69
Views
12
CrossRef citations to date
0
Altmetric
Drug Evaluation

O-raffinose-polymerised haemoglobin. A biochemical and pharmacological profile of an oxygen carrier

&
Pages 121-127 | Published online: 23 Feb 2005

  • VANDEGRIFF KD: Haemoglobin-based oxygen carriers. Exp. Opin. Invest. Drugs (2000) 9:1967–1984.
  • ••An excellent review on pharmacological aspects ofhaemoglobin-based oxygen carriers.
  • CARMICHAEL FJL: Development status of hemolink (o-raffinose crosslinked human haemoglobin). Workshop on Criteria for Safety and Efficacy Evaluation of Oxygen Therapeutics as Red Cell Substitutes. Rockville, USA (1999).
  • CARON A, MENU P, FAIVRE-FIORINA B, LABRUDE P, ALAYASH Al, VIGNERON C: Cardiovascular and hemorheological effects of three modified human haemoglobin solutions in hemodiluted rabbits. J Appl. Physiol. (1999) 86:541–548.
  • ROHLFS RJ, BRUNER E, CHIU A et al: Arterial blood pressure responses to cell-free haemoglobin solutions and the reaction with nitric oxide. J Biol. Chem. (1998) 273:12128–12134.
  • LIEBERTHAL W, FUHRO R, FREEDMAN JE, TOOLAN G,LOSCALZO J, VALERI CR: 0-raffinose cross-linking markedly reduces systemic and renal vasoconstrictor effects of unmodified human haemoglobin. J. Pharmacol. Exp. Ther. (1999) 288:1278–1287.
  • BAINES AD, CHRISTOFF B, WICKS D, WIFFEN D, PLIURA D: Cross-linked haemoglobin increases fractional reabsorption and GFRin hypoxic isolated perfused rat kidneys. Am. J Physiol. (1995) 269:F628–636.
  • KERGER H, TSAI AG, SALTZMAN DJ, WINSLOW RM, INTAGLIETTA M: Fluid resuscitation with 02 vs.non-02 carriers after 2 h of hemorrhagic shock in conscious hamsters. Am. J. Physic]. (1997) 272:H525–H537.
  • LIEBERTHAL W, FUHRO R, ANDRY C, VALERI CR: Effectsof haemoglobin-based oxygen-carrying solutions in anesthetized rats with acute ischemic renal failure. J Lab. Clin. Med. (2000) 135:73–81.
  • MENU P, BLEEKER W, LONGROIS D et al.: In vivo effectsof Fib solutions on blood viscosity and rheologic behavior of RBCs: comparison with clinically used volume expanders. Transfusion (2000) 40:1095–1103.
  • CARON A, MENU P, FAIVRE-FIORINA B et al: Systemic and renal hemodynamics after moderate hemodilu-tion with HbOCs in anesthetized rabbits. Am. J. Physiol. Heart Circ. Physiol (2000) 278:H1974–1983.
  • WONG LT, ER SS, NING J, CHRISTOFF B, CARMICHAEL FJ: Hemolink-induced effects on intestinal motor function and attenuation of these effects by selected agents. Aril]: Cells Blood Substit. Immobil Biotechnoi (1998) 26:529–548.
  • XUE S, PATERSON W, VALDEZ D et al.: Effect of an o-raffinose cross-linked haemoglobin product on oesophageal and lower oesophageal sphincter motor function. Neurogastroenterol Mott]. (1999) 11:421–430.
  • FREILICH D, BRANDA R, HACKER M et al.: Decreased lactic acidosis and anemia after transfusion of o-raffinose cross-linked and polymerised haemoglobin in severe murine malaria. Am. J Trop. Med. Hyg. (1999) 60:322–328.
  • HSIA JC, SONG DL, ER SS et al: Pharmacokinetic studies in the rat on a o-raffinose polymerised human haemoglobin. Biomater. Arid: Cells Immobilization Biotechnol (1992) 20:587–595.
  • CARMICHAEL FJ, ALI AC, CAMPBELL JA et al.: A Phase I study of oxidized raffinose cross-linked human haemoglobin. Crit. Care Med. (2000) 28:2283–2292.
  • CHANG TMS: Future prospects for artificial blood. Trends Biotech. (1999) 17:61–67.
  • ••Comprehensive review of the blood substitutes.
  • GULATI A, BARVE A, SEN AP: Pharmacology of haemoglobin therapeutics. J Lab. Clin. Med. (1999) 133:112–119.
  • GIARDINA B, MESSANA I, SCATENA R, CASTAGNOLA M: The multiple functions of haemoglobin. Crit. Rev. Biochem. Biol. (1995) 30:165–196.
  • ALAYASH Al: Haemoglobin based blood substitutes: oxygen carriers, pressor agents, or oxidants? Nature Biotech. (1999) 17:545–549.
  • ••A description of toxicological aspects of HBOCs.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.