Advanced search
Publication Cover
Expert Opinion on Biological Therapy Volume 9, 2009 - Issue 1
Submit an article Journal homepage
81
Views
32
CrossRef citations to date
0
Altmetric
Reviews

Epitopic peptides with low similarity to the host proteome: towards biological therapies without side effects

Darja Kanduc University of Bari, Department of Biochemistry and Molecular Biology, Via Orabona 4, 70126 Bari, Italy +39 080 5443321; +39 080 5443317; [email protected]; [email protected]
Pages 45-53 | Published online: 08 Dec 2008

Bibliography

  • Livingston PO, Shiku H, Bean MA, et al. Cell-mediated cytotoxicity for cultured autologous melanoma cells. Int J Cancer 1979;24:34-44
  • Livingston PO, Takeyama H, Pollack MS, et al. Serological responses of melanoma patients to vaccines derived from allogeneic cultured melanoma cells. Int J Cancer 1983;31:567-75
  • Verma S, Quirt I, McCready D, et al. Systematic review of systemic adjuvant therapy for patients at high risk for recurrent melanoma. Cancer 2006;106:1431-42
  • van den Eertwegh AJ. Active specific immunotherapy in colon cancer. Recent Results Cancer Res 2005;165:260-7
  • Wood C, Srivastava P, Bukowski R, et al. An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised Phase III trial. Lancet 2008;372:145-54
  • van der Burg SH. Therapeutic vaccines in cancer: moving from immunomonitoring to immunoguiding. Expert Rev Vaccines 2008;7:1-5
  • Suri A. Cancer testis antigens–their importance in immunotherapy and in the early detection of cancer. Expert Opin Biol Ther 2006;6:379-89
  • Amato RJ. 5T4-modified vaccinia Ankara: progress in tumor-associated antigen-based immunotherapy. Expert Opin Biol Ther 2007;7:1463-9
  • Scheibenbogen C, Nagorsen D, Seliger B, et al. Long-term freedom from recurrence in 2 stage IV melanoma patients following vaccination with tyrosinase peptides. Int J Cancer 2002;99:403-8
  • Gjertsen MK, Bjorheim J, Saeterdal I, et al. Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12Val) peptide vaccination of a patient, recognize 12Val-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation. Int J Cancer 1997;72:784-90
  • Gjertsen MK, Gaudernack G. Mutated Ras peptides as vaccines in immunotherapy of cancer. Vox Sang 1998;74:489-95
  • Gritzapis AD, Mahaira LG, Perez SA, et al. Vaccination with human HER-2/neu (435-443) CTL peptide induces effective antitumor immunity against HER-2/neu-expressing tumor cells in vivo. Cancer Res 2006;66:5452-60
  • Krause I, Blank M, Shoenfeld Y. Peptide immunotherapy in autoimmune diseases. Drug News Perspect 2000;13:78-84
  • Sela M. Immunomodulatory vaccines against autoimmune diseases. Rejuvenation Res 2006;9:126-33
  • Paas-Rozner M, Sela M, Mozes E. The nature of the active suppression of responses associated with experimental autoimmune myasthenia gravis by a dual altered peptide ligand administered by different routes. Proc Natl Acad Sci USA 2001;98:12642-7
  • Saï P, Rivereau AS, Granier C, et al. Immunization of non-obese diabetic (NOD) mice with glutamic acid decarboxylase-derived peptide 524-543 reduces cyclophosphamide-accelerated diabetes. Clin Exp Immunol 1996;105:330-37
  • Goulvestre C, Chereau C, Nicco C, et al. A mimic of p21WAF1/CIP1 ameliorates murine lupus. J Immunol 2005;175:6959-67
  • Kong JS, Teuber SS, Gershwin ME. Potential adverse events with biologic response modifiers. Autoimmun Rev 2006;5:471-85
  • Creelan B, Ferber A. A fatal case of alemtuzumab-associated interstitial pneumonitis. Am J Ther 2008;15:82-4
  • Loh Y, Oyama Y, Statkute L, et al. Development of a secondary autoimmune disorder after hematopoietic stem cell transplantation for autoimmune diseases: role of conditioning regimen used. Blood 2007;109:2643-548
  • Haynes BF, Fleming J, St Clair EW, et al. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science 2005;308:1906-8
  • Kanduc D. Immunogenicity in peptide-immunotherapy: from self/nonself to similar/dissimilar sequences. In: Sigalov AB, editor, Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease, Landes Biosciences, Austin, TX; 2008. p. 198-207
  • Lucchese G, Stufano A, Trost B, et al. Peptidology: short amino acid modules in cell biology and immunology. Amino Acids 2007;33:703-7
  • Kanduc D, Lucchese A, Mittelman A. Non-redundant peptidomes from DAPs: towards “the vaccine”? Autoimmun Rev 2007;6:290-4
  • Kanduc D. Correlating low-similarity peptide sequences and allergenic epitopes. Curr Pharm Des 2008;14:289-95
  • Kanduc D, Serpico R, Lucchese A, et al. Correlating low-similarity peptide sequences and HIV B-cell epitopes. Autoimmun Rev 2008;7:291-6
  • Angelini G, Bonamonte D, Lucchese A, et al. Preliminary data on Pemphigus vulgaris treatment by a proteomics-defined peptide: a case report. J Transl Med 2006;4:43. Published online 24 October 2006, doi:10.1186/1479-5876-4-43
  • Wasniowska K, Petit-Leroux Y, Tournamille C, et al. Structural characterization of the epitope recognized by the new anti-Fy6 monoclonal antibody NaM 185-2C3. Transfus Med 2002;12:205-11
  • Orlandi R, Formatici C, Menard S, et al. A linear region of a monoclonal antibody conformational epitope mapped on p185HER2 oncoprotein. Biol Chem 2005;378:1387-92
  • Yoon SK, Lim NK, Ha SA, et al. The human cervical cancer oncogene protein is a biomarker for human hepatocellular carcinoma. Cancer Res 2004;64:5434-41
  • Hahn M, Winkler D, Welfle K, et al. Cross-reactive binding of cyclic peptides to an anti-TGFα antibody Fab fragment: an X-ray structural and thermodynamic analysis. J Mol Biol 2001;314:293-309
  • Kikuchi Y, Irie M, Ikebuchi H, et al. Antigenic determinants on rat metallothionein: fine epitope mapping for a murine monoclonal antibody and rabbit polyclonal antisera. J Biochem 1990;107:650-4
  • Windberg E, Uray K, Illyes E, et al. Heteroclitic recognition of combinatorial TX1TX2T peptide mixtures by mucin-2 protein specific monoclonal antibody. J Pept Sci 2004;10:56-65
  • Kishimoto J, Fukuma Y, Mizuno A, et al. Identification of the pentapeptide constituting a dominant epitope common to all eukaryotic heat shock protein 90 molecular chaperones. Cell Stress Chaperones 2005;10:296-311
  • Burgess K, Han I, Zhang A, et al. DiSSiMiL: Diverse Small Size Mini-Libraries applied to simple and rapid epitope mapping of a monoclonal antibody. J Pept Res 2001;57:68-76
  • Nastainczyk W, Issinger OG, Guerra B. Epitope analysis of the MAb 1AD9 antibody detection site in human protein kinase CK2α-subunit. Hybridoma Hybridomics 2003;22:87-90
  • Lu D, Kussie P, Pytowski B, et al. Identification of the residues in the extracellular region of KDR important for interaction with vascular endothelial growth factor and neutralizing anti-KDR antibodies. J Biol Chem 2000;275:14321-30
  • Perosa F, Luccarelli G, Prete M, et al. β2-microglobulin-free HLA class I heavy chain epitope mimicry by monoclonal antibody HC-10-specific peptide. J Immunol 2003;171:1918-26
  • Sun W, Lou YH, Dean J, Tung KS. A contraceptive peptide vaccine targeting sulfated glycoprotein ZP2 of the mouse zona pellucida. Biol Reprod 1999;60:900-7
  • Papadouli I, Sakarellos C, Tzartos SJ. High-resolution epitope mapping and fine antigenic characterization of the main immunogenic region of the acetylcholine receptor. Improving the binding activity of synthetic analogues of the region. Eur J Biochem 1993;211:227-34
  • Skirgello OE, Balyasnikova IV, Binevski PV, et al. Inhibitory antibodies to human angiotensin-converting enzyme: fine epitope mapping and mechanism of action. Biochemistry 2006;45:4831-47
  • Goel M, Krishnan L, Kaur S, et al. Plasticity within the antigen-combining site may manifest as molecular mimicry in the humoral immune response. J Immunol 2004;173:7358-67
  • Kerkar N, Choudhuri K, Ma Y, et al. Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type1-positive liver disease. J Immunol 2003;170:1481-9
  • Zhang XM, Liu G, Sun MJ. Epitopes of human brain acetylcholinesterase. Brain Res 2000;868:157-64
  • Deitiker P, Ashizawa T, Atassi MZ. Antigen mimicry in autoimmune disease. Can immune responses to microbial antigens that mimic acetylcholine receptor act as initial triggers of Myasthenia gravis? Hum Immunol 2000;61:255-65
  • Mayo I, Arribas J, Villoslada P, et al. The proteasome is a major autoantigen in multiple sclerosis. Brain 2002;125:2658-67
  • He XL, Radu C, Sidney J, et al. Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au. Immunity 2002;17:83-94
  • Crowe PD, Boehme, SA, Wong T, et al. Differential signaling and hierarchical response thresholds induced by an immunodominant peptide of myelin basic protein and an altered peptide ligand in human T cells. Hum Immunol 1998;59:679-89
  • Dharmasaroja P. Specificity of autoantibodies to epitopes of myelin proteins in multiple sclerosis. J Neurol Sci 2003;206:7-16
  • Thrasyvoulides A, Sakarellos-Daitsiotis M, Philippou G, et al. B-cell autoepitopes on the acetylcholinesterase-homologous region of human thyroglobulin: association with Graves' disease and thyroid eye disease. Eur J Endocrinol 2001;145:119-27
  • Yamamura T, Konola JT, Wekerle H, LEES MB. Monoclonal antibodies against myelin proteolipid protein: identification and characterization of two major determinants. J Neurochem 1991;57:1671-80
  • Bluthner M, Mahler M, Muller DB, et al. Identification of an α-helical epitope region on the PM/Scl-100 autoantigen with structural homology to a region on the heterochromatin p25β autoantigen using immobilized overlapping synthetic peptides. J Mol Med 2000;78:47-54
  • Krzyzanowska D, Ozyhar A, Lalik A, et al. Juvenile hormone binding protein and transferrin from Galleria mellonella share a similar structural motif. Biol Chem 2001;382:1027-37
  • Xie K, Snyder M. Two short autoepitopes on the nuclear dot antigen are similar to epitopes encoded by the Epstein-Barr virus. Proc Natl Acad Sci USA 1995;92:1639-43
  • Tchernychev B, Rabinkov A, Miron T, Wilchek M. Natural antibodies against alliinase in human serum and polyclonal antibodies elicited in rabbit share the same immunogenic determinants. Immunol Lett 2000;71:43-7
  • Shimonkevitz R, Colon S, Kappler JW, et al. Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen. J Immunol 1984;133:2067-74
  • Pang LT, Kum WW, Chow AW. Inhibition of staphylococcal enterotoxin B-induced lymphocyte proliferation and tumor necrosis factor alpha secretion by MAb5, an anti-toxic shock syndrome toxin 1 monoclonal antibody. Infect Immun 2000;68:3261-8
  • Williamson P, Matthews R. Epitope mapping the Fim2 and Fim3 proteins of Bordetella pertussis with sera from patients infected with or vaccinated against whooping cough. FEMS Immunol Med Microbiol 1996;13:69-78
  • Da Costa AV, Lafitte S, Fontaine J, et al. Definition and mapping of epitopes recognized by specific monoclonal antibodies to Schistosoma bovis 28 kDa glutathione S-transferase: relation with anti-egg viability immunity. Parasite Immunol 1999;21:9-18
  • Larreta R, Guzman F, Patarroyo ME, et al. Antigenic properties of the Leishmania infantum GRP94 and mapping of linear B-cell epitopes. Immunol Lett 2002;80:199-205
  • Sakakibara N, Kabeya H, Ohashi K, et al. Epitope mapping of bovine leukemia virus transactivator protein tax. J Vet Med Sci 1998;60:599-605
  • Lindner K, Mole SE, Lane DP, Kenny MK. Epitope mapping of antibodies recognising the N-terminal domain of simian virus large tumour antigen. Intervirology 1998;41:10-6
  • Holzem A, Nahring JM, Fischer R. Rapid identification of a tobacco mosaic virus epitope by using a coat protein gene-fragment-pVIII fusion library. J Gen Virol 2001;82:9-15
  • Lai MZ, Huang SY, Briner TJ, et al. T cell receptor gene usage in the response to λ repressor cI protein. An apparent bias in the usage of a Vα gene element. J Exp Med 1988;168:1081-97
  • Tunbäck P, Liljeqvist JA, Löwhagen GB, Bergström T. Glycoprotein G of herpes simplex virus type 1: identification of type-specific epitopes by human antibodies. J Gen Virol 2000;81:1033-40
  • Parker CE, Deterding LJ, Hager-Braun C, et al. Fine definition of the epitope on the gp41 glycoprotein of human immunodeficiency virus type 1 for the neutralizing monoclonal antibody 2F5. J Virol 2001;75:10906-11
  • Cardoso RM, Zwick MB, Stanfield RL, et al. Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41. Immunity 2005;22:163-73
  • Korber BTM, Brander C, Haynes BF, et al. HIV Immunology and HIV/SIV Vaccine Databases 2003. Los Alamos, New Mexico: Los Alamos National Laboratory, Theoretical Biology and Biophysics. 2003. Available from: http://www.hiv.lanl.gov/content/immunology/contents2003.html [Last accessed 12 November 2008]
  • Kanduc D, Stufano A, Lucchese G, Kusalik A. Massive peptide sharing between viral and human proteomes. Peptides 2008;29:1755-66
  • Trost B, Kanduc D, Kusalik A. Rare peptide segments are found significantly more often in proto-oncoproteins than control proteins: implications for immunology and oncology. J R Soc Interface 2009;6:123-7
  • Kanduc D, Capone GM. The similarity profile of the human proteome as a fractal dimension. Biol Forum 2008;101:142-5
  • Kunkl A, Fenoglio D, Manca F, et al. Kinetic immunodominance: functionally competing antibodies against exposed and cryptic epitopes of Escherichia coli β-galactosidase are produced in time sequence. Int Immunol 1992;4:627-36
  • Vanderlugt CL, Miller SD. Epitope spreading in immune-mediated diseases: implications for immunotherapy. Nat Rev Immunol 2002;2:85-95
  • Kramer A, Keitel T, Winkler K, et al. Molecular basis for the binding promiscuity of an anti-p24 (HIV-1) monoclonal antibody. Cell 1997;91:799-809
  • Keitel T, Kramer A, Wessner H, et al. Crystallographic analysis of anti-p24 (HIV-1) monoclonal antibody cross-reactivity and polyspecificity. Cell 1997;91:811-20
  • Thomson CA, Bryson S, Mclean GR, et al. Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus. EMBO J 2008;27:2592-602
  • Pantaleo G, Demarest JF, Schacker T, et al. The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc Natl Acad Sci USA 1997;94:254-8
  • Case LK, Petell L, Yurkovetskiy L, et al. Replication of beta- and gammaretroviruses is restricted in I/LnJ mice via the same genetic mechanism. J Virol 2008;82:1438-47
  • Florins A, Gillet N, Asquith B, et al. Cell dynamics and immune response to BLV infection: a unifying model. Front Biosci 2007;12:1520-31

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.