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Drug Evaluations

Morphine-6-glucuronide: potency and safety compared with morphine

, MD, , MD PhD & , MD PhD
Pages 1955-1961 | Published online: 16 Jul 2008

Bibliography

  • Osborne R, Joel S, Trew D, Slevin M. Analgesic activity of morphine-6-glucuronide. Lancet 1988;8589:828
  • Romberg R, Sarton E, Teppema L, et al. Comparison of morphine-6-glucuronide and morphine on respiratory depression and antinociceptive responses in wild type and μ-opioid receptor knockout mice. Br J Anaesth 2003;89:553-60
  • Kilpatrick GJ, Smith TW. Morphine-6-glucuronide: actions and mechanisms. Med Res Rev 2005;25:521-44
  • van Dorp ELA, Romberg R, Sarton E, et al. Morphine-6-glucuronide: morphine's successor for postoperative pain relief? Anesth Analg 2006;102:1789-97
  • US National Library of Medicine. Available from: http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed
  • Google Scholar beta. Available from: www.scholar.google.nl
  • Christrup LL. Morphine metabolites. Acta Anaesthesiol Scand 1997;41:116-22
  • Glattard E, Angelone T, Aunis D, et al. Rethinking the opiate system? Morphine and morphine-6-glucuronide as new endocrine and neuroendocrine mediators. Med Sci Monit 2006;12:SR25-7
  • Goumon Y, Muller A, Glattard E, et al. Identification of morphine-6-glucuronide in chromaffin cell secretory granules. J Biol Chem 2006;12:8082-9
  • Dahan A, van Dorp E, Smith T, Yassen A. Morphine-6-glucuronide (M6G) for postoperative pain relief. Eur J Pain 2008;12:403-11
  • Hasselstrom J, Sawe J. Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations. Clin Pharmacokinet 1993;24:344-54
  • Penson RT, Joel SP, Roberts M, et al. The bioavailability and pharmacokinetics of subcutaneous, nebulized and oral morphine-6-glucuronide. Br J Clin Phramacol 2002;53:347-54
  • Lötsch J, Skarke C, Schmidt H, et al. The transfer half-life of morphine-6-glucuronide from plasma to effect site assessed by pupil size measurement in healthy volunteers. Anesthesiology 2001;95:1329-38
  • Skarke C, Darimont J, Schidt H, et al. Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers. Clin Pharmacol Ther 2003;73:107-21
  • Romberg R, Olofsen E, Sarton E, et al. Pharmacokinetic-pharmacodynamic modeling morpgine-6-glucuronide-induced analgesia in healthy volunteers: absence of sex differences. Anesthesiology 2004;100:120-33
  • Romberg R, Olofsen E, Bijl H, et al. Polymorphism of the μ-opioid receptor gene (OPRM1:c.118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response. Anesthesiology 2005;102:522-30
  • Sarton E, Olofsen E, Romberg E, et al. Sex differences in morphine analgesia: an experimental study in healthy volunteers. Anesthesiology 2000;93:1245-54
  • Stain-Texier F, Sandouk P, Scherrmann JM. Intestinal absorption and stability of morphine-6-glucuronide in different physiological; compartments of the rat. Drug Metab Dispos 1998;26:383-7
  • Zelcer N, van de Wetering K, Hillebrand M, et al. Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception. Proc Natl Acad Sci USA 2005;102:7274-9
  • Hanna MH, D'Costa F, Peat J, et al. Morphine-6-glucuronide disposition in renal impairment. Br J Anaesth 1993;70:511-4
  • Angst MS, Bührer M, Lötsch J. Insidious intoxication after morphine treatment in renal failure: delayed onset of morphine-6-glucuronide action. Anesthesiology 2000;92:1473-6
  • Osborne R, Thompson P, Joel S, et al. The analgesic activity of morphine-6-glucuronide. Br J Clin Pharmacol 1992;34:130-8
  • Motamed C, Mazoit X, Ghanouchi K, et al. Preemptive intravenous morphine-6-glucuronide is ineffective for postoperative pain relief. Anesthesiology 2000;92:355-60
  • Cann C, Curran J, Milner T, Ho B. Unwanted effects of morphine-6-glucoronide and morphine. Anaesthesia 2002;57:1200-3
  • Binning S, Coggins S, Davidson A, Millinga KR. Comparison of two dosing regimens of morphine-6-glucuronide versus morphine for analgesia following total hip replacement [abstract no. 587.T]. Prague: 4th Congress of EFIC; 2003
  • Romberg R, van Dorp E, Hollander J, Kruit, et al. A randomized, double-blind, placebo-controlled pilot study of i.v. morphine-6-glucuronide for postoperative pain relief after knee replacement surgery. Clin J Pain 2007;23:197-203
  • Hanna MH, Elliott KM, Fung M. Randomized, double-blind study of the analgesic efficacy of morphine-6-glucuronide versus morphine sulphate for postoperative pain in major surgery. Anesthesiology 2005;102:815-21
  • van Dorp E, Sarton E, Bonsing B, et al. Een gerandomiseerde dubbelblinde studie naar de effecten van morfine-6-glucuronide (M6G) versus morfine na open abdominale chirurgie: pijnstilling, misselijkheid en braken (A randomized double-blind study on the effect of morphine-6-glucuronide (M6G) versus morphine after open abdominal surgery: analgesia, nausea and vomiting). In Dutch. Ned Tijdsch Pijn Bestrijding 2007;26(32):6-10
  • Dahan A, van Dorp E, Sarton E. Postoperative morphine-6-glucuronide versus morphine: equal analgesia but reduced nausea/vomiting [abstract]. Anesthesiology 2007;107:A1744
  • Dahan A, Teppema LJ. Influence of anaesthesia and analgesia on the control of breathing. Br J Anaesth 2003;91:40-9
  • Penson RT, Joel SP, Bakshi K, et al. Randomized placebo-controlled trial of the activity of the morphine glucuronides. Clin Pharmacol Ther 2000;68:667-76
  • Romberg R, Sarton E, Olofsen E, et al. Pharmacodynamic effect of morphine-6-glucuronide versus morphine on hypoxic and hypercapnic breathing in healthy female volunteers. Anesthesiology 2003;99:788-98
  • Smith TW, Binning AR, Dahan A. Efficacy and safety of morphine-6-glucuronide (M6G) for postoperative pain relief: a randomized, double-blind study. Eur J Pain In press
  • Nestler EJ. Historical review: molecular and cellular mechanisms of opiate and cocaine addiction. Trends Pharmacol Sci 2004;25:210-8
  • Lötsch J, Geisslinger G. Relevance of frequent mu-opioid receptor polymorphisms for opioid activity in healthy volunteers. Pharmacogenomics J 2006;6:200-10
  • van Dorp E, Yassen A, Sarton E, et al. Naloxoone reversal of buprenorphine-induced respiratory depression. Anesthesiology 2006;105:51-7
  • Yassen A, Olofsen E, Sarton E, et al. Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in human volunteers. Clin Pharmacol Ther 2007;81:50-8
  • Yassen A, Olofsen E, van Dorp E, et al. Mechanism-based pharmacokinetic-pharmacodynamic modeling of the reversal of buprenorphine-induced respiratory depression by naloxone: a study in healthy volunteers. Clin Pharmacokinetic 2007;46:965-80

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