360
Views
20
CrossRef citations to date
0
Altmetric
Drug Evaluations

Dapoxetine for premature ejaculation

, MBBS FAChSHM
Pages 1741-1752 | Published online: 14 Jun 2010

Bibliography

  • Semans JH. Premature ejaculation: a new approach. South Med J 1956;49:353-8
  • Masters WH, Johnson VE. Human sexual inadequacy. Little Brown, Boston; 1970
  • Jannini EA, Simonelli C, Lenzi A. Sexological approach to ejaculatory dysfunction. Int J Androl 2002;25:317-23
  • Olivier B, van Oorschot R, Waldinger MD. Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour. Int Clin Psychopharmacol 1998;13:S9-14
  • Waldinger MD, Rietschel M, Nothen MM, Familial occurrence of primary premature ejaculation. Psychiatr Genet 1998;8:37-40
  • Pattij T, Olivier B, Waldinger MD. Animal models of ejaculatory behavior. Curr Pharm Des 2005;11:4069-77
  • Waldinger MD, Zwinderman AH, Schweitzer DH, Olivier B. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. Int J Impot Res 2004;16:369-81
  • Metz ME, Pryor JL, Nesvacil LJ, Premature ejaculation: a psychophysiological review. J Sex Marital Ther 1997;23:3-23
  • Symonds T, Roblin D, Hart K, Althof S. How does premature ejaculation impact a man's life? J Sex Marital Ther 2003;29:361-70
  • Waldinger MD, Quinn P, Dilleen M, A multinational population survey of intravaginal ejaculation latency time. J Sex Med 2005;2:492-7
  • Patrick DL, Althof SE, Pryor JL, Premature ejaculation: an observational study of men and their partners. J Sex Med 2005;2:58-367
  • Porst H, Montorsi F, Rosen RC, The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: prevalence, comorbidities, and professional help-seeking. Eur Urol 2007;51:816-23
  • Giuliano F, Patrick DL, Porst H, Premature ejaculation: results from a five-country European observational study. Eur Urol 2008;53:1048-57
  • Reading A, Wiest W. An analysis of self-reported sexual behavior in a sample of normal males. Arch Sex Behav 1984;13:69-83
  • Nathan SG. The epidemiology of the DSM-III psychosexual dysfunctions. J Sex Marital Ther 1986;12:267-81
  • Spector KR, Boyle M. The prevalence and perceived aetiology of male sexual problems in a non-clinical sample. Br J Med Psychol 1986;59:351-8
  • Spector IP, Carey M. Incidence and prevalence of the sexual dysfunctions: a critical review of the empirical literature. Arch Sex Behav 1990;19:389-408
  • Grenier G, Byers ES. The relationships among ejaculatory control, ejaculatory latency, and attempts to prolong heterosexual intercourse. Arch Sex Behav 1997;26:27-47
  • Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999;281:537-44
  • Schapiro B. Premature ejaculation, a review of 1130 cases. J Urol 1943;50:374-9
  • Jern P, Santtila P, Witting K, Premature and delayed ejaculation: genetic and environmental effects in a population-based sample of Finnish twins. J Sex Med 2007;4(6):1739-49
  • Janssen PK, Bakker SC, Rethelyi J, Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. J Sex Med 2009;6:276-84
  • Hartmann U, Schedlowski M, Kruger TH. Cognitive and partner-related factors in rapid ejaculation: differences between dysfunctional and functional men. World J Urol 2005;23(2):93-101
  • Laumann EO, Nicolosi A, Glasser DB, Sexual problems among women and men aged 40 – 80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. Int J Impot Res 2005;17:39-57
  • Screponi E, Carosa E, Di Stasi SM, Prevalence of chronic prostatitis in men with premature ejaculation. Urology 2001;58:198-202
  • Carani C, Isidori AM, Granata A, Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients. J Clin Endocrinol Metab 2005;90:6472-9
  • Adson DE, Kotlyar M. Premature ejaculation associated with citalopram withdrawal. Ann Pharmacother 2003;37:1804-6
  • Peugh J, Belenko S. Alcohol, drugs and sexual function: a review. J Psychoactive Drugs 2001;33:223-32
  • McMahon CG, Althof SE, Waldinger MD, An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation. J Sex Med 2008;5:1590-606
  • Porst H, McMahon CG, Althof SE, Baseline characteristics and treatment outcomes for men with acquired or lifelong premature ejaculation with mild or no erectile dysfunction: integrated analyses of two phase 3 dapoxetine trials. J Sex Med 2010. [Epub ahead of print]
  • Sorbera LA, Castaner J, Castaner RM. Dapoxetine hydrochloride. Drugs Future 2004;29:1201-5
  • Gengo RJ, Giuliano F, McKenna KE, Monoaminergic transporter binding and inhibition profile of dapoxetine, a medication for the treatment of premature ejaculation [abstract 878]. J Urol 2005;173:230
  • Livni E, Satterlee W, Robey RL, Synthesis of [11C]dapoxetine.HCl, a serotonin re-uptake inhibitor: biodistribution in rat and preliminary PET imaging in the monkey. Nucl Med Biol 1994;21:669-75
  • Dresser MJ, Lindert K, Lin D. Pharmacokinetics of single and multiple escalating doses of dapoxetine in healthy volunteers [abstract P1]. Clin Pharmacol Ther 2004;75:113
  • Dresser MJ, Kang D, Staehr P, Pharmacokinetics of dapoxetine, a new treatment for premature ejaculation: impact of age and effects of a high-fat meal. J Clin Pharmacol 2006;46:1023-9
  • Modi NB, Dresser MJ, Simon M, Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation. J Clin Pharmacol 2006;46:301-9
  • Thyssen A, Sharma O, Tianmei S, Pharmacokinetics of dapoxetine hydrochloride in healthy Chinese, Japanese, and Caucasian Men. J Clin Pharmacol 2010. [Epub ahead of print]
  • Clement P, Bernabe J, Gengo P, Supraspinal site of action for the inhibition of ejaculatory reflex by dapoxetine. Eur Urol 2007;51:825-32
  • Clement P, Bernabe P, Gengo P, Dapoxetine inhibits p-chloroamphetamine-induced ejaculation in anesthetized ratsBook of Abstracts, 8th Congress of the European Society for Sexual Medicine. J Sex Med 2006;55: abstract P-02-159
  • Giuliano F, Bernabe J, Gengo P, Effect of acute dapoxetine administration on the pudendal motoneuron reflex in anesthetized rats: comparison with paroxetine. J Urol 2007;177:386-9
  • Gengo PJ, Marson L, Gravitt A. Actions of dapoxetine in ejaculation and sexual behaviour in ratsBook of Abstracts, 8th Congress of the European Society for Sexual Medicine. J Sex Med 2006;28: abstract MP-01-074
  • Hellstrom WJ, Gittelman M, Althof S. Dapoxetine HCl for the treatment of premature ejaculation: a phase II, randomised, double-blind, placebo controlled study [abstract 097]. J Sex Med 2004;1(Suppl 1):59
  • Hellstrom WJ, Althof S, Gittelman M, Dapoxetine for the treatment of men with premature ejaculation (PE):dose-finding analysis [abstract 877]. J Urol 2005;173:238
  • Pryor JL, Althof SE, Steidle C, Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials. Lancet 2006;368:929-37
  • Buvat J, Tesfaye F, Rothman M, Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries. Eur Urol 2009;55:957-67
  • Kaufman JM, Rosen RC, Mudumbi RV, Treatment benefit of dapoxetine for premature ejaculation: results from a placebo-controlled phase III trial. BJU Int 2009;103:651-8
  • McMahon C, Kim SW, Park NC, Treatment of premature ejaculation in the Asia-Pacific region: results from a phase III double-blind, parallel-group study of dapoxetine. J Sex Med 2010;7:256-68
  • Patrick DL, Giuliano F, Ho KF, The Premature ejaculation profile: validation of self-reported outcome measures for research and practice. BJU Int 2009;103:358-64
  • Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH. Geometric mean IELT and premature ejaculation: appropriate statistics to avoid overestimation of treatment efficacy. J Sex Med 2008;5:492-9
  • McMahon CG. Clinical trial methodology in premature ejaculation observational, interventional, and treatment preference studies–part II–study design, outcome measures, data analysis, and reporting. J Sex Med 2008;5:1817-33
  • Byers ES, Grenier G. Premature or rapid ejaculation: heterosexual couples' perceptions of men's ejaculatory behavior. Arch Sex Behav 2003;32:261-70
  • Metz ME, Pryor JL. Premature ejaculation: a psychophysiological approach for assessment and management. J Sex Marital Ther 2000;26:293-320
  • Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. J Clin Psychiatry 2001;62:10-21
  • Lane RM. A critical review of selective serotonin reuptake inhibitor-related sexual dysfunction; incidence, possible aetiology and implications for management. J Psychopharmacol 1997;11:72-82
  • Modi NB, Nath R, Staehr P, Pharmacokinetic, pharmacodynamic, and electrocardiographic effects of dapoxetine and moxifloxacin compared with placebo in healthy adult male subjects. J Clin Pharmacol 2009;49:634-42
  • Coupland NJ, Bell CJ, Potokar JP. Serotonin reuptake inhibitor withdrawal. J Clin Psychopharmacol 1996;16:356-62
  • Zajecka J, Tracy KA, Mitchell S. Discontinuation symptoms after treatment with serotonin reuptake inhibitors: a literature review. J Clin Psychiatry 1997;58:291-7
  • Tamam L, Ozpoyraz N. Selective serotonin reuptake inhibitor discontinuation syndrome: a review. Adv Ther 2002;19:17-26
  • Khan A, Khan S, Kolts R, Brown WA. Suicide rates in clinical trials of SSRIs, other antidepressants, and placebo: analysis of FDA reports. Am J Psychiatry 2003;160:790-2
  • Mann JJ, Emslie G, Baldessarini RJ, ACNP task force report on SSRIs and suicidal behavior in youth. Neuropsychopharmacology 2006;31:473-92
  • Zajecka J, Fawcett J, Schaff M, The role of serotonin in sexual dysfunction: fluoxetine-associated orgasm dysfunction. J Clin Psychiatry 1991;52:66-8
  • Ditto KE. SSRI discontinuation syndrome. Awareness as an approach to prevention. Postgrad Med 2003;114:79-84
  • Black K, Shea CA, Dursun S, Kutcher S. Selective serotonin reuptake inhibitor discontinuation syndrome: proposed diagnostic criteria. J Psychiatry Neurosci 2000;25:255-61
  • Waldinger MD. Premature ejaculation: definition and drug treatment. Drugs 2007;67:547-68
  • Modi NB, Dresser M, Desai D, Dapoxetine has no pharmacokinetic or cognitive interactions with ethanol in healthy male volunteers. J Clin Pharmacol 2007;47:315-22
  • Dresser MJ, Desai D, Gidwani S, Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors. Int J Impot Res 2006;18:104-10
  • Modi NB, Kell S, Aquilina J, Rivas D. Effect of dapoxetine on the pharmacokinetics and hemodynamic effects of tamsulosin in men on a stable dose of tamsulosin. J Clin Pharmacol 2008;48:1438-50
  • McMahon CG, Althof SE, Waldinger MD, An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation. J Sex Med 2008;5(7):1590-606
  • Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH. Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data. J Sex Med 2005;2:498-507
  • Giuliano F, Patrick DL, Porst H, Premature ejaculation: results from a five-country european observational study. Eur Urol 2007. [Epub 16 October 2007]
  • Waldinger M, Hengeveld M, Zwinderman A, Olivier B. An empirical operationalization of DSM-IV diagnostic criteria for premature ejaculation. Int J Psychiatry Clin Pract 1998;2:287-93
  • McMahon CG. Long term results of treatment of premature ejaculation with selective serotonin re-uptake inhibitors. Int J Impot Res 2002;14:S19
  • Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH. The majority of men with lifelong premature ejaculation prefer daily drug treatment: an observation study in a consecutive group of Dutch men. J Sex Med 2007;4:1028-37
  • McMahon CG, Abdo C, Incrocci I, Disorders of orgasm and ejaculation in men. In: Lue TF, Basson R, Rosen R, , editors. Sexual medicine: sexual dysfunctions in men and women (2nd international consultation on sexual dysfunctions-Paris). Health Publications, Paris; 2004. p. 409-68
  • Waldinger MD, Berendsen HH, Blok BF, Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system. Behav Brain Res 1998;92:111-18
  • Waldinger M. Towards evidenced based drug treatment research on premature ejaculation: a critical evaluation of methodology. Int J Impot Res 2003;15:309-13
  • Radley DC, Finkelstein SN, Stafford RS. Off-label prescribing among office-based physicians. Arch Intern Med 2006;166:1021-6
  • Atmaca M, Kuloglu M, Tezcan E, Semercioz A. The efficacy of citalopram in the treatment of premature ejaculation: a placebo-controlled study. Int J Impot Res 2002;14:502-5
  • McMahon CG. Treatment of premature ejaculation with sertraline hydrochloride: a single-blind placebo controlled crossover study. J Urol 1998;159:1935-8
  • Kara H, Aydin S, Yucel M, The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind placebo controlled study. J Urol 1996;156:1631-2
  • Waldinger MD, Hengeveld MW, Zwinderman AH. Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study. Am J Psychiatry 1994;151:1377-9
  • Goodman RE. An assessment of clomipramine (Anafranil) in the treatment of premature ejaculation. J Int Med Res 1980;8:53-9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.