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Expert Opinion on Pharmacotherapy Volume 9, 2008 - Issue 7
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Review

Developments in the pharmacotherapeutic management of spontaneous preterm labor

KY Ronald Kam Research Fellow Imperial College London, Department of Obstetrics and Gynaecology, Northwick Park and St Mark's NHS Trust, Watford Road, Harrow, Middlesex HA1 3UJ, UK
, BSc &
Ronald F Lamont Consultant and Reader Imperial College London, Department of Obstetrics and Gynaecology, Northwick Park and St Mark's NHS Trust, Watford Road, Harrow, Middlesex HA1 3UJ, UK Tel: +44 20 8869 2862; +44 20 8869 2864; E-mail: [email protected]
, BSc MB ChB MD FRCOG
Pages 1153-1168 | Published online: 21 Apr 2008

Bibliography

  • Villar J, Ezcurra EJ, Gurtner De La Fuente V, Campodonico L. Pre-term delivery syndrome: the unmet need. New perspectives for the effective treatment of pre-term labour – an international consensus. Res Clin Forums 1994;163:9-38
  • Magowan BA, Bain M, Juszczak E, McInneny K. Neonatal mortality amongst Scottish preterm singleton births (1985 – 1994). Br J Obstet Gynaecol 1998;105(9):1005-10
  • Finnstrom O, Olausson PO, Sedin G, et al. The Swedish national prospective study on extremely low birthweight (ELBW) infants. Incidence, mortality, morbidity and survival in relation to level of care. Acta Paediatr 1997;86(5):503-11
  • Wood NS, Marlow N, Costeloe K, et al. Neurologic and developmental disability after extremely preterm birth. N Engl J Med 2000;343(6):378-84
  • Keirse MJ. New perspectives for the effective treatment of preterm labor. Am J Obstet Gynecol 1995;173(2):618-28
  • Petrou S. The economic consequences of preterm birth during the first 10 years of life. Br J Obstet Gynaecol 2005;112(Suppl):110-5
  • Di Renzo GC, Roura LC. Guidelines for the management of spontaneous preterm labor. J Perinat Med 2006;34(5):359-66
  • Brown AG, Leite RS, Strauss JF. Mechanisms underlying ‘functional’ progesterone withdrawal at parturition. Ann NY Acad Sci 2004;1034(1):36-49
  • Lopez Bernal A. Mechanisms of labour – biochemical aspects. Br J Obstet Gynaecol 2003;110(Suppl 20):39-45
  • Pieber D, Allport VC, Hills F, et al. Interactions between progesterone receptor isoforms in myometrial cells in human labour. Mol Hum Reprod 2001;7(9):875-9
  • Mesiano S. Myometrial progesterone responsiveness and the control of human parturition. J Soc Gynecol Invest 2004;11(4):193-202
  • Smith R, Mesiano S, Nicholson R, et al. Control of the length of gestation: lessons from women. In: Critchley H, Bennett P, Thornton S, editors, Preterm Birth. London: RCOG Press; 2004. p. 13-27
  • Mesiano S, Chan EC, Fitter JT, et al. Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium. J Clin Endocrinol Metab 2002;87(6):2924-30
  • Loudon JAZ, Groom KM, Bennett PR. Prostaglandin inhibitors in preterm labour. Best Pract Res Clin Obstet Gynaecol 2003;17(5):731-44
  • Allport VC, Pieber D, Slater DM, et al. Human labour is associated with nuclear factor-{{kappa}}B activity which mediates cyclo-oxygenase-2 expression and is involved with the ‘functional progesterone withdrawal’. Mol Hum Reprod 2001;7(6):581-6
  • Kalkhoven E, Wissink S, Van Der Saag PT, Van Der Burg B. Negative interaction between the RelA(p65) subunit of NF-kappa B and the progesterone receptor. J Biol Chem 1996;271(11):6217-24
  • Liu SF, Malik AB. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 2006;290(4):L622-45
  • Lindstrom TM, Bennett PR. The role of nuclear factor kappa B in human labour. Reproduction 2005;130(5):569-81
  • Zhang KY, Ibrahim PN, Gillette S, Bollag G. Phosphodiesterase-4 as a potential drug target. Expert Opin Ther Targets 2005;9(6):1283-305
  • Mehats C, Tanguy G, Paris B, et al. Pregnancy induces a modulation of the cAMP phosphodiesterase 4-conformers ratio in human myometrium: consequences for the utero-relaxant effect of PDE4-selective inhibitors. J Pharmacol Exp Ther 2000;292(2):817-23
  • National Institutes of Health: Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH Consens Statement 1994;12(2):1-24
  • Antenatal corticosteroids to prevent respiratory distress syndrome. Royal College of Obstetricians and Gynaecologists, Clinical Green Top Guidelines. Guideline no. 7. London: RCOG, 2004. Available from: http://www.rcog.org.uk/resources/Public/pdf/Antenatal_corticosteroids_No7.pdf [Last accessed 26 January 2008]
  • Liggins GC, Howie RN. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 1972; 50(4):515-25
  • Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2006;(3):CD004454
  • Jobe AH. Animal models of antenatal corticosteroids: clinical implications. Clin Obstet Gynecol 2003;46(1):174-89
  • Jobe AJ. The new BPD: an arrest of lung development. Pediatr Res 1999;46(6):641-3
  • Jobe AH, Polk DH, Ervin MG, et al. Preterm betamethasone treatment of fetal sheep: outcome after term delivery. J Soc Gynecol Invest 1996;3(5):250-8
  • Crowley P. Steroids. In: Critchley HOD, Bennett P, Thornton S, editors, Preterm Birth. London: RCOG Press; 2004. p. 244-57
  • Tan RC, Ikegami M, Jobe AH, et al. Developmental and glucocorticoid regulation of surfactant protein mRNAs in preterm lambs. Am J Physiol Lung Cell Mol Physiol 1999;277(6):L1142-8
  • Ballard PL, Ning Y, Polk D, et al. Glucocorticoid regulation of surfactant components in immature lambs. Am J Physiol 1997;273(5 Part 1):L1048-57
  • Crowther CA, Harding J. Repeat doses of prenatal corticosteroids for women at risk of preterm birth for preventing neonatal respiratory disease. Cochrane Database Syst Rev 2003;(3):CD003935
  • Schwab M, Roedel M, Anwar MA, et al. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol 2000;528(Part 3):619-32
  • Benediktsson R, Lindsay RS, Noble J, et al. Glucocorticoid exposure in utero: new model for adult hypertension. Lancet 1993;341(8841):339-41
  • Dalziel SR, Rea HH, Walker NK, et al. Long term effects of antenatal betamethasone on lung function: 30 year follow up of a randomised controlled trial. Thorax 2006;61(8):678-83
  • Dalziel SR, Lim VK, Lambert A, et al. Antenatal exposure to betamethasone: psychological functioning and health related quality of life 31 years after inclusion in randomised controlled trial. BMJ 2005;331(7518):665
  • Dalziel SR, Walker NK, Parag V, et al. Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial. Lancet 2005;365(9474):1856-62
  • McLaughlin KJ, Crowther CA, Walker N, Harding JE. Effects of a single course of corticosteroids given more than 7 days before birth: a systematic review. Aust NZ J Obstet Gynaecol 2003;43(2):101-6
  • Brocklehurst P, Gates S, Kenzie-Mcharg K, et al. Are we prescribing multiple courses of antenatal corticosteroids? A survey of practice in the UK. Br J Obstet Gynaecol 1999;106(9):977-9
  • Crowther CA, Haslam RR, Hiller JE, et al. Neonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: a randomised controlled trial. Lancet 2006;367(9526):1913-9
  • Abbasi S, Hirsch D, Davis J, et al. Effect of single versus multiple courses of antenatal corticosteroids on maternal and neonatal outcome. Am J Obstet Gynecol 2000;182(5):1243-9
  • Banks BA, Cnaan A, Morgan MA, et al. Multiple courses of antenatal corticosteroids and outcome of premature neonates. North American Thyrotropin-Releasing Hormone Study Group. Am J Obstet Gynecol 1999;181(3):709-17
  • French NP, Hagan R, Evans SF, et al. Repeated antenatal corticosteroids: size at birth and subsequent development. Am J Obstet Gynecol 1999;180(1):114-21
  • Wapner RJ, Sorokin Y, Thom EA, et al. Single versus weekly courses of antenatal corticosteroids: evaluation of safety and efficacy. Am J Obstet Gynecol 2006;195(3):633-42
  • Ashwood PJ, Crowther CA, Willson KJ, et al. Neonatal adrenal function after repeat dose prenatal corticosteroids: a randomized controlled trial. Am J Obstet Gynecol 2006;194(3):861-7
  • Davis EP, Townsend EL, Gunnar MR, et al. Effects of prenatal betamethasone exposure on regulation of stress physiology in healthy premature infants. Psychoneuroendocrinology 2004;29(8):1028-36
  • National Institutes of Health. Antenatal corticosteroids revisited: repeat courses – National Institutes of Health Consensus Development Conference Statement; 2000 August 17 – 18. Obstet Gynecol 2001;98(1):144-50
  • Spellacy WN, Cruz AC, Birk SA, Buhi WC. Treatment of premature labor with ritodrine: a randomized controlled study. Obstet Gynecol 1979;54(2):220-3
  • Besinger RE, Iannucci TA. Tocolytic therapy. In: Elder MG, Romero R, Lamont RF, editors, Preterm Labor. New York: Churchill Livingstone; 1997. p. 243-97
  • Canadian Preterm Labor Investigators Group. Treatment of preterm labor with the beta-adrenergic agonist ritodrine. N Engl J Med 1992;327(5):308-12
  • Leveno KJ, Cunningham FG. Beta-adrenergic agonists for preterm labor. N Engl J Med 1992;327(5):349-51
  • Lamont RF. The pathophysiology of pulmonary oedema with the use of beta-agonists. Br J Obstet Gynaecol 2000;107(4):439-44
  • Tocolytic drugs for women in preterm labour. Royal College of Obstetricians and Gynaecologists, Clinical Guideline no. 1(B). London: RCOG, 2002. Available from: http://www.rcog.org.uk/resources/Public/pdf/Tocolytic_Drugs_No1(B).pdf [Last accessed 26 January 2008]
  • Lyndrup J, Lamont RF. The choice of tocolytic for the treatment of preterm labour: a critical evaluation of nifedipine versus atosiban. Expert Opin Investig Drugs 2007;16:843-53
  • Boos J. Off label use – label off use? Ann Oncol 2003;14(1):1-5
  • Huszar G, Roberts JM. Biochemistry and pharmacology of the myometrium and labor: regulation at the cellular and molecular levels. Am J Obstet Gynecol 1982;142(2):225-37
  • Anotayanonth S, Subhedar NV, Garner P, et al. Betamimetics for inhibiting preterm labour. Cochrane Database Syst Rev 2004;(4):CD004352
  • Gyetvai K, Hannah ME, Hodnett ED, Ohlsson A. Tocolytics for preterm labor: a systematic review. Obstet Gynecol 1999;94(5 Part 2):869-77
  • Brown SM, Tejani NA. Terbutaline sulfate in the prevention of recurrence of premature labor. Obstet Gynecol 1981;57(1):22-5
  • Creasy RK, Golbus MS, Laros RK, et al. Oral ritodrine maintenance in the treatment of preterm labor. Am J Obstet Gynecol 1980;137(2):212-9
  • Dodd JM, Crowther CA, Dare MR, Middleton P. Oral betamimetics for maintenance therapy after threatened preterm labour. Cochrane Database Syst Rev 2006;(1):CD003927
  • Lewis R, Mercer BM, Salama M, et al. Oral terbutaline after parenteral tocolysis: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol 1996;175(4 Part 1):834-7
  • Rust OA, Bofill JA, Arriola RM, et al. The clinical efficacy of oral tocolytic therapy. Am J Obstet Gynecol 1996;175(4 Part 1):838-42
  • Thornton JG. Maintenance tocolysis. Br J Obstet Gynaecol 2005;112(Suppl.1):118-21
  • Benedetti TJ. Treatment of preterm labor with the beta-adrenergic agonist ritodrine. N Engl J Med 1992;327(24):1758
  • Lamont RF, Fisk NM. The role of infection in the pathogenesis of preterm labour. In: Studd JWW, editor, Progress in obstetrics and gynaecology. Volume 10. London: Churchill Livingstone; 1993. p. 135-58
  • Hudgens DR, Conradi SE. Sudden death associated with terbutaline sulfate administration. Am J Obstet Gynecol 1993;169(1):120-1
  • MacLennan FM, Thomson MA, Rankin R, et al. Fatal pulmonary oedema associated with the use of ritodrine in pregnancy. Case report. Br J Obstet Gynaecol 1985;92(7):703-5
  • Page IJ, Atalla A, Young K. Fatal pulmonary oedema associated with the use of ritodrine in pregnancy. Br J Obstet Gynaecol 1986;93(2):197
  • Price PH. Review of betamimetic drugs for tocolysis. Report to Special FDA Public Meeting on Re-evaluation of Ritodrine Labelling; 1992
  • Taslimi MM, Sibai BM, Amon E, et al. A national survey on preterm labor. Am J Obstet Gynecol 1989;160(6):1352-7
  • Bernstein IM, Catalano PM. Ketoacidosis in pregnancy associated with the parenteral administration of terbutaline and betamethasone. A case report. J Reprod Med 1990;35(8):818-20
  • Halpren EW, Soifer NE, Haenel LC, et al. Ketoacidosis secondary to oral ritodrine use in a gestational diabetic patient: report of a case. J Am Osteopath Assoc 1988;88(2):241-4
  • Schilthuis MS, Aarnoudse JG. Fetal death associated with severe ritodrine induced ketoacidosis. Lancet 1980;1(8178):1145
  • Tibaldi JM, Lorber DL, Nerenberg A. Diabetic ketoacidosis and insulin resistance with subcutaneous terbutaline infusion: a case report. Am J Obstet Gynecol 1990;163(2):509-10
  • Braden GL, Von Oeyen PT, Germain MJ, et al. Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences. Kidney Int 1997;51(6):1867-75
  • Smith SR, Kendall MJ. Metabolic responses to beta 2 stimulants. J R Coll Phys Lond 1984;18(3):190-4
  • Smith SK, Thompson D. The effect of intravenous salbutamol upon plasma and urinary potassium during premature labour. Br J Obstet Gynaecol 1977;84(5):344-7
  • Cano A, Tovar I, Parrilla JJ, Abad L. Metabolic disturbances during intravenous use of ritodrine: increased insulin levels and hypokalemia. Obstet Gynecol 1985;65(3):356-60
  • Hurlbert BJ, Edelman JD, David K. Serum potassium levels during and after terbutaline. Anesth Analg 1981;60(10):723-5
  • Moravec MA, Hurlbert BJ. Hypokalemia associated with terbutaline administration in obstetrical patients. Anesth Analg 1980;59(12):917-20
  • Kuczkowski KM, Benumof JL. Rebound hyperkalemia after cessation of intravenous tocolytic therapy with terbutaline in the treatment of preterm labor: anesthetic implications. J Clin Anesth 2003;15(5):357-8
  • Kotani N, Kushikata T, Hashimoto H, et al. Rebound perioperative hyperkalemia in six patients after cessation of ritodrine for premature labor. Anesth Analg 2001;93(3):709-11
  • Gokay Z, Ozcan T, Copel JA. Changes in fetal hemodynamics with ritodrine tocolysis. Ultrasound Obstet Gynecol 2001;18(1):44-6
  • Gemelli M, De LF, Manganaro R, et al. Transient electrocardiographic changes suggesting myocardial ischaemia in newborn infants following tocolysis with beta-sympathomimetics. Eur J Pediatr 1990;149(10):730-3
  • Kurtoglu S, Akcakus M, Keskin M, et al. Severe hyperinsulinaemic hypoglycaemia in a baby born to a mother taking oral ritodrine therapy for preterm labour. Horm Res 2005;64(2):61-3
  • Fuchs AR, Fuchs F, Husslein P, et al. Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor. Science 1982;215(4538):1396-8
  • Husslein P, Fuchs AR, Fuchs F. Oxytocin and the initiation of human parturition. I. Prostaglandin release during induction of labor by oxytocin. Am J Obstet Gynecol 1981;141(6):688-93
  • Lamont RF. The development and introduction of anti-oxytocic tocolytics. Br J Obstet Gynaecol 2003;110(Suppl 20):108-12
  • Akerlund M, Stromberg P, Hauksson A, et al. Inhibition of uterine contractions of premature labour with an oxytocin analogue. Results from a pilot study. Br J Obstet Gynaecol 1987;94(11):1040-1044.
  • Andersen LF, Lyndrup J, Akerlund M, Melin P. Oxytocin receptor blockade: a new principle in the treatment of preterm labor? Am J Perinatol 1989;6(2):196-9
  • Goodwin TM, Paul R, Silver H, et al. The effect of the oxytocin antagonist atosiban on preterm uterine activity in the human. Am J Obstet Gynecol 1994;170(2):474-8
  • Goodwin TM, Valenzuela GJ, Silver H, Creasy G. Dose ranging study of the oxytocin antagonist atosiban in the treatment of preterm labor. Atosiban Study Group. Obstet Gynecol 1996;88(3):331-6
  • Goodwin TM, Valenzuela G, Silver H, et al. Treatment of preterm labor with the oxytocin antagonist atosiban. Am J Perinatol 1996;13(3):143-6
  • Romero R, Sibai BM, Sanchez-Ramos L, et al. An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: a randomized, double-blind, placebo-controlled trial with tocolytic rescue. Am J Obstet Gynecol 2000;182(5):1173-83
  • Moutquin JM, Cabrol D, Fisk NM. Effectiveness and safety of the oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of preterm labour. The Worldwide Atosiban versus Beta-agonists Study Group. Br J Obstet Gynaecol 2001;108(2):133-42
  • Cabrol D, Gillet JY, Madelenat P. Treatment of preterm labor with the oxytocin antagonist atosiban: a double-blind, randomized, controlled comparison with salbutamol. Eur J Obstet Gynecol Reprod Biol 2001;98(2):177-85
  • Marsal K, Fisk NM, Calder AA. The oxytocin antagonist atosiban versus the beta-agonist terbutaline in the treatment of preterm labor. A randomized, double-blind, controlled study. Acta Obstet Gynecol Scand 2001;80(5):413-22
  • Moutquin JM, Sherman D, Cohen H, et al. Double-blind, randomized, controlled trial of atosiban and ritodrine in the treatment of preterm labor: a multicenter effectiveness and safety study. Am J Obstet Gynecol 2000;182(5):1191-9
  • Valenzuela GJ, Sanchez-Ramos L, Romero R, et al. Maintenance treatment of preterm labor with the oxytocin antagonist atosiban. The Atosiban PTL-098 Study Group. Am J Obstet Gynecol 2000;182(5):1184-90
  • Papatsonis D, Flenady V, Cole S, Liley H. Oxytocin receptor antagonists for inhibiting preterm labour. Cochrane Database Syst Rev 2005;(3):CD004452
  • Goodwin TM. Feedback on: oxytocin receptor antagonists for inhibiting preterm labour. Chichester: Cochrane Database Syst Rev 2005. Available from: http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD004452/sect0.html#CD004452-sec1-0016 [Last accessed 26 January 2008]
  • Lamont RF, Greenfield P. Anti-oxytocic tocolytic agents. In: Sturdee D, Olah K, Purdie D, Keane D, editors, The yearbook of obstetrics and gynaecology. London: RCOG Press; 2002. p. 130-40
  • Ervin MG. Perinatal fluid and electrolyte regulation: role of arginine vasopressin. Semin Perinatol 1988;12(2):134-42
  • Greig PC, Massmann GA, Demarest KT, et al. Maternal and fetal cardiovascular effects and placental transfer of the oxytocin antagonist atosiban in late-gestation pregnant sheep. Am J Obstet Gynecol 1993;169(4):897-902
  • Papatsonis DN, Lok CA, Bos JM, et al. Calcium channel blockers in the management of preterm labor and hypertension in pregnancy. Eur J Obstet Gynecol Reprod Biol 2001;97(2):122-40
  • Read MD, Wellby DE. The use of a calcium antagonist (nifedipine) to suppress preterm labour. Br J Obstet Gynaecol 1986;93(9):933-7
  • Bracero LA, Leikin E, Kirshenbaum N, Tejani N. Comparison of nifedipine and ritodrine for the treatment of preterm labor. Am J Perinatol 1991;8(6):365-9
  • Ferguson JE, Dyson DC, Schutz T, Stevenson DK. A comparison of tocolysis with nifedipine or ritodrine: analysis of efficacy and maternal, fetal, and neonatal outcome. Am J Obstet Gynecol 1990;163(1 Part 1):105-11
  • Garcia-Velasco JA, Gonzalez GA. A prospective, randomized trial of nifedipine vs. ritodrine in threatened preterm labor. Int J Gynaecol Obstet 1998;61(3):239-44
  • Janky E, Leng JJ, Cormier PH, et al. A randomized study of the treatment of threatened premature labor. Nifedipine versus ritodrine. J Gynecol Obstet Biol Reprod (Paris) 1990;19(4):478-82
  • Koks CA, Brolmann HA, De Kleine MJ, Manger PA. A randomized comparison of nifedipine and ritodrine for suppression of preterm labor. Eur J Obstet Gynecol Reprod Biol 1998;77(2):171-6
  • Kupferminc M, Lessing JB, Yaron Y, Peyser MR. Nifedipine versus ritodrine for suppression of preterm labour. Br J Obstet Gynaecol 1993;100(12):1090-4
  • Papatsonis DN, Van Geijn HP, Ader HJ, et al. Nifedipine and ritodrine in the management of preterm labor: a randomized multicenter trial. Obstet Gynecol 1997;90(2):230-4
  • Glock JL, Morales WJ. Efficacy and safety of nifedipine versus magnesium sulfate in the management of preterm labor: a randomized study. Am J Obstet Gynecol 1993;169(4):960-4
  • Haghighi L. Prevention of preterm delivery: nifedipine or magnesium sulfate. Int J Gynecol Obstet 1999;66(3):297-8
  • Smith CS, Woodland MB. Clinical comparison of oral nifedipine and subcutaneous terbutaline for initial tocolysis. Am J Perinatol 1993;10(4):280-4
  • Weerakul W, Chittacharoen A, Suthutvoravut S. Nifedipine versus terbutaline in management of preterm labor. Int J Gynaecol Obstet 2002;76(3):311-3
  • King JF, Flenady VJ, Papatsonis DN, et al. Calcium channel blockers for inhibiting preterm labour. Cochrane Database Syst Rev 2003;(1):CD002255
  • Oei SG, Mol BW, De Kleine MJ, Brolmann HA. Nifedipine versus ritodrine for suppression of preterm labor; a meta-analysis. Acta Obstet Gynecol Scand 1999;78(9):783-8
  • Tsatsaris V, Papatsonis D, Goffinet F, et al. Tocolysis with nifedipine or beta-adrenergic agonists: a meta-analysis. Obstet Gynecol 2001;97(5 Part 2):840-7
  • Lamont RF, Khan KS, Beattie B, et al. The quality of nifedipine studies used to assess tocolytic efficacy: a systematic review. J Perinat Med 2005;33(4):287-95
  • Bal L, Thierry S, Brocas E, et al. Pulmonary edema induced by calcium-channel blockade for tocolysis. Anesth Analg 2004;99(3):910-1 (Table)
  • Vaast P, Dubreucq-Fossaert S, Houfflin-Debarge V, et al. Acute pulmonary oedema during nicardipine therapy for premature labour; report of five cases. Eur J Obstet Gynecol Reprod Biol 2004;113(1):98-9
  • Oei SG, Oei SK, Brolmann HA. Myocardial infarction during nifedipine therapy for preterm labor. N Engl J Med 1999; 340(2):154
  • Verhaert D, Van AR. Acute myocardial infarction during pregnancy. Acta Cardiol 2004;59(3):331-9
  • Hodges R, Barkehall-Thomas A, Tippett C. Maternal hypoxia associated with nifedipine for threatened preterm labour. Br J Obstet Gynaecol 2004;111(4):380-1
  • Parasuraman R, Gandhi MM, Liversedge NH. Nifedipine tocolysis associated atrial fibrillation responds to DC cardioversion. Br J Obstet Gynaecol 2006;113(7):844-5
  • Economy KE, Abuhamad AZ. Calcium channel blockers as tocolytics. Semin Perinatol 2001;25(5):264-71
  • Impey L. Severe hypotension and fetal distress following sublingual administration of nifedipine to a patient with severe pregnancy-induced hypertension at 33 weeks. Br J Obstet Gynaecol 1993;100(10):959-61
  • Van Veen AJ, Pelinck MJ, Van Pampus MG, Erwich JJ. Severe hypotension and fetal death due to tocolysis with nifedipine. Br J Obstet Gynaecol 2005;112(4):509-10
  • Thornton J. The drugs we deserve. Br J Obstet Gynaecol 2003;110(11):969-70
  • Johnson KA, Mason GC. Severe hypotension and fetal death due to tocolysis with nifedipine. Br J Obstet Gynaecol 2005;112(11):1583
  • Kandysamy V, Thomson AJ. Severe hypotension and fetal death due to tocolysis with nifedipine. Br J Obstet Gynaecol 2005;112(11):1582-4
  • Danielsson BR, Danielson M, Rundqvist E, Reiland S. Identical phalangeal defects induced by phenytoin and nifedipine suggest fetal hypoxia and vascular disruption behind phenytoin teratogenicity. Teratology 1992;45(3):247-58
  • Yoshida T, Kanamori S, Hasegawa Y. Hyperphalangeal bones induced in rat pups by maternal treatment with nifedipine. Toxicol Lett 1988;40(2):127-32
  • Houtzager BA, Hogendoorn SM, Papatsonis DN, et al. Long-term follow up of children exposed in utero to nifedipine or ritodrine for the management of preterm labour. Br J Obstet Gynaecol 2006;113(3):324-31
  • Guiet-Bara A, Bara M, Durlach J. Comparative study of the effects of two tocolytic agents (magnesium sulfate and alcohol) on the ionic transfer through the isolated human amnion. Eur J Obstet Gynecol Reprod Biol 1985;20(5):297-304
  • Crowther CA, Hiller JE, Doyle LW. Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database Syst Rev 2002;(4):CD001060
  • Grimes DA, Nanda K. Magnesium sulfate tocolysis: time to quit. Obstet Gynecol 2006;108(4):986-9
  • Mittendorf R, Covert R, Boman J, et al. Is tocolytic magnesium sulphate associated with increased total paediatric mortality? Lancet 1997;350(9090):1517-18
  • Mittendorf R, Covert R, Elin R, et al. Umbilical cord serum ionized magnesium level and total pediatric mortality. Obstet Gynecol 2001;98(1):75-8
  • Mittendorf R, Dambrosia J, Dammann O, et al. Association between maternal serum ionized magnesium levels at delivery and neonatal intraventricular hemorrhage. J Pediatr 2002;140(5):540-6
  • Mitchell BF, Olson DM. Prostaglandin endoperoxide H synthase inhibitors and other tocolytics in preterm labour. Prostaglandins Leukot Essent Fatty Acids 2004;70(2):167-87
  • King J, Flenady V, Cole S, Thornton S. Cyclo-oxygenase (COX) inhibitors for treating preterm labour. Cochrane Database Syst Rev 2005;(2):CD001992
  • Panter KR, Hannah ME, Amankwah KS, et al. The effect of indomethacin tocolysis in preterm labour on perinatal outcome: a randomised placebo-controlled trial. Br J Obstet Gynaecol 1999;106(5):467-73
  • Zuckerman H, Shalev E, Gilad G, Katzuni E. Further study of the inhibition of premature labor by indomethacin. Part II double-blind study. J Perinat Med 1984;12(1):25-9
  • Sawdy RJ, Lye S, Fisk NM, Bennett PR. A double-blind randomized study of fetal side effects during and after the short-term maternal administration of indomethacin, sulindac, and nimesulide for the treatment of preterm labor. Am J Obstet Gynecol 2003;188(4):1046-51
  • Eronen M, Pesonen E, Kurki T, et al. Increased incidence of bronchopulmonary dysplasia after antenatal administration of indomethacin to prevent preterm labor. J Pediatr 1994;124(5 Part 1):782-8
  • Norton ME, Merrill J, Cooper BA, et al. Neonatal complications after the administration of indomethacin for preterm labor. N Engl J Med 1993;329(22):1602-7
  • Souter D, Harding J, McCowan L, et al. Antenatal indomethacin – adverse fetal effects confirmed. Aust NZ J Obstet Gynaecol 1998;38(1):11-6
  • Loe SM, Sanchez-Ramos L, Kaunitz AM. Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis. Obstet Gynecol 2005;106(1):173-9
  • Natuzzi ES, Ursell PC, Harrison M, et al. Nitric oxide synthase activity in the pregnant uterus decreases at parturition. Biochem Biophys Res Commun 1993;194(1):1-8
  • Riemer RK, Buscher C, Bansal RK, et al. Increased expression of nitric oxide synthase in the myometrium of the pregnant rat uterus. Am J Physiol 1997;272(6 Part 1):E1008-15
  • Bansal RK, Goldsmith PC, He Y, et al. A decline in myometrial nitric oxide synthase expression is associated with labor and delivery. J Clin Invest 1997;99(10):2502-8
  • Yallampalli C, Garfield RE, Byam-Smith M. Nitric oxide inhibits uterine contractility during pregnancy but not during delivery. Endocrinology 1993;133(4):1899-902
  • Yallampalli C, Izumi H, Byam-Smith M, Garfield RE. An L-arginine-nitric oxide-cyclic guanosine monophosphate system exists in the uterus and inhibits contractility during pregnancy. Am J Obstet Gynecol 1994;170(1 Part 1):175-85
  • Smith GN, Walker MC, McGrath MJ. Randomised, double-blind, placebo controlled pilot study assessing nitroglycerin as a tocolytic. Br J Obstet Gynaecol 1999;106(7):736-9
  • Duckitt K, Thornton S. Nitric oxide donors for the treatment of preterm labour. Cochrane Database Syst Rev 2002;(3):CD002860
  • Bisits A, Madsen G, Knox M, et al. The randomized nitric oxide tocolysis trial (RNOTT) for the treatment of preterm labor. Am J Obstet Gynecol 2004;191(3):683-90
  • Lees CC, Lojacono A, Thompson C, et al. Glyceryl trinitrate and ritodrine in tocolysis: an international multicenter randomized study. GTN Preterm Labour Investigation Group. Obstet Gynecol 1999;94(3):403-8
  • Romero R, Espimosa J, Gotsch F, et al. The use of high-dimensional biology (genomics, transcriptomics, proteomics and metabolomics) to understand the preterm parturition syndrome. Br J Obstet Gynaecol 2006;113(3):118-35
  • Balchin I, Whittaker JC, Steer PJ, Lamont RF. Are reported preterm birth rates reliable? An analysis of interhospital differences in the calculation of the weeks of gestation at delivery and preterm birth rate. Br J Obstet Gynaecol 2004;111(2):160-3
  • Coomarasamy A, Knox EM, Gee H, et al. Effectiveness of nifedipine versus atosiban for tocolysis in preterm labour: a meta-analysis with an indirect comparison of randomised trials. Br J Obstet Gynaecol 2003;110(12):1045-9
  • Al-Omari WR, Al-Shammaa HB, Al-Tikriti EM, Ahmed KW. Atosiban and nifedipine in acute tocolysis: a comparative study. Eur J Obstet Gynecol Reprod Biol 2006;128(1/2):129-34
  • Kashanian M, Akbarian AR, Soltanzadeh M. Atosiban and nifedipin for the treatment of preterm labor. Int J Gynaecol Obstet 2005;91(1):10-4
  • Lamont RF, Kam KYR. Atosiban for the treatment of spontaneous preterm labor. Expert Rev Obstet Gynecol 2008;3(2):163-74
  • Goodwin TM. Regulatory and methodologic challenges to tocolytic development. Br J Obstet Gynaecol 2006;113(3):100-4
  • Steinwall M, Bossmar T, Brouard R, et al. The effect of relcovaptan (SR 49059), an orally active vasopressin V1a receptor antagonist, on uterine contractions in preterm labor. Gynecol Endocrinol 2005;20:104-9
  • Reinheimer TM, Hellman GJ, Resendez JC, et al. Barusiban, an effective long term treatment of oxytocin-induced preterm labor in non-human primates. Biol Reprod 2006;75:809-14
  • Rasmussen AD, Nelson JK, Chellman GJ, et al. Use of barusiban in a novel study design for evaluation of tocolytic agents in pregnant and neonatal monkeys, including behavioural and immunological endpoints. Reprod Toxicol 2007;23:471-9
  • Ingemarsson I. Combination therapy. Br J Obstet Gynaecol 2005;112(Suppl 1):89-93

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