Focal adhesion kinase as a potential target in oncology

Bibliography

• ULLRICH A, COUSSENS L, HAYFLICK JS, DULL TJ, GREY A, TAM AW et al.: Human epidermal growth factor receptor cDNA Sequence and aberrant expression of the amplified gene in A432 epidermoid carcinoma cells. Nature (1984) 309:418–425.
   PubMed Web of Science ®Google Scholar
• HANKS SK, POLTE TR: Signalling through focal adhesion kinase. Bioessays (1997) 19:137–145.
   PubMed Web of Science ®Google Scholar
• RICHARDSON A, PARSONS JT: Signal transduction through integrins: a central role for focal adhesion kinase? Bioessays (1995) 17:229–236.
   PubMed Web of Science ®Google Scholar
• SCHALLER MD, PARSONS _IT: Focal adhesion kinase and associated proteins. Curt-. Opin. Cell Biol. (1994) 6:705–710.
   PubMed Web of Science ®Google Scholar
• ANDRE E, BECKER-ANDRE M Expression of an N-terminally truncated form of human focal adhesion kinase in brain. Biochem. Biophys. Res. Commun. (1993) 190:140–147.
   PubMed Web of Science ®Google Scholar
• GRANT SG, KARL KA, KIEBLER MA, KANDEL ER: Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice. Genes Dev. (1995) 9:1909–1921.
   PubMed Web of Science ®Google Scholar
• HANKS SK, CALALB MB,HARPER MC, PATEL SK: Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc. Nati Acad. Sci. USA (1992) 89:8487–8491.
   PubMed Web of Science ®Google Scholar
• SCHALLER MD, BORGMAN CA,COBB BS, VINES RR, REYNOLDS AB, PARSONS JT: pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc. Natl. Acad. Sci. USA (1992) 89:5192–5196.
   PubMed Web of Science ®Google Scholar
• HAN DC, SHEN TL, GUAN JL: Role ofGrb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration. Biol. Chem. (2000) 275:28911–28917.
   Web of Science ®Google Scholar
• IZAGUIRRE G, AGUIRRE L, HU YP et al.: The cytoskeletal/non-muscle isoform of a-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase. Biol. Chem. (2001) 276:28676–28685.
   Web of Science ®Google Scholar
• ILIC D, DAMSKY CH, YAMAMOTO T: Focal adhesion kinase: at the crossroads of signal transduction. Cell Set. (1997) 110:401–407.
   PubMed Web of Science ®Google Scholar
• CALALB MB, POLTE TR, HANKS SK: Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Ma Cell. Biol. (1995) 15:954–963.
   Web of Science ®Google Scholar
• CALALB MB, ZHANG X, POLTE TR, HANKS SK: Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src. Biochem. Biophys. Res. Commun. (1996) 228:662–668.
   PubMedGoogle Scholar
• HILDEBRAND JD, TAYLOR JM, PARSONS JT: An 5H3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Ma Cell. Biol. (1996) 16:3169–3178.
   Web of Science ®Google Scholar
• CHEN H, GUAN J: Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA (1994) 91:10148–10152.
   PubMed Web of Science ®Google Scholar
• SCHLAEPFER DD, HANKS SK,HUNTER T, VAN DER GEER P: Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature (1994) 372:786–791.
   PubMed Web of Science ®Google Scholar
• SCHALLER MD, OTEY CA,HILDEBRAND JD, PARSONS JT: Focal adhesion kinase and paxillin bind to peptides mimicking 13 integrin cytoplasmic domains. I Cell Biol. (1995) 130:1181–1187.
   Google Scholar
• DANKER K, GABRIEL B, HEIDRICH C, REUTTER W: Focal adhesion kinase pp125FAK and the 131 integrin subunit are constitutively complexed in HaCaT cells. Exp. Cell Res. (1998) 239:326–331.
   PubMed Web of Science ®Google Scholar
• CHISHTI A, KIM A, MARFATIA S et al.: The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem. Sci. (1998) 23:281–282.
   PubMed Web of Science ®Google Scholar
• GIRAULT JA, LABESSE G, MORNON JP, CALLEBAUT I: The N-termini of FAK and JAKs contain divergent band 4.1 domains. Trends Biochem. Sci. (1999) 24:54–57.
   Google Scholar
• CRITCHLEY DR: Focal adhesions - the cytoskeletal connection. Curt: Opin. Cell Biol. (2000) 12:133–139.
   PubMed Web of Science ®Google Scholar
• MANGEAT P, ROY C, MARTIN M: ERM proteins in cell adhesion and membrane dynamics. Trends Cell Biol. (1999) 9:187–192.
   PubMed Web of Science ®Google Scholar
• CARY LA, HAN DC, POLTE TR, HANKS SK, GUAN JL: Identification of p130CAS as a mediator of focal adhesion kinase-promoted cell migration.Cell Biol. (1998) 140:211–221.
   PubMed Web of Science ®Google Scholar
• HILDEBRAND JD, SCHALLER MD, PARSONS JT: Identification of sequencesrequired for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions. J. Cell Biol. (1993) 123:993–1005.
   PubMed Web of Science ®Google Scholar
• MA A, RICHARDSON A,SCHAEFER EM, PARSONS JT: Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130 (Cas).Biol. CO (2001) 12:1–12.
   Google Scholar
• YAMAKITA Y, TOTSUKAWA G, YAMASHIRO S et al.: Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK. J. Cell Biol. (1999) 144:315–324.
   PubMed Web of Science ®Google Scholar
• TAMURA M, GU J, DANEN EH, TAKINO T, MIYAMOTO S,YAMADA KM: PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J. Biol. Chem. (1999) 274:20693–20703.
   PubMed Web of Science ®Google Scholar
• TAMURA M, GU J, MATSUMOTO K, AOTA S, PARSONS R, YAMADA KM: Inhibition of cell migration, spreading and focal adhesions by tumour suppressor PTEN. Science (1998) 280:1614–1617.
   PubMed Web of Science ®Google Scholar
• SCHALLER MD, BORGMAN CA, PARSONS JT: Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK. Ma Cell. Biol. (1993) 13:785–791.
   Web of Science ®Google Scholar
• NOLAN K, LACOSTE J, PARSONS JT:Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase. Ma Cell. Biol. (1999) 19:6120–6129.
   Web of Science ®Google Scholar
• TAYLOR JM, MACK CP, NOLAN K, REGAN CP, OWENS GK, PARSONS JT: Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells. Ma Cell. Biol. (2001) 21:1565–1572.
   Web of Science ®Google Scholar
• ILIC D, FURUTA Y, KANAZAWA S, TAKEDA N, SOBUE K, NAKATSUJI N et al.: Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice.Nature (1995) 377:539–544.
   PubMed Web of Science ®Google Scholar
• RICHARDSON A, PARSONS T: A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK. Nature (1996) 380:538–540.
   PubMed Web of Science ®Google Scholar
• FINCHAM VJ, FRAME MC: The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J. (1998) 17:81–92.
   PubMed Web of Science ®Google Scholar
• FINCHAM VJ, WYKE JA, FRAME MC: v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts. Oncogene (1995) 10:2247–2252.
   PubMed Web of Science ®Google Scholar
• MCLEAN GW, FINCHAM VJ, FRAME MC: v-Src induces tyrosine phosphorylation of focal adhesion kinase independently of tyrosine 397 and formation of a complex with Src. Biol. Chem. (2000) 275:23333–23339.
   Web of Science ®Google Scholar
• CARY LA, CHANG JF, GUAN JL: Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J. Cell Sri. (1996) 109:1787–1794.
   PubMed Web of Science ®Google Scholar
• AKASAKA T, VAN LEEUWEN RL, YOSHINAGA IG, MIHM MC Jr, BYERS HR: Focal adhesion kinase (p125FAK) expression correlates with motility of human melanoma cell lines. J. Invest. Dermatol (1995) 105:104–108.
   PubMed Web of Science ®Google Scholar
• PARSONS JT, MARTIN KH, SLACK JK, TAYLOR JM, WEED SA: Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement.Oncogene (2000) 19:5606–5613.
   PubMed Web of Science ®Google Scholar
• WANG D, GRAMMER JR, COBBS CS, STEWART JE Jr, LIU Z, RHODEN R, HECKER TP, DING Q, GLADSON CL: p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in viva J. Cell Sci. (2000) 113 :4221–4230.
   PubMed Web of Science ®Google Scholar
• AVIZIENYTE E, WYKE AW, JONES RJ, MCLEAN GW, WESTHOFF MA, BRUNTON VG, FRAME MC: Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nat. Cell Biol. (2002) 4:632–638.
   PubMed Web of Science ®Google Scholar
• GATES RE, KING LE Jr, HANKS SK, NANNEY LB: Potential role for focal adhesion kinase in migrating and proliferating keratinocytes near epidermal wounds and in culture. Cell Growth Differ. (1994) 5:891–899.
   PubMedGoogle Scholar
• FRISCH SM, VUORI K, RUOSLAHTI E, CHAN-HUI PY: Control of adhesion-dependent cell survival by focal adhesion kinase. J. Cell Biol. (1996) 134:793–799.
   PubMed Web of Science ®Google Scholar
• CHAN PC, LAI JF, CHENG CH, TANG MJ, CHIU CC, CHEN HC: Suppression of ultraviolet irradiation-induced apoptosis by overexpression of focal adhesion kinase in Madin-Darby canine kidney cells. J. Biol. Chem. (1999) 274:26901–26906.
   PubMed Web of Science ®Google Scholar
• GOLUBOVSKAYA V, BEVIGLIA L, XULH, EARP HS, CRAVEN R, CANCE W: Dual inhibition of focal adhesion kinase (FAK) and epidermal growth factor receptor (EGER) pathways cooperatively induces death receptor- mediated apoptosis in human breast cancer cells. J. Biol. Chem. (2002) 277:38978–38987.
   PubMed Web of Science ®Google Scholar
• •Evidence that supports the view that elevated expression of FAK in human cancer cells may be linked survival of tumour cells.
   Google Scholar
• IRBY RB, MAO W, COPPOLA D et al.:Activating SRC mutation in a subset of advanced human colon cancers. Nat. Genet. (1999) 21:187–190.
   PubMed Web of Science ®Google Scholar
• ROBERTSON SC, TYNAN J, DONOGHUE DJ: RTK mutations and human syndromes: when good receptors turn bad. Trends Genet. (2000) 16:368–369.
   PubMed Web of Science ®Google Scholar
• AGOCHIYA M, BRUNTON VG, OWENS DW et al: Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. Oncogene (1999) 18:5646–5653.
   PubMed Web of Science ®Google Scholar
• BRUNTON VG, OZANNE BW, PARASKEVA C, FRAME MC: A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer. Oncogene (1997) 14:283–293.
   PubMed Web of Science ®Google Scholar
• MCCORMACK SJ, BRAZINSKI SE, MOORE JL Jr, VVERNESS BA, GOLDSTEIN DJ: Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirusType 18. Oncogene (1997) 15:265–274.
   PubMed Web of Science ®Google Scholar
• TREMBLAY L, HAUCK W,APRIKIAN AG, BEGIN LR, CHAPDELAINE A, CHEVALIER S: Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p5OCSK in human metastatic prostate carcinoma. hat. J. Cancer (1996) 68:164–171.
   PubMed Web of Science ®Google Scholar
• OWENS LV, XU L, CRAVEN RJ, DENT GA et al.: Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumours. Cancer Res. (1995) 55:2752–2755.
   PubMed Web of Science ®Google Scholar
• KORNBERG LJ: Focal adhesion kinase expression in oral cancers. Head Neck (1998) 20:634–639.
   Google Scholar
• OWENS LV, XU L, DENT GA, YANG X et al.: Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer. Ann. Surg. Oncol (1996) 3:100–105.
   PubMed Web of Science ®Google Scholar
• JUDSON PL, HE X, CANCE WG, VAN LE L: Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer (1999) 86:1551–1556.
   PubMed Web of Science ®Google Scholar
• KORNBERG LJ: Focal adhesion kinase andits potential involvement in tumour invasion and metastasis. Head Neck (1998) 20:745–752.
   PubMed Web of Science ®Google Scholar
• HAUCK CR, SIEG DJ, HSIA DA et al.: Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signalling promoting the migration of invasive human carcinoma cells. Cancer Res. (2001) 61:7079–7090.
   PubMed Web of Science ®Google Scholar
• HAUCK CR, HSIA DA, ILIC D, SCHLAEPFER DD: v-Src 5H3-enhanced interaction with focal adhesion kinase at 131 integrin-containing invadopodia promotes cell invasion. J. Biol. Chem. (2002) 277:12487–12490.
   PubMed Web of Science ®Google Scholar
• •Describes a further important role for FAK during the in vitro invasive process.
   Google Scholar
• HAUCK CR, HSIA DA, PUENTE XS et al.: FRNK blocks v-Src stimulated invasion and experimental metastases without effects on cell motility or growth. EMBDIournak an press).
   Google Scholar
• ••Important evidence that the role ofFAK in migration and invasion are separable events.
   Google Scholar
• HAUCK CR, HSIA DA,SCHLAEPFER DD: The focal adhesion kinase - a regulator of cell migration and invasion. IUBMB Life (2002) 53:115–119.
   PubMed Web of Science ®Google Scholar
• ••An excellent recent review focusing onFAK's role in cell motility.
   Google Scholar
• SHIBATA K, KIKKAWA F, NAWA A et al.: Both focal adhesion kinase and c-Ras are required for the enhanced matrix metalloproteinase 9 secretion by fibronectin in ovarian cancer cells. Cancer Res. (1998) 58:900–903.
   PubMed Web of Science ®Google Scholar
• MCLEAN GW, BROWN K,ARBUCKLE MI et al.: Decreased focal adhesion kinase suppresses papilloma formation during experimental mouse skin carcinogenesis. Cancer Res. (2001) 61:8385–8389.
   Google Scholar
• ••First evidence for an causative role for FAKduring in vivo turnourogenesis.
   Google Scholar
• ABDEL-GHANY M, CHENG HC, ELBLE RC, PAULI BU: Focal adhesion kinase activated by f34 integrin ligation to mCLCA1 mediates early metastatic growth. J. Biol. Chem. (2002) 10:10.
   Google Scholar
• GOLEMIS EA, OCHS MF,PUGACHEVA EN: Signal transduction driving technology driving signaltransduction: factors in the design oftargeted therapies.Biochem. Stipp].(2001) Suppl. 37:42–52.
   Google Scholar
• SHARMA SV, ONEYAMA C, YAMASHITA Y et al: UCS15A, a non-kinase inhibitor of Src signal transduction. Oncogene (2001) 20:2068–2079.
   PubMed Web of Science ®Google Scholar
• ONEYAMA C, NAKANO H, SHARMA SV: UCS15A, a novel small molecule, 5H3 domain-mediated protein-protein interaction blocking drug. Oncogene (2002) 21:2037–2050.
   PubMed Web of Science ®Google Scholar
• SIEG DJ, HAUCK CR,SCHLAEPFER DD: Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migrationCell Sri. (1999) 112:2677–2691.
   Google Scholar
• LU Z, JIANG G, BLUME-JENSENP, HUNTER T: Epidermal growth factor-induced tumour cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Ma Cell. Biol. (2001) 21:4016–4031.
   Web of Science ®Google Scholar
• KAHANA 0, MICKSCHE M, WITZ IP, YRON I: The focal adhesion kinase (P125FAK) is constitutively active in human malignant melanoma.Oncogene (2002) 21:3969–3977.
   PubMed Web of Science ®Google Scholar
• •Correlation between constituent FAK kinase activity and malignant potential.
   Google Scholar
• NEWELL SW, PERCHELLET JP, PERCHELLET EM, ULUG ET: Alterations in focal adhesion kinase activity and associated proteins during malignant conversion of mouse keratinocytes.Carcinog. (1999) 25:73–83.
   Web of Science ®Google Scholar
• LEVITZKI A: Protein tyrosine kinase inhibitors as novel therapeutic agents. Pharmacol Ther. (1999) 82:231–239.
   PubMed Web of Science ®Google Scholar
• FRY DW: Site-directed irreversible inhibitors of the erbB family of receptor tyrosine kinases as novel chemotherapeutic agents for cancer. Anti-Cancer Drug Des. (2000) 15:3–16.
   PubMedGoogle Scholar
• MORIN MJ: From oncogene to drug: development of small molecule tyrosine kinase inhibitors as antitumour and antiangiogenic agents.Oncogene (2000) 19:6574–6583.
   PubMed Web of Science ®Google Scholar
• MUGHAL TI, GOLDMAN JM: Chronicmyeloid leukaemia. STI 571 magnifies the therapeutic dilemma. Ear: .1. Cancer (2001) 37:561–568.
   Google Scholar