300
Views
12
CrossRef citations to date
0
Altmetric
Reviews

Hox transcription factor regulation of adult bone-marrow-derived cell behaviour during tissue repair and regeneration

&
Pages 1079-1090 | Published online: 22 Apr 2011

Bibliography

  • Wu Y, Wang JF, Scott PG, Tredget EE. Bone marrow-derived stem cells in wound healing: a review. Wound Repair Regen 2007;15:S18-26
  • Grove JE, Bruscia E, Krause DS. Plasticity of bone marrow-derived stem cells. Stem Cells 2004;22:487-500
  • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76
  • McGinnis W, Krumlauf R. Homeobox genes and axial patterning. Cell 1992;68:283-302
  • Yamamoto M, Takai D, Yamamoto F. Comprehensive expression profiling of highly homologous 39 hox genes in 26 different human adult tissues by the modified systematic multiplex RT-pCR method reveals tissue-specific expression pattern that suggests an important role of chromosomal structure in the regulation of hox gene expression in adult tissues. Gene Expr 2003;11:199-210
  • Rinn JL, Wang JK, Allen N, A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes Dev 2008;22:303-7
  • Chen F, Capecchi MR. Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Proc Natl Acad Sci USA 1999;96:541-6
  • Hansen SL, Myers CA, Charboneau A, HoxD3 accelerates wound healing in diabetic mice. Am J Pathol 2003;163:2421-31
  • Mace KA, Hansen SL, Myers C, HOXA3 induces cell migration in endothelial and epithelial cells promoting angiogenesis and wound repair. J Cell Sci 2005;118:2567-77
  • Argiropoulos B, Humphries RK. Hox genes in hematopoiesis and leukemogenesis. Oncogene 2007;26:6766-76
  • Thorsteinsdottir U, Sauvageau G, Hough MR, Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. Mol Cell Biol 1997;17:495-505
  • Fischbach NA, Rozenfeld S, Shen W, HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo. Blood 2005;105:1456-66
  • Sauvageau G, Thorsteinsdottir U, Eaves CJ, Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 1995;9:1753-65
  • Morrison SJ, Spradling AC. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 2008;132:598-611
  • Zhang DE, Zhang P, Wang ND, Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci USA 1997;94:569-74
  • Lawrence HJ, Helgason CD, Sauvageau G, Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Blood 1997;89:1922-30
  • Kim YC, Wu Q, Chen J, The transcriptome of human CD34+ hematopoietic stem-progenitor cells. Proc Natl Acad Sci USA 2009;106:8278-83
  • Sauvageau G, Lansdorp PM, Eaves CJ, Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci USA 1994;91:12223-7
  • Greer JM, Puetz J, Thomas KR, Capecchi MR. Maintenance of functional equivalence during paralogous Hox gene evolution. Nature 2000;403:661-5
  • Bijl J, Thompson A, Ramirez-Solis R, Analysis of HSC activity and compensatory Hox gene expression profile in Hoxb cluster mutant fetal liver cells. Blood 2006;108:116-22
  • Izon DJ, Rozenfeld S, Fong ST, Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes. Blood 1998;92:383-93
  • Lawrence HJ, Christensen J, Fong S, Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells. Blood 2005;106:3988-94
  • Ko KH, Lam QL, Zhang M, Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrow. Exp Hematol 2007;35:465-75
  • Sauvageau G, Thorsteinsdottir U, Hough MR, Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation. Immunity 1997;6:13-22
  • Fuller JF, McAdara J, Yaron Y, Characterization of HOX gene expression during myelopoiesis: role of HOX A5 in lineage commitment and maturation. Blood 1999;93:3391-400
  • Lill MC, Fuller JF, Herzig R, The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation. Blood 1995;85:692-7
  • Krishnaraju K, Hoffman B, Liebermann DA. Lineage-specific regulation of hematopoiesis by HOX-B8 (HOX-2.4): inhibition of granulocytic differentiation and potentiation of monocytic differentiation. Blood 1997;90:1840-9
  • Mahdipour E, Charnock JC, Mace KA. Hoxa3 promotes the differentiation of hematopoietic progenitor cells into proangiogenic Gr-1+CD11b+ myeloid cells. Blood 2011;117(3):815-26
  • Taghon T, Stolz F, De Smedt M, HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor. Blood 2002;99:1197-204
  • Yang L, DeBusk LM, Fukuda K, Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 2004;6:409-21
  • Phinney DG, Gray AJ, Hill K, Pandey A. Murine mesenchymal and embryonic stem cells express a similar Hox gene profile. Biochem Biophys Res Commun 2005;338:1759-65
  • Chung N, Jee BK, Chae SW, HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells. Mol Biol Rep 2009;36:227-35
  • Fathke C, Wilson L, Hutter J, Contribution of bone marrow-derived cells to skin: collagen deposition and wound repair. Stem Cells 2004;22:812-22
  • Asahara T, Masuda H, Takahashi T, Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 1999;85:221-8
  • Tepper OM, Capla JM, Galiano RD, Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow-derived cells. Blood 2005;105:1068-77
  • Sasaki M, Abe R, Fujita Y, Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type. J Immunol 2008;180:2581-7
  • Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood 2003;102:3483-93
  • Huttmann A, Li CL, Duhrsen U. Bone marrow-derived stem cells and “plasticity”. Ann Hematol 2003;82:599-604
  • Asahara T, Murohara T, Sullivan A, Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-7
  • Grunewald M, Avraham I, Dor Y, VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 2006;124:175-89
  • Kaplan RN, Riba RD, Zacharoulis S, VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005;438:820-7
  • Kucia M, Wojakowski W, Reca R, The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner. Arch Immunol Ther Exp (Warsz) 2006;54:121-35
  • Galiano RD, Tepper OM, Pelo CR, Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol 2004;164:1935-47
  • Eming SA, Krieg T, Davidson JM. Gene therapy and wound healing. Clin Dermatol 2007;25:79-92
  • Hristov M, Zernecke A, Liehn EA, Weber C. Regulation of endothelial progenitor cell homing after arterial injury. Thromb Haemost 2007;98:274-7
  • Ceradini DJ, Kulkarni AR, Callaghan MJ, Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 2004;10:858-64
  • Abbott JD, Huang Y, Liu D, Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 2004;110:3300-5
  • Ip JE, Wu Y, Huang J, Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment. Mol Biol Cell 2007;18:2873-82
  • Brittan M, Braun KM, Reynolds LE, Bone marrow cells engraft within the epidermis and proliferate in vivo with no evidence of cell fusion. J Pathol 2005;205:1-13
  • Badiavas EV, Abedi M, Butmarc J, Participation of bone marrow derived cells in cutaneous wound healing. J Cell Physiol 2003;196:245-50
  • Mace KA, Restivo TE, Rinn JL, HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells. Stem Cells 2009;27:1654-65
  • Lin WR, Brittan M, Alison MR. The role of bone marrow-derived cells in fibrosis. Cells Tissues Organs 2008;188:178-88
  • Borue X, Lee S, Grove J, Bone marrow-derived cells contribute to epithelial engraftment during wound healing. Am J Pathol 2004;165:1767-72
  • Gillitzer R, Goebeler M. Chemokines in cutaneous wound healing. J Leukoc Biol 2001;69:513-21
  • Tsirogianni AK, Moutsopoulos NM, Moutsopoulos HM. Wound healing: immunological aspects. Injury 2006;37(Suppl 1):S5-12
  • Noonan DM, De Lerma Barbaro A, Vannini N, Inflammation, inflammatory cells and angiogenesis: decisions and indecisions. Cancer Metastasis Rev 2008;27:31-40
  • Lucas T, Waisman A, Ranjan R, Differential roles of macrophages in diverse phases of skin repair. J Immunol 2010;184:3964-77
  • Martin P, Leibovich SJ. Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol 2005;15:599-607
  • Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, Apelqvist J. The global burden of diabetic foot disease. Lancet 2005;366:1719-24
  • Boulton AJ. The diabetic foot: grand overview, epidemiology and pathogenesis. Diabetes Metab Res Rev 2008;24(Suppl 1):S3-6
  • Goren I, Kampfer H, Podda M, Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators. Diabetes 2003;52:2821-32
  • Wetzler C, Kampfer H, Stallmeyer B, Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair. J Invest Dermatol 2000;115:245-53
  • Acosta JB, del Barco DG, Vera DC, The pro-inflammatory environment in recalcitrant diabetic foot wounds. Int Wound J 2008;5:530-9
  • Stepanovic V, Awad O, Jiao C, Leprdb diabetic mouse bone marrow cells inhibit skin wound vascularization but promote wound healing. Circ Res 2003;92:1247-53
  • Awad O, Jiao C, Ma N, Obese diabetic mouse environment differentially affects primitive and monocytic endothelial cell progenitors. Stem Cells 2005;23:575-83
  • Khanna S, Biswas S, Shang Y, Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice. PLoS One 2010;5(3):e9539
  • Tepper OM, Galiano RD, Capla JM, Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 2002;106:2781-6
  • Gallagher KA, Liu ZJ, Xiao M, Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest 2007;117:1249-59
  • Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest 2007;117:1219-22
  • Capla JM, Grogan RH, Callaghan MJ, Diabetes impairs endothelial progenitor cell-mediated blood vessel formation in response to hypoxia. Plast Reconstr Surg 2007;119:59-70
  • Awad O, Dedkov EI, Jiao C, Differential healing activities of CD34+ and CD14+ endothelial cell progenitors. Arterioscler Thromb Vasc Biol 2006;26:758-64
  • Rehman J, Li J, Orschell CM, March KL. Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 2003;107:1164-9
  • Sivan-Loukianova E, Awad OA, Stepanovic V, CD34+ blood cells accelerate vascularization and healing of diabetic mouse skin wounds. J Vasc Res 2003;40:368-77
  • Oettgen P. Transcriptional regulation of vascular development. Circ Res 2001;89:380-8
  • Cantile M, Schiavo G, Terracciano L, Cillo C. Homeobox genes in normal and abnormal vasculogenesis. Nutr Metab Cardiovasc Dis 2008;18:651-8
  • Uyeno LA, Newman-Keagle JA, Cheung I, Hox D3 expression in normal and impaired wound healing. J Surg Res 2001;100:46-56
  • Myers C, Charboneau A, Boudreau N. Homeobox B3 promotes capillary morphogenesis and angiogenesis. J Cell Biol 2000;148:343-51
  • Myers C, Charboneau A, Cheung I, Sustained expression of homeobox D10 inhibits angiogenesis. Am J Pathol 2002;161:2099-109
  • Mack JA, Maytin EV. Persistent inflammation and angiogenesis during wound healing in K14-directed Hoxb13 transgenic mice. J Invest Dermatol 2010;130:856-65
  • Khavari PA, Krueger GG. Cutaneous gene therapy. Dermatol Clin 1997;15:27-35
  • Mulligan RC. The basic science of gene therapy. Science 1993;260:926-32
  • Li J, Li X, Zhang Y, Gene therapy for psoriasis in the K14-VEGF transgenic mouse model by topical transdermal delivery of interleukin-4 using ultradeformable cationic liposome. J Gene Med 2010;12:481-90
  • Chen M, Kasahara N, Keene DR, Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa. Nat Genet 2002;32:670-5
  • Tyrone JW, Mogford JE, Chandler LA, Collagen-embedded platelet-derived growth factor DNA plasmid promotes wound healing in a dermal ulcer model. J Surg Res 2000;93:230-6
  • Felgner PL, Rhodes G. Gene therapeutics. Nature 1991;349:351-2
  • Ortiz-Urda S, Thyagarajan B, Keene DR, Stable nonviral genetic correction of inherited human skin disease. Nat Med 2002;8:1166-70
  • Mace KA, Boudreau NB. Plasmid-based gene transfer of homeobox genes and improved wound healing. In: Sen CK, editor, Advances in Wound Care. 1st edition. Mary Ann Liebert, Inc., New Rochelle, NY; 2010. p. 388-93
  • Boudreau N, Andrews C, Srebrow A, Induction of the angiogenic phenotype by Hox D3. J Cell Biol 1997;139:257-64
  • Derossi D, Calvet S, Trembleau A, Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent. J Biol Chem 1996;271:18188-93
  • Derossi D, Joliot AH, Chassaing G, Prochiantz A. The third helix of the Antennapedia homeodomain translocates through biological membranes. J Biol Chem 1994;269:10444-50
  • Schimmer AD, Hedley DW, Chow S, The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2. Cell Death Differ 2001;8:725-33
  • Amsellem S, Pflumio F, Bardinet D, Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein. Nat Med 2003;9:1423-7
  • Gordillo GM, Roy S, Khanna S, Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds. Clin Exp Pharmacol Physiol 2008;35:957-64
  • Liu ZJ, Velazquez OC. Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing. Antioxid Redox Signal 2008;10:1869-82
  • Semenza GL. HIF-1: using two hands to flip the angiogenic switch. Cancer Metastasis Rev 2000;19:59-65
  • Mazure NM, Brahimi-Horn MC, Pouyssegur J. Protein kinases and the hypoxia-inducible factor-1, two switches in angiogenesis. Curr Pharm Des 2003;9:531-41
  • Sheikh AY, Gibson JJ, Rollins MD, Effect of hyperoxia on vascular endothelial growth factor levels in a wound model. Arch Surg 2000;135:1293-7
  • Kang TS, Gorti GK, Quan SY, Effect of hyperbaric oxygen on the growth factor profile of fibroblasts. Arch Facial Plast Surg 2004;6:31-5
  • Yuan J, Handy RD, Moody AJ, Bryson P. Response of blood vessels in vitro to hyperbaric oxygen (HBO): modulation of VEGF and NOx release by external lactate or arginine. Biochim Biophys Acta 2009;1787:828-34
  • Dulak J, Jozkowicz A. Regulation of vascular endothelial growth factor synthesis by nitric oxide: facts and controversies. Antioxid Redox Signal 2003;5:123-32
  • Boykin JV Jr, Baylis C. Hyperbaric oxygen therapy mediates increased nitric oxide production associated with wound healing: a preliminary study. Adv Skin Wound Care 2007;20:382-8
  • Aicher A, Heeschen C, Mildner-Rihm C, Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003;9:1370-6
  • Saaristo A, Tammela T, Farkkila A, Vascular endothelial growth factor-C accelerates diabetic wound healing. Am J Pathol 2006;169:1080-7
  • Cianfarani F, Zambruno G, Brogelli L, Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential. Am J Pathol 2006;169:1167-82
  • Keswani SG, Katz AB, Lim FY, Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds. Wound Repair Regen 2004;12:497-504
  • Fang RC, Galiano RD. A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers. Biologics 2008;2:1-12
  • Liu L, Marti GP, Wei X, Age-dependent impairment of HIF-1alpha expression in diabetic mice: correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. J Cell Physiol 2008;217:319-27
  • Ziady AG, Davis PB, Konstan MW. Non-viral gene transfer therapy for cystic fibrosis. Expert Opin Biol Ther 2003;3:449-58
  • Li L, Hoffman RM. The feasibility of targeted selective gene therapy of the hair follicle. Nat Med 1995;1:705-6
  • Carlesso G, Kozlov E, Prokop A, Nanoparticulate system for efficient gene transfer into refractory cell targets. Biomacromolecules 2005;6:1185-92
  • Kaul G, Amiji M. Tumor-targeted gene delivery using poly(ethylene glycol)-modified gelatin nanoparticles: in vitro and in vivo studies. Pharm Res 2005;22:951-61
  • Chen R, Chiba M, Mori S, Periodontal gene transfer by ultrasound and nano/microbubbles. J Dent Res 2009;88:1008-13
  • Neely AN, Clendening CE, Gardner J, Greenhalgh DG. Gelatinase activities in wounds of healing-impaired mice versus wounds of non-healing-impaired mice. J Burn Care Rehabil 2000;21:395-402

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.