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Expert Opinion on Pharmacotherapy Volume 17, 2016 - Issue 1
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Reviews

Novel systemic therapies for the treatment of psoriasis

Ki-Wei TanDermatology Centre, Manchester Academic Health Science Centre, Salford Royal Hospital, University of Manchester, Manchester, UK;Department of Dermatology, Changi General Hospital, Singapore
&
Christopher EM GriffithsDermatology Centre, Manchester Academic Health Science Centre, Salford Royal Hospital, University of Manchester, Manchester, UKCorrespondence[email protected]
Pages 79-92 | Published online: 07 Nov 2015

Bibliography

  • Papers of special note have been highlighted as either of interest (*) or of considerable interest (**) to readers.
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* Discusses the link between psoriasis and major cardiovascular events.

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** Discussion on the rationale for targeting IL-17 in psoriasis.

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* Explains the roles of JAK/STAT pathway and possible risks of inhibition.

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* Paper that demonstrates the efficacy of secukinumab and its superiority to ustekinumab.

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** Looks at theoretical risks of IL-23 and IL-17 blockade including possible infective risks.

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