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Review

Prospects for the treatment of Parkinson’s disease using neurotrophic factors

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Pages 1531-1543 | Published online: 24 Feb 2005

Bibliography

  • BARKER RA: Prospects for the treatment of Parkinson's disease using neural grafts. Expert Opin. Pharmacother. (2000) 1:889–902.
  • ••A useful review article on neural transplantation as a therapy for PD.
  • DUNNETT SB, BJORKLUND A: Prospects for new restorative and neuroprotective treatments in Parkinson's disease. Nature (1999) 399:A32–A39.
  • ••A useful review article outlining the recentadvances in PD and possible new therapeutic approaches.
  • SNIDER WD, JOHNSON EMJ: Neurotrophic molecules. Ann. Neural (1989) 26:489–506.
  • BARKER RA, DUNNETT SB, FAWCETT JW: Neurotrophic factors and neural grafts: a growing field. Seminars in the Neurosciences (1993) 5:431–441.
  • BRADFORD HE ZHOU J, PLIEGO-RIVERO B, STERN GM, JAUNIAUX E: Neurotrophins in the pathogenesis and potential treatment of Parkinson's disease. Adv. Neural (1999) 80:19–25.
  • LINDSAY RM, ALTAR CA, CEDARBAUM JM, HYMAN C, WIEGAND SJ: The therapeutic potential of neurotrophic factors in the treatment of Parkinson's disease. Exp. Neural. (1993) 124:103–118.
  • BRUNDIN P, KARLSSON J, EMGARD M et al.: Improving the survival of grafted dopaminergic neurons: a review over current approaches. Cell Transplant. (2000) 9:179–195.
  • ••A useful review of different approachesbeing employed to increase dopaminergic neuronal survival following grafting in models of PD.
  • LIN LE DOHERTY DH, LILE JD, BEKTESH S, COLLINS F: GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science (1993) 260:1130–1132.
  • •An important study that first demonstrated the dopaminotrophic effects of GDNE
  • MEYER M, JOHANSEN J, GRAMSBERGEN JB, JOHANSEN TE, ZIMMER J: Improved survival of embryonic porcine dopaminergic neurons in coculture with a conditionally immortalized GDNF-producing hippocampal cell line. Exp. Neural (2000) 164:82–93.
  • SAUTTER J, MEYER M, SPENGER C, SEILER RW, WIDMER HR: Effects of combined BDNF and GDNF treatment on cultured dopaminergic midbrain neurons. Neurareport (1998) 9:1093–1096.
  • CLARKSON ED, ZAWADA WM, FREED CR: GDNF improves survival and reduces apoptosis in human embryonic dopaminergic neurons in vitro. Cell Tissue Res. (1997) 289:207–210.
  • HOU JG, LIN LF, MYTILINEOU C: Glial cell line-derived neurotrophic factor exerts neurotrophic effects on dopaminergic neurons in vitro and promotes their survival and regrowth after damage by 1-methy1-4-phenylpyridinium. I Neurochem. (1996) 66:74–82.
  • CLARKSON ED, ZAWADA WM, FREED CR: GDNF reduces apoptosis in dopaminergic neurons in vitro. Neurareport (1995) 7:145–149.
  • BURKE RE, ANTONELLI M, SULZER D: Glial cell line-derived neurotrophic growth factor inhibits apoptotic death of postnatal substantia nigra dopamine neurons in primary culture. I Neurochem. (1998) 71:517–525.
  • LINGOR P, UNSICKER K, KRIEGLSTEIN K: GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide. Exp. Neural (2000) 163:55–62.
  • EGGERT K, SCHLEGEL J, OERTEL W, WURZ C, KRIEG JC, VEDDER H: Glial cell line-derived neurotrophic factor protects dopaminergic neurons from 6-hydroxydopamine toxicity in vitro. Neurosci. Lett. (1999) 269:178–182.
  • KRAMER BC, GOLDMAN AD, MYTILINEOU C: Glial cell line derived neurotrophic factor promotes the recovery of dopamine neurons damaged by 6-hydroxydopamine in vitro. Brain Res. (1999) 851:221–227.
  • HORGER BA, NISHIMURA MC, ARMANINI MP et al.: Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons. Neurosci. (1998) 18:4929–4937.
  • •This study demonstrates the beneficial effects of another TGFP family member, neurturin, on dopaminergic neuronal survival.
  • ROSENBLAD C, KIRIK D, BJORKLUND A: Neurturin enhances the survival of intrastriatal fetal dopaminergic transplants. Neuromport (1999) 10:1783–1787.
  • ROSENBLAD C, KIRIK D, DEVAUX B, MOFFAT B, PHILLIPS, HS BJORKLUND A: Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle. Eur j NeuroscL (1999) 11:1554–1566.
  • AKERUD P, ALBERCH J, EKETJALL S, WAGNER J, ARENAS E: Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons. j Neurochem. (1999) 73:70–78.
  • MILBRANDT J, DE SAUVAGE FJ, FAHRNER TJ et al: Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron (1998) 20:245–253.
  • •This study identifies a new member of the TGFP family, persephin, and shows that it has similar effects to GDNF on dopaminergic neuronal survival.
  • GRUNBLATT E, MANDEL S, YOUDIM MB: MPTP and 6-hydroxydopamine-induced neurodegeneration as models for Parkinson's disease: neuroprotective strategies. j. Neural. (2000) 247\(Suppl. 2):I195–11102.
  • UNGERSTEDT U, ARBUTHNOTT G: Quantitative recording of rotational behavior in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system. Brain Res. (1970) 24:485–493.
  • BRECKNELL JE, DUNNETT SB, FAWCETT JW: A quantitative study of cell death in the substantia nigra following a mechanical lesion of the medial forebrain bundle. Neuroscience (1995) 64:219–227.
  • KORDOWER JH, EMBORG ME, BLOCH J etal.: Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science (2000) 290:767–773.
  • ••A convincing study that demonstrates thebeneficial restorative effects of GDNF following MPTP-induced parkinsonism in Rhesus monkeys.
  • HOFFER BJ, HOFFMAN A, BOWENKAMP K et al: Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo. Neurosci. Lett. (1994) 182:107–111.
  • BECK KD, VALVERDE J, ALEXI T et al:Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature (1995) 373:339–341.
  • BOWENKAMP KE, HOFFMAN AE GERHARDT GA et al: Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. J. Comp. Neural (1995) 355:479–489.
  • WINKLER C, SAUER H, LEE CS, BJORKLUND A: Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease. j NeuroscL (1996) 16:7206–7215.
  • •This study shows that short-term intranigral administration of GDNF following a partial 6-0HDA results in long-term beneficial effects.
  • LU X, HAGG T: Glial cell line-derived neurotrophic factor prevents death, but not reductions in tyrosine hydroxylase, of injured nigrostriatal neurons in adult rats. Comp. Neural (1997) 388:484–494.
  • ROSENBLAD C, MARTINEZ-SERRANO A, BJORKLUND A: Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease. Neuroscience (1998) 82:129–137.
  • •This study demonstrates the restorative effects of GDNF following intrastriatal administration in a rat model of PD.
  • AOI M, DATE I, TOMITA S, OHMOTO T: Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system. Neural Res. (2000) 22:832–836.
  • AOI M, DATE I, TOMITA S, OHMOTO T: The effect of intrastriatal single injection of GDNF on the nigrostriatal dopaminergic system in hemiparkinsonian rats: behavioral and histological studies using two different dosages. Neurosci. Res. (2000) 36:319–325.
  • BOWENKAMP KE, LAPCHAK PA, HOFFER BJ, MILLER PJ, BICKFORD PC: Intracerebroventricular glial cell line-derived neurotrophic factor improves motor function and supports nigrostriatal dopamine neurons in bilaterally 6-hydroxydopamine lesioned rats. Exp. Neural (1997) 145:104–117.
  • KEARNS CM, GASH DM: GDNF protects nigral dopamine neurons against 6-hydroxydopamine in viva Brain Res. (1995) 672:104–111.
  • OPACKA-JUFFRY J, ASH WORTH S, HUME SP, MARTIN D, BROOKS DJ, BLUNT SB: GDNF protects against 6-OHDA nigrostriatal lesion: in vivo study with microdialysis and PET. Neurareport (1995) 7:348–352.
  • SHULTS CW, KIMBER T, MARTIN D: Intrastriatal injection of GDNF attenuates the effects of 6-hydroxydopamine. Neurareport (1996) 7:627–631.
  • LAPCHAK PA, MILLER PJ, COLLINS E PAO S: Glial cell line-derived neurotrophic factor attenuates behavioural deficits and regulates nigrostriatal dopaminergic and peptidergic markers in 6-hydroxydopamine-lesioned adult rats: comparison of intraventricular and intranigral delivery. Neuroscience (1997) 78:61–72.
  • AOI M, DATE I, TOMITA S, OHMOTO T: GDNF induces recovery of the nigrostriatal dopaminergic system in the rat brain following intracerebroventricular or intraparenchymal administration. Acta Neurachit: (Wien) (2000) 142:805–810.
  • ROSENBLAD C, KIRIK D, BJORKLUND A: Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-0HDA lesion model. Exp. Neural (2000) 161:503–516.
  • KIRIK D, ROSENBLAD C, BJORKLUND A: Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-0HDA lesion model depends on the site of administration of the trophic factor. Eur NeuroscL (2000) 12:3871–3882.
  • SULLIVAN AM, OPACKA-JUFFRY J, BLUNT SB: Long-term protection of the rat nigrostriatal dopaminergic system by glial cell line-derived neurotrophic factor against 6-hydroxydopamine in viva Eur NeuroscL (1998) 10:57–63.
  • TOMAC A, LINDQVIST E, LIN LF et al: Protection and repair of the nigrostriatal dopaminergic system by GDNF in viva Nature (1995) 373:335–339.
  • CHENG FC, NI DR, WU MC, KUO JS, CHIA LG: Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice. NeuroscL Lett. (1998) 252:87–90.
  • DATE I, AOI M, TOMITA S, COLLINS F, OHMOTO T: GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged parkinsonian mice. Neurareport (1998) 9:2365–2369.
  • GASH DM, ZHANG Z, OVADIA A et al: Functional recovery in parkinsonianmonkeys treated with GDNF. Nature (1996) 380:252–255.
  • •This study demonstrates that singled injections of GDNF into the striatum or nigra in MPTP-treated Rhesus monkeys results in improvement in parkinsonian symptoms.
  • GERHARDT GA, CASS WA, HUETTL P, BROCK S, ZHANG Z, GASH DM: GDNF improves dopamine function in the substantia nigra but not the putamen of unilateral MPTP-lesioned rhesus monkeys. Brain Res. (1999) 817:163–171.
  • ZHANG Z, MIYOSHI Y, LAPCHAK PA et al: Dose response to intraventricular glial cell line-derived neurotrophic factor administration in parkinsonian monkeys. Pharmacy]. Exp. Ther. (1997) 282:1396–1401.
  • MIYOSHI Y, ZHANG Z, OVADIA A et al.: Glial cell line-derived neurotrophic factor-levodopa interactions and reduction of side effects in parkinsonian monkeys. Ann. Neural (1997) 42:208–214.
  • KORDOWER JH, PALFI S, CHEN EY et al.: Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease. Ann. Neural (1999) 46:419–424.
  • •An important study demonstrating that intracerebroventricular administration does not provide any benefit in a PD patient.
  • LINDNER MD, WINN SR, BAETGE EE eta].: Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine depletions and parkinsonian symptoms. Exp. Neural (1995) 132:62–76.
  • TSENG JL, BAETGE EE, ZURN AD, AEBISCHER P: GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. Neurosci. (1997) 17:325–333.
  • NAKAO N, YOKOTE H, NAKAI K, ITAKURA T: Promotion of survival and regeneration of nigral dopamine neurons in a rat model of Parkinson's disease after implantation of embryonal carcinoma-derived neurons genetically engineered to produce glial cell line-derived neurotrophic factor. j Neurosurg. (2000) 92 :659–670.
  • CHOI-LUNDBERG DL, UN Q, CHANG YN etal.: Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science (1997) 275:838–841.
  • •The first study to demonstrate restorative effects following adenoviral delivery of GDNF in a rat model of PD.
  • CHOI-LUNDBERG DL, UN Q, SCHALLERT T et al.: Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor. Exp. Neural. (1998) 154:261–275.
  • BILANG-BLEUEL A, REVAH F, COLIN P etal.: Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson's disease. Proc. Natl. Acad. Li. USA (1997) 94:8818–8823.
  • CONNOR B, KOZLOWSKI DA, SCHALLERT T, TILLERSON JL, DAVIDSON BL, BOHN MC: Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat. Gene Ther. (1999) 6:1936–1951.
  • KOZLOWSKI DA, CONNOR B, TILLERSON JL, SCHALLERT T, BOHN MC: Delivery of a GDNF gene into the substantia nigra after a progressive 6-OHDA lesion maintains functional nigrostriatal connections. Esp. Neural. (2000) 166:1–15.
  • LAPCHAK PA, ARAUJO DM, HILT DC, SHENG J, PAO S: Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease. Blain Res. (1997) 777:153–160.
  • KOJIMA H, ABIRU Y, SAKAJIRI K etal.: Adenovirus-mediated transduction with human glial cell line-derived neurotrophic factor gene prevents 1-methy1-4-phenyl-1 2,3,6-tetrahydropyridine-induced dopamine depletion in striatum of mouse brain. Biochem. Biophys. Res. Commun. (1997) 238:569–573.
  • MANDEL RJ, SNYDER RO, LEFF SE: Recombinant adeno-associated viral vector-mediated glial cell line-derived neurotrophic factor gene transfer protects nigral dopamine neurons after onset of progressive degeneration in a rat model of Parkinson's disease. Exp. Neural. (1999) 160:205–214.
  • MANDEL RJ, SPRATT SK, SNYDER RO, LEFF SE: Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc. Nati Acad. Sri. USA (1997) 94:14083–14088.
  • •The first study to show that adeno-associated viral vector delivery of GDNF increases dopaminergic survival in a rat model of PD.
  • KIRIK D, ROSENBLAD C, BJORKLUND A, MANDEL RJ: Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system. j Neurosci. (2000) 20:4686–4700.
  • DEGLON N, TSENG JL, BENSADOUN JC et al.: Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease. Hum. Gene Ther. (2000) 11:179–190.
  • ROSENBLAD C, GRONBORG M, HANSEN C et al.: In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin. Mai Cell Neurosci. (2000) 15:199–214.
  • BENSADOUN JC, DEGLON N, TSENG JL, RIDET JL, ZURN AD, AEBISCHER P: Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-0HDA model of Parkinson's disease using GDNF. Exp. Neural. (2000) 164:15–24.
  • LINDVALL 0, HAGELL P: Clinical observations after neural transplantation in Parkinson's disease. Prog. Blain Res. (2000) 127:299–320.
  • CLARKSON ED, FREED CR: Development of fetal neural transplantation as a treatment for Parkinson's disease. Life Se/. (1999) 65:2427–2437.
  • PICCINI P, LINDVALL 0, BJORKLUND A et al.: Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts. Ann. Neural. (2000) 48:689–695.
  • FREED CR, GREENE PE, BREEZE RE etal.: Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl. J Med. (2001) 344:710–719.
  • STROMBERG I, BJORKLUND L, JOHANSSON M et al.: Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo. Exp. Neural. (1993) 124:401–412.
  • JOHANSSON M, FRIEDEMANN M, HOFFER B, STROMBERG I: Effects of glial cell line-derived neurotrophic factor on developing and mature ventral mesencephalic grafts in oculo. Exp. Neural. (1995) 134:25–34.
  • ROSENBLAD C, MARTINEZ- SERRANO A, BJORKLUND A: Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts. Neuroscience (1996) 75:979–985.
  • •This study demonstrates the beneficial effects of GDNF on increasing dopaminergic neuronal survival and improving functional deficits following transplantation of foetal ventral mesencephalic tissue.
  • YUREK DM, FLETCHER-TURNER A: GDNF partially protects grafted fetal dopaminergic neurons against 6-hydroxydopamine neurotoxicity. Blain Res. (1999) 845:21–27.
  • WANG Y, TIEN LT, LAPCHAK PA, HOFFER BJ: GDNF triggers fiber outgrowth of fetal ventral mesencephalic grafts from nigra to striatum in 6-0HDA-lesioned rats. Cell Tissue Res. (1996) 286:225–233.
  • TANG Fl, TIEN LT, ZHOU FC, HOFFER BJ, WANG Y: Intranigral ventral mesencephalic grafts and nigrostriatal injections of glial cell line-derived neurotrophic factor restore dopamine release in the striatum of 6-hydroxydopamine-lesioned rats. Exp. Brain Res. (1998) 119:287–296.
  • WINKLER C, KIRIK D, BJORKLUND A, DUNNETT SB: Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement. Prog. Brain Res. (2000) 127:233–265.
  • SULLIVAN AM, POHL J, BLUNT SB: Growth/differentiation factor 5 and glial cell line-derived neurotrophic factor enhance survival and function of dopaminergic grafts in a rat model of Parkinson's disease. Eur. j Neurosci. (1998) 10:3681–3688.
  • GRANHOLM AC, MOTT JL, BOWENKAMP K et al: Glial cell line-derived neurotrophic factor improves survival of ventral mesencephalic grafts to the 6-hydroxydopamine lesioned striatum. Exp. Brain Res. (1997) 116:29–38.
  • ZAWADA WM, ZASTROW DJ, CLARKSON ED, ADAMS FS, BELL KP FREED CR: Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats. Brain Res. (1998) 786:96–103.
  • MEHTA V, HONG M, SPEARS J, MENDEZ I: Enhancement of graft survival and sensorimotor behavioral recovery in rats undergoing transplantation with dopaminergic cells exposed to glial cell line-derived neurotrophic factor. I Neurosurg. (1998) 88:1088–1095.
  • TORNQVIST N, BJORKLUND L, ALMQVIST E WAHLBERG L, STROMBERG I: Implantation of bioactive growth factor-secreting rods enhances fetal dopaminergic graft survival, outgrowth density, and functional recovery in a rat model of Parkinson's disease. Exp. Neural (2000) 164:130–138.
  • ESPEJO M, CUTILLAS B, ARENAS TE, AMBROSIO S: Increased survival of dopaminergic neurons in striatal grafts of fetal ventral mesencephalic cells exposed to neurotrophin-3 or glial cell line-derived neurotrophic factor. Cell Transplant. (2000) 9:45–53.
  • WILBY MJ, SINCLAIR SR, MUIR EM et al.: A glial cell line-derived neurotrophic factor-secreting clone of the Schwann cell line SCTM41 enhances survival and fiber outgrowth from embryonic nigral neurons grafted to the striatum and to the lesioned substantia nigra. j Neurosci. (1999) 19:2301–2312.
  • YUREK DM: Glial cell line-derived neurotrophic factor improves survival of dopaminergic neurons in transplants of fetal ventral mesencephalic tissue. Exp. Neural (1998) 153:195–202.
  • THAJEB P, LING ZD, POTTER ED, CARVEY PM: The effects of storage conditions and trophic supplementation on the survival of fetal mesencephalic cells. Cell Transplant. (1997) 6:297–307.
  • NIKKHAH G, EBERHARD J, OLSSON M, BJORKLUND A: Preservation of fetal ventral mesencephalic cells by cool storage: in-vitro viability and TH-positive neuron survival after microtransplantation to the striatum. Brain Res. (1995) 687:22–34.
  • KORDOWER JH, FREEMAN TB, SNOW BJ et al: Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl. j. Med. (1995) 332:1118–1124.
  • SAUER H, BRUNDIN P: Effects of coolstorage on survival and function of intrastriatal ventral mesencephalic grafts. Restorative Neurology and Neuroscience (1991) 2:123–135.
  • FREEMAN TB, KORDOWER JH: Human cadaver embryonic substantia nigra grafts: ontogeny, preoperative graft preparation and tissue storage. In Intracerebral Transplantation in Movement Disorders. Lindvall 0, Björklund A, Widner H (Eds.), Elsevier Press, Amsterdam (1990:163–170.
  • MENDEZ I, DAGHER A, HONG M et al.: Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line--derived neurotrophic factor in patients with Parkinson's disease. Report of two cases and technical considerations. j. Neurosurg. (2000) 92:863–869.
  • APOSTOLIDES C, SANFORD E, HONG M, MENDEZ I: Glial cell line-derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells. Neuroscience (1998) 83:363–372.
  • PETERSEN A, HANSSON 0, EMGARD M, BRUNDIN P: Grafting of nigral tissue hibernated with tirilazad mesylate and glial cell line-derived neurotrophic factor. Cell Transplant. (2000) 9:577–584.
  • KNOSEL B, WINSLOW JW, ROSENTHAL A et al.: Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3. Proc. Natl. Acad. Sci. USA (1991) 88:961–965.
  • HYMAN C, HOFER M, BARDE YA et al: BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature (1991) 350:230–232.
  • •The first study to show that BDNF promotes dopaminergic neuronal survival.
  • SON JH, CHUN HS, JOH TH, CHO S, CONTI B, LEE JW: Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos. j. NeuroscL (1999) 19:10–20.
  • HOGLINGER GU, SAUTTER J, MEYER M et al.: Rat fetal ventral mesencephalon grown as solid tissue cultures: influence of culture time and BDNF treatment on dopamine neuron survival and function. Brain Res. (1998) 813:313–322.
  • OSTERGAARD K, JONES SA, HYMAN C, ZIMMER J: Effects of donor age and brain-derived neurotrophic factor on the survival of dopaminergic neurons and axonal growth in postnatal rat nigrostriatal cocultures. Exp. Neural. (1996) 142:340–350.
  • KRIEGLSTEIN K, MAYSINGER D, UNSICKER K: The survival response of mesencephalic dopaminergic neurons to the neurotrophins BDNF and NT-4 requires priming with serum: comparison with members of the TGF-beta superfamily and characterization of the serum-free culture system. I Neural Transnr. Suppl. (1996) 47:247–258.
  • SPENGER C, HYMAN C, STUDER Let al.: Effects of BDNF on dopaminergic, serotonergic, and GABAergic neurons in cultures of human fetal ventral mesencephalon. Exp. Neural. (1995) 133:50–63.
  • ZHOU J, BRADFORD HF, STERN GM: The response of human and rat fetal ventral mesencephalon in culture to the brain-derived neurotrophic factor treatment. Brain Res. (1994) 656:147–156.
  • FADDA E, NEGRO A, FACCI L, SKAPER SD: Ganglioside GM1 cooperates with brain-derived neurotrophic factor to protect dopaminergic neurons from 6-hydroxydopamine-induced degeneration. Neurosci. Lett. (1993) 159:147–150.
  • SKAPER SD, NEGRO A, FACCI L, DAL TOSO R: Brain-derived neurotrophic factor selectively rescues mesencephalic dopaminergic neurons from 2,4,5-trihydroxyphenylalanine-induced injury. _J. Neurosci. Res (1993) 34:478–487.
  • SPINA MB, SQUINTO SP, MILLER J, LINDSAY RM, HYMAN C: Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methy1-4-phenylpyridinium ion toxicity: involvement of the glutathione system. Neurochern. (1992) 59:99-106. los.
  • HYMAN C, JUHASZ M, JACKSON C, WRIGHT P, IP NY, LINDSAY RM: Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. Neurosci (1994) 14:335–347.
  • MAGAL E, BURNHAM P, VARON S, LOUIS JC: Convergent regulation by ciliary neurotrophic factor and dopamine of tyrosine hydroxylase expression in cultures of rat substantia nigra. Neuroscience (1993) 52:867–881.
  • PARK TH, MYTILINEOU C: Protection from 1-methy1-4-phenylpyridinium (MPP+) toxicity and stimulation of regrowth of MPP(+)-damaged dopaminergic fibers by treatment of mesencephalic cultures with EGF and basic FGE Brain Res. (1992) 599:83–97.
  • FERRARI G, TOFFANO G, SKAPER SD: Epidermal growth factor exerts neuronotrophic effects on dopaminergic and GABAergic CNS neurons: comparison with basic fibroblast growth factor. J. Neurosci. Res (1991) 30:493–497.
  • ENGELE J, BOHN MC: The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia. I Neurosci. (1991) 11:3070–3078.
  • FERRARI G, MINOZZI MC, TOFFANO G, LEON A, SKAPER SD: Basic fibroblast growth factor promotes the survival and development of mesencephalic neurons in culture. Dev. Biol. (1989) 133:140–147.
  • •The first study to demonstrate that bFGF enhances survival of cultured dopaminergic neurons.
  • MAYER E, DUNNETT SB, FAWCETT JW: Mitogenic effect of basic fibroblast growth factor on embryonic ventral mesencephalic dopaminergic neurone precursors. Brain Res. Dev. Brain Res. (1993) 72:253–258.
  • MAYER E, DUNNETT SB, PELLITTERI R, FAWCETT JW: Basic fibroblast growth factor promotes the survival of embryonic ventral mesencephalic dopaminergic neurons--I. Effects in vitro. Neuroscience (1993) 56:379–388.
  • HOU JG, COHEN G, MYTILINEOU C: Basic fibroblast growth factor stimulation of glial cells protects dopamine neurons from 6-hydroxydopamine toxicity: involvement of the glutathione system. J. Neurochein. (1997) 69:76–83.
  • SILANI V, MARIANI D, DONATO FM et al.: Development of dopaminergic neurons in the human mesencephalon and in vitro effects of basic fibroblast growth factor treatment. Esp. Neural. (1994) 128:59–76.
  • STRELAU J, SULLIVAN A, BOTTNER M et al.: Growth/Differentiation factor-15/ Macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons In vivo. J. Neurosci. (2000) 20:8597–8603.
  • •This study identifies a new member of the TGF p family, GDF-15/MIC-1, and demonstrates that it possesses similar dopaminotrophic properties to GDNE
  • KRIEGLSTEIN K, SUTER- CRAZZOLARA C, HOTTEN G, POHL J, UNSICKER K: Trophic and protective effects of growth/differentiation factor 5, a member of the transforming growth factor-beta superfamily, on midbrain dopaminergic neurons. J. Neurosci. Res. (1995) 42:724–732.
  • LEON A, DAL TOSO R, PRESTI D et al: Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: II. Modulatory effects of gangliosides. I Neurosci. (1988) 8:746–753.
  • AKANEYA Y, TAKAHASHI M, HATANAKA H: Interleukin-1 beta enhances survival and interleukin-6 protects against MPP+ neurotoxicity in cultures of fetal rat dopaminergic neurons. Exp. Neural. (1995) 136:44–52.
  • HAMA T, KUSHIMA Y, MIYAMOTO M, KUBOTA M, TAKEI N, HATANAKA H: Interleukin-6 improves the survival of mesencephalic catecholaminergic and septet cholinergic neurons from postnatal, two-week-old rats in cultures. Neuroscience (1991) 40:445–452.
  • KNOSEL B, MICHEL PP, SCHWABER JS, HEFTI F: Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II. J Neurosci. (1990) 10:558–570.
  • STUDER L, SPENGER C, SEILER RW, ALTAR CA, LINDSAY RM, HYMAN C: Comparison of the effects of the neurotrophins on the morphological structure of dopaminergic neurons in cultures of rat substantia nigra. Eur. Neurosci. (1995) 7:223–233.
  • HYNES MA, POULSEN K, ARMANINI M, BERKEMEIER L, PHILLIPS H, ROSENTHAL A: Neurotrophin-4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures. Neurosci. Res (1994) 37:144–154.
  • NIKKHAH G, ODIN P, SMITS A etal.: Platelet-derived growth factor promotes survival of rat and human mesencephalic dopaminergic neurons in culture. Exp. Brain Res. (1993) 92:516–523.
  • OTHBERG A, ODIN P, BALLAGI A, AHGREN A, FUNA K, LINDVALL 0: Specific effects of platelet derived growth factor (PDGF) on fetal rat and human dopaminergic neurons in vitro. Exp. Brain Res. (1995) 105:111–122.
  • PIETZ K, ODIN P, FUNA K, LINDVALL 0: Protective effect of platelet-derived growth factor against 6-hydroxydopamine-induced lesion of rat dopaminergic neurons in culture. Neurosci. Lett. (1996) 204: 101–104.
  • ALEXI T, HEFTI F: Trophic actions of transforming growth factor alpha on mesencephalic dopaminergic neurons developing in culture. Neuroscience (1993) 55:903–918.
  • KRIEGLSTEIN K, SUTER-CRAZZOLARA C, FISCHER WH, UNSICKER K: TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. EMBO J. (1995) 14:736–742.
  • POULSEN KT, ARMANINI MP, KLEIN RD, HYNES MA, PHILLIPS HS, ROSENTHAL A: TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons. Neuron (1994) 13:1245–1252.
  • LEVIVIER M, PRZEDBORSKI S, BENCSICS C, KANG UJ: Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. J. Neurosci. (1995) 15:7810–7820.
  • FRIM DM, UHLER TA, GALPERN WR, BEAL MF, BREAKEFIELD XO, ISACSON 0: Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methy1-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. Proc. Nati Acad. Sci. USA (1994) 91:5104–5108.
  • HAGG T: Neurotrophins prevent death and differentially affect tyrosine hydroxylase of adult rat nigrostriatal neurons in vivo. Esp. Neural. (1998) 149:183–192.
  • KLEIN RL, LEWIS MH, MUZYCZKA N, MEYER EM: Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer. Brain Res. (1999) 847:314–320.
  • SCHNEIDER JS, SMITH MG, DISTEFANO L, BERRIAN J: GM1 ganglioside treatment partially reverses the nigrostriatal dopamine defect in the weaver mutant mouse. Brain Res. (1994) 636:353–356.
  • CONSOLAZIONE A, TOFFANO G: Ganglioside treatment in the recovery of the DA nigrostriatal system in different experimental conditions. Ann. NY Acad. Sci. (1988) 515:395–402.
  • AGNATI LF, FUXE K, CALZA L et al: Further studies on the effects of the GM1 ganglioside on the degenerative and regenerative features of mesostriatal dopamine neurons. Acta Physial Land. Suppl. (1984) 532:37–44.
  • AGNATI LF, FUXE K, CALZA L et al: Gangliosides increase the survival of lesioned nigral dopamine neurons and favour the recovery of dopaminergic synaptic function in striatum of rats by collateral sprouting. Acta Physial Scand. (1983) 119:347–363.
  • HOGLINGER GU, WIDMER HR, SPENGER C et al: Influence of time in culture and BDNF pretreatment on survival and function of grafted embryonic rat ventral mesencephalon in the 6-0HDA rat model of Parkinson's disease. Exp. Neural (2001) 167:148–157.
  • YUREK DM, LU W, HIPKENS S, WIEGAND SJ: BDNF enhances the functional reinnervation of the striatum by grafted fetal dopamine neurons. Exp. Neural. (1996) 137:105–118.
  • SAUER H, FISCHER W, NIKKHAH G et al.: Brain-derived neurotrophic factor enhances function rather than survival of intrastriatal dopamine cell-rich grafts. Brain Res. (1993) 626:37–44.
  • MATSUDA S, SAITO H, NISHIYAMA N: Basic fibroblast growth factor ameliorates rotational behavior of substantia nigral-transplanted rats with lesions of the dopaminergic nigrostriatal neurons. hm. Pharmacy]. (1992) 59:365–370.
  • STEINBUSCH HW, VERMEULEN RJ, TONNAER JA: Basic fibroblast growth factor enhances survival and sprouting of fetal dopaminergic cells implanted in the denervated rat caudate-putamen: preliminary observations. Frog. Brain Res. (1990) 82:81–86.
  • ZENG BY, JENNER E MARSDEN CD: Altered motor function and graft survival produced by basic fibroblast growth factor in rats with 6-0HDA lesions and fetal ventral mesencephalic grafts are associated with glial proliferation. Exp. Neural. (1996) 139:214–226.
  • TAKAYAMA H, RAY J, RAYMON HK, BAIRD A, HOGG J, FISHER LJ, GAGE FH: Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease. Nat. Med. (1995) 1:53–58.
  • MAYER E, FAWCETT JW, DUNNETT SB: Basic fibroblast growth factor promotes the survival of embryonic ventral mesencephalic dopaminergic neurons--II. Effects on nigral transplants in vivo. Neuroscience (1993) 56:389–398.
  • HAQUE NS, HLAVIN ML, DU JS, FAWCETT JW, DUNNETT SB: In vivo effects of kFGF on embryonic nigral grafts in a rat model of Parkinson's disease. Neurareport (1995) 6:2177–2181.
  • HAQUE NS, HLAVIN ML, FAWCETT JW, DUNNETT SB: The neurotrophin NT4/5, but not NT3, enhances the efficacy of nigral grafts in a rat model of Parkinson's disease. Brain Res. (1996) 712:45–52.
  • GIACOBINI MM, ALMSTROM S, FUNA K, OLSON L: Differential effects of platelet-derived growth factor isoforms on dopamine neurons in vivo: -BB supports cell survival, -AA enhances fiber formation. Neuroscience (1993) 57:923–929.

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