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Review

New anti-epileptic drugs for the 21st century

Pages 633-674 | Published online: 24 Feb 2005

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  • •Good review of overall incidence of rash and other AEs.
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  • ••Good review of severe rash associated with LTG
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  • •Initial pilot study showing efficacy of TPM in this syndrome.
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  • ••Shows efficacy of ZNS in this syndrome.
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  • ••Shows efficacy of drug in this syndrome, particularly withtuberous sclerosis.
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  • •Reviews long-term efficacy and tolerability of CLB in various seizure types.
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  • •Reviews potential identifiers of which patients may develop tolerance to CLB.
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  • MESSENHEIMER JA: Rash in adult and pediatric patients treated with lamotrigine. Can. J. Neurol. Sci. (1998) 25:S14–S18.
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  • CANADIAN STUDY GROUP FOR CHILDHOOD EPILEPSY: Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Epilepsia (1998) 39(9):952–959.
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  • ••Good review of seizure exacerbation related to AED use. MORELLO CM, LECKBAND SG, STONER CP, MOORHOUSE DF, SAHAGIAN GA: Randomized double-blind study comparing the efficacy of gabapentin with amitrip-tyline on diabetic peripheral neuropathy pain. Arch. Intern. Med. (1999) 159:1931–1937.
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