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Miscellaneous

Primary Sjögren’s syndrome: oral aspects on pathogenesis, diagnostic criteria, clinical features and approaches for therapy

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Pages 1415-1436 | Published online: 25 Feb 2005

REFERENCES

  • STRAND V, TALAL N: Advances in the diagnosis and concept of Sjogren's syndrome (autoimmune exocrinopathy). Bull. Rheum. Dis. (1980) 30:1046–1050.
  • MOUTSOPOULOS HM, TALAL N: Immunological abnormalities in Sjogren's syndrome. In: Shigrert's Syndrome. Clinical and Immunological Aspects Talal N, Moutsopoulos HM, Kassan SS (Eds.), Springer Verlag, Heidelberg (1987):258–265.
  • MANTHORPE R, OXHOLM E PRAUSE JU, SCHIODT M: The Copenhagen criteria for Sjogrens syndrome. Scam/. Rheumatol (1986) (Suppl. 61):19–21.
  • MOUTSOPOULOS HM, CHUSED TM, MANN DL et al: Sjogren's syndrome (sicca syndrome): current issues. Ann. Int. Med. (1980) 92:212–226.
  • TALAL N: Recent developments in the immunology of Sjogren's syndrome (autoimmune exocrinopathy). Scam/. Rheumatol. (1986) (Suppl. 61):76–82
  • KONTTINEN YT, HUKKANEN M, KEMPINEN P et al.: Peptide-containing nerves in labial salivary glands in Sjogren's syndrome. Arthritis Rheum. (1992) 7:815-820. **Immunohistochemical study demonstrating lack of peptide-containing nerves in central areas of focal lymphocytic infiltrates in labial salivary glands biopsies from patients with SS.
  • PEDERSEN AM, DISSING S, FAHRENKRUG J, HANNIBAL J, REIBEL J, NAUNTOFTE B: Innervation pattern and Ca2+ signalling in labial salivary glands of healthy individuals and patients with primary Sjogren's syndrome. ..J. Oral. Path. Med. (2000) 29:97-109. ••A surprising finding of functional intactreceptor system on the surface membrane of labial salivary gland cells isolated from patients with pSS.
  • MANDL T, BORNMYR SV, CARSTENFORS J, JACOBSSON LT, MANTHORPE R, WOLLMER P: Sympathetic dysfunction in patients with primary Sjogren's syndrome. j Rheumatol (2001) 28(2):296–301.
  • BLOCH KJ, BUCHANAN WW, WOHL MJ, BUNIM JJ: Sjogren's syndrome: a clinical, pathological and serological study of sixty-two cases. Medicine (1965) 44:187–231.
  • FOX RI, HOWELL FV, BONE RC, MICHELSON P: Primary Sjogren's syndrome: clinical and immunopathological features. Semi]. Arthritis Rheum. (1984) 14:77–103.
  • OXHOLM E ASMUSSEN K: Primary Sjogren's syndrome: the challenge for classification of disease manifestations. mt. Med. (1996) 239:467-474. ••Proposal of a new classification system(wheel) for disease manifestations of SS.
  • WHALEY K, BUCHANAN WW: Sjogren's syndrome and associated diseases. In: Clinical Immunology Vali Parker CW (Ed.), Saunders, Philadelphia, PA, USA (1980):632–666.
  • HARLEY JB: Autoantibodies in Sjogren's syndrome. In: Shigrert's Syndrome. Clinical and Immunological Aspects. Talal N, Moutsopoulos HM, Kassan SS (Eds.), Springer Verlag, Berlin, Heidelberg, New York, London, Paris, Tokyo (1987):218–234.
  • KASSAN SS, THOMAS TL, MOUTSOPOULOS HM et al.: Increased risk of lymphoma in sicca syndrome. Ann. Intern. Med. (1978) 89:888–892.
  • ZUFFEREY P, MEYER OC, GROSSIN M,KAHN MF: Primary Sjogren's syndrome (SS) and malignant lymphoma. Land. Rheumatol (1995) 24:342–345.
  • MANTHORPE R, KIRTAVA Z, AXELL T, HENRISSON V, TABERY H, JACOBSSON L. Clinical and demographic data at the time of diagnosis for primary Sjogren's syndrome. In: Shigreris Syndrome - State of the Ad. Proceedings of the Fourth International Symposium, Tokyo Japan 1993. Homma M, Sugai S, Tojo T, Miyasaka N, Akizuki M (Eds.), Kugler Publications,Amsterdam/New York (1994):367–369.
  • CHUDWIN DS, DANIELS TE, WARA DW et al: Spectrum of Sjogren's syndrome in children. j Pediatr (1981) 98:213–235.
  • STILLER M, GOLDER W, WRING E, BIEDERMANN T: Primary and secondary Sjogren's syndrome in children - a comparative study. Clin. Oral Invest. (2000) 4:176–182.
  • HAGA HJ, JONSSON R: The influence ofAge on Disease Manifestations and Serological Characteristics in Primary Sjogren's Syndrome. Land. j Rheumatol (1999) 28:227–232.
  • JACOBSSON LTH, MANTHORPE R: Epidemiology of Sjogren's syndrome. Rheumatol Europe (1995) 24:46–47.
  • JACOBSSON LTH, AXELL TE, HANSEN BU et al.: Dry eyes or mouth - An epidemiological study in Swedish adults, with special reference to primary Sjogren's syndrome. J. Autoimmun. (1989) 2:521–527.
  • BJERRUM K: Primary Sjogren's syndrome and keratoconjunctivitis sicca: diagnostic methods, frequency and social disease aspects. (Thesis). Munksgaard, Copenhagen, Denmark. Acta Opthalmol Scam/. (2000) 78\(Suppl. 231):1–37. •An excellent overview and discussion of the diagnosis of KCS.
  • DANIELS TE: Sjogren's syndrome: Clinical Spectrum and Current Diagnostic Controversies. Adv. Dent. Res. (1996) 10(1):3–8.
  • MANTHORPE R, JACOBSSON LTH: *gran 's syndrome. Bailliere's Clinical Rheumatology (1995) 9:483–496.
  • FOX RI, ROBINSON CA, CURD J, MICHELSON P, BONER, HOWELL FV: First International Symposium on Sjogren's syndrome: suggested criteria for classification. Scand. j Rheumatol (1986) (Suppl. 61):28–30.
  • SKOPOULI FN, DROSOS AA, PAPAIOANNOU T, MOUTSOPOULOS HM: Preliminary diagnostic criteria for Sjogren's syndrome. Scam/. j Rheumatol (1986) (Suppl. 61):22–25.
  • HOMMA M, TOJO T, AKIZUKI M, YAGAMATA H: Criteria for Sjogren's syndrome in Japan. Scam/. I Rheumatol. (1986) (Suppl. 61):26–27.
  • VITALI C, BOMBARDIERI S, MOUTSOPOULOS HM et al: Preliminary criteria for the classification of the Sjogren's syndrome. Results of the prospective concerted action supported by the European Community. Arthritis Rheum. (1993) 36:340–347.
  • VITALI C, BOMBARDIERI S, MOUTSOPOULOS HM et al: Assessment of the European classification criteria for Sjogren's syndrome in a series of clinically defined cases: results of a prospective multicenter study. Ann. Rheum. D (1996) 55(2):116–121.
  • VITALI C, BOMBARDIERI S, MOUTSOPOULOS HM et al: The European classification criteria for Sjogren's syndrome (SS): proposal for a modification of the rules for classification suggested by the analysis of the receiver operating characteristic (ROC) curve of the criteria performance. j Rheumatol (1997) 24\(Suppl. 50):38. Abstract. ••A proposed revision of the EEC criteriawould include antibodies to SS-A/SS-B and/or presence of focus 1.
  • VITALI C, BOMBARDIERI S, MOUTSOPOULOS HM etal.: A proposal for modification of the European classification criteria for Sjogren's syndrome. Chit. Exp. Rheumatol (2000) 18:118. Abstract.
  • DANIELS TE, BENN DK: Is sialography effective in diagnosing the salivary component of Sjogren's syndrome?Adv. Dent. Res. (1996) 10(1):25–28.
  • WHALEY K, WILLIAMSON J, CHISHOLM DM, WEBB J, MASON DK, BUCHANAN WW: Sjogren's syndrome. I. Sicca components. Q. I Med. (1973) 42:279–304.
  • CHISHOLM DM, BLAIR GS, LOW PS, WHALEY K: Hydrostatic sialography as an index of salivary gland disease in Sjogren's syndrome. Acta Radial. (Diagn) (Stockholm). (1971) 11:577–585.
  • GONZALEZ L, MACKENZIE AH, TARAR RA: Parotid sialography in Sjogren's syndrome. Radiology (1970) 97:91–93.
  • DIJKSTRA PF: Classification and differential diagnosis of sialographic characteristics in Sjogren's syndrome. Semin. Arthritis Rheum. (1980) 10:10–16.
  • SCHIODT M, THORN J: Criteria for the salivary component of Sjogren's syndrome. A review. Clin. Exp. Rheumatol (1989) 7:119–122.
  • VITALI C, MONTI P, GIUGGIOLI C et al.: Parotid sialography and lip biopsy in the evaluation of oral component in Sjogren's syndrome. Chit. Exp. Rheumatol (1989) 7:131–135.
  • LINDVALL AM, JONSSON R. The salivary gland component of Sjogren's syndrome: an evaluation of diagnostic methods. Oral Surg. Oral Med. Oral Pathol. (1986) 62:32–42.
  • BERTRAM U: Xerostomia: clinical aspects, pathology and pathogenesis. Acta Odontol Scam/. (1967) 2: (Suppl. 49).
  • HELMAN J, TURNER RJ, FOX PC et al: 99" Tc-pertechnetate uptake in rat parotid acinar cells by the Na/K/Cl cotransport system. j Clin. Invest. (1987) 60:1310–1313.
  • SUGIHARA T, YOSHIMURA Y: Scintigraphic evaluation of the salivary glands in patients with Sjogren's syndrome. Int. J. Oral Maxillofac. Surg. (1988) 17:71–75.
  • SCHALL GL, ANDERSON LG, WOLF RO et al: Xerostomia in Sjogren's syndrome; evaluation by sequential salivary scintigraphy. J. Am. Med. Assoc. (1971) 216:2109–2116.
  • DANIELS TE, POWELL MR, SYLVESTER RA, TALAL N: An evaluation of salivary scintigraphy in Sjogren's syndrome. Arthritis Rheum. (1979) 22:809–814.
  • KOHN WG, SHIP JA, ATKINSON JC, PATTON LL, FOX PC: Salivary gland 99'T c-sci nt i gr ap hy : a grading scale and correlation with major salivary gland flow rates. J. Oral Pathol Med. (1992) 21:70–74.
  • HAKANSSON U, JACOBSSON L, LILJA B, MANTHORPE R, HENRIKSSON V: Salivary gland scintigraphy in subjects with and without symptoms of dry mouth and/ or eyes, and in patients with primary Sjogren's syndrome. Scam/. I Rheumatol (1994) 23:326–333.
  • VALESINI G, GUALDI GF, PRIORI R et al.: Magnetic Resonance Imaging of parotid glands and lip biopsy in the evaluation of xerostomia in Sjogren's syndrome. Land. Rheumatol (1994) 23:103–106.
  • BRADUS RJ, HYBARGER P, GOODING GAW: Parotid gland: US findings in Sjogren's syndrome. Radiology (1988) 169:749–751.
  • MARCH DE, VIJAY RIVI, ZWILLENBERG D: Computed tomography of salivary glands in Sjogren's syndrome. Arch. Otolaryngol Head Neck Surg. (1989) 115:105–106.
  • DAWES C: Physiological factors affecting salivary flow rate, oral sugar clearance and the sensation of dry mouth in man. I Dent. Res. (1987) 66:648–653.
  • SHIP JA, FOX PC, BAUM BJ. How much saliva is enough? 'Normal' function defined. J. Am. Dent. Assoc. (1991) 122:63–69.
  • DANIELS TE: Labial salivary gland biopsy in Sjogren's syndrome. Assessment and a diagnostic criterion in 362 suspected cases. Arthritis Rheum. (1984) 27:147–156.
  • PEDERSEN AM, REIBEL J, NORDGARDEN H, BERGEM HO, JENSEN JL, NAUNTOFTE B: Primary Sjogren's syndrome: salivary gland function and clinical oral findings. Oral Dis. (1999) 5:128–138.
  • VITALI C, MOUTSOPOULOS HM, BOMBARDIERI S et al: The European Community Study Group for Sjogren's syndrome. Sensitivity and specificity of tests for ocular and oral involvement in Sjogren's syndrome. Ann. Rheum. Dis. (1994) 53:637–647.
  • SPEIGHT PM, PAUL A, MELSOM RD: ME: Measurement of whole unstimulated salivary flow in the diagnosis of Sjogren's syndrome. Ann. Rheum. Dis. (1992) 51:499–502.
  • PEDERSEN AM, REIBEL J, NAUNTOFTE B: Primary Sjogren's syndrome: subjective symptoms and salivary findings. j Oral Pat. Med. (1999) 28:303–311.
  • SCULLY C: Sjogren's syndrome: Clinicaland laboratory features, immunopathogenesis, and management. Oral Surg. Oral Med. Oral Pathel. (1986) 65:510–523.
  • DAWSON LJ, HOLT DJ, LONGMAN LP, FIELD EA: A comparison of salivary gland hypofunction in primary and secondary Sjogren's syndrome. Oral Dis. (2001) 7:28–30.
  • ERICSON S: The importance of sialography for the determination of the parotid flow. The normal variation in salivary output in relation to the size of the gland at stimulation with citric acid. Acta Otolaryngol. (1971) 72:437–444.
  • ATKINSON JC, TRAVIS WD, SLOCUM L, EBBS WL, FOX PC: Serum anti-SS-B/ La and IgA rheumatoid factor are markers of salivary gland disease activity in primary Sjogren's syndrome. Arthritis Rheum. (1992) 35:1368–1372.
  • DANIELS TE, FOX PC: Salivary and oralcomponents of Sjogren 's syndrome. Rheum. Dis. Clin. North Am. (1992) 18(3):571–589.
  • OSTERBERG T, LANDAHL S, HEDEGARD B: Salivary flow, saliva, pH and buffering capacity in 70-year-old men and women: correlation to dental health, dryness in the mouth, disease and drug treatment. j Oral Rehabil (1984) 11:157–170.
  • SREEBNY LM, SCHWARTZ SS: A reference guide to drugs and dry mouth - 2nd edition. Cerodontology (1997) 14(1):33–47.
  • BAUM BJ: Salivary gland fluid secretion during aging. J. Am. Cetiatr. Soc. (1989) 37: 453–458.
  • WU AJ, ATKINSON JC, FO PC et al: Cross-sectional and longitudinal analyses of stimulated parotid salivary constituents in healthy, different aged subjects. j Cerontol. Med. Sci. (1993) 48:219–224.
  • FOX PC, BUSCH KA, BAUM BJ: Subjective reports of xerostomia and objective measures of salivary gland performance. J. Am. Dent. Assoc. (1987) 115:581–584.
  • THORN JJ, PRAUSE JU, OXHOLM P: Sialochemistry in Sjogren's syndrome: a review. ..J. Oral Pathol. Med. (1989) 18:457–468.
  • TISHLER M, YARON I, SHIRAZI I, YARON M: Saliva: an additional diagnostic tool in Sjogren's syndrome. &min Arthritis Rheum. (1997) 27:173–179.
  • FERGUSON DB: The flow rate and composition of human labial saliva. Arch. Oral Biol. (1999) 44(1):11–14.
  • ATKINSON JC, TRAVIS WD, PILLEMER SR et al.: Major salivary gland function in primary Sjogren's syndrome and its relationship to clinical findings. Rheumatol. (1990) 17:318–322.
  • PEDERSEN AM, BARD OW A, NAUNTOFTE B: Buffer Capacity of Parotid Saliva in Primary Sjogren's Syndrome. I Dent. Res. (2001). In Press.
  • SIDAGIS J, UENO K, WANG ZH, HANAMURE Y, FUTURA S, OHYAMA M: Expression of glycoconjugates in normal and Sjogren's syndrome labial glands. Acta Otolalyngol. (Stockh) (1997) 117:871–877.
  • AZEN EA, HELLEKANT G, SABATINI LM et al.: mRNAs for PRPs, statherin and histatins in von Ebner's gland tissues. Dent. Res. (1990) 69:1724–1730.
  • LAMKIN MS, OPPENHEIM FG: Structural features and salivary function. Grit. Rev Oral Biol. Med. (1993) 4:251–260.
  • GREENSPAN JS, DANIELS TE, TALAL N, SYLVESTER RA: The histopathology of Sjogrens syndrome in labial salivary gland biopsies. Oral Surg. Oral Med. Oral Pathel. (1974) 37:217–229.
  • PENNEC YL, LEROY JP, JOUQUAN J, LELONG A, KATSIKIS P, YOUINOU P: Comparison of labial and sublingual salivary gland biopsies in the diagnosis of Sjogren's syndrome. Ann. Rheum. Dis. (1990) 49: 37–39.
  • KATZ J, YAMASE H, PARKE A: A case of Sjogren's syndrome with repeatedly negative findings on lip biopsy. Arthritis Rheum. (1991) 34(10):1325–1328.
  • MANTHORPE R, BENONI C, KIRTAVA Z et al: Lower frequency of focal lip sialadenitis (focus score) in smoking patients. Can tobacco diminish the salivary gland involvement in Sjogren's syndrome? Ann. Rheum. Dis. (2000) 59(1):54–60.
  • TAKEDA Y, KOMORI A: Focal lymphocytic infiltration in the human labial salivary glands: a post mortem study. ..J. Oral Pathel. (1986) 15:83–86.
  • DE WILDE PCM, KATER L, BAAK JPA, VAN HOUWELINGEN JC, SLOOTWEG PJ: A new and highly sensitive immunohistologic diagnostic criterion for Sjogren's syndrome. Arthritis Rheum. (1989) 32:1214–1220.
  • VERED M, BUCHNER A, HAIMOVICI E, HISS Y, DAYAN D: Focal lymphocytic infiltration in aging human palatal salivary glands: a comparative study with labial salivary glands. I Oral Pathol. Med. (2001) 30:7–11.
  • SCOTT J: Qualitative and quantitative observations on the histology of human labial salivary glands obtained post mortem. Biol. Buccale (1980) 8:87–200.
  • SYRJANEN S: Age-related changes in structure of labial salivary glands. Age Aging (1984) 13:159–165.
  • SCOTT J: Quantitative age changes in the histological structure of human submandibular salivary glands. Arch. Oral Biol. (1977) 22:221–227.
  • KURSHIMA C, HIROKAWA K: Age-related increase of focal lymphocytic infiltration in the human submandibular glands. J. Oral Pathol. (1986) 15:172–178.
  • SEGERBERG-KONTTINEN M: Focal adenitis in lacrimal and salivary glands. A Post-mortem Study. Land. j Rheum. (1988) 17:379–385.
  • HEFT HW, BAUM BJ: Unstimulated and stimulated parotid salivary flow rate in individuals of different ages. I Dent. Res. (1984) 63:1182–1186.
  • BODEUTSCH C, DE WILDE PCM, KATER L et al.: Labial salivary gland biopsy in Sjogren's syndrome. Netherlands J. Med. (1992) 40:148–157.
  • JONSSON R, KRONELD U, BACKMAN K, MAGNUSSON B, TARKOWSKI A: Progression of sialadenitis in Sjogren's syndrome. Br j Rheumatol. (1993) 32: 578–581.
  • LINDAHL G, HEDFORS E: Lymphocytic infiltrates and epithelial HLA-DR expression in lip salivary glands in connective tissue disease patient lacking sicca: a prospective study. Br j Rheumatol. (1989) 28:293–298.
  • HANSEN BU, LINDGREN S, ERIKSON S et al.: Clinical and immunological features of Sjogren's syndrome in patients with primary biliary cirrhosis with emphasis on focal sialadenitis. Acta Med. Scand (1988) 224:611–619.
  • MARKOPOULOS AK, BELAZI M: Histopathological and immunohistochemical features of the labial salivary glands in children with Type I diabetes. j Diabetes Complications (1998) 12:39–42.
  • KASSIMOS DG, SHIRLAW PJ, CHOY EH et al.: Chronic sialadenitis in patients with nodal osteoarthritis. Br j Rheum. (1997) 36:1312–1317.
  • NAKHLEH RE, MILLER W, SNOVER DC: Significance of mucosal vs. salivary gland changes in lip biopsies in the diagnosis of chronic graft- vs-host disease. Arch. Pathol Lab. Med. (1989) 113:932–934.
  • ITESCU S: Diffuse infiltrative lymphocytosis syndrome in human deficiency virus infection - Sjogren's like disease. Rheum. Dis. North Am. (1991) 17:99–115.
  • MELSOM RD, SPEIGHT PM, RYAN J, PERRY JD: Sarcoidosis in a patient presenting with clinical and histopathological features in primary Sjogren's syndrome. Ann. Rheum. Dis. (1988) 14:77–103.
  • HADDAD J, DENY P, MUNZ-GOTHEIL C, AMBROSINI JC: Lymphocytic Sialoadenitis of Sjogren's Syndrome Associated With Chronic Hepatitis C Virus Liver Disease. Lancet (1992) 8:321–323.
  • VITALI C, TAVONI A, NERI R et al: Fibromyalgia features in patients with primary Sjogren's syndrome. Evidence of a relationship with psychological depression. Scant/. Rheumatol (1989) 18:21–27.
  • FOX RI, KANG HIL: Pathogenesis of Sjogren's syndrome. Rheum. Dis. North Am. (1992) 18(3):517–538.
  • CHISHOLM DM, WATERHOUSE JP, MASON DK: Lymphocytic sialoadenitis in the major and minor glands: A correlation in post mortem subjects. j Clin. Pathol (1970) 23: 690–694.
  • WISE CM, AGUDELO CA, SEMBLE EL et al.: Comparison of parotid and minor salivary gland biopsy specimens in the diagnosis of Sjogren's syndrome. Arthritis Rheum. (1988) 31: 662–666.
  • MARX RE, HARTMANN KS, RETHMANN KV: A prospective study comparing incisional labial to incisional parotid biopsies in detection and confirmation of sarcoidosis, Sjogren's syndrome sialosis and lymphoma. Rheumatol (1988) 15:621–629.
  • LEROY JP, PENNEC YL, SOULIER C, BERTHELOT JM, LETOUX G, YOUINOU P: Follow-up study of labial salivary gland lesions in primary Sjogren's syndrome. Ann. Rheum. Dis. (1992) 51:777–780.
  • TALAL N: Sjogren's syndrome: historical overview and clinical spectrum of disease. Rheum. Dis. Clin. North Am. (1992) 18(3):507–515.
  • DAMATO BE, ALLAN D, MURRAY SB, LEE WR: Senile atrophy of the human lacrimal gland: contribution of chronic inflammatory disease. Br j Ophthalmol (1984) 68:674–680.
  • MADDISON PJ: Autoantibodies in Sjogren's syndrome: their origins and pathological consequences. In: Autoimmune Diseases-Focus on Spigren's Syndrome. Isenberg DA, Horsfall AC (Eds), Bios Scientific Publishers, Oxford, UK (1994):89–100.
  • MOLLER K, MANTHORPE R, PERMIN H, HOIER-MADSEN, OXHOLM P: Circulating IgM Rheumatoid Factors in Patients with Primary Sjogren's Syndrome. Scant/. J. Rheum. (1988) (Suppl. 75):265–268.
  • MARKUSSE HM, OTTEN HG, VROOM TM etal.: rheumatoid factor isotypes in serum and salivary fluid of patients with primary Sjogren's syndrome. Immunolog. Immunpathol (1993) 66(1):26–32.
  • HORSFALL AC, ROSE LM, MAINI RN: Autoantibody synthesis in salivary glands of Sjogren's syndrome patients. Autoimmunity (1989) 2:559–568.
  • TAN EM, FELTKAMP TE, SMOLEN JS et al: Range of antinuclear antibodies in 'healthy' individuals. Arthritis Rheum. (1997) 40(9):1601–1611. •Interesting study demonstrating a high prevalence of positive antinuclear antibodies in 'healthy' individuals.
  • KELLY CA, FOSTER H, PAL B et al: Primary Sjogrens syndrome in North East England - a longitudinal study. Br. Rheumatol (1991) 30:437–442.
  • ALEXANDER EL, ARNETT FC, PROVOST Ti STEVENS MB: Sjogren's syndrome: Association of anti-Ro (SS-A) antibodies with vasculitis, hematologic abnormalities and serologic hyperreactivity. Ann. Intern. Med. (1983) 98:155–159.
  • GERLI R, MUSCAT C, GIANSANTI M, DANIELI MG et al: Quantitative assessment of salivary gland inflammatory infiltration in primary Sjogren's syndrome: its relationship to different demographic, clinical and serological features of the disorder. Br j Rheumatol (1997) 36:969–975.
  • MOLINA R, PROVOST H, PAL B et al: Peripheral inflammatory vascular disease in Sjogren's syndrome: an association with nervous system complications. Arthritis Rheum. (1985) 28:1341–1347.
  • HALSE A, HARLEY JB, KRONELD U, JONSSON R: Ro/SS-A-reactive B-lymphocytes in salivary glands and peripheral blood of patients with Sjogren's syndrome. CM]. Exp. Immunol (1999) 115:203–207.
  • TENGNER P, HALSE AK, HAGA HJ, JONSSON R, WAHREN-HERLENIUS M: Detection of anti-Ro/SSA and anti-La/ SSB autoantibody-producing cells in salivary glands from patients with Sjogren's syndrome. Arthritis Rheum. (1998) 41:2238–2248.
  • AL-HASHIMI I, KHUDER S, HAGHIGHAT N, ZIPP M: Frequency and predictive value of the clinical manifestations in Sjogren's syndrome. Oral Pathol. Med. (2001) 30:1–6.
  • KINO-OHSAKI J, NISHIMORI I, MORITA M et al: Serum antibodies to carbonic anhydrase I and II in patients with idiopathic chronic pancreatitis and Sjogren's syndrome. Gastroenterology (1996) 10:1579–1586.
  • HANSEN BU, ERICSSON UB, HENRICSSON V, LARSSON A, MANTHORPE R, WARFVINGE G: Autoimmune thyroiditis and primary Sjogren's syndrome: clinical and laboratory evidence of the coexistence of the two diseases. Clin. Exp. Rheumatol (1991) 9:137–141.
  • BARENDREGT PJ, VISSER MRM, SMETS EMA etal.: Fatigue in primary Sjogren's syndrome. Ann. Rheum. Dis. (1998) 57(5):291–295.
  • GUDBJORNSSON B, BROMAN JE, HETTA J, HALLGREN R: Sleep disturbances in patients with primary Sjogrens syndrome. Br. J. RheumataL (1993) 32:1072–1076.
  • PEASE CT, SHATTLES W, BARRETT NK, MAINI RN: The arthropathy of Sjogren's syndrome. Br j Rheum. (1993) 32:609–613.
  • MANTHORPE R, FROST-LARSEN K, ISAGER H et al.: Sjogren's syndrome. A review with emphasis on immunological features. Allergy (1981) 36:139–153.
  • KATZ J, MARMARY A, DANON Y. Drug allergy in Sjogren's syndrome. Lancet (1991) (Letter):239.
  • HASHIMOTO S, MICHALSKI JP, BERMAN MA, McCOMBS C: Mechanism of a lymphocyte abnormality associated with HLA-B8/DR3: role of interleukin-1. Chu. Exp. Immune] (1990) 79:227–232.
  • MANTHORPE T, MANTHORPE R: Congenital complete heart block in children of mothers with primary Sjogren's syndrome. Lancet (1992) 340:1359–1360.
  • THEANDER E, BRUCATO A, GUDMUNDSSON S, SALOMONSSON S, WAHREN-HERLENIUS M, MANTHORPE R: Primary Sjogren's syndrome - treatment of fetal incomplete atrioventricular block with dexamethasone. RheumataL (2001) 28(2):373–376.
  • HENKIN RI, TALAL N, LARSSON AL, MATTERN CFT: Abnormalities of taste and smell in Sjogren's syndrome. Ann. Intern. Med. (1972) 76:375–383.
  • WEIFFENBACH JM, SCHWARTZ LK, ATKINSON JC, FOX PC: Taste performance in Sjogren's syndrome. Phys. Behavior (1995) 57(1):89–96.
  • TSIANOS EB, VASAKOS S, DROSOS AA et al.: The gastrointestinal involvement in primary Sjogren's syndrome. Land. RheumataL (1986) (Suppl. 61):151–155.
  • CARUSO AJ, SONIES BC, ATKINSON JC, FOX PC: Objective measures of swallowing in patients with primary Sjogren's syndrome. Dysphagia (1989) 4:101–105.
  • BERTRAM U: Xerostomia. Clinical aspects, pathology and pathogenesis. (Thesis). Acta OdontaL Scam/. (1967) 25\(Suppl. 49).
  • TAPPER-JONES L, ALDRED M, WALKER DM: Prevalence and intraoral distribution of Candida albicarts in Sjogren's syndrome. j Chu. PathaL (1980) 33:282–287.
  • HERNANDEZ YL, DANIELS TE: Oral candidiasis in Sjogren's syndrome: prevalence, clinical correlations and treatment. Oral Surg. Oral Med. Oral PathaL (1989) 68:324–329.
  • RHODUS NL, BLOMQUIST C, LILJEMARK W, BEREUTER J: Prevalence, density, and manifestations of oral Candida albicans in patients with Sjogren's syndrome. j OtalaryrigaL (1997) 26(5):300–305.
  • ABRAHAM CM, AL-HASHIMI I, HAGHIGHAT N: Evaluation of the levels of oral Candida in patients with Sjogren's syndrome. Oral Surg. Oral Med. Oral PathaL Oral Rad. Ended. (1998) 86:65–68.
  • ALMSTAHL A, KRONELD U, TARKOWSKI A, WIKSTROM M: Oral microbial flora in Sjogren's syndrome. RheumataL (1999) 26(1):110–114.
  • BAUDET-POMMEL M, ALBUISSON E, KEMENY JL et al.: Early dental loss in Sjogren's syndrome. Oral Surg. Oral Med. Oral PathaL (1994) 78:181–186.
  • BARDOW A, NYVAD B, NAUNTOFTE B: Relationships between medication intake, complaints of dry mouth, salivary flow rate and composition, and the rate of tooth demineralization in situ. Arch. Oral Biol. (2001) 46:413–423.
  • TSENG CC, WOLFF LF, RHODUS N, AEPPLI DM: The periodontal status of patients with Sjogren's syndrome. I Chu. Periodontal. (1990) 17:329–330.
  • MUTLU S, PORTER SR, RICHARDS A, PORTER KM, MADDISON P, SCULLY C: Periodontal disease in Sjogren's syndrome. Chu. Exp. Rheum. (1991) 9:317. Abstract.
  • NAJERA MP, AL-HASHIMI I, PLEMONS JM et al.: Prevalence of periodontal disease in patients with Sjogren's syndrome. Oral Surg. Oral Med. Oral PathaL Oral Rad. Ended. (1997) 83:453–457.
  • PFLUGFELDER SC: Differential diagnosis of dry eye conditions. Adv. Dent. Res. (1996) 10(1):9–12.
  • STROMBECK B, EKDAHL C, MANTHORPE R, WIKSTROM I, JACOBSSON L: Health-related quality of life in primary Sjogren's syndrome, rheumatoid arthritis and fibromyalgia compared to normal population using SF-36. Scam/. J. RheumataL (2000) 29(1):20–28.
  • MAUCH E, VOLK C, KRATZCH G, KRAPF H et al.: Neurological and neuropsychiatric dysfunction in primary Sjogren's syndrome. Acta Neural. Scam/. (1994) 89:31–35.
  • VALTYSDOTTIR ST, GUDBJORNSSON B, LINDQUIST U, HALLGREN R, HETTA J: Anxiety and Depression in patients with primary Sjogren's syndrome. RheumataL (2000) 27(1):165–169.
  • REVEILLE JD, ARNETT FC: The immunogenetics of Sjogren's syndrome. In: .5:Ogren's Syndrome. Fox RI (Ed.). Rheum. Dis. Chu. North Am. (1992) 18:539–550.
  • SULLIVAN DA: Sex Hormones and Sjogren's Syndrome. j RheumataL (1997) 24\(Suppl. 50):17–32.
  • VALTYSDOTTIR ST, WIDE L, HALLGREN R: Low serum dehydroepiandrosterone sulfate in women with Sjogren's syndrome as an isolated sign of impaired HPA axis function. RheumataL (2001) 28(6):1259–1265.
  • BACCAGLINI L, PILLEMER SR, BAUM BJ: Sjogren's syndrome: a possible pathogenic mechanism involving somatostatin. Oral Dis. (2000) 6:264–266.
  • ADAMSON TC, FOX RI, FRISMAN DM, HOWELL FV: Immunohistologic analysis of lymphoid infiltrates in primary Sjogren's syndrome using monoclonal antibodies. J. Immurid. (1983) 130:203–208.
  • SAITO I, TERAUCHI K, SHIMUTA Met al.: Expression of cell adhesion molecules in the salivary and lacrimal glands of Sjogren's syndrome. j Chu. Lab. Anal. (1993) 7(3): 180–187.
  • ALPERT S, KANG H, WEISSMAN I, FOX R: Granzyme Expression in Sjogren's Syndrome. Arthritis Rheum. (1994) 37:1048–1054.
  • KONG L, OGAWA N, MCGUFF HS et al.: Bc1-2 family expression in salivary glands from patients with primary Sjogren's syndrome: involvement of Bax in salivary gland destruction. Chu. ImmunaL ImmunapathaL (1998) 88:133–141.
  • OHLSSON M, SKARSTEIN K, BOLSTAD Al, JOHANNESEN AC, JONSSON R: Fas-induced apoptosis is a rare event in Sjogren's syndrome. Lab. Invest. (2001) 81(1):95–105.
  • XANTHOU G, POLIHRONIS M, TZIOFAS AG et al.: 'Lymphoid' chemokine messenger RNA expression by epithelial cells in the chronic inflammatory lesion of the salivary glands of Sjogren's syndrome patients: possible participation in lymphoid structure formation. Arthritis Rheum. (2001) 44(2):408–418.
  • BERTRAM U, HALBERG PA: Specific antibody against the epithelium of the salivary ducts in sera from patients with Sjogren's syndrome. Acta Allergol (1964) 19:458–466.
  • FELTKAMP TEW, VAN ROSSUM AL: Antibodies to salivary duct cells and other autoantibodies in patients with Sjogren's syndrome. Chu. Exp. Immunol. (1968) 3:1–16.
  • ATKINSON JC, ROYCE LS, WELLNER R, PILLEMER SR, BERMUDEZ D, FOX PC: Anti-salivary antibodies in primary Sjogren's syndrome. J. Ora] Pathol. Med. (1995) 24:206–212.
  • HANEJI N, NAKAMURA T, TAKIO K et al.: Identification of alpha-fodrin as a candidate autoantigen in primary Sjogren's syndrome. Science (1997) 276(5312)604-607. ••Identification of an apoptotic breakdownproduct of the cytoskeletal molecule (fodrin) as a target antigen in the submandibular gland of an animal model.
  • GRIFFITH KJ, CHAN EK, LUNG CC et al.: Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjogren's syndrome. Arthritis Rheum. (1997) 40(9):1693–1702.
  • VENABLES PJW, RIGBY SP: Viruses in the Etiopathogenesis of Sjogren's Syndrome. Rheumatol (1997) 24\(Suppl. 50):3–5.
  • SCHIODT M, GREENSPAN D, DANIELS TE et al: Parotid gland enlargement and xerostomia associated with labial sialoadenitis in HIV-Infected patients. Autoimmun. (1989) 2:415–425.
  • JONSSON R, KRONELD U, TARKOWSKI A: Histologic and functional features of salivary glands in rheumatic patients with oral sicca symptoms. Scand. Rheumatol (1988) 17:387–391.
  • ANDOH Y, SHIMURA S, SAWAI T, SASKI H, TAKISHIMA T, SHIRATO K: Morphometric analysis of secretory glands in Sjogren's syndrome. Tohokuj Esp. Med. (1993) 146:1358–1362.
  • HUMPHREYS-BEHER MG, BRAYER J, YAMACHIKA S, PECK AB, JONSSON R: An alternative perspective to the immune response in autoimmune exocrinopathy: induction of functional quiescence rather than destructive autoaggression. Scand. Immunol (1999) 49:7-10. **Excellent review on the possibility that the pathogenesis of SS comprises immune-mediated neurohormonal events.
  • LOOMS DK, TRITSARIS K, DISSING S, JORGENSEN T, NAUNTOFTE B: Regulation of salivary secretion: interactions between signalling pathways. In: Oral Biology at the Turn of the Century: Misconceptions, Truths, Challenges and Prospects. Guggenheim B, Shapiro S (Eds.), Karger AG, Basel (1998):179–188.
  • TORNWALL J, KONTTINEN YT, TOUMENIN RK, TORNWALL M: Protein-kinase C expression in salivary gland acinar epithelial cells in Sjogren's syndrome. Lancet (1997) 349:1814–1815.
  • STEINFELD S, COGAN E, KING LS, AGRE P, KISS R, DELPORTE C: Abnormal distribution of aquaporin-5 water channel protein in salivary glands from Sjogren's syndrome patients. Lab. Invest. (2001) 81(3):143–148.
  • OXHOLM P, DANIELS TE, BENDTZEN K: Cytokine expression in labial salivary glands from patients with primary Sjogren's syndrome. Autoimmunih, (1992) 12:185–191.
  • DAWSON LJ, SMITH PM: Intracellular calcium signalling in mouse submandibular acinar cells co-cultured with activated splenic lymphocytes. J. Physiol (1998) 509:107.
  • BACMAN S, STERIN-BORDA L, CAMUSSO JJ, ARANA R, HUBSCHER 0, BORDA E: Circulating antibodies against rat parotid M3 muscarinic receptors in primary Sjogren's syndrome. Chu. Exp. Immunol (1996) 104:454-459. ••Interesting study suggesting thatcirculating antibodies interfere with the M3 muscarinic receptors and thereby prevent an adequate response of the exocrine glands to neural stimulation.
  • ROBINSON CP, BRAYER J, YAMACHIKA et al: Transfer of human serum IgG to nonobese diabetic Igd'ull mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjogren's syndrome. Proc. Nat] Acad. Li. USA (1998) 95:7538–7543.
  • WATERMAN SA, GORDON TP, RISCHMUELLER M: Inhibitory effects of muscarinic receptors on parasympathetic neurotransmission in Sjogren's syndrome. Arthritis Rheum. (2000) 43:1647–1654.
  • ATKINSON JC, FOX PC: Sjogren's syndrome: oral and dental considerations. J. Am. Dent. Assoc. (1993) 124(3):74–86.
  • ISIDOR F, BRONDUM K, HANSEN HJ, JENSEN J, SINDET-PEDERSEN S: Outcome of treatment with implant-retained dental prostheses. Int. J. Oral Maxillofac. Implants (1999) 14(5):736–743.
  • FARDAL 0, TURNBULL RS: A review of the literature on the use of chlorhexidine in dentistry. JADA (1986) 112:865–869.
  • BLOM M, LUNDEBERG T: Long-term follow-up of patients treated with acupuncture for xerostomia and the influence of additional treatment. Ora] Dis. (2000) 6(1):15–24.
  • FOX PC, MANDEL ID: Effects of pilocarpine on salivary flow in patients with primary Sjogren's syndrome. Oral Surg. Oral Med. Oral Pathol (1992) 74:315–318.
  • VIVINO FB, AL-HASHIMI I, KHAN Z et al: Pilocarpine Tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjogren's syndrome: a randomized, placebo-controlled, fixed-dose multicenter trial. Arch. Intern. Med. (1999) 159:174–181.
  • FOX R, PENTRONE J, CONDEMI R, FIFE P: Randomized, placebo controlled trial of SNI-2011, a novel M3 muscarinic receptor agonist, for the treatment of Sjogren's syndrome. Arthritis Rheum. (1998) 41:288.
  • EPSTEIN JB, DECOTEAU WE, WILKINSON A: Effect of Sialor on treatment of xerostomia in Sjogren's syndrome. Ora] Surg. (1983) 56:495–499.
  • SCHIODT M, OXHOLM P, JACOBSEN A. Treatment of xerostomia in patients with primary Sjogren's with Sulfarlem. Scand. I Rheumatol (1986) (Suppl. 61):250–252.
  • SHIP JA, FOX PC, MICHALEK JE, CUMMINS MJ, RICHARDS AB. Treatment of primary Sjogren's syndrome with low-dose natural human interferon-alpha administered by the oral mucosa route: a Phase II clinical trial. IFN Protocol Study Group. J. Interferon Cytokine Res. (1999) 19:943–951.
  • FROST-LARSEN K, ISAGER H, MANTHORPE R: Sjogren's syndrome treated with bromhexine: a randomized clinical study. Br. Med. J. (1978) 1:1579–1581.
  • FOX RI, DIXON R, GUARRASI V, KRUBEL S: Treatment of primary Sjogren's syndrome with hydroxychloroquine: a retrospective, open-label study. Lupus (1996) 5\(Supp1.1):S31–36.
  • DROSOS AA, SKOPOULI FN, COSTOPOULOS JS, PAPDIMITRIOU CS, MOUTSOPOULOS HM: Cyclosporin A (CyA) in primary Sjogren's syndrome: A double blind study. Ann. Rheum. Dis. (1986) 45:732–735.
  • DROSOS AA, VAN VLIET-DASCALOPOULOU E, ANDONOPOULOS AP et al.: Nandrolone decanoate in primary Sjogren's syndrome: a double blind pilot study. CM]. Exp. Rheumatol. (1996) 6:53–57.
  • STEINFELD SD, DEMOLS P, VAN VOOREN JP, COGAN E, APPELBOOM T. Zidovudine in primary Sjogren's syndrome. Rheumatology (1999) 38(9) 814–817.
  • PEDERSEN A, GERNER N, PALMVANG I, HØIER-MADSEN: LongoVital in the treatment of Sjogren's syndrome. CM]. Exp. Rheumatol. (1999) 17(5):533–538.
  • S'GRAVENMADE EJ, VISSINK A: Mucin-containing lozenges in the treatment of intraoral problems associated with Sjogren's syndrome. Oral Surg. Oral Med. Oral Pathol. (1993) 75:466–471.
  • PEDERSEN AM, ANDERSEN TORPET L, REIBEL J, HOLMSTRUP E NAUNTOFTE B: Primary Sjogren's syndrome and oral lichen planus: effects of colostrum-containing dentrifrices. j. Dent. Res. (2001) 80(9):1267. Abstract.
  • PAL B: Use of alternative medicine by Sjogren's syndrome patients. Clin. Exp. Rheumatol. (Letter) (1998) 16:763.

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