Advanced search
Publication Cover
Expert Opinion on Pharmacotherapy Volume 1, 2000 - Issue 4
Submit an article Journal homepage
35
Views
6
CrossRef citations to date
0
Altmetric
Review

Pharmacotherapeutic agents in xenotransplantation

M Basker Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Building 149-9019, 13th Street, Boston, MA 02129, USA. [email protected]
,
L Buhler Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Building 149-9019, 13th Street, Boston, MA 02129, USA. [email protected]
,
IPJ Alwayn Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Building 149-9019, 13th Street, Boston, MA 02129, USA. [email protected]
,
JZ Appel III Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Building 149-9019, 13th Street, Boston, MA 02129, USA. [email protected]
&
DKC Cooper Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Building 149-9019, 13th Street, Boston, MA 02129, USA. [email protected]
Pages 757-769 | Published online: 24 Feb 2005

Bibliography

  • Xenotransplantation - The Transplantation Of Organs AndTissues Between Species. (Edition 2). Cooper DKC, Kemp E, Platt JL, White DJG (Eds.), Springer, Heidelberg, Germany (1997).
  • Xeno - The Promise of Transplanting Animal Organs into Humans. Cooper DKC, Lanza RP (Eds.), Oxford University Press, New York, USA (2000).
  • ••Review of all aspects of xenotransplantation for the generalreader.
  • COOPER DKC, YE Y, ROLF LL JR, ZUHDI N: The pig as a 'potential 'organ 'donor 'for 'man. In: Xenotranplantation. Cooper DKC, Kemp E, Reemtsma K, White DJG (Eds.), Springer, Heidelberg, Germany (1990:481–500.
  • YE Y, NIEKRASZ M, KOSANKE S et al 'The 'pig 'as 'a potential organ donor for man. A study of potentially Exp. Opin. Pharmacother. (2000) 1(4) transferable disease from donor pig to recipient man. Transplantation (1994) 57:694–703.
  • SACHS DH: The pig as a potential xenograft donor. Vet. Immunol. Immunopath. (1994) 43:185–191.
  • GOOD AH, COOPER DKC, MALCOLM AJ et al.: Identifica-tion of carbohydrate structures that bind human anti-porcine antibodies: implications for discordant xenog,rafting in humans. Transplant. Proc. (1992) 24:559–562.
  • •The first identification of the importance of anti-Gal antibodies in xenotransplantation.
  • ORIOL R, YE Y, KOREN E, COOPER DKC: Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation. Transplantation (1993) 56:1433–1442.
  • COOPER DKC, KOREN E, ORIOL R: Oligosaccharides and discordant xenotransplantation. Immunol. Rev. (1994) 141:31–58.
  • SANDRIN MS, VAUGHAN HA, DABKOWSKI PL, MCKENZIEIFC: Anti-pig IgM antibodies in human serum react predominantly with Gal(1-3)Gal epitopes. Proc. Natl. Acad. Sci. USA (1993) 90:11391.
  • GALILI U, CLARK MR, SHOHET SB, BUEHLER J, MACHER BA: Evolutionary relationship between the natural antiaGal antibody and the Gala 1-3Gal epitope in primates. Proc. Natl. Acad. Sci. USA (1987) 84:1369–1373.
  • COOPER DKC, HUMAN PA, LEXER G et al.: Effects of cyclosporin and antibody adsorption on pig cardiac xenograft survival in the baboon. J. Heart Transplant. (1988) 7:238–246.
  • PERPER RJ, NAJARIAN JS: Experimental renal hetero-transplantation. 1. In widely divergent species. Transplantation (1966) 4:377–388.
  • ROSE AG, COOPER DKC, HUMAN PA, REICHENSPURNER H, REICHART B: Histopathology of hyperacute rejection of the heart: experimental and clinical observations in allografts and xenografts. J. Heart Lung Transplant. (1991) 10:223–234.
  • PLATT JL, FISCHEL RJ, MATAS AJ et al.: Immunopa-thology of hyperacute xenograft rejection in a swine-to-primate model. Transplantation (1991) 52:214–220.
  • ALEXANDRE GPJ, GIANELLO P, LATINNE D et al.: Plasma-pheresis and splenectomy in experimental renal xenotransplantation. In: Xenograft 25. Hardy MA (Ed.), Elsevier, New York, USA (1989):259–266.
  • COOPER DKC, CAIRNS TDH, TAUBE DH: Extracorporeal irnmunoadsorption of anti-pig antibody in pigs using aGal oligosaccharide inimmnoaffinity columns. Xeno (1996) 4:27–29.
  • XU Y, LORF T, SABLINSKI T et al.: Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Gala 1-3 Gall31-4G1c-X immunoaffinity column. Transplantation (1998) 65:172–179.
  • KOZLOWSKI T, SHIMIZU A, LAMBRIGTS D et al Porcine kidney and heart transplantation in baboons undergoing a tolerance inducing regimen and antibody adsorption. Transplantation (1999) 67:18–30.
  • LEVENTHAL JR, DALMASSO AP, CROMWELL JW et al.:Prolongation of cardiac xenograft survival by depletion of complement. Transplantation (1993) 55:857–865.
  • PRUITT SK, BOLLINGER RR, COLLINS BH et al.: Effect ofcontinuous complement inhibition using soluble complement receptor Type 1 on survival of pig-to-primate cardiac xenografts. Transplantation (1997) 63:900–902.
  • KOBAYASHI T, TANIGUCHI S, NEETHLING FA et al.: Delayed xenograft rejection of pig-to-baboon cardiac transplants after cobra venom factor therapy. Transplantation (1997) 64:1255–1261.
  • COZZI E, WHITE DJG: The generation of transgenic pigsas potential organ donors for humans. Nature Med. (1995) 1:964.
  • MCCURRY KR, KOOYMAN DL, ALVARADO CG et al.: Human complement regulatory proteins protect swine to primate cardiac xenografts from human injury. Nature Med. 1995: 1:423–427.
  • SCHMOECKEL M, BHATTI FN, ZAIDI A et al.: Orthotopic heart transplantation in a transgenic pig-to-primate model. Transplantation (1998) 65:1570–1507.
  • ZAIDI A, SCHMOECKEL M, BHATTI F et al.: Life-supporting pig-to-primate renal xenotransplanta-tion using genetically modified donors. Transplanta-tion (1998) 65:1584–1590.
  • •Illustrates current results that can be obtained with the use of hDAF pig organs transplanted into non-human primates.
  • BHATTI FN, SCHMOECKEL M, ZAIDI A et al.: Three-month survival of hDAF transgenic pig hearts transplanted into primates. Transplant. Proc. (1999) 31:958.
  • LAMBRIGTS D, VAN CALSTER P, XU Y et al.: Pharma-cologic irnmunosuppressive therapy and extracorpo-real immunoadsorption in the suppression of antiaGal antibody in the baboon. Xenotransplantation (1998) 5:274–283.
  • LAMBRIGTS D, SACHS DH, COOPER DKC: Discordant organ xenotransplantation in primates. World experi-ence and current status. Tranplantation (1998) 66:547–561.
  • •Comprehensive review of therapeutic approaches and results achieved in the pig-to-non-human primate model.
  • BACH FH, WINKLER H, FERRAN C, HANCOCK WW, ROBSON SC: Delayed xenograft rejection. Immunol. Today. (1996) 17:379–384.
  • •Description of factors involved in acute vascular xenograft rejection.
  • GOODMAN DL, MILLAN MT, FERRAN C et al.: Mechanisms of delayed xenograft rejection. In: Xenotransplantation - The Transplantation Of Organs And Tissues Between Species (Second Edition), Cooper DKC, Kemp E, Platt JL, White DJG (Eds.), Springer, Heidelberg, Germany (1997):77–94.
  • UN SS, WEIDNER BC, BYRNE GW et al.: The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants./ Clin. Invest. (1998) 101: 1745-1756.
  • ALWAYN IPJ, BASKER M, BUHLER L, COOPER DKC: The problem of antipig antibodies in pig-to-primate xenografting: current and novel methods of depletion and/or suppression of production of antipig antibodies. Xenotransplantation (1999) 6:157–168.
  • BUHLER L, AWWAD M, BASKER M et al.: High-dose porcine hematopoietic cell transplantation combined with CD4OL blockade in baboons prevents an induced antipig humoral response. Transplantation (In Press).
  • •The first report demonstrating that co-stimulatory blockade with an anti-CD154 mAb prevents the induced humoral response in a large animal xenograft model.
  • IERINO FL, KOZLOWSKI T, SIEGEL JB etai.: Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts. Transplantation (1998) 66:1439–1450.
  • BUHLER L, BASKER M, ALWAYN IPJ et al.: Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation (In Press).
  • •Describes and discusses the thrombotic microangiopathy and DIG that can be associated with xenotransplantation.
  • KOPP CW, SIEGEL JB, HANCOCK WW et al.: Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors. Transplantation (1997) 63:749–758
  • SAADI S, HOLZKNECHT RA, PATTE CP et al.: Comple-ment regulation of tissue factor activity in endothe-lium./ Exp. Med. (1995) 182: 1807-1814
  • ROBINSON LA, TU L, STEEBER DA et al.: The role of adhesion molecules in human leukocyte attachment to porcine vascular endothelium: implications for xenotransplantation. J. Immunol. (1998) 161:6931–6938
  • KOPP CW, ROBSON SC, SIEGEL JB et al.: Regulation of monocyte tissue factor activity by allogeneic and xenogeneic endothelial cells. Thromb. Haemost. (1996) 79:529–538
  • YAMADA K, SACHS DH, DERSIMONIAN H: Human antiporcine xenogeneic T-cell response: evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition. J. Immunol. (1995) 155:5249–5256
  • YAMADA K, SEEBACH JD, DERSIMONIAN H, SACHS DH. Human antipig T-cell mediated cytotoxicity. Xenotrans-plantation (1996) 3:179–187
  • CHAVEZ G, COZZI E, THIRU S et al.: Pig to primate cellular xenograft rejection, a humoral independent process. Abstract presented at the 5th Congress of the International Xenotransplantation Association. Nagoya, Japan (1999).
  • LECHLER RI: Manipulating xenoreactive T-cells: Role of T-cell responses in rejection. Plenary session presented at the 5th Congress of the International Xenotransplantation Association. Nagoya, Japan (1999).
  • SYKES M, SACHS DH: Xenogeneic tolerance through hematopoietic cell and thymic transplantation. In: Xenotransplantation - The Transplantation Of Organs And Tissues Between Species, (Second Edition). Cooper DKC, Kemp E, Platt JL, White DJG (Eds.), Springer, Heidelberg, Germany (1997):496–518.
  • ••Excellent review of work attempting to induce tolerance toxenografts.
  • SACHS DH, SYKES M, GREENSTEIN JL, COSIMI AB: Tolerance and xenograft survival. Nature Med. (1995) 1:969.
  • BARTHOLOMEW AM, POWELSON J, SACHS DH et al.:Tolerance in a concordant nonhuman primate model. Transplantation (1999) 68:1709.
  • OHDAN H, YANG YG, SHIMIZU A et al.: Mixed chimerism induced without lethal conditioning prevents T-cell- and antiGal a 1,3Gal-mediated graft rejection. J. Clin. Invest. (1999) 104:281–290.
  • BRACY JL, SACHS DH, IACOMINI J: Inhibition of xenore-active natural antibody production by retroviral gene therapy. Science (1998) '281:1845–1847.
  • •First description of gene therapy to induce B-cell tolerance of relevance to xenotransplantation.
  • IERINO FL, GOJO S, BANERJEE PT eta/.: Transfer of swine major histocompatibility complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers. Transplantation (1999) 67:1119–1128.
  • YAMADA K, SHIMIZU A, IERINO FL et al.: Thymic transplantation in miniature swine: 1. Development and function of the ihymokidney'. Transplantation (1999) '68:1684–1692.
  • KAWAI T, COSIMI B, COLVIN R et al. Mixed allogeneicchimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation (1995) 59:256–262.
  • SPITZER TR, DELMONICO F, TOLKOFF-RUBIN N et al.: Combined histocompatible leukocyte antigen-matched donor bone marrow and renal transplanta-tion for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplanta-tion (1999) 68:480–484.
  • •Report of patient in whom immunologic tolerance was induced following concomitant bone marrow and kidney transplantation from the same donor.
  • NASH K, CHANG Q, WATTS A et al.: Peripheral blood progenitor cell mobilization and leukapheresis in pigs. Lab. Anim. Sci. (1999) 49:645–649.
  • VAN ROOIJEN N, SANDERS A. Liposome mediated depletion of macrophages: mechanism of action, preparation ofliposomes and applications./ Immunol. Methods (1994) 174: 83–93
  • BUHLER L, GOEPFERT M, KITAMURA H et al Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by a thrombotic microangio-pathy. (Submitted)
  • ALWAYN IPJ, APPEL JZ III, GOEPFERT C, BUHLER L, COOPER DKC, ROBSON SC: Inhibition of platelet aggregation in baboons: therapeutic implications for xenotransplantation. (Submitted).
  • COOPER DKC, KOREN E, ORIOL R: Genetically engineered pigs [letter]. Lancet (1993) 342:682–683.
  • OSMAN N, MCKENZIE IF, OSTENRIED K et al.: Combinedtransgenic expression of a-galactosidase and a 1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Gala (1,3) Gal. Proc. Natl. Acad. Sci. USA (1997) 94:14677–14682.
  • SHINKEL TA, CHEN CG, SALVARIS E et al.: Changes in cellsurface glycosylation in a 1,3-galactosyltransferase knockout and a 1,2-fucosyltransferase transgenic mice. Transplantation (1997) 64:197–204.
  • SANDRIN MS, FODOR WL, MOUHTOURIS E et al.: Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis. Nature Med. (1995) 1:1261–1267.
  • CHEN D, RIESBECK K, KEMBALL-COOK G et al.: Inhibi-tion of tissue factor-dependent and-independent coagulation by cell surface expression of novel antico-agulant fusion proteins. Transplantation (1999) 67:467–474
  • ALEXANDRE GPJ, SQUIFFLET JP, DE BRUYERE M et al.:Present experience in a series of 26 abo-incompatible living donor renal allografts. Transplant. Proc. (1987) 19:4538.
  • BACH FH, PLATT J, COOPER DKC: Accommodation - therole of natural antibody and complement in discor-dant xenograft rejection. In: Xenotranp/antation. Cooper DKC, Kemp E, Reemtsma K, White DJG (Eds.), Springer, Heidelberg, Germany (1991):81–99.
  • BACH FH, TURMAN MA, VERCELLOTTI GM, PLATT JL,DALMASSO AP: Accommodation: a working paradigm for progressing toward clinical discordant xenografting. Transplant. Proc. (1991) 23:205–207.
  • TANEMURA M, MARUYAMA S, GALILI U: Differential expressionofa-GALepitopes(Gala1-3Galf31-4GkNAc-R) on pig and mouse organs. Transplantation (2000) 69:187–190.
  • TANEMURA M, YIN D, CHONG AS, GALILI U: Differential immune responses to a-gal epitopes on xenografts and allografts: implications for accommodation in xenotransplantation. J. Clin. Invest. (2000) 105:301–310.
  • •Interesting studies on factors influencing success or failure of achieving accommodation of allografts and xenografts.
  • LACHMANN PJ, HALBWACHS L: The influence of c3b inactivator (kaf) concentration on the ability of serum to support complement activation. Clin. Exp. Immunol. (1975) 21:109–114.
  • COOPER DKC: Xenoantigens and xenoantibodies. Xenotransplantation (1998) 5:6–17.

Websites

  • BUHLER L, FRIEDMAN T, IACOMINI J, COOPER DKC: Xenotransplantation - state of the art: update 1999. Front. Biosci. (1999) 4:D416-432. http://www.Bioscience.Org/1999N4/D/Buhler/ Fulltext.Htm
  • •Reviews immunologic barriers to successful xenotransplan-tation and therapeutic approaches being explored.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.