUNI E: Further study of the inhibition of premature labor by in-domethacin. Part II. Double blind study. J. Perinat. Med. (1984) 12:25–29. [41] and [421 are the first studies dealing with the possibilities of indomethacin as a prostaglandin synthesis inhibitor for tocolytic therapy.
   PubMed Web of Science ®Google Scholar
• GROSPIETSCH G: ZUSATZ BZW. Begleittherapie. In: Toko-lyse mit Betastimulatoren, Grospietsch G, Kuhn W (Eds.) Thieme, Stuttgart, New York, 1983, p186–187.
   Google Scholar
• CARLAN SJ, O'BRIAN WF, O'LEARY 11D, MASTROGIANNIS D: Randomized comparative trial of indomethacine and sulindac for treatment of refractory pre-term labour. Obstetrics and Gynecology (1992) 79:223–228.
   PubMed Web of Science ®Google Scholar
• TIEERY M, AMY JJ: Inhibition of labour. In: Prostaglandins, and their inhibitors in clinical obstetrics and gynecology. Bygdeman M, Berger GS, Keith LG (Eds), MTP Press Ltd., Lancaster, 1986, p203–231.
   Google Scholar
• QUAAS L, HOFFMANN B, ZAHRADNIK HP: Wechsel- wirkungen von Sexualsteroiden, Prostaglandinen (6-keto-PGF1a, PGF2a) und 13-adrenergen Agonisten (Adrenalin, Fenoterol-PartusistenR) int menschlichen nicht-schwangeren Myometrium in vitro. Z. Geburtsh. u. Perinat. (1986) 190:204–209.
   PubMedGoogle Scholar
• Important in vitro study for the understanding of the involvement of prostacyclin in the pharmacologic action of tocolytics.
   Google Scholar
• BROUGHTON PIPIUN F, SYMONDS EM: Pregnancy-in-duced hypertension. In: Prostaglandins, and their inhibi-tors in clinical obstetrics and gynecology. Bygdexnan M, Berger GS, Keith LG (Eds) MTP Press Ltd., Lancaster, 1986, p337–366.
   Google Scholar
• INTERSAN (Institute for clinical and pharmaceutical investi-gations) (Ed): Prostacyclin-Synthese-Stimulation in der Hochdrucktherapie (1989) Mainzer Verlagsanstalt.
   Google Scholar