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The pharmacological treatment of nystagmus: a review

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Pages 1805-1816 | Published online: 14 Jul 2009

Bibliography

  • Gottlob I. Nystagmus. Curr Opin Ophthalmol 2001;12(5):378-83
  • Stahl J, Plant G, Leigh R. Medical treatment of nystagmus and its visual consequences. J R Soc Med 2002;95:235-7
  • Curcio CA, Sloan KR, Kalina RE, Hendrickson AE. Human photoreceptor topography. J Comp Neurol 1990;292(4):497-523
  • Chung ST, Bedell HE. Velocity criteria for “foveation periods” determined from image motions simulating congenital nystagmus. Optom Vis Sci 1996;73(2):92-103
  • Leigh RJ, Zee DS. The neurology of eye movements. 4th edition. Oxford: Oxford University Press; 2006
  • Choudhuri I, Sarvananthan N, Gottlob I. Survey of management of acquired nystagmus in the United Kingdom. Eye 2007;21(9):1194-7
  • Abadi RV, Bjerre A. Motor and sensory characteristics of infantile nystagmus. Br J Ophthalmol 2002;86(10):1152-60
  • van der Geest JN, Frens MA. Recording eye movements with video-oculography and scleral search coils: a direct comparison of two methods. J Neurosci Methods 2002;114(2):185-95
  • Roberti G, Russo P, Segre G. Spectral analysis of electro-oculograms in the quantitative evaluation of nystagmus surgery. Med Biol Eng Comput 1987;25(5):573-6
  • Abadi RV, Whittle J. The nature of head postures in congenital nystagmus. Arch Ophthalmol 1991;109(2):216-20
  • Pilling RF, Thompson JR, Gottlob I. Social and visual function in nystagmus. Br J Ophthalmol 2005;89(10):1278-81
  • Stayte M, Reeves B, Wortham C. Ocular and vision defects in preschool children. Br J Ophthalmol 1993;77(4):228-32
  • Sarvananthan N, Surendran M, Roberts E et al. The Prevalence of Nystagmus: The Leicestershire Nystagmus Survey. IOVS (In Press)
  • Leigh RJ, Das VE, Seidman SH. A neurobiological approach to acquired nystagmus. Ann NY Acad Sci 2002;956:380-90
  • Bronstein AM. Vision and vertigo: some visual aspects of vestibular disorders. J Neurol 2004;251(4):381-7
  • Averbuch-Heller L, Leigh RJ. Medical treatments for abnormal eye movements: pharmacological, optical and immunological strategies. Aust NZ J Ophthalmol 1997;25(1):7-13
  • Das VE, Oruganti P, Kramer PD, Leigh RJ. Experimental tests of a neural-network model for ocular oscillations caused by disease of central myelin. Exp Brain Res 2000;133(2):189-97
  • Buttner-Ennever JA, Horn AK. Pathways from cell groups of the paramedian tracts to the floccular region. Ann NY Acad Sci 1996;781:532-40
  • Lopez LI, Bronstein AM, Gresty MA, et al. Clinical and MRI correlates in 27 patients with acquired pendular nystagmus. Brain 1996;119(Pt 2):465-72
  • Arnold DB, Robinson DA, Leigh RJ. Nystagmus induced by pharmacological inactivation of the brainstem ocular motor integrator in monkey. Vis Res 1999;39(25):4286-95
  • Straube A, Kurzan R, Buttner U. Differential effects of bicuculline and muscimol microinjections into the vestibular nuclei on simian eye movements. Exp Brain Res 1991;86(2):347-58
  • Ruigrok TJ, de Zeeuw CI, Voogd J. Hypertrophy of inferior olivary neurons: a degenerative, regenerative or plasticity phenomenon. Eur J Morphol 1990;28(2-4):224-39
  • Jabbari B, Rosenberg M, Scherokman B, et al. Effectiveness of trihexyphenidyl against pendular nystagmus and palatal myoclonus: evidence of cholinergic dysfunction. Mov Disord 1987;2(2):93-8
  • Herishanu Y, Louzoun Z. Trihexyphenidyl treatment of vertical pendular nystagmus. Neurology 1986;36(1):82-4
  • Leigh RJ, Burnstine TH, Ruff RL, Kasmer RJ. Effect of anticholinergic agents upon acquired nystagmus: a double-blind study of trihexyphenidyl and tridihexethyl chloride. Neurology 1991;41(11):1737-41
  • Barton JJ, Huaman AG, Sharpe JA. Muscarinic antagonists in the treatment of acquired pendular and downbeat nystagmus: a double-blind, randomized trial of three intravenous drugs. Ann Neurol 1994;35(3):319-25
  • Traccis S, Rosati G, Monaco MF, et al. Successful treatment of acquired pendular elliptical nystagmus in multiple sclerosis with isoniazid and base-out prisms. Neurology 1990;40(3 Pt 1):492-4
  • Schon F, Hart PE, Hodgson TL, et al. Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis.[see comment]. Neurology 1999;53(9):2209-10
  • Averbuch-Heller L, Tusa RJ, Fuhry L, et al. A double-blind controlled study of gabapentin and baclofen as treatment for acquired nystagmus. Ann Neurol 1997;41(6):818-25
  • Stahl JS, Rottach KG, Averbuch-Heller L, et al. A pilot study of gabapentin as treatment for acquired nystagmus. Neuro Ophthalmol 1996;16(2):107-13
  • Fabre K, Smet-Dieleman H, Zeyen T. Improvement of acquired pendular nystagmus by gabapentin: case report. Bull Soc Belge Ophtalmol 2001;(282):43-6
  • Bandini F, Castello E, Mazzella L, et al. Gabapentin but not vigabatrin is effective in the treatment of acquired nystagmus in multiple sclerosis: How valid is the GABAergic hypothesis? J Neurol Neurosurg Psychiatry 2001;71(1):107-10
  • Starck M, Albrecht H, Pollmann W, et al. Drug therapy for acquired pendular nystagmus in multiple sclerosis. J Neurol 1997;244(1):9-16
  • Wagner JN, Glaser M, Brandt T, Strupp M. Downbeat nystagmus: aetiology and comorbidity in 117 patients. J Neurol Neurosurg Psychiatry 2008;79(6):672-7
  • Stone LS, Lisberger SG. Visual responses of Purkinje cells in the cerebellar flocculus during smooth-pursuit eye movements in monkeys. II. Complex spikes. J Neurophysiol 1990;63(5):1262-75
  • Zee DS, Yamazaki A, Butler PH, Gucer G. Effects of ablation of flocculus and paraflocculus of eye movements in primate. J Neurophysiol 1981;46(4):878-99
  • Dieterich M, Brandt T. Functional brain imaging of peripheral and central vestibular disorders. Brain 2008;131(Pt 10):2538-52
  • Bense S, Best C, Buchholz HG, et al. 18F-fluorodeoxyglucose hypometabolism in cerebellar tonsil and flocculus in downbeat nystagmus. Neuroreport 2006;17(6):599-603
  • Kalla R, Deutschlander A, Hufner K, et al. Detection of floccular hypometabolism in downbeat nystagmus by fMRI. Neurology 2006;66(2):281-3
  • Marti S, Straumann D, Buttner U, Glasauer S. A model-based theory on the origin of downbeat nystagmus. Exp Brain Res 2008;188(4):613-31
  • Currie JN, Matsuo V. The use of clonazepam in the treatment of nystagmus-induced oscillopsia. Ophthalmology 1986;93(7):924-32
  • Young YH, Huang TW. Role of clonazepam in the treatment of idiopathic downbeat nystagmus. Laryngoscope 2001;111(8):1490-3
  • Dieterich M, Straube A, Brandt T, et al. The effects of baclofen and cholinergic drugs on upbeat and downbeat nystagmus. J Neurol Neurosurg Psychiatry 1991;54(7):627-32
  • Strupp M, Schuler O, Krafczyk S, et al. Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study.[see comment]. Neurology 2003;61(2):165-70
  • Pierrot-Deseilligny C, Milea D. Vertical nystagmus: clinical facts and hypotheses. Brain 2005;128(Pt 6):1237-46
  • Ito M, Nisimaru N, Yamamoto M. Specific patterns of neuronal connexions involved in the control of the rabbit's vestibulo-ocular reflexes by the cerebellar flocculus. J Physiol 1977;265(3):833-54
  • Leigh RJ. Potassium channels, the cerebellum, and treatment for downbeat nystagmus.[comment]. Neurology 2003;61(2):158-9
  • Strupp M, Kalla R, Glasauer S, et al. Aminopyridines for the treatment of cerebellar and ocular motor disorders. Prog Brain Res 2008;171:535-41
  • Kalla R, Glasauer S, Buttner U, et al. 4-aminopyridine restores vertical and horizontal neural integrator function in downbeat nystagmus. Brain 2007;130(Pt 9):2441-51
  • Lee AG, Brazis PW. Localizing forms of nystagmus: symptoms, diagnosis, and treatment. Curr Neurol Neurosci Rep 2006;6(5):414-20
  • Iwata A, Takao F, Kunimoto M, Inoue K. Primary position upbeat nystagmus reversed with carbamazepine. Eur J Neurol 1996;3:260-3
  • Glasauer S, Kalla R, Buttner U, et al. 4-aminopyridine restores visual ocular motor function in upbeat nystagmus. J Neurol Neurosurg Psychiatry 2005;76(3):451-3
  • Waespe W, Cohen B, Raphan T. Dynamic modification of the vestibulo-ocular reflex by the nodulus and uvula. Science 1985;228(4696):199-202
  • Cohen B, Henn V, Raphan T, Dennett D. Velocity storage, nystagmus, and visual-vestibular interactions in humans. Ann NY Acad Sci 1981;374:421-33
  • Leigh RJ, Robinson DA, Zee DS. A hypothetical explanation for periodic alternating nystagmus: instability in the optokinetic-vestibular system. Ann NY Acad Sci 1981;374:619-35
  • Cohen B, Helwig D, Raphan T. Baclofen and velocity storage: a model of the effects of the drug on the vestibulo-ocular reflex in the rhesus monkey. J Physiol 1987;393:703-25
  • Halmagyi GM, Rudge P, Gresty MA, et al. Treatment of periodic alternating nystagmus. Ann Neurol 1980;8(6):609-11
  • Nuti D, Ciacci G, Giannini F, et al. Aperiodic alternating nystagmus: report of two cases and treatment by baclofen. Italian J Neurol Sci 1986;7(4):453-9
  • Uemura T, Inoue H, Hirano T. The effects of baclofen on periodic alternating nystagmus and experimentally induced nystagmus. Adv Otorhinolaryngol 1988;42:254-9
  • Troost BT, Janton F, Weaver R. Periodic alternating oscillopsia: a symptom of alternating nystagmus abolished by baclofen. J Clin Neuro Ophthalmol 1990;10(4):273-7
  • Plant GT. Periodic alternating nystagmus in a case of hereditary ataxia and its treatment with baclofen. J Neurol Neurosurg Psychiatry 1982;45(12):1170-1
  • Larmande P. Baclofen as a treatment for nystagmus. Ann Neurol 1982;11(2):213
  • Garbutt S, Thakore N, Rucker J, et al. Effects of visual fixation and convergence on periodic alternating nystagmus due to MS. Neuro Ophthalmol 2004;28(5-6):221-9
  • Jacobs JB, Dell'Osso LF. Congenital nystagmus: hypotheses for its genesis and complex waveforms within a behavioral ocular motor system model. J Vis 2004;4(7):604-25
  • Tarpey P, Thomas S, Sarvananthan N, et al. Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus. Nat Genet 2006;38(11):1242-4
  • Dell'Osso LF, Daroff RB. Congenital nystagmus waveforms and foveation strategy. Doc Ophthalmol 1975;39(1):155-82
  • Abadi RV, Worfolk R. Retinal slip velocities in congenital nystagmus. Vis Res 1989;29(2):195-205
  • Goldstein HP, Gottlob I, Fendick MG. Visual remapping in infantile nystagmus. Vis Res 1992;32(6):1115-24
  • Dell'Osso LF, Jacobs JB. An expanded nystagmus acuity function: intra- and intersubject prediction of best-corrected visual acuity. Doc Ophthalmol 2002;104(3):249-76
  • Comer RM, Dawson EL, Lee JP. Baclofen for patients with congenital periodic alternating nystagmus. Strabismus 2006;14(4):205-9
  • Solomon D, Shepard N, Mishra A. Congenital periodic alternating nystagmus: response to baclofen. Ann NY Acad Sci 2002;956:611-5
  • Gradstein L, Reinecke RD, Wizov SS, Goldstein HP. Congenital periodic alternating nystagmus. Diagn Manag Ophthalmol 1997;104(6):918-28; discussion 28-9
  • Pradeep A, Thomas S, Roberts EO, et al. Reduction of congenital nystagmus in a patient after smoking cannabis. Strabismus 2008;16(1):29-32
  • Sarvananthan N, Proudlock FA, Choudhuri I, et al. Pharmacologic treatment of congenital nystagmus. Arch Ophthalmol 2006;124(6):916-8
  • Shery T, Proudlock FA, Sarvananthan N, et al. The effects of gabapentin and memantine in acquired and congenital nystagmus: a retrospective study. Br J Ophthalmol 2006;90(7):839-43
  • McLean R, Proudlock F, Thomas S, et al. Congenital nystagmus: randomized, controlled, double-masked trial of memantine/gabapentin.[see comment]. Ann Neurol 2007;61(2):130-8
  • Nelson LB, Ervin-Mulvey LD, Calhoun JH, et al. Surgical management for abnormal head position in nystagmus: the augmented modified Kestenbaum procedure. Br J Ophthalmol 1984;68(11):796-800
  • Campos EC, Schiavi C, Bellusci C. Surgical management of anomalous head posture because of horizontal gaze palsy or acquired vertical nystagmus.[see comment]. Eye 2003;17(5):587-92
  • von Noorden G, Sprunger D. Large rectus muscle recessions for the treatment of congenital nystagmus. Acta Ophthalmol 1991;109:221-4
  • Atilla H, Erkam N, Isikcelik Y. Surgical treatment in nystagmus. [see comment]. Eye 1999;13(Pt 1):11-5
  • Hertle RW, Dell'Osso LF, FitzGibbon EJ, et al. Horizontal rectus muscle tenotomy in children with infantile nystagmus syndrome: a pilot study. J AAPOS 2004;8(6):539-48
  • Wang ZI, Dell'osso LF, Tomsak RL, Jacobs JB. Combining recessions (nystagmus and strabismus) with tenotomy improved visual function and decreased oscillopsia and diplopia in acquired downbeat nystagmus and in horizontal infantile nystagmus syndrome. J AAPOS 2007;11(2):135-41
  • Repka MX, Savino PJ, Reinecke RD. Treatment of acquired nystagmus with botulinum neurotoxin A. Arch Ophthalmol 1994;112(10):1320-4
  • Leigh RJ, Tomsak RL, Grant MP, et al. Effectiveness of botulinum toxin administered to abolish acquired nystagmus. Ann Neurol 1992;32(5):633-42
  • Tomsak RL, Remler BF, Averbuch-Heller L, et al. Unsatisfactory treatment of acquired nystagmus with retrobulbar injection of botulinum toxin. Am J Ophthalmol 1995;119(4):489-96
  • Spielmann A. Nystagmus. Curr Opin Ophthalmol 1994;5(5):20-4
  • Barton JJ, Cox TA, Digre KB. Acquired convergence-evoked pendular nystagmus in multiple sclerosis. J Neuro Ophthalmol 1999;19(1):34-8
  • Abadi RV, Carden D, Simpson J. A new treatment for congenital nystagmus. Br J Ophthalmol 1980;64(1):2-6
  • Jain S, Proudlock F, Constantinescu CS, Gottlob I. Combined pharmacologic and surgical approach to acquired nystagmus due to multiple sclerosis. Am J Ophthalmol 2002;134(5):780-2
  • Kumar A, Thomas S, McLean R, et al. Treatment of acquired periodic alternating nystagmus with memantine – a case report. J Clin Neuropharmacol 2008 In Press

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