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Drug Evaluation

Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers

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Pages 211-218 | Published online: 23 Feb 2005

Bibliography

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  • •This paper summarises the burden of diabetic foot ulcerations.
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  • ••Important clinical trial. This study reportsthe benefits of becaplermin for the treatment of ulcerations in the lower extremities of diabetics.
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  • ••A good summary outlining the salientfeatures of wound healing.
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  • ••An excellent review article of woundhealing.
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  • ••An extensive review of becaplermin for thehealing of diabetic foot ulcers.
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  • WIEMAN TJ, SMIELL JM, SU Y: Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers. A Phase III randomized placebo-controlled double-blind study. Diabetes Care (1998) 21:822–827.
  • ••Important study highlighting theimportance of becaplermin for the management of diabetic foot ulcerations.
  • D'HEMERCOURT PA, SMIELL JM, KARIM MR: Effect of sodium carboxymethylcellulose aqueous-based gel vs. becaplerin gel in patients with non-healing lower extremity diabetic ulcers. Wounds (1998) 10:69–75.
  • ••This study summarises the role ofbecaplermin for the healing of diabetic foot ulcerations.
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  • ••The role of becaplermin in the healing ofdiabetic foot ulcerations is reviewed in this publication.
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  • ••This study describes the results of an open label evaluation of becaplermin, using standardised weight displacement techniques.
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