Advanced search
Publication Cover
Expert Opinion on Pharmacotherapy Volume 10, 2009 - Issue 11
Submit an article Journal homepage
149
Views
11
CrossRef citations to date
0
Altmetric
Drug Evaluations

Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases

Hiroyuki Murota Osaka University, Graduate School of Medicine, Course of Integrated Medicine, Dermatology Department, 2-2, Yamadaoka, Suita-city, Osaka, 5650871, Japan +81 6 6879 3031; +81 6 6879 3039; [email protected]
, MD PhD &
Ichiro Katayama Osaka University, Graduate School of Medicine, Course of Integrated Medicine, Dermatology Department, 2-2, Yamadaoka, Suita-city, Osaka, 5650871, Japan +81 6 6879 3031; +81 6 6879 3039; [email protected]
, MD PhD
Pages 1859-1867 | Published online: 28 Jun 2009

Bibliography

  • Akdis CA, Simons FE. Histamine receptors are hot in immunopharmacology. Eur J Pharmacol 2006;533:69-76
  • Hatamochi A, Ueki H, Mauch C, et al. Effect of histamine on collagen and collagen m-RNA production in human skin fibroblasts. J Dermatol Sci 1991;2:407-12
  • Abe M, Yokoyama Y, Amano H, et al. Effect of activated human mast cells and mast cell-derived mediators on proliferation, type I collagen production and glycosaminoglycans synthesis by human dermal fibroblasts. Eur J Dermatol 2002;12:340-6
  • Murota H, Bae S, Hamasaki Y, et al. Emedastine difumarate inhibits histamine-induced collagen synthesis in dermal fibroblasts. J Investig Allergol Clin Immunol 2008;18:245-52
  • Katayama I, Nishioka K. Substance P augments fibrogenic cytokine-induced fibroblast proliferation: possible involvement of neuropeptide in tissue fibrosis. J Dermatol Sci 1997;15:201-6
  • Numata Y, Terui T, Okuyama R, et al. The accelerating effect of histamine on the cutaneous wound-healing process through the action of basic fibroblast growth factor. J Invest Dermatol 2006;126:1403-9
  • Sykes JB. The concise Oxford dictionary. New York: Oxford University Press, 1986
  • Bousquet J, Jacot W, Vignola AM, et al. Allergic rhinitis: a disease remodeling the upper airways? J Allergy Clin Immunol 2004;113:43-9
  • Ohno I, Ohtani H, Nitta Y, et al. Eosinophils as a source of matrix metalloproteinase-9 in asthmatic airway inflammation. Am J Respir Cell Mol Biol 1997;16:212-9
  • Lemjabbar H, Gosset P, Lamblin C, et al. Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus. Am J Respir Crit Care Med 1999;159:1298-307
  • Vignola AM, Mirabella F, Costanzo G, et al. Airway remodeling in asthma. Chest 2003;123:417S-22S
  • Hoshino M, Nakamura Y, Sim J, et al. Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation. J Allergy Clin Immunol 1998;102:783-8
  • Salib RJ, Howarth PH. Remodelling of the upper airways in allergic rhinitis: is it a feature of the disease? Clin Exp Allergy 2003;33:1629-33
  • Baiardini I, Giardini A, Pasquali M, et al. Quality of life and patients' satisfaction in chronic urticaria and respiratory allergy. Allergy 2003;58:621-3
  • Kawashima M, Harada S, Tango T. Review of fexofenadine in the treatment of chronic idiopathic urticaria. Int J Dermatol 2002;41:701-6
  • Meltzer EO, Casale TB, Nathan RA, et al. Once-daily fexofenadine HCl improves quality of life and reduces work and activity impairment in patients with seasonal allergic rhinitis. Ann Allergy Asthma Immunol 1999;83:311-7
  • Spector SL, Shikiar R, Harding G, et al. The effect of fexofenadine hydrochloride on productivity and quality of life in patients with chronic idiopathic urticaria. Cutis 2007;79:157-62
  • Thompson AK, Finn AF, Schoenwetter WF. Effect of 60 mg twice-daily fexofenadine HCl on quality of life, work and classroom productivity, and regular activity in patients with chronic idiopathic urticaria. J Am Acad Dermatol 2000;43:24-30
  • Davies DE, Wicks J, Powell RM, et al. Airway remodeling in asthma: new insights. J Allergy Clin Immunol 2003;111:215-25; quiz 26
  • Leung DY. Atopic dermatitis: the skin as a window into the pathogenesis of chronic allergic diseases. J Allergy Clin Immunol 1995;96:302-18; quiz 19
  • Trautmann A, Schmid-Grendelmeier P, Kruger K, et al. T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma. J Allergy Clin Immunol 2002;109:329-37
  • White SR. Epithelium as a target. Philadelphia: Lippincott-Raven, 1997
  • Tschumperlin DJ, Drazen JM. Mechanical stimuli to airway remodeling. Am J Respir Crit Care Med 2001;164:S90-4
  • Roche WR, Beasley R, Williams JH, et al. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1989;1:520-4
  • Carroll N, Elliot J, Morton A, et al. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 1993;147:405-10
  • O'Byrne PM, Gauvreau GM, Brannan JD. Provoked models of asthma: what have we learnt? Clin Exp Allergy 2009;39:181-92
  • Kunzmann S, Schmidt-Weber C, Zingg JM, et al. Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodeling. J Allergy Clin Immunol 2007;119:1398-407
  • Hebda PA, Collins MA, Tharp MD. Mast cell and myofibroblast in wound healing. Dermatol Clin 1993;11:685-96
  • Artuc M, Hermes B, Steckelings UM, et al. Mast cells and their mediators in cutaneous wound healing: active participants or innocent bystanders? Exp Dermatol 1999;8:1-16
  • Trautmann A, Toksoy A, Engelhardt E, et al. Mast cell involvement in normal human skin wound healing: expression of monocyte chemoattractant protein-1 is correlated with recruitment of mast cells which synthesize interleukin-4 in vivo. J Pathol 2000;190:100-6
  • Noli C, Miolo A. The mast cell in wound healing. Vet Dermatol 2001;12:303-13
  • Gailit J, Marchese MJ, Kew RR, et al. The differentiation and function of myofibroblasts is regulated by mast cell mediators. J Invest Dermatol 2001;117:1113-9
  • Weller K, Foitzik K, Paus R, et al. Mast cells are required for normal healing of skin wounds in mice. FASEB J 2006;20:2366-8
  • Katayama I, Yokozeki H, Nishioka K. Mast-cell-derived mediators induce epidermal cell proliferation: clue for lichenified skin lesion formation in atopic dermatitis. Int Arch Allergy Immunol 1992;98:410-4
  • Maurer M, Opitz M, Henz BM, et al. The mast cell products histamine and serotonin stimulate and TNF-alpha inhibits the proliferation of murine epidermal keratinocytes in situ. J Dermatol Sci 1997;16:79-84
  • Schubert ML, Peura DA. Control of gastric acid secretion in health and disease. Gastroenterology 2008;134:1842-60
  • Ishihara Y, Okabe S. Effects of antiulcer agents on healing of mepirizole-induced duodenal ulcers in rats. Digestion 1983;27:29-35
  • Tsuchida T, Tsukamoto Y, Segawa K, et al. Effects of cimetidine and omeprazole on angiogenesis in granulation tissue of acetic acid-induced gastric ulcers in rats. Digestion 1990;47:8-14
  • Antoine M, Wirz W, Tag CG, et al. Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. Biochem Biophys Res Commun 2006;346:224-33
  • Olofsson B, Korpelainen E, Pepper MS, et al. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc Natl Acad Sci USA 1998;95:11709-14
  • Werner S, Alzheimer C. Roles of activin in tissue repair, fibrosis, and inflammatory disease. Cytokine Growth Factor Rev 2006;17:157-71
  • Takehara K. Growth regulation of skin fibroblasts. J Dermatol Sci 2000;24(Suppl 1):S70-7
  • Wozney JM. Bone morphogenetic proteins. Prog Growth Factor Res 1989;1:267-80
  • Mou C, Jackson B, Schneider P, et al. Generation of the primary hair follicle pattern. Proc Natl Acad Sci USA 2006;103:9075-80
  • Lim MC, Taylor RM, Naclerio RM. The histology of allergic rhinitis and its comparison to cellular changes in nasal lavage. Am J Respir Crit Care Med 1995;151:136-44
  • van Toorenenbergen AW, Gerth van Wijk R, Vermeulen AM. Allergen-induced matrix metalloproteinase-9 in nasal lavage fluid. Allergy 1999;54:293-4
  • Sanai A, Nagata H, Konno A. Extensive interstitial collagen deposition on the basement membrane zone in allergic nasal mucosa. Acta Otolaryngol 1999;119:473-8
  • Shimizu T, Kanai K, Asano K, et al. Suppression of matrix metalloproteinase production in nasal fibroblasts by tranilast, an antiallergic agent, in vitro. Mediators Inflamm 2005;2005:150-9
  • Asano K, Kanai KI, Suzaki H. Suppressive activity of fexofenadine hydrochloride on metalloproteinase production from nasal fibroblasts in vitro. Clin Exp Allergy 2004;34:1890-8
  • Shaida A, Kenyon G, Devalia J, et al. Matrix metalloproteinases and their inhibitors in the nasal mucosa of patients with perennial allergic rhinitis. J Allergy Clin Immunol 2001;108:791-6
  • Leonardi A, Radice M, Fregona IA, et al. Histamine effects on conjunctival fibroblasts from patients with vernal conjunctivitis. Exp Eye Res 1999;68:739-46
  • Leonardi A. Role of histamine in allergic conjunctivitis. Acta Ophthalmol Scand Suppl 2000;230:18-21
  • Sharif NA, Xu SX, Yanni JM. Olopatadine (AL-4943A): ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitis. J Ocul Pharmacol Ther 1996;12:401-7
  • Fukuda T, Morimoto Y, Iemura R, et al. Effect of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimida zole difumarate (KB-2413), a new antiallergic, on chemical mediators. Arzneimittelforschung 1984;34:801-5
  • Saito H, Yamamoto N, Tomita S, et al. Effect of emedastine difumarate on CC chemokine-elicited eosinophil migration. Int Arch Allergy Immunol 2001;125(Suppl 1):22-8
  • Kohda F, Koga T, Uchi H, et al. Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes. J Dermatol Sci 2002;28:34-41
  • Saito T, Hagihara A, Igarashi N, et al. Inhibitory effects of emedastine difumarate on histamine release. Jpn J Pharmacol 1993;62:137-43
  • Herranz U, Rusca A, Assandri A. Emedastine-ketoconazole: pharmacokinetic and pharmacodynamic interactions in healthy volunteers. Int J Clin Pharmacol Ther 2001;39:102-9
  • Brunner M, Kletter K, Assandri A, et al. Pharmacokinetic and mass balance study of unlabelled and (14)C-labelled emedastine difumarate in healthy volunteers. Xenobiotica 2002;32:761-70
  • Pons-Guiraud A, Nekam K, Lahovsky J, et al. Emedastine difumarate versus loratadine in chronic idiopathic urticaria: a randomized, double-blind, controlled European multicentre clinical trial. Eur J Dermatol 2006;16:649-54
  • Weeke ER. Epidemiology of hay fever and perennial allergic rhinitis. Monogr Allergy 1987;21:1-20
  • Borazan M, Karalezli A, Akova YA, et al. Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial. Acta Ophthalmol 2008, doi:10.1111/j.1755-3768.01265.x
  • Bielory L, Lien KW, Bigelsen S. Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis. Drugs 2005;65:215-28
  • Orfeo V, Vardaro A, Lena P, et al. Comparison of emedastine 0.05% or nedocromil sodium 2% eye drops and placebo in controlling local reactions in subjects with allergic conjunctivitis. Eur J Ophthalmol 2002;12:262-6
  • D'Arienzo PA, Leonardi A, Bensch G. Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model. Clin Ther 2002;24:409-16
  • Abelson MB, Kaplan AP. A randomized, double-blind, placebo-controlled comparison of emedastine 0.05% ophthalmic solution with loratadine 10 mg and their combination in the human conjunctival allergen challenge model. Clin Ther 2002;24:445-56
  • Verin P, Easty DL, Secchi A, et al. Clinical evaluation of twice-daily emedastine 0.05% eye drops (Emadine eye drops) versus levocabastine 0.05% eye drops in patients with allergic conjunctivitis. Am J Ophthalmol 2001;131:691-8
  • Pinto CG, Lafuma A, Fagnani F, et al. Cost effectiveness of emedastine versus levocabastine in the treatment of allergic conjunctivitis in 7 European countries. Pharmacoeconomics 2001;19:255-65
  • Netland PA, Leahy C, Krenzer KL. Emedastine ophthalmic solution 0.05% versus levocabastine ophthalmic suspension 0.05% in the treatment of allergic conjunctivitis using the conjunctival allergen challenge model. Am J Ophthalmol 2000;130:717-23
  • Secchi A, Ciprandi G, Leonardi A, et al. Safety and efficacy comparison of emedastine 0.05% ophthalmic solution compared to levocabastine 0.05% ophthalmic suspension in pediatric subjects with allergic conjunctivitis. Emadine Study Group. Acta Ophthalmol Scand Suppl 2000;230:42-7
  • Secchi A, Leonardi A, Discepola M, et al. An efficacy and tolerance comparison of emedastine difumarate 0.05% and levocabastine hydrochloride 0.05%: reducing chemosis and eyelid swelling in subjects with seasonal allergic conjunctivitis. Emadine Study Group. Acta Ophthalmol Scand Suppl 2000;230:48-51
  • Discepola M, Deschenes J, Abelson M. Comparison of the topical ocular antiallergic efficacy of emedastine 0.05% ophthalmic solution to ketorolac 0.5% ophthalmic solution in a clinical model of allergic conjunctivitis. Acta Ophthalmol Scand Suppl 1999;228:43-6
  • Horak F, Stubner P, Zieglmayer R, et al. Clinical study of the therapeutic efficacy and safety of emedastine difumarate versus cetirizine in the treatment of seasonal allergic rhinitis. Arzneimittelforschung 2004;54:666-72
  • Yamagiwa M. Acoustic evaluation of the efficacy of medical therapy for allergic nasal obstruction. Eur Arch Otorhinolaryngol 1997;254(Suppl 1):S82-4
  • Vermeeren A, Ramaekers JG, O'Hanlon JF. Effects of emedastine and cetirizine, alone and with alcohol, on actual driving of males and females. J Psychopharmacol 2002;16:57-64
  • Saito T, Fukuda T, Tajima S, et al. General pharmacology of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate. 2nd communication: Effects on the circulation and the other systems. Arzneimittelforschung 1988;38:267-72
  • Ono SJ, Abelson MB. Allergic conjunctivitis: update on pathophysiology and prospects for future treatment. J Allergy Clin Immunol 2005;115:118-22

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.