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Review

Sex hormones and their impact on dementia and depression: a clinical perspective

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Pages 527-535 | Published online: 24 Feb 2005

Bibliography

  • UNITED NATIONS: World Population Prospects 1988.Publication No. 106. Department of Economic and Social Affairs, New York, USA, (1998).
  • VAN DER WEYDEN M: The burden of disease and injuryin Australia: time for action. Med. J Aust. (1999) 171:581–582.
  • HENDERSON AS, JORM AF: Dementia in Australia. Agedand Community Care Service Development and Evaluation Reports, Canberra, Australia (1998).
  • HENDERSON AS, JORM AF, MACKINNON A et al: Theprevalence of depressive disorders and the distribu-tion of depressive symptoms in later life: a survey using Draft ICD-10 and DSM-III-R. Psycho]. Med. (1993) 23:719–729.
  • JOHNSON J, WEISSMAN MM, KLERMAN GL: Serviceutilization and social morbidity associated with depressive symptoms in the community. JAMA (1992) 267:1478–1483
  • HENDERSON AS, KORTEN AE, JACOMB PA et al: Thecourse of depression in the elderly: a longitudinal community-based study in Australia. Psycho]. Med. (1997) 27:119–129.
  • YAFFE K, SAWAYA G, LIEBERBURG I, GRADY D: Estrogentherapy in postmenopausal women: effects on cognitive function and dementia. JAMA (1998) 279:688–695.
  • MCEWEN BS, ALVES SE, BULLOCH K, WEILAND NG:Clinically relevant basic science studies of gender differences and sex hormone effects. Psychopharmacol Bull. (1998) 34:251–259.
  • PETANCESKA SS, NAGY V, FRAIL D, GANDY S: Ovariec-tomy and 1 713-estradiol modulate the levels of Alzheimer's amyloid 13 peptides in brain. Neurology (2000) 54:2212–2217.
  • EBERLING JL, REED BR, COLEMAN JE, JAGUST WJ: Effectof estrogen on cerebral glucose metabolism in postmenopausal women. Neurology (2000) 55:875–877.
  • YAFFE K, LUI LY, GRADY D, CAULEY J, KRAMER J,CUMMINGS SR: Cognitive decline in women in relation to non-protein-bound oestradiol concentrations. Lancet (2000) 356:708–712.
  • •Previous similar studies have mostly measured serum concentrations of total oestradiol and have found little relationship with cognitive performance. This study reported that women with higher non-protein bound and bioavailable oestradiol were less likely to have developed cognitive impairment at 6 years follow-up (n = 425).
  • YAFFE K, HAAN M, BYERS A, TANGEN C, KULLER L: Estrogen use, APOE and cognitive decline: evidence of gene-environment interaction. Neurology (2000) 54:1949–1954.
  • •This paper demonstrated an important gene interaction in a large sample of women (n = 2586). Among APOE-E4 negative women, current oestrogen use reduced the risk of cognitive impairment compared with never-users by almost half. There was no change in the risk of cognitive impair-ment amongst APOE-E4 carriers.
  • MANLY JJ, MERCHANT CA, JACOBS DM et al.: Endoge-nous estrogen levels and Alzheimer's disease among postmenopausal women. Neurology (2000) 54:833–837.
  • TANG MX, JACOBS D, STERN Y et al.: Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet (1996) 348:429–432.
  • ••This paper was the first prospective study to report a signifi-cant reduction in the risk of AD amongst 1124 women who had used ERT.
  • KAWAS C, ROSNICK S, MORRISON A et al.: A prospectivestudy of estrogen replacement therapy and the risk of developing Alzheimer's disease in the Baltimore longitudinal study of aging. Neurology (1997) 48:1517–1521.
  • BALDERESCHI M, DI CARLO A, LEPORE V et al.: Estrogen-replacement therapy and Alzheimer's disease in the Italian Longitudinal Study on Aging. Neurology (1998) 50:996–1002.
  • WARING SC, ROCCA WA, PETERSEN RC, O'BRIEN PC, TANGALOS EG, KOKMEN E: Postmenopausal estrogen replacement therapy and risk of AD: a population-based study. Neurology (1999) 52:965–970.
  • HENDERSON VW, PAGANINI-HILL A, MILLER BL et al.: Estrogen for Alzheimer's disease in women: random-ized, double-blind, placebo-controlled trial. Neurology (2000) 54:295–301.
  • MULNARD RA, COTMAN CW, KAWAS C et al.: Estrogen replacement therapy for treatment of mild to moderate Alzheimer's disease. JAMA (2000) 283:1007–1015.
  • ••This is currently the largest placebo-controlled study of ERTfor the treatment of patients with AD showing patients with AD do not benefit from oestrogen treatment.
  • WANG PN, LIAO SQ, LIU RS eta].: Effects of estrogen on cognition, mood and cerebral blood flow in AD: a controlled study. Neurology (2000) 54:2061–2066.
  • MICHAEL RP, REES HD, BONSALL RW: Sites in the male primate brain at which testosterone acts as androgen. Brain Res. (1989) 502:11–20.
  • SIMERLY RB, CHANG C, MURAMATSU M, SWANSON LW:Distribution of androgen and estrogen receptor mRNA-containing cells in rat brain: an in situ hybridi-zation study. J. Comp. Neurol. (1990) 294:76–95.
  • DAY JR, FRANK AT, O'CALLAGHAN JP, JONES BC, ANDERSON JE: The effect of age and testosterone on the expression of glial fibrillary acidic protein in the rat cerebellum. Exp. Neurol. (1998) 151:343–346.
  • PAPASOZOMENOS SC: The heat shock-induced hyperphsophorylation of tau is estrogen-independent and prevented by androgen: implications for Alzheimer's disease. Proc. Natl. Acad. Sci. USA (1997) 94:6612–6617.
  • •This paper presents interesting evidence suggesting an interaction between sex hormones and the pathogenic process of AD in an animal (rat) model.
  • GOURAS GK, XU H, GROSS RS et al.: Testosterone reduces neuronal secretion of Alzheimer's 13-amyloid peptides. Proc. Natl. Acad. Sci. USA (2000) 97:1202–1205.
  • •This study used neuronal cultures from the brains of rats (N2a cells and primary cerebrocortical neurones) to demonstrate that testosterone reduces the levels of P-amyloid secreted by brain cells.
  • JANOWSKY JS, OVIATT SK, ORWOLL ES: Testosterone influences spatial cognition in older men. Behav. Neurosci. (1994) 108:325–332.
  • MOFFAT SD, HAMPSON E: A curvilinear relationship between testosterone and spatial cognition in humans: possible influences of hand preference. Psychoendocrinology (1996) 21:323–337.
  • VAN GOOZEN SHM, COHEN-KETTENIS PT, GOOREN LJG et al: Activating effects of androgens on cognitive performance: causal evidence in a group of female-to-male transsexuals. Neuropsychologia (1994) 32:1153–1157.
  • •This paper shows the development of a traditionally 'male' cognitive pattern in female-to-male transsexuals, following 3 months of testosterone administration.
  • ALMEIDA OP, RIONO A, CLARNETTE R, MARTINS RN: Decreased plasma testosterone levels in Alzheimer's disease and aged controls from Australia. Alzheimer's Reports (2000) 3:15–18.
  • TWIST SJ, TAU PR GA, WEDDELL A, WEIGHTMAN DR,EDWARDSON JA, MORRIS CM: Brain oestradiol and testosterone levels in Alzheimer's disease. Neurosci. Lett. (2000) 286:1–4.
  • PARKER LN, LEVIN ER, LIFRAK ET: Evidence of adreno-cortical adaptation to severe illness. J. Clin. Endocrinol. Metab. (1985) 60:947–952.
  • HUPPERT FA, VAN NIEKERK JK, HERBERT J: Dehydroepi-androsterone (DHEA) supplementation for cognition and well-being (Cochrane Review). In: Cochrane Library (Issue 1). Update Software, Oxford (2001).
  • HALBREICH U: Role of estrogen in postmenopausal depression. Neurology (1997) 48 (Suppl. 7):16–19.
  • CASPER RF, HEARN MT: The effect of hysterectomy andbilateral oophorectomy in women with severe premenstrual syndrome. Am. J. Obstet. Gynecol. (1990) 162:105–109.
  • ANGOLD A, COSTELLO EJ, ERKANLI A, WORTHMAN CM:Pubertal changes in hormone levels and depression in girls. Psycho]. Med. (1999) 29:1043–1053.
  • WATSON NR, STUDD JWW, SAVVAS M, BABER RJ: Thelong-term effects of estradiol implant therapy for the treatment of premenstural syndrome. Gynecol Endocrinol. (1990) 4:99–107
  • SCHMIDT PJ, NIEMAN LK, DANACEAU MA, ADAMS LF,RUBINOW DR: Differential behavioral effects of gonadal steroids in women with and in those without premenstrual syndrome. N. Engl. J. Med. (1998) 338:209–216.
  • •This paper demonstrated that 10/20 women with premen-strual dysphoria improved following administration of a gonadotropin-releasing hormone agonist. When hormones were re-introduced, symptoms were again present.
  • SICHEL DA, COHEN LS, ROBERTSON LM, RUTTEMBERG A,ROSENBAUM JF: Prophylactic estrogen in recurrent postpartum affective disorder. Biol. Psychiatry (1995) 38:814–818.
  • BLOCH M, SCHMIDT PJ, DANACEAU M, MURPHY J, NIEMAN L, RUBINOW DR: Effects of gonadal steroids in women with a history of postpartum depression. Am. Psychiatry (2000) 157:924–930.
  • •This interesting study was designed to mimic the hormonal environment of pregnancy in women with and without a history of postpartum depression. The authors were able to demonstrate that most of the women with a history of postpartum depression and none of the controls developed depressive symptoms.
  • LAWRIE TA, HOFMEYER GJ, DE JAGER M, BERK M, PAIKER J, VILJOEN E: A double-blind randomised placebo-controlled trial of postnatal norethisterone enanthate: the effect on postnatal depression and serum hormones. Br.J. Obstet. Gynaecol (2000) 105:1082–1090.
  • •This paper reports the effects of a random assignment of 180 women to a single im. injection progestogen (200 mg) or placebo within 48 h of giving birth. It was demonstrated that those receiving progestogen were significantly more likely to report depressive symptoms.
  • GREGOIRE AJP, KUMAR R, EVERITT B, HENDERSON AF, STUDD JWW: Transdermal oestrogen for treatment of severe postnatal depression. Lancet (1996) 3 47:930–933.
  • ••This trial demonstrated a superior antidepressant effect ofoestrogen replacement compared to placebo in women who became depressed following childbirth.
  • NOVAES C, ALMEIDA OP, MELO NR: Mental health among perimenopausal women attending a menopause clinic: possible association with premen-strual syndrome? Climacteric (1998) 1:264–270.
  • COOPE J: Is oestrogen therapy effective in thetreatment of menopausal depression? J R. Gen. Pract (1981) 31:134–140.
  • CAMPBELL S, WHITEHEAD M: Oestrogen therapy andthe menopause syndrome. Clin. Obstet. Gynaecol. (1977) 4 :31–47.
  • PEARCE J, HAWTON K, BLAKE F et al: Psychological effects of continuation versus discontinuation of hormone replacement therapy by estrogen implants: a placebo-controlled study. J Psychosom. Res. (1997) 42:177–186.
  • SCHMIDT PJ, NIEMAN L, DANACEAU MA et al: Estrogen replacement in perimenopause-related depression: a preliminary report. Am. J. Obstet. Gynecol. (2000) 183:414–420.
  • •Most studies of the relationship between oestrogen and mood after the menopause use random community samples of volunteers, which may not have a high prevalence of depression. At the time of writing, this study was the only available clinical trial of the effects of oestrogen replacement in perimenopausal women with clinical depression.
  • SOARES CN, ALMEIDA OP, JOFFE H, COHEN LS: Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women. Arch Gen. Psychiatry (In Press).
  • GONZALES MI, FARABOLLINI F, ALBONETTI E, WILSON CA: Interaction between 5-hydroxytryptamine (5-111) and testosterone in the control of sexual and nonsexual behaviour in male and female rats. Pharmacol Biochem. Behav. (1994) 47:591–601.
  • GRAY A, BERLIN JA, MCKINLAY JB, LONGCOPE C: An examination of research design effects on the associa-tion of testosterone and male aging: results of a meta-analysis. J Gun. Epidemiol (1991) 7:671–684.
  • DABS JM, HARGROVE MF, JURKOVIC GJ: Testosterone differences among college fraternities: well-behaved vs. rambunctious. Personal. Individ. Diff. (1996) 20:157–161.
  • POPE JR HG, KOURI EM, HUDSON JI: Effects ofsupraphysiologic doses of testosterone on mood and aggression in normal men: a randomized controlled trial. Arch. Gen. Psychiatry (2000) 57 :133–140.
  • MAZUR A: Biosocial models of deviant behavior among male army veterans. Biol. Psychol (1995) 41:271–293.
  • BOOTH A, JOHNSON DR, GRANGER DA: Testosterone and men's depression: the role of social behavior. J Health Soc. Behav. (1999) 40:130–140.
  • •This study of a large sample of 4393 men showed an inverse relationship between testosterone levels and depression scores.
  • SCHWEIGER U, DEUSCHELE M, WEBER B et al.: Testos- terone, gonadotropin and cortisol secretion in male patients with major depression. Psychosom. Med. (1999) 61:292–296.
  • SEIDMAN SN, RABKIN JG: Testosterone replacement therapy for hypogonadal men with SSRI-refractory depression. J. Affect. Disord. (1998) 48:157–161.
  • RABKIN JG, WAGNER GJ, RABKIN R: A double-blind, placebo-controlled trial of testosterone therapy for H1V-positive men with hypogonadal symptoms. Arch. Gen. Psychiatry (2000) 57:141–147.
  • •This short, placebo-controlled study was able to demonstrate a significant reduction of depressive scores amongst HIV infected men following the administration of testosterone.
  • HEUSER I, DEUSCHLE M, LUPPA P, SCHWEIGER U, STANDHARDT H, WEBER B: Increased diurnal plasma concentrations of dehydroepiandrosterone in depressed patients. J. Clin. Endocrinol Metab. (1998) 83:3130–3133.
  • BARRETT-CONNOR E, VON MÜHLEN D, LAUGHLIN GA,KRIPKE A: Endogenous levels of dehydroepiandros-terone sulfate but not other sex hormones, are associ-ated with depressed mood in older women: the Rancho Bernardo study. J. Am. Geriatr. Soc. (1999) 47:685–691.
  • BARNHART KT, FREEMAN E, GRISSO JA et al.: The effectof deydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters and health-related quality of life. J. Clin. Endocrinol. Metab. (1999) 84:3896–3902.
  • BLOCH M, SCHMIDT PJ, DANACEAU M, ADAMS LF, RUBINOW DR: Dehydroepiandrosterone treatment of midlife dysthymia. Biol. Psychiatry (1999) 45:1533–1541.
  • WOLKOWITZ OM, REUS VI, KEEBLER A et al.: Double-blind treatment of major depression with dehydroepi-androsterone. Am. J Psychiatry (1999) 156:646–649.

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