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New pharmacotherapy options for multiple myeloma

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Pages 181-192 | Received 15 Jun 2015, Accepted 28 Oct 2015, Published online: 18 Dec 2015

References

  • Papers of special note have been highlighted as either of interest (•) or of considerable interest (••) to readers.
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•• A phase III study showing the superiority of Rd continuously over the standard MPT in transplant-ineligible patients.

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•• VTD is considered a standard approach in transplant-eligible patients.

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• A phase III trial showing the superiority of the four-drug combination VMPT plus VT maintenance over the standard VMP.

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•• Based on this phase III study, VMP is now considered a standard of care for transplant-ineligible patients.

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•• A recent study supporting the role of transplantation in the era of novel agents.

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• A recent study supporting the role of transplantation in the era of novel agents.

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•• A study providing important evidence for survival benefits with pomalidomide in relapsed/refractory patients.

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• A relevant trial demonstrating the non-inferior efficacy and the improved safety profile of subcutaneous bortezomib compared with standard intravenous bortezomib.

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• A relevant study with the new proteasome inhibitor carfilzomib.

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• An interesting study showing the synergistic activity of panobinostat, bortezomib and dexamethasone in the relapsed setting.

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• An important study about a new and effective proteasome inhibitor.

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