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Drug Evaluation

Tolterodine for the treatment of overactive bladder: a review

Pages 653-666 | Published online: 22 Apr 2005

Bibliography

  • ABRAMS P, CARDOZO L, FALL M et al.:The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society. Urology (2003) 61:37–49.
  • •This is a recent update on the terminology utilised in the field of voiding dysfunction.
  • STEWART WF, VAN ROOYEN JB, CUNDIFF GW et al.: Prevalence and burden of overactive bladder in the United States. World J. Urol (2003) 20:327–336.
  • HU TW, WAGNER TH, BENTKOVER JD et al: Estimated economic costs of overactive bladder in the United States. Urology (2003) 61:1123–1128.
  • HEALTH NIO: Disease-specific estimates of direct and indirect costs of illness and NIH support: fiscal year 2000 update. (2004).
  • GARNETT S, ABRAMS P: The natural history of the overactive bladder and detrusor overactivity. A review of the evidence regarding the long-term outcome of the overactive bladder. J. Urol. (2003) 169:843–848.
  • MILSOM I, ABRAMS P, CARDOZO L, ROBERTS RG, THUROFF J, WEIN AJ: How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study. BJU Int (2001) 87:760–766.
  • HEIDRICH SM, WELLS TJ: Effects of urinary incontinence: psychological well being and distress in older community-dwelling women. J. Gerontol Nurs. (2004) 30:47–54.
  • BROWN JS, VITTINGHOFF E, WYMAN JF et al: Urinary incontinence: does it increase risk for falls and fractures? Study of Osteoporotic Fractures Research Group. J. Am. Geriatr. Soc. (2000) 48:721–725.
  • HU KK, BOYKO EJ, SCHOLES D et al: Risk factors for urinary tract infections in postmenopausal women. Arch. Intern. Med. (2004) 164:989–993.
  • BROWN JS, MCGHAN WF, CHOKROVERTY S: Comorbidities associated with overactive bladder. Am. J. Manag Care (2000) 6(11 Suppl.):5574–5579.
  • WEIN AJ, ROVNER ES: The overactive bladder: an overview for primary care health providers. Int. J. Fend Womens Med. (1999) 44:56–66.
  • ANDERSSON KE, YOSHIDA M: Antimuscarinics and the overactive detrusor-which is the main mechanism of action? Eur. Urol (2003) 43:1–5.
  • CHAPPLE CR: Muscarinic receptor antagonists in the treatment of overactive bladder. Urology (2000) 55:33-46; discussion 50.
  • ••This is an excellent review of availabledrugs for treating OAB by one of the leading investigators in the world.
  • CHAPPLE CR, YAIVIANISHI T, CHESS-WILLIAMS R: Muscarinic receptor subtypes and management of the overactive bladder. Urology (2002) 60:82-88; discussion 8–9.
  • CAULFIELD MP: Muscarinic receptors-characterization, coupling and function. Pharmacol Ther. (1993) 58:319–379.
  • NAKAMURA T, MATSUI M, UCHIDA K et al: M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation. Physiol (2004) 558:561–575.
  • NILVEBRANT L, ANDERSSON KE, GILLBERG PG, STAHL M, SPARF B: Tolterodine-a new bladder-selective antimuscarinic agent. Eur. J. Pharmacol. (1997) 327:195–207.
  • STAHL MM, EKSTROM B, SPARF B, MATTIASSON A. ANDERSSON KE: Urodynamic and other effects of tolterodine: a novel antimuscarinic drug for
  • •• the treatment of detrusor overactivity. Neurourol Urodyn. (1995) 14:647–655.
  • VAN KERREBROECK P, KREDER K, JONAS U, ZINNER N, WEIN A: Tolterodine once-daily: superior efficacy and tolerability in the treatment of the overactive bladder. Urology (2001) 57:414–421.
  • •The pivotal study demonstrating the improved efficacy and tolerability of the ER versus IR formulation of tolterodine.
  • ROVNER ES, WEIN AJ: Once-daily, extended-release formulations of antimuscarinic agents in the treatment of overactive bladder: a review. Eur. Urol (2002) 41:6–14.
  • ABRAMS P: Evidence for the efficacy and safety of tolterodine in the treatment of overactive bladder. Expert Opin. Pharmacother. (2001) 2:1685–1701.
  • OLSSON B, SZAMOSI J: Multiple dose pharmacokinetics of a new once daily extended release tolterodine formulation versus immediate release tolterodine. Clin. Pharmacokinet. (2001) 40:227–235.
  • HILLS CJ, WINTER SA, BALFOUR JA: Tolterodine. Drugs (1998) 55:813-20; discussion 21–22.
  • CLEMETT D, JARVIS B: Tolterodine: areview of its use in the treatment of overactive bladder. Drugs Aging (2001) 18:277–304.
  • NILVEBRANT L, GILLBERG PG, SPARF B: Antimuscarinic potency and bladder selectivity of PNU-200577, a major metabolite of tolterodine. Pharmacol Toxicol (1997) 81:169–172.
  • NILVEBRANT L: Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists. Pharmacol. Toxicol (2002) 90:260–267.
  • CHAPPLE C: Tolterodine once daily: selectivity for the bladder over effects on salivation compared to Ditropan XL. J. Urol (2001) 165:253.
  • CHAPPLE CR, NILVEBRANT L: Tolterodine: selectivity for the urinary bladder over the eye (as measured by visual accommodation) in healthy volunteers. Drugs RD (2002) 3:75–81.
  • OLSSON B, SZAMOSI J: Food does not influence the pharmacokinetics of a new extended release formulation of tolterodine for once daily treatment of patients with overactive bladder. Clin. Pharmacokinet. (2001) 40:135–143.
  • SATHYAN G, DMOCHOWSKI RR, APPELL RA, GUO C, GUPTA SK: Effect of antacid on the pharmacokinetics of extended-release form of tolterodine and oxybutynin. Clin. Pharmacokinet. (2004) 43:1059–1068.
  • ROMANZI L: Tolterodine extended-release action not affected by stomach pH. IUGA/CFA. Melbourne, Australia (2001).
  • BRYNNE N, STAHL MM, HALLEN B et al: Pharmacokinetics and pharmacodynamics of tolterodine in man: a new drug for the treatment of urinary bladder overactivity. Int. J. Clin. Pharmacol Ther. (1997) 35:287–295.
  • PAHLMAN I, GOZZI P: Serum protein binding of tolterodine and its major metabolites in humans and several animal species. Biopharm. Drug Dispos. (1999) 20:91–99.
  • POSTLIND H, DANIELSONA, LINDGREN A, ANDERSSON SH: Tolterodine, a new muscarinic receptor antagonist, is metabolized by cytochromes P450 2D6 and 3A in human liver microsomes. Drug Metab. Dispos. (1998) 26:289–293.
  • ALVAN G, BECHTEL P, ISELIUS L, GUNDERT-REMY U: Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. Eur. J. Clin. Pharmacol (1990) 39:533–537.
  • BRYNNE N, DALEN P, ALVAN G, BERTILSSON L, GABRIELSSON J: Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine. Clin. Pharmacol Ther. (1998) 63:529–539.
  • BRYNNE N, SVANSTROM C, ABERG-WISTEDT A, HALLEN B, BERTILSSON L: Fluoxetine inhibits the metabolism of tolterodine-pharmacokinetic implications and proposed clinical relevance. Br. J. Clin. Pharmacol (1999) 48:553–563.
  • HUA TC, PAN A. CHAN C et ell.: Effectof duloxetine on tolterodine pharmacokinetics in healthy volunteers. Br. J. Clin. Pharmacol (2004) 57:652–656.
  • BRYNNE N, FORSLUND C, HALLEN B, GUSTAFSSON LL, BERTILSSON L: Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity. Br. J. Clin. Pharmacol. (1999) 48:564–572.
  • RAHIMY M, HALLEN B, NARANG P: Effect of tolterodine on the anticoagulant actions and pharmacokinetics of single-dose warfarin in healthy volunteers. Arzneimittelfirschung (2002) 52:890–895.
  • OLSSON B, LANDGREN BM: The effect of tolterodine on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive containing ethinyl estradiol and levonorgestrel. Clin. Ther. (2001) 23:1876–1888.
  • EDWARDS KR, O'CONNOR JT: Risk ofdelirium with concomitant use of tolterodine and acetylcholinesterase inhibitors. J. Am. Geriatr. Soc. (2002) 50:1165–1166.
  • DONNELLAN CA, FOOK L, MCDONALD P, PLAYFER JR: Oxybutynin and cognitive dysfunction. Br. Med. J. (1997) 315:1363–1364.
  • •Antimuscarinic compounds may have CNS effects, as noted in this study.
  • LEVIEN TL, BAKER DR: Cytochrome P450 drug interactions. Pharmacist's Letter (2004) Detail document no. 150400.
  • KREDER KJ, BRUBAKER L, MAINPRIZE T: Tolterodine is equally effective in patients with mixed incontinence and those with urge incontinence alone. BJU Int. (2003) 92:418–421.
  • •Patients with urge-predominant mixed incontinence may respond to drug therapy directed at the urge component, as seen in this study.
  • KHULLAR V, HILLS, LAVAL K-U, SCHIOTZ HA, JONAS U, VERSI E: Treatment of urge-predominant mixed urinary incontinence with tolterodine extended release: A randomized, placebo-controlled trial. Urology (2004) 64:269–275.
  • DIOKNO AC, APPELL RA, SAND PK et al: Prospective, randomized, double-blind study of the efficacy and tolerability of the extended-release formulations of oxybutynin and tolterodine for overactive bladder: results of the OPERA trial. Mayo Clin. Proc. (2003) 78:687–695.
  • ••In a severely symptomatic patientpopulation, both tolterodine and oxybutynin demonstrated satisfactory efficacy in treating the symptoms of OAB.
  • HOMMA Y, PAICK JS, LEE JG, KAWABE K: Clinical efficacy and tolerability of extended-release tolterodine and immediate-release oxybutynin in Japanese and Korean patients with an overactive bladder: a randomized, placebo- controlled trial. BJU Int. (2003) 92:741–747.
  • SUSSMAN D, GARELY A: Treatment of overactive bladder with once-daily extended-release tolterodine or oxybutynin: the antimuscarinic clinical effectiveness trial (ACET). Curr. Med. Res. Opin. (2002) 18:177–184.
  • COYNE K, MATZA L: Patient perceptionof bladder condition is a valid tool for evaluating the efficacy of overactive bladder therapy. Int. Urogynecol J. Pelvic Floor Dysfiinct. (2002) 13:S83.
  • DMOCHOWSKI RR, SAND PK, ZINNER NR, GITTELMAN MC, DAVILA GW, SANDERS SW: Comparative efficacy and safety of transdermal oxybutynin and oral tolterodine versus placebo in previously treated patients with urge and mixed urinary incontinence. Urology (2003) 62:237–242.
  • •The oxybutynin patch compared favourably to tolterodine in treating the symptoms of OAB. Both agents were well tolerated, although the incidence of patch site reactions in the oxybutynin group was notable.
  • APPELL RA: Clinical efficacy and safety of tolterodine in the treatment of overactive bladder: a pooled analysis. Urology (1997) 50:90-96; discussion 7–9.
  • RICCI JA, BAGGISH JS, HUNT TL et al: Coping strategies and health care-seeking behavior in a US national sample of adults with symptoms suggestive of overactive bladder. Clin. Ther. (2001) 23:1245–1259.
  • HERZOG AR, FULTZ NH, NORMOLLE DP: Methods used to managed urinary incontinence by older adults in the community. J. Am. Geriatr. Soc. (1989) 37:339–347.
  • SIAMI P, SEIDMAN LS, LAMA D: A multicenter, prospective, open-label study of tolterodine extended-release 4 mg for overactive bladder: the speed of onset of therapeutic assessment trial (STAT). Clin. Ther. (2002) 24:616–628.
  • LANDIS JR, KAPLAN SA, SWIFT S: Efficacy of antimuscarinic therapy for overactive bladder with varying degrees of incontinence severity. J. Urol (2004) 171:752–756.
  • FREEMAN R, HILLS, MILLARD R, SLACK M, SUTHERST J: Reduced perception of urgency in treatment of overactive bladder with extended-release tolterodine. Obstet. GynecoL (2003) 102:605–611.
  • APPELL RA, ABRAMS P, DRUTZ HP, VAN KERREBROECK PE, MILLARD R, WEIN A: Treatment of overactive bladder: long-term tolerability and efficacy of tolterodine. World J. Urol (2001) 19:141–147.
  • ABRAMS P, MALONE-LEE J, JACQUETIN B et al.: Twelve-month treatment of overactive bladder: efficacy and tolerability of tolterodine. Drugs Aging (2001) 18:551–560.
  • KREDER K, MAYNE C, JONAS U: Long-term safety, tolerability and efficacy of extended-release tolterodine in the treatment of overactive bladder. Eur. Urol (2002) 41:588–595.
  • KELLEHER CJ, CARDOZO LD, KHULLAR V, SALVATORE S: A medium-term analysis of the subjective efficacy of treatment for women with detrusor instability and low bladder compliance. Br. J. Obstet. Gynaecol (1997) 104:988–993.
  • LAWRENCE M, GUAY DR, BENSON SR, ANDERSON MJ: Immediate-release oxybutynin versus tolterodine in detrusor overactivity: a population analysis. Pharmacotherapy (2000) 20:470–475.
  • CALLAHAN MJ: Irritable bowel syndrome neuropharmacology. A review of approved and investigational compounds. J. Clin. Gastroenterol (2002) 35:S58–S67.
  • CHOPPIN A, EGLEN RM: Pharmacological characterization of muscarinic receptors in dog isolated ciliary and urinary bladder smooth muscle. Br. J. Pharmacol (2001) 132:835–842.
  • HABGOOD MD, BEGLEY DJ, ABBOTT NJ: Determinants of passive drug entry into the central nervous system. Cell. Mol NeurobioL (2000) 20:231–253.
  • NILVEBRANT L: Clinical experiences with tolterodine. Life Sci. (2001) 68:2549–2556.
  • TODOROVA A, VONDERHEID-GUTH B, DIMPFEL W: Effects of tolterodine, trospium chloride, and oxybutynin on the central nervous system. J. Clin. Pharmacol. (2001) 41:636–644.
  • TSAO JW, HEILMAN KM: Transient memory impairment and hallucinations associated with tolterodine use. N Engl. J. Med. (2003) 349:2274–2275.
  • SIEGLER EL, REIDENBERG M: Treatment of urinary incontinence with anticholinergics in patients taking cholinesterase inhibitors for dementia. Clin. Pharmacol Ther. (2004) 75:484–488.
  • WOMACK KB, HEILMAN KM: Tolterodine and memory: dry but forgetful. Arch. NeuroL (2003) 60:771–773.
  • MALONE-LEE JG, WALSH JB, MAUGOURD MF: Tolterodine: a safe and effective treatment for older patients with overactive bladder./ Am. Geriatr. Soc. (2001) 49:700–705.
  • MALONE-LEE J, SHAFFU B, ANAND C, POWELL C: Tolterodine: superior tolerability than and comparable efficacy to oxybutynin in individuals 50 years old or older with overactive bladder: a randomized controlled trial. J. Urol (2001) 165:1452–1456.
  • •It is important to note that both tolterodine and oxybutynin are efficacious in older patients, a group which is disproportionately affected by this condition.
  • MICHEL MC, SCHNEIDER T, KREGE S, GOEPEL M: Does gender or age affect the efficacy and safety of tolterodine?J. Urol (2002) 168:1027–1031.
  • ZINNER NR, MATTIASSON A. STANTON SL: Efficacy, safety, and tolerability of extended-release once-daily tolterodine treatment for overactive bladder in older versus younger patients. J. Am. Geriatr. Soc. (2002) 50:799–807.
  • MILLARD R, TUTTLE J, MOORE K et al.: Clinical efficacy and safety of tolterodine compared to placebo in detrusor overactivity. J. Urol (1999) 161:1551–1555.
  • VAN KERREBROECK P, ALE: Clinical efficacy and safety of tolterodine compared to oxybutynin in patients with overactive bladder. NeurouroL Urodyn. (1997) 16:478–479.
  • ABRAMS P, FREEMAN R, ANDERSTROM C, MATTIASSON A: Tolterodine, a new antimuscarinic agent: as effective but better tolerated than oxybutynin in patients with an overactive bladder. Br. J. Urol (1998) 81:801–810.
  • DRUTZ HP, APPELL RA, GLEASON D, KLIMBERG I, RADOMSKI S: Clinical efficacy and safety of tolterodine compared to oxybutynin and placebo in patients with overactive bladder. Int. Urogynecol. J. Pelvic Floor Dysfiinct. (1999) 10:283–289.
  • WALLIS RM, NAPIER CM: Muscarinic antagonists in development for disorders of smooth muscle function. Life Sci. (1999) 64:395–401.
  • NEWGREEN DT, ANDERSON CWP, CARTER AJ, NAYLOR AM: Darifenacin-a novel bladder-selective agent for the treatment of urge incontinence. NeurouroL Urodyn. (1995) 14:95–96.
  • SMULDERS RA, KRAUWINKEL WJ, SWART PJ, HUANG M: Pharmacolcinetics and safety of solifenacin succinate in healthy young men. J. Clin. PharmacoL (2004) 44:1023–1033.
  • KUIPERS M, TRAN DD, KRAUWINKEL WJ, ABILA B, MULDER H: Absolute bioavailability of YM905 in healthy male volunteers: a single-dose, randomized, two-period crossover study. NeurouroL Urodyn. (2002) 4:296–297.
  • IKEDA K, KOBAYASHI S, SUZUKI M et al.: M(3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland. Naunyn Schmiedebergs Arch. Pharm. (2002) 366:97–103.
  • CHAPPLE CR, ARANO P, BOSCH JL, DE RIDDER D, KRAMER AE, RIDDER AM: Solifenacin appears effective and well tolerated in patients with symptomatic idiopathic detrusor overactivity in a placebo- and tolterodine-controlled Phase II dose-finding study. BJU Int. (2004) 93:71–77.
  • CHAPPLE CR, RECHBERGER T, AL-SHUKRI S et al.: Randomized, double-blind placebo- and tolterodine-controlled trial of the once-daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladder. BJU Int. (2004) 93:303–310.
  • MADERSBACHER H, STOHRER M, RICHTER R, BURGDORFER H, HACHEN HJ, MURTZ G: Trospium chloride versus oxybutynin: a randomized, double-blind, multicentre trial in the treatment of detrusor hyper-reflexia. Br. J. UroL (1995) 75:452–456.

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