62
Views
5
CrossRef citations to date
0
Altmetric
Review

Andropause: an androgen deficiency state in the ageing male

Pages 183-190 | Published online: 02 Mar 2005

Bibliography

  • MATSUMOTO AM: Andropause: clinical implications of the decline in serum testosterone levels with aging in men. Cerentel Med. Sci. (2002) 57A(2):M76–M99.
  • FRONTERA WR, HUGHES VA, LUTZ KJ, EVANS WJ: A cross-sectional study of muscle strength and mass in 45-78 year old men and women.Appl Physiel (1991) 71:644–650.
  • GALLAGHER D, VISSER M, DEMEERSMAN RE et al.: Appendicular skeletal muscle mass: effects of age, gender and ethnicity. Appl. Physiel (1997) 83:229–239.
  • LARSSON L, RAMAMURTHY B: Aging-related changes in skeletal muscle. Mechanisms and interventions. Drugs Aging (2000) 17(4):303–316.
  • HUGHES VA, FRONTERA WR, WOOD M et al.: Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity and health. Cerentel Biel Sci. (2001) 56A:B209–B217.
  • JOHANNES CB, ARAUJO AB, FELDMAN HA, DERBY CA, KLEINMAN KP, MCKINLAY JB: Incidence of erectile dysfunction in men 40-60 years old: longitudinal results from the Massachusetts male aging study.Um]. (2000) 163:460–463.
  • ROWLAND DL, GREENLEAF WJ, DORFMAN LJ, DAVIDSON JM: Aging and sexual function in men. Arch. Sex. Behav. (1993) 22:545–557.
  • BOSWORTH HB, SCHAIE KW, WILLIS SL: Cognitive and sociodemographic risk factors for mortality in the Seattle Longitudinal Study. Cerentel Psych. Sci. (1999) 54B:P273–P282.
  • SPRATT DI, COX P, ORAY J, MOLONEY J, BIGOS T: Reproductive axis suppression in acute illness is related to disease severity. Clin. Endocrine]. Metab. (1993) 76:1548–1554.
  • SPARROW D, BOSSE R, ROWE JW: The influence of age, alcohol consumption and body fluid on gonodal function in men. Gin. Endocrine]. Metab. (1980) 51:508–512.
  • SWERDLOFF RS, WANG C: Androgens and aging in men. Exp. Cerentel (1993) 28:435–446.
  • VERMEULEN A: Androgens in the agingmale. Clin. Endrecrinel Metab. (1991) 73:221–224.
  • MANNI A, PARDRIDGE WM, CEFALU W et al.: Bioavailability of albumin-bound testosterone. J. Clin. Endocrine]. Metab. (1985) 61:705–710.
  • •A seminal study documenting in vitro and in vivo the relative bioavailability of absolute free testosterone and albumin-bound testosterone into the brain as a percent of total circulating testosterone and the unavailability of testosterone bound to sex hormone binding globulin.
  • VERMEULEN A, VERDONCK L, KAUFMAN JM: A critical evaluation of simple methods for the estimation of free testosterone in serum. Clin. Endocrine]. Metab. (1999) 84:3666–3672.
  • HARMAN SM, METTER EJ, TOBIN JD,PEARSON J, BLACKMAN MR: Longitudinal effects of aging in serum totaland free testosterone levels in healthy men.Baltimore longitudinal study of aging. Clin. Endocrine]. Metab. (2001) 86:724–731.
  • •Examined the issue of ageing versus chronic illness on changes in total and free testosterone in a large population-based longitudinal study. The study was carried out over a 30-year period and showed a significant, independent, age-invariant, longitudinal effect of age on total and free testosterone. The study revealed a higher incidence of hypogonadal testosterone levels with age (20% over 60 years; 30% over 70 years and 50% over 80 years).
  • GRAY A, FELDMAN HA,MCKINLAY JB, LONGCOPE C: Age, disease and changing sex hormone levels in middle-aged men: results of the massachusetts male aging study. Clin. Endocrine]. Metab. (1991) 73:1016–1025.
  • •First large scale epidemiological study examining in detail hormonal changes in men of age 39–70. Study showed that free and bioavailable testosterone declines by 1.2%/year over this period.
  • KAUFMAN JM, VERMEULEN A: Declining gonodal function in ederly men. Bailieres Clin. Endocrine]. Metab. (1997) 11:289–309.
  • MALARKEY WB, HALL JC, RICE RR et al: The influence of age on endocrine responses to ultraendurance stress. Cerentel (1993) 48(4):M134–M139.
  • GRIFFIN JE, WILSON JD: Disorders of the testes and the male reproductive tract. In: Williams Textbook of Endocrinology 9th edn. JD Wilson, DW Foster, HM Kronenberg, PR Larsen (Eds). WB Saunders (1998):Chapter 16.
  • BARTSCH W: Interrelationships betweenSHBG and testosterone, 5a DHT and 17-0 estradiol in blood of normal men. Maturitas (1980) 2:109–118.
  • SODERGARD R, BACKSTROM T, SHANBHAG V, CARSTENSEN H: Calculation of free and bound fractions of testosterone and 17-0 estradiol to human plasma proteins at body temperature. J. Steroid Biochem. (1982) 16(6):801–810.
  • NEAVES WB, JOHNSON L,PORTER JC, PARKER CR, PETTY CS: Leydig cell numbers, daily sperm production and serum gonadotropin levels in aging men. I. Clin. Endocrinol Metab. (1984) 59:756–763.
  • JOHANNES CB, ARAUJO AB, FELDMAN HA, DERBY CA, KLEINMAN KP, MCKINLAY JB: Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study." Urol. (2000) 163:460–463.
  • ROWLAND DI, GREENLEAF WJ, DORFMAN LJ, DAVIDSON JM: Aging and sexual function in men. Arch. Sex. Behav. (1993) 22:545–557.
  • HAJJAR RR, KAISER FE, MORLEY JE:Outcomes of long-term testosterone replacement in older hypogonodal males: a retrospective analysis. " Clin. Endocrinol Metab. (1997) 82:3793–3796.
  • TENOVER JS, MATSUMOTO AM, CLIFTON DK, BREMNER WJ: Age related alterations in the circadian rhythms of pulsatile luteinizing hormone and testosterone secretion in healthy men. Gerontol Med. Sci. (1988) 43:M163–M169.
  • PINCUS SM, MULLIGAN T, IRANMANESH A, GHEORGHIU S, GODSCHALK M, VELDHUIS JD: Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males. Proc. Natl. Acad. Sci. USA (1996) 93:14100–14105.
  • VERMEULEN A, DESLYPERE JP, KAUFMAN JM: Influence of anti-opioids on luteinizing hormone pulsalility in aging men. I Clin. Endocrinol Metab. (1989) 68:68–72.
  • MIKUMA N, KUMAMOTO Y, MARUTA H, NITTA T: The role of the hypothalamic opioidergic system in the control of gonadotropin secretion in elderly men. Audrologia (1994) 26:39–45.
  • BAULIEU EE, THOMAS G, LEGRAIN Set al.: Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge study to a sociobiomedical issue. Proc. Natl. Acad. Sri. USA (2000) 97:4279–4284.
  • ORENTREICH N, BRIND JL, VOGELMAN JH, ANDRES R, BALDWIN H: Long termlongitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men. I Gin. Endocrinol Metab. (1992) 75:1002–1004.
  • ORENTREICH N, BRIND JL, RIZER RL, VOGELMAN JH: Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. Clin. Endocrinol Metab. (1984) 59:551–555.
  • ALESCI S, KOCH CA, BORNSTEIN SR, PACAK K: Adrenal androgen regulation and andrenopause. Endocr. Regal (2001) 35(2):95–100.
  • ROLF C, NIESCHLAG E: Potential adverse effects of long-term testosterone therapy. Baillieres Clin. Endocrinol Metab. (1988) 12:521–534.
  • BAKHSHI V, ELLIOTT M, GENTILI A, GODSCHALK M, MULLIGAN T: Testosterone improves rehabilitatin outcomes in ill older men.J. Ain. Geriatric Soc. (2000) 48:550–553.
  • BENKERT 0, WITT W, ADAM W, LEITZ A: Effects of testosterone undecanoate on sexual potency and the hypothalamic pituitary gonadal axis of impotent males. Arch. Sex. Behav. (1979) 8:471–479.
  • CHERRIER MM, ASTHANA S, PLYMATE S et al.: Testosterone Supplementation improves spatial and verbal memory in healthy older men. Neurology (2001) 57:80–88.
  • KENNY AM, PRESTWOOD KM, GRUMAN CA, MARCELLO KM, RAISZ LG: Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels.' Gerontol Med. Sci. (2001) 56A:M266–M272.
  • SCHIAVI RC, WHITE D, MANDELI J, LEVINE AC: Effect of testosterone administration on sexual behavior and mood in men with erectile dysfunction. Arch. Sex. Behav. (1997) 26:231–241.
  • SIH R, MORLEY JE, KAISER FE, PERRY HM, PATRICK P, ROSS C:Testosterone replacement in older hypogonadal men: a 12 month randomized clinical trial. I. Clin. Endocrinol. Metab. (1997) 82:1661–1667.
  • •First published study on the beneficial effects of long term testosterone treatment in older men (> 50 years) with low bioavailable testosterone levels. Hormone replacement therapy increased grip strength and haemoglobin levels and had no significant effects on serum PSA levels or prostate gland size as determined by digital rectal examination.
  • SNYDER PH, PEACHEY H, HANNOUSH P et al: Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. I Clin. Endocrinol Metab. (1999) 84:2647–2653.
  • DRINKA PJ, JOCHEN AL,CUISINIER M, BLOOM R, RUDMAN I, RUDMAN D: Polycythemia as a complication of testosterone replacement therapy in nursing home men with low testosterone levels. " Am. Geriatric Soc. (1995) 43:899–901.
  • SCHNEIDER BK, PICKETT CK, ZWILLICH CW et al.: Influence of testosterone on breathing during sleep. Appl. Physic] (1986) 61:618–623.
  • GANN PH, HENNEKENS CH, MA J, LONGCOPE C, STAMPFER MJ: Prospective study of sex hormone levels and risk of prostate cancer. J. Natl. Cancer Inst. (1996) 88:1118–1126.
  • SNYDER PH, LAWRENCE DA: Treatment of male hypogonadism with testosterone enanthate. Clin.Endocrinol. Metab. (1980) 51:1335–1339.
  • AHMED SR, BOUCHER AE, MANNI A, SANTEN RJ, DEMERS LM: Transdermal testosterone therapy in the treatment of male hypogonadism. Clin. Endocrinol Metab. (1990) 66(3):546–551.
  • MCCLELLAN KJ, GOA KU: Transdermal testosterone. Drugs (1998) 55:253–258.
  • WANG C, SWERDLOFF R, IRANMANESH A et al.: Transdermal testosterone gel improves sexual function, mood, muscle strength and body composition parameters in hypogonadal men. I Clin. Endocrinol Metab. (2000) 85:2839–2853.
  • •Large, randomised, multi-centre clinical trial of a well characterised population of hypogonadal men evaluating the efficacy of a testosterone gel preparation on sexual function and other measures of androgen

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.