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Key Paper Evaluation

Aspirin and esomeprazole are superior to clopidogrel in preventing recurrent ulcer bleeding

CHAN FK, CHING MP, HUNG LC et al.: Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N. Engl. J. Med. (2005) 352:238-244 [1].

Pages 1253-1256 | Published online: 15 Jun 2005

Bibliography

  • CHAN FK, CHING MP, HUNG LC et aL: Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N Engl. J. Med. (2005) 352:238–244.
  • CAPRIE STEERING COMMITTEE: A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events. Lancet (1996) 348:1329–1339.
  • GASPOZ JM, CONDON PG, GOLDMAN PA et al.: Cost effectiveness of aspirin, clopidogrel, or both for secondary prevention of coronary heart disease. N Engl. J. Med. (2002) 346:1800–1806.
  • DERRY S, LOKE YK: Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. Br. Med. J. (2000) 321:1183–1187.
  • LAI KC, LAM SK, CHU KM et ell.: Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl. J. Med. (2002) 346:2033–2038.
  • RAGHUNATH AS, GREEN JR, EDWARDS SJ: A review of the clinical and economic impact of using esomeprazole or lansoprazole for the treatment of erosive esophagitis. Clin. Ther. (2003) 25:2088–2101.
  • NG FH, WONG SY, CHANG CM et al.:High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease. Aliment. Pharmacol Ther. (2003) 18:443–449.
  • KATZ PO: Effectiveness of proton pump inhibitors: beyond cost. Rev. Gastroenterol Disord. (2004) 4\(Suppl. 4):58–515.
  • GALMICHE JP, SACHER-HUVELIN S, BRULEY DES VARANNES S et al.: A comparative study of the early effects of tenatoprazole 40 mg and esomeprazole 40 mg on intragastric pH in healthy volunteers. Aliment. Pharmacol Ther. (2005) 21:575-582. Website
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