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Review

Advances in the management of organophosphate poisoning

, MD DNB (Med) FRACP, , MBBS FRACP FJFICM MD & , BSc MS PhD
Pages 1451-1464 | Published online: 30 Jul 2007

Bibliography

  • KARALLIEDDE L, SENANAYAKE N: Acute organophosphorus insecticide poisoning in Sri Lanka. Forensic Sci. Int. (1988) 36:97-100.
  • SHAH AC, TRIVEDI AM, VISHWANATH N et al.: Intensive respiratory care service. Organisation, orientation, system and future. Our experience of management of 288 cases. J. Assoc. Physicians India (1990) 38:140-143.
  • JAMIL H: Organophosphorus insecticide poisoning. J. Pak. Med. Assoc. (1989) 39:27-31.
  • PETER JV, CHERIAN AM: Organic insecticides. Anaest. Intensive Care (2000) 28:11-21.
  • PETER JV, MORAN JL, GRAHAM P: Oxime therapy and outcomes in human organophosphate poisoning: an evaluation using meta-analytic techniques. Crit. Care Med. (2006) 34:502-510.
  • EDDLESTON M, SZINICZ L, EYER P, BUCKLEY N: Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials. QJM (2002) 95:275-283.
  • LUDOMIRSKY A, KLEIN HO, SARELLI P et al.: QT prolongation and polymorphous (‘torsade de pointes’) ventricular arrhythmias associated with organophosphorus insecticide poisoning. Am. J. Cardiol. (1982) 49:1654-1658.
  • ABRAHAM S, OZ N, SAHAR R, KADAR T: QTc prolongation and cardiac lesions following acute organophosphate poisoning in rats. Proc. West. Pharmacol. Soc. (2001) 44:185-186.
  • GASPARI RJ, PAYDARFAR D: Pathophysiology of respiratory failure following acute dichlorvos poisoning in a rodent model. Neurotoxicology (2007) [Epub ahead of print].
  • VENKATESH S, KAVITHA ML, ZACHARIAH A, OOMMEN A: Progression of type I to type II paralysis in acute organophosphorus poisoning: is oxidative stress significant. Arch. Toxicol. (2006) 80:854-861.
  • JUNI P, WITSCHI A, BLOCH R, EGGER M: The hazards of scoring the quality of clinical trials for meta-analysis. JAMA (1999) 282:1054-1060.
  • DER SIMONIAN R, LAIRD N: Meta-analysis in clinical trials. Control Clin. Trials (1986) 7:177-188.
  • SUTTON AJ, ABRAMS KR, JONES DR, SHELDON TA, SONG F: Systematic reviews of trials and other studies. Health Technol. Assess. (1998) 2:1-276.
  • LUMLEY T: rmeta: meta-analysis. R package version 2.12 (2004).
  • CHERIAN AM, PETER JV, SAMUEL J et al.: Effectiveness of P2AM (PAM – Pralidoxime) in the treatment of organophosphate poisoning (OPP). A randomized, double-blind placebo-controlled clinical trial. J. Assoc. Physicians India (1997) 45:22-24.
  • JOHNSON S, PETER JV, THOMAS K, JEYASEELAN L, CHERIAN AM: Evaluation of two treatment regimens of pralidoxime (1 gm single bolus vs 12 gm infusion) in the management of organophosphorus poisoning. A randomized, double-blind controlled clinical trial. J. Assoc. Physicians India (1996) 44:529-531.
  • CHERIAN MA, ROSHINI C, VISALAKSHI J, JEYASEELAN L, CHERIAN AM: Biochemical and clinical profile after organophosphate poisoning – a placebo-controlled trial using pralidoxime. J. Assoc. Physicians India (2005) 53:427-431.
  • PAWAR KS, BHOITE RR, PILLAY CP, CHAVAN SC, MALSHIKARE DS, GARAD SG: Continuous pralidoxime infusion versus repeated bolus injection to treat organophosphorus insecticide poisoning: a randomised controlled trial. Lancet (2006) 368:2136-2141.
  • DE SILVA HJ, WIJEWICKREMA R, SENANAYAKE N: Does pralidoxime affect outcome of management in acute organophosphorus poisoning? Lancet (1992) 339:1136-1138.
  • ABDOLLAHI M, JAFARI A, JALALI N, BALALI-MOOD M, KEBRIAEEZADEH A, NIKFAR S: A new approach to the efficacy of oximes in the management of acute organophosphorus poisoning. Ir. J. Med. Sci. (1995) 20:105-109.
  • DUVAL G, RAKOUER JM, TILLANT D, AUFFRAY JC, NIGOND J, DELUVALLEE G: Acute poisoning by insecticides with anticholinesterase activity. Evaluation of the efficacy of a cholinesterase reactivator, pralidoxime [French]. J. Toxicol. Clin. Exp. (1991) 11:51-58.
  • SUNGUR M, GUVEN M: Intensive care management of organophosphate insecticide poisoning. Critical Care (London) (2001) 5:211-215.
  • ZHENG G, SONG S, LI M: Comparison of effects between concentrated-dose and non-concentrated dose pralidoxime chloride on respiratory muscle paralysis in acute organophosphorus pesticide poisoning [Chinese]. Zhonghua Nei Ke Za Zhi (2000) 39:655-657.
  • SHIVAKUMAR S, RAGHAVAN K, ISHAQ RM, GEETHA S: Organophosphorus poisoning: a study on the effectiveness of therapy with oximes. J. Assoc. Physicians India (2006) 54:210-211.
  • CHUGH SN, AGGARWAL N, DABLA S, CHHABRA B: Comparative evaluation of ‘atropine alone’ and ‘atropine with pralidoxime (PAM)’ in the management of organophosphorus poisoning. JIACM (2005) 6:33-37.
  • BALALI-MOOD M, SHARIAT M: Treatment of organophosphate poisoning. Experience of nerve agents and acute pesticide poisoning on the effect of oximes. J. Physiol. Paris (1998) 92:375-378.
  • SINGH S, CHAUDHRY D, BEHERA D, GUPTA D, JINDAL SK: Aggressive atropinisation and continuous pralidoxime (2-PAM) infusion in patients with severe organophosphate poisoning: experience of a northwest Indian hospital. Hum. Exp. Toxicol. (2001) 20:15-18.
  • RAHIMI R, NIKFAR S, ABDOLLAHI M: Increased morbidity and mortality in acute human organophosphate-poisoned patients treated by oximes: a meta-analysis of clinical trials. Hum. Exp. Toxicol. (2006) 25:157-162.
  • PETER JV, MORAN JL: Role of oximes in human organophosphate poisoning – a critical look at the evidence. In: Critical Care Update. Nayyar V (Ed.), Jaypee Brothers Medical Publishers (P) Ltd., New Delhi (2004):153-163.
  • BUCKLEY NA, EDDLESTON M, SZINICZ L: Oximes for acute organophosphate pesticide poisoning. Cochrane Database Syst. Rev. (2005) (1):CD005085.
  • PAJOUMAND A, SHADNIA S, REZAIE A, ABDI M, ABDOLLAHI M: Benefits of magnesium sulfate in the management of acute human poisoning by organophosphorus insecticides. Hum. Exp. Toxicol. (2004) 23:565-569.
  • GUVEN M, SUNGUR M, ESER B, SARI I, ALTUNTAS F: The effects of fresh frozen plasma on cholinesterase levels and outcomes in patients with organophosphate poisoning. J. Toxicol. Clin. Toxicol. (2004) 42:617-623.
  • ALTINTOP L, AYGUN D, SAHIN H et al.: In acute organophosphate poisoning, the efficacy of hemoperfusion on clinical status and mortality. J. Intensive Care Med. (2005) 20:346-350.
  • PENG A, MENG F, SUN L, JI Z, LI Y: Therapeutic efficacy of charcoal hemoperfusion in patients with acute severe dichlorvos poisoning. Acta. Pharmacol. Sin. (2004) 25:15-21.
  • ROBERTS D, BUCKLEY NA: Alkalinisation for organophosphorus pesticide poisoning. Cochrane Database Syst. Rev. (2005) (1):CD004897.
  • BALALI-MOOD M, AYATI M, ALI-AKBARIAN H: Effect of high doses of sodium bicarbonate in acute organophosphorus pesticide poisoning. J. Toxicol. Clin. Toxicol. (2003) 41:383 (Abstract).
  • OKUMURA T, TAKASU N, ISHIMATSU S et al.: Report on 640 victims of the Tokyo subway sarin attack. Ann. Emerg. Med. (1996) 28:129-135.
  • NOZAKI H, AIKAWA N, SHINOZAWA Y: Sarin poisoning in Tokyo subway. Lancet (1995) 345:980-981.
  • PETER JV, MORAN JL, GRAHAM P: Oxime use after deliberate release. Crit. Care Med. (2006) 34:3065; author reply 3066.
  • DART RC, GOLDFRANK LR, CHYKA PA et al.: Combined evidence-based literature analysis and consensus guidelines for stocking of emergency antidotes in the United States. Ann. Emerg. Med. (2000) 36:126-132.
  • EDDLESTON M, BUCKLEY NA, CHECKETTS H et al.: Speed of initial atropinisation in significant organophosphorus pesticide poisoning – a systematic comparison of recommended regimens. J. Toxicol. Clin. Toxicol. (2004) 42:865-875.
  • NEWMARK J: The birth of nerve agent warfare: lessons from Syed Abbas Foroutan. Neurology (2004) 62:1590-1596.
  • EYER P, BUCKLEY N: Pralidoxime for organophosphate poisoning. Lancet (2006) 368:2110-2111.
  • BESSER R, WEILEMANN LS, GUTMANN L: Efficacy of obidoxime in human organophosphorus poisoning: determination by neuromuscular transmission studies. Muscle Nerve (1995) 18:15-22.
  • THIERMANN H, MAST U, KLIMMEK R et al.: Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients. Hum. Exp. Toxicol. (1997) 16:473-490.
  • KHAN S, HEMALATHA R, JEYASEELAN L, OOMMEN A, ZACHARIAH A: Neuroparalysis and oxime efficacy in organophosphate poisoning: a study of butyrylcholinesterase. Hum. Exp. Toxicol. (2001) 20:169-174.
  • REINER E, PLESTINA R: Regeneration of cholinesterase activities in humans and rats after inhibition of O, O-dimethyl-2, 2-dichlorovinyl phosphate. Toxicol. Appl. Pharmacol. (1979) 49:451-454.
  • WOREK F, DIEPOLD C, EYER P: Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and ageing kinetics. Arch. Toxicol. (1999) 73:7-14.
  • EDDLESTON M, EYER P, WOREK F et al.: Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study. Lancet (2005) 366:1452-1459.
  • WOREK F, BACKER M, THIERMANN H et al.: Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning. Hum. Exp. Toxicol. (1997) 16:466-472.
  • JOHNSON MK, JACOBSEN D, MEREDITH TJ et al.: Evaluation of antidotes for poisoning by organophosphorus pesticides. Emerg. Med. (2000) 12:22-37.
  • BAILIE DB, INOUE H, KASEDA S, BEN-DAVID J, ZIPES DP: Magnesium suppression of early after depolarisations and ventricular tachyarrhythmias induced by cesium in dogs. Circulation (1988) 77:1395-1402.
  • KEREN A, TZIVONI D: Magnesium therapy in ventricular arrhythmias. Pacing Clin. Electrophysiol. (1990) 13:937-945.
  • BRADLEY RJ: Calcium or magnesium concentration affects the severity of organophosphate-induced neuromuscular block. Eur. J. Pharmacol. (1986) 127:275-278.
  • NAGLER J, BRAECKMAN RA, WILLEMS JL, VERPOOTEN GA, DE BROE ME: Combined hemoperfusion-hemodialysis in organophosphate poisoning. J. Appl. Toxicol. (1981) 1:199-201.
  • DOCTOR BP, SAXENA A: Bioscavengers for the protection of humans against organophosphate toxicity. Chem. Biol. Interact. (2005) 157-158:167-171.
  • FULTON JA, BOUCHARD NC, BECKER ML, GERTZ S, HOFFMAN RS: FFP in organophosphate poisoning: what's the secret ingredient? Clin. Toxicol. (Phila.) (2005) 43:215.
  • PEEPLES ES, SCHOPFER LM, DUYSEN EG et al.: Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. Toxicol. Sci. (2005) 83:303-312.
  • KIDERLEN D, WOREK F, KLIMMEK R, EYER P: The phosphoryl oxime-destroying activity of human plasma. Arch. Toxicol. (2000) 74:27-32.
  • ROBERTS DA, KARUNARATHNA A, BUCKLEY NA, MANUWEERA G, SHERIFF MHR, EDDLESTON M: Influence of pesticide regulation on acute poisoning deaths in Sri Lanka. Bull. World Health Organ. (2003) 81:789-798.
  • KAR N: Lethality of suicidal organophosphorus poisoning in an Indian population: exploring preventability. Ann. Gen. Psychiatry (2006) 5:17.
  • DAVID D, GEORGE IA, PETER JV: Toxicology of the newer neonicotinoid insecticides: imidacloprid poisoning in a human. Clin. Toxicol. (2007) 45(5):485-486.
  • HAWTON K, TOWNSEND E, DEEKS J et al.: Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and after study. BMJ (2001) 322:1203-1207.
  • SUDARSANAM TD, PICHAMUTHU K, ZACHARIAH A, JOHN G: Oximes in acute organophosphate poisoning. Crit. Care Med. (2006) 34:2265.
  • PETER JV, MORAN JL, GRAHAM P: Morality reduction in acute organophosphate poisoning: a challenging task ahead (author response). Crit. Care Med. (2006) 34:2265-2266.

Websites

  • http://www.R-project.org R Development Core Team: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria, ISBN 3-900051-07-0 (2004).
  • http://www.sactrc.org/publications.html PIERIS R, WEERASINGHE M: Safe storage boxes for pesticides in Sri Lanka. Final report on the use survey of croplife pesticide storage boxes at Polonnaruwa, Sri Lanka. Pesticide safe storage project, (SACTRC) & University of Copenhagen, (2005) (Accessed January 2007).

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