Current developments in cell- and biomaterial-based approaches for stroke repair

Bibliography

• Faralli A, Bigoni M, Mauro A, et al. Noninvasive strategies to promote functional recovery after stroke. Neural Plast 2013;2013:854597
   PubMedGoogle Scholar
• Ortega FJ, Jolkkonen J. Restorative therapies to enhance sensorimotor recovery following cerebral ischemia. Acta Neurobiol Exp 2013;73:66-78
   PubMed Web of Science ®Google Scholar
• Peplow PV. Growth factor- and cytokine-stimulated endothelial progenitor cells in post-ischemic cerebral neovascularization. Neural Regen Res 2014;9(15):1425-9
   PubMed Web of Science ®Google Scholar
• Shah PP, Szaflarski JP, Allendorfer J, Hamilton RH. Induction of neuroplasticity and recovery in post-stroke aphasia by non-invasive brain stimulation. Front Hum Neurosci 2013;7:888
   PubMed Web of Science ®Google Scholar
• Gomi M, Takagi Y, Morizane A, et al. Functional recovery of the murine brain ischemia model using human induced pluripotent stem cell-derived telencephalic progenitors. Brain Res 2012;1459:52-60
   PubMed Web of Science ®Google Scholar
• Polentes J, Jendelova P, Cailleret M, et al. Human induced pluripotent stem cells improve stroke outcome and reduce secondary degeneration in the recipient brain. Cell Transplant 2012;21(12):2587-602
   PubMed Web of Science ®Google Scholar
• Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131(5):861-72
   PubMed Web of Science ®Google Scholar
• Koch P, Opitz T, Steinbeck JA, et al. A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc Natl Acad Sci USA 2009;106(9):3225-30
   PubMed Web of Science ®Google Scholar
• Chambers SM, Fasano CA, Papapetrou EP, et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol 2009;27(3):275-80
   PubMed Web of Science ®Google Scholar
• Erceg S, Lainez S, Ronaghi M, et al. Differentiation of human embryonic stem cells to regional specific neural precursors in chemically defined medium conditions. PLoS One 2008;3(5):e2122
   PubMed Web of Science ®Google Scholar
• Falk A, Koch P, Kesavan J, et al. Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons. PLoS One 2012;7(1):e29597
   PubMed Web of Science ®Google Scholar
• Roese-Koerner B, Stappert L, Koch P, et al. Pluripotent stem cell-derived somatic stem cells as tool to study the role of microRNAs in early human neural development. Curr Mol Med 2013;13(5):707-22
   PubMed Web of Science ®Google Scholar
• Jin K, Mao X, Xie L, et al. Delayed transplantation of human neural precursor cells improves outcome from focal cerebral ischemia in aged rats. Aging Cell 2010;9(6):1076-83
   PubMed Web of Science ®Google Scholar
• Daadi MM, Li Z, Arac A, et al. Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain. Mol Ther 2009;17(7):1282-91
   PubMed Web of Science ®Google Scholar
• Chang DJ, Oh SH, Lee N, et al. Contralaterally transplanted human embryonic stem cell-derived neural precursor cells (ENStem-A) migrate and improve brain functions in stroke-damaged rats. Exp Mol Med 2013;45:e53
   PubMed Web of Science ®Google Scholar
• Seminatore C, Polentes J, Ellman D, et al. The postischemic environment differentially impacts teratoma or tumor formation after transplantation of human embryonic stem cell-derived neural progenitors. Stroke 2010;41(1):153-9
   PubMed Web of Science ®Google Scholar
• Hicks AU, Lappalainen RS, Narkilahti S, et al. Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: cell survival and functional recovery. Eur J Neurosci 2009;29(3):562-74
   PubMed Web of Science ®Google Scholar
• Chen SJ, Chang CM, Tsai SK, et al. Functional improvement of focal cerebral ischemia injury by subdural transplantation of induced pluripotent stem cells with fibrin glue. Stem Cells Dev 2010;19(11):1757-67
   PubMed Web of Science ®Google Scholar
• Jiang M, Lv L, Ji H, et al. Induction of pluripotent stem cells transplantation therapy for ischemic stroke. Mol Cell Biochem 2011;354(1-2):67-75
   PubMed Web of Science ®Google Scholar
• Tornero D, Wattananit S, Gronning Madsen M, et al. Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery. Brain 2013;136(Pt 12):3561-77
   PubMed Web of Science ®Google Scholar
• Kim D, Kim CH, Moon JI, et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 2009;4(6):472-6
   PubMed Web of Science ®Google Scholar
• Ban H, Nishishita N, Fusaki N, et al. Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors. Proc Natl Acad Sci USA 2011;108(34):14234-9
   PubMed Web of Science ®Google Scholar
• Velasco I, Salazar P, Giorgetti A, et al. Concise review: Generation of neurons from somatic cells of healthy individuals and neurological patients through induced pluripotency or direct conversion. Stem Cells 2014;32(11):2811-17
   PubMed Web of Science ®Google Scholar
• Meneghello G, Verheyen A, Ingen MV, et al. Evaluation of established human iPSC - derived neurons to model neurodegenerative diseases. Neuroscience 2015;301:204-12
   PubMed Web of Science ®Google Scholar
• O’Brien LC, Keeney PM, Bennett JPJr. Differentiation of human neural stem cells into motor neurons stimulates mitochondrial biogenesis and decreases glycolytic flux. Stem Cells Dev 2015;24(17):1984-94
   PubMed Web of Science ®Google Scholar
• Hu W, He Y, Xiong Y, et al. Derivation, expansion, and motor neuron differentiation of human-induced pluripotent stem cells with non-integrating episomal vectors and a defined xenogeneic-free culture system. Mol Neurobiol 2015. [Epub ahead of print]
   Google Scholar
• D’Aiuto L, Zhi Y, Kumar Das D, et al. Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation. Organogenesis 2014;10(4):365-77
   PubMed Web of Science ®Google Scholar
• Lindvall O, Kokaia Z. Stem cell research in stroke: how far from the clinic? Stroke 2011;42(8):2369-75
   PubMed Web of Science ®Google Scholar
• Kawai H, Yamashita T, Ohta Y, et al. Tridermal tumorigenesis of induced pluripotent stem cells transplanted in ischemic brain. J Cereb Blood Flow Metab 2010;30(8):1487-93
   PubMed Web of Science ®Google Scholar
• Darsalia V, Kallur T, Kokaia Z. Survival, migration and neuronal differentiation of human fetal striatal and cortical neural stem cells grafted in stroke-damaged rat striatum. Eur J Neurosci 2007;26(3):605-14
   PubMed Web of Science ®Google Scholar
• Zhang ZG, Jiang Q, Zhang R, et al. Magnetic resonance imaging and neurosphere therapy of stroke in rat. Ann Neurol 2003;53(2):259-63
   PubMed Web of Science ®Google Scholar
• Jiang Q, Zhang ZG, Ding GL, et al. Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat using MRI. Neuroimage 2005;28(3):698-707
   PubMed Web of Science ®Google Scholar
• Chu K, Kim M, Chae SH, et al. Distribution and in situ proliferation patterns of intravenously injected immortalized human neural stem-like cells in rats with focal cerebral ischemia. Neurosci Res 2004;50(4):459-65
   PubMed Web of Science ®Google Scholar
• Nelson PT, Kondziolka D, Wechsler L, et al. Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation. Am J Pathol 2002;160(4):1201-6
   PubMed Web of Science ®Google Scholar
• Tajiri N, Quach DM, Kaneko Y, et al. Behavioral and histopathological assessment of adult ischemic rat brains after intracerebral transplantation of NSI-566RSC cell lines. PloS One 2014;9(3):e91408
   PubMed Web of Science ®Google Scholar
• Pollock K, Stroemer P, Patel S, et al. A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke. Exp Neurol 2006;199(1):143-55
   PubMed Web of Science ®Google Scholar
• Hicks C, Stevanato L, Stroemer RP, et al. In vivo and in vitro characterization of the angiogenic effect of CTX0E03 human neural stem cells. Cell Transplant 2013;22(9):1541-52
   PubMed Web of Science ®Google Scholar
• Arvidsson A, Collin T, Kirik D, et al. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 2002;8(9):963-70
   PubMed Web of Science ®Google Scholar
• Androutsellis-Theotokis A, Leker RR, Soldner F, et al. Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 2006;442(7104):823-6
   PubMed Web of Science ®Google Scholar
• Chou J, Harvey BK, Chang CF, et al. Neuroregenerative effects of BMP7 after stroke in rats. J Neurol Sci 2006;240(1-2):21-9
   PubMed Web of Science ®Google Scholar
• Plane JM, Whitney JT, Schallert T, Parent JM. Retinoic acid and environmental enrichment alter subventricular zone and striatal neurogenesis after stroke. Exp Neurol 2008;214(1):125-34
   PubMed Web of Science ®Google Scholar
• Sims JR, Lee SW, Topalkara K, et al. Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation. Stroke 2009;40(11):3618-26
   PubMed Web of Science ®Google Scholar
• Kernie SG, Parent JM. Forebrain neurogenesis after focal Ischemic and traumatic brain injury. Neurobiol Dis 2010;37(2):267-74
   PubMed Web of Science ®Google Scholar
• Drago D, Cossetti C, Iraci N, et al. The stem cell secretome and its role in brain repair. Biochimie 2013;95(12):2271-85
   PubMed Web of Science ®Google Scholar
• Bacigaluppi M, Pluchino S, Peruzzotti-Jametti L, et al. Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain 2009;132(Pt 8):2239-51
   PubMed Web of Science ®Google Scholar
• Cusimano M, Biziato D, Brambilla E, et al. Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord. Brain 2012;135(Pt 2):447-60
   PubMed Web of Science ®Google Scholar
• Huang W, Mo X, Qin C, et al. Transplantation of differentiated bone marrow stromal cells promotes motor functional recovery in rats with stroke. Neurol Res 2013;35(3):320-8
   PubMed Web of Science ®Google Scholar
• Chen J, Li Y, Wang L, et al. Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neurol Sci 2001;189(1-2):49-57
   PubMed Web of Science ®Google Scholar
• Liu N, Deguchi K, Yamashita T, et al. Intracerebral transplantation of bone marrow stromal cells ameliorates tissue plasminogen activator-induced brain damage after cerebral ischemia in mice detected by in vivo and ex vivo optical imaging. J Neurosci Res 2012;90(11):2086-93
   PubMed Web of Science ®Google Scholar
• Yoo KH, Jang IK, Lee MW, et al. Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues. Cell Immunol 2009;259(2):150-6
   PubMed Web of Science ®Google Scholar
• Yoo SW, Kim SS, Lee SY, et al. Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model. Exp Mol Med 2008;40(4):387-97
   PubMed Web of Science ®Google Scholar
• Kang SK, Lee DH, Bae YC, et al. Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats. Exp Neurol 2003;183(2):355-66
   PubMed Web of Science ®Google Scholar
• Kim JM, Lee ST, Chu K, et al. Systemic transplantation of human adipose stem cells attenuated cerebral inflammation and degeneration in a hemorrhagic stroke model. Brain Res 2007;1183:43-50
   PubMed Web of Science ®Google Scholar
• Gutierrez-Fernandez M, Rodriguez-Frutos B, Ramos-Cejudo J, et al. Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke. Stem Cell Res Ther 2013;4(1):11
   PubMed Web of Science ®Google Scholar
• Tajiri N, Acosta S, Glover LE, et al. Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats. PLoS One 2012;7(8):e43779
   PubMed Web of Science ®Google Scholar
• Onda T, Honmou O, Harada K, et al. Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia. J Cereb Blood Flow Metab 2008;28(2):329-40
   PubMed Web of Science ®Google Scholar
• Horita Y, Honmou O, Harada K, et al. Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat. J Neurosci Res 2006;84(7):1495-504
   PubMed Web of Science ®Google Scholar
• Liu H, Honmou O, Harada K, et al. Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia. Brain 2006;129(Pt 10):2734-45
   PubMed Web of Science ®Google Scholar
• Nomura T, Honmou O, Harada K, et al. I.V. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Neuroscience 2005;136(1):161-9
   PubMed Web of Science ®Google Scholar
• Toyama K, Honmou O, Harada K, et al. Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia. Exp Neurol 2009;216(1):47-55
   PubMed Web of Science ®Google Scholar
• Jeong CH, Kim SM, Lim JY, et al. Mesenchymal stem cells expressing brain-derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model. BioMed Res Int 2014;2014:129145
   PubMed Web of Science ®Google Scholar
• Katsuda T, Kosaka N, Takeshita F, Ochiya T. The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Proteomics 2013;13(10-11):1637-53
   PubMed Web of Science ®Google Scholar
• Xin H, Li Y, Cui Y, et al. Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab 2013;33(11):1711-15
   PubMed Web of Science ®Google Scholar
• Mitkari B, Nitzsche F, Kerkela E, et al. Human bone marrow mesenchymal stem/stromal cells produce efficient localization in the brain and enhanced angiogenesis after intra-arterial delivery in rats with cerebral ischemia, but this is not translated to behavioral recovery. Behav Brain Res 2014;259:50-9
   PubMed Web of Science ®Google Scholar
• Steiner B, Roch M, Holtkamp N, Kurtz A. Systemically administered human bone marrow-derived mesenchymal stem home into peripheral organs but do not induce neuroprotective effects in the MCAo-mouse model for cerebral ischemia. Neurosci Lett 2012;513(1):25-30
   PubMed Web of Science ®Google Scholar
• Chen J, Cui X, Zacharek A, et al. White matter damage and the effect of matrix metalloproteinases in type 2 diabetic mice after stroke. Stroke 2011;42(2):445-52
   PubMed Web of Science ®Google Scholar
• Amemori T, Jendelova P, Ruzickova K, et al. Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat. Cytotherapy 2010;12(2):212-25
   PubMed Web of Science ®Google Scholar
• Sandvig I, Hoang L, Sardella TC, et al. Labelling of olfactory ensheathing cells with micron-sized particles of iron oxide and detection by MRI. Contrast Media Mol Imaging 2012;7(4):403-10
   PubMed Web of Science ®Google Scholar
• Su Z, He C. Olfactory ensheathing cells: biology in neural development and regeneration. Prog Neurobiol 2010;92(4):517-32
   PubMed Web of Science ®Google Scholar
• Doeppner TR, Ewert TA, Tonges L, et al. Transduction of neural precursor cells with TAT-heat shock protein 70 chaperone: therapeutic potential against ischemic stroke after intrastriatal and systemic transplantation. Stem Cells 2012;30(6):1297-310
   PubMed Web of Science ®Google Scholar
• Shen LH, Li Y, Chen J, et al. Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke. J Cereb Blood Flow Metab 2007;27(1):6-13
   PubMed Web of Science ®Google Scholar
• Darsalia V, Allison SJ, Cusulin C, et al. Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain. J Cereb Blood Flow Metab 2011;31(1):235-42
   PubMed Web of Science ®Google Scholar
• Mine Y, Tatarishvili J, Oki K, et al. Grafted human neural stem cells enhance several steps of endogenous neurogenesis and improve behavioral recovery after middle cerebral artery occlusion in rats. Neurobiol Dis 2013;52:191-203
   PubMed Web of Science ®Google Scholar
• Okazaki T, Magaki T, Takeda M, et al. Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats. Neurosci Lett 2008;430(2):109-14
   PubMed Web of Science ®Google Scholar
• Jin K, Sun Y, Xie L, et al. Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat. Neurobiol Dis 2005;18(2):366-74
   PubMed Web of Science ®Google Scholar
• Wang J, Yang W, Xie H, et al. Ischemic stroke and repair: current trends in research and tissue engineering treatments. Regen Med Res 2014;2(1):3
   PubMedGoogle Scholar
• Kubinova S, Sykova E. Biomaterials combined with cell therapy for treatment of spinal cord injury. Regen Med 2012;7(2):207-24
   PubMed Web of Science ®Google Scholar
• Kubinová Š. New trends in spinal cord tissue engineering. Future Neurol 2015;10(2):129-45
   Google Scholar
• Jin KL, Mao XO, Xie L, et al. Transplantation of human neural precursor cells in Matrigel scaffolding improves outcome from focal cerebral ischemia after delayed postischemic treatment in rats. J Cereb Blood Flow Metab 2010;30(3):534-44
   PubMed Web of Science ®Google Scholar
• Yu HW, Cao B, Feng MY, et al. Combinated transplantation of neural stem cells and collagen type I promote functional recovery after cerebral ischemia in rats. Anat Rec 2010;293(5):911-17
   Google Scholar
• Zhong J, Chan A, Morad L, et al. Hydrogel matrix to support stem cell survival after brain transplantation in stroke. Neurorehabil Neural Repair 2010;24(7):636-44
   PubMed Web of Science ®Google Scholar
• Nakayama KH, Lee CC, Batchelder CA, Tarantal AF. Tissue specificity of decellularized rhesus monkey kidney and lung scaffolds. PLoS One 2013;8(5):e64134
   PubMed Web of Science ®Google Scholar
• Bible E, Dell’Acqua F, Solanky B, et al. Non-invasive imaging of transplanted human neural stem cells and ECM scaffold remodeling in the stroke-damaged rat brain by (19)F- and diffusion-MRI. Biomaterials 2012;33(10):2858-71
   PubMed Web of Science ®Google Scholar
• Ellis-Behnke RG, Liang YX, You SW, et al. Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc Natl Acad Sci USA 2006;103(13):5054-9
   PubMed Web of Science ®Google Scholar
• Guo J, Leung KK, Su H, et al. Self-assembling peptide nanofiber scaffold promotes the reconstruction of acutely injured brain. Nanomedicine 2009;5(3):345-51
   PubMed Web of Science ®Google Scholar
• Bible E, Qutachi O, Chau DYS, et al. Neo-vascularization of the stroke cavity by implantation of human neural stem cells on VEGF-releasing PLGA microparticles. Biomaterials 2012;33(30):7435
   PubMed Web of Science ®Google Scholar
• Jin Y, Kim IY, Kim ID, et al. Biodegradable gelatin microspheres enhance the neuroprotective potency of osteopontin via quick and sustained release in the post-ischemic brain. Acta Biomater 2014;10(7):3126-35
   PubMed Web of Science ®Google Scholar
• Reddy MK, Labhasetwar V. Nanoparticle-mediated delivery of superoxide dismutase to the brain: an effective strategy to reduce ischemia-reperfusion injury. FASEB J 2009;23(5):1384-95
   PubMed Web of Science ®Google Scholar
• Cooke MJ, Wang YF, Morshead CM, Shoichet MS. Controlled epi-cortical delivery of epidermal growth factor for the stimulation of endogenous neural stem cell proliferation in stroke-injured brain. Biomaterials 2011;32(24):5688-97
   PubMed Web of Science ®Google Scholar
• Wang YF, Cooke MJ, Morshead CM, Shoichet MS. Hydrogel delivery of erythropoietin to the brain for endogenous stem cell stimulation after stroke injury. Biomaterials 2012;33(9):2681-92
   PubMed Web of Science ®Google Scholar
• Caicco MJ, Cooke MJ, Wang YF, et al. A hydrogel composite system for sustained epi-cortical delivery of Cyclosporin A to the brain for treatment of stroke. J Control Release 2013;166(3):197-202
   PubMed Web of Science ®Google Scholar
• Wang YF, Cooke MJ, Sachewsky N, et al. Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke. J Control Release 2013;172(1):1-11
   PubMed Web of Science ®Google Scholar
• Hermann DM, Zechariah A. Implications of vascular endothelial growth factor for postischemic neurovascular remodeling. J Cereb Blood Flow Metab 2009;29(10):1620-43
   PubMed Web of Science ®Google Scholar
• Zhang ZG, Zhang L, Jiang Q, et al. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest 2000;106(7):829-38
   PubMed Web of Science ®Google Scholar
• Emerich DF, Silva E, Ali O, et al. Injectable VEGF hydrogels produce near complete neurological and anatomical protection following cerebral ischemia in rats. Cell Transplant 2010;19(9):1063-71
   PubMed Web of Science ®Google Scholar
• Ju RK, Wen YJ, Gou RB, et al. The experimental therapy on brain ischemia by improvement of local angiogenesis with tissue engineering in the mouse. Cell Transplant 2014;23:S83-95
   Google Scholar
• Stem cell therapies as an emerging paradigm in stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke. Stroke 2009;40(2):510-15
   PubMed Web of Science ®Google Scholar
• Savitz SI, Chopp M, Deans R, et al. Stem cell therapy as an emerging paradigm for stroke (STEPS) II. Stroke 2011;42(3):825-9
   PubMed Web of Science ®Google Scholar
• Savitz SI, Cramer SC, Wechsler L. Stem cells as an emerging paradigm in stroke 3: enhancing the development of clinical trials. Stroke 2014;45(2):634-9
   PubMed Web of Science ®Google Scholar
• Bhasin A, Srivastava MV, Kumaran SS, et al. Autologous mesenchymal stem cells in chronic stroke. Cerebrovasc Dis Extra 2011;1(1):93-104
   PubMedGoogle Scholar
• Lee JS, Hong JM, Moon GJ, et al. A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells 2010;28(6):1099-106
   PubMed Web of Science ®Google Scholar
• Suarez-Monteagudo C, Hernandez-Ramirez P, Alvarez-Gonzalez L, et al. Autologous bone marrow stem cell neurotransplantation in stroke patients. An open study. Restor Neurol Neurosci 2009;27(3):151-61
   PubMed Web of Science ®Google Scholar
• Doeppner TR, Hermann DM. Stem cell-based treatments against stroke: observations from human proof-of-concept studies and considerations regarding clinical applicability. Front Cell Neurosci 2014;8:357
   PubMed Web of Science ®Google Scholar
• Sobesky J. Refining the mismatch concept in acute stroke: lessons learned from PET and MRI. J Cereb Blood Flow Metab 2012;32(7):1416-25
   PubMed Web of Science ®Google Scholar
• Canazza A, Minati L, Boffano C, et al. Experimental models of brain ischemia: a review of techniques, magnetic resonance imaging, and investigational cell-based therapies. Front Neurol 2014;5:19
   PubMedGoogle Scholar
• Rueger MA, Backes H, Walberer M, et al. Noninvasive imaging of endogenous neural stem cell mobilization in vivo using positron emission tomography. J Neurosci 2010;30(18):6454-60
   PubMed Web of Science ®Google Scholar
• Sandvig I, Sandvig A. Using manganese-enhanced MRI to assess optic nerve regeneration. Methods Mol Biol 2014;1162:233-49
   PubMedGoogle Scholar
• Sandvig I, Thuen M, Hoang L, et al. In vivo MRI of olfactory ensheathing cell grafts and regenerating axons in transplant mediated repair of the adult rat optic nerve. NMR Biomed 2012;25(4):620-31
   PubMed Web of Science ®Google Scholar
• Jendelova P, Herynek V, Urdzikova L, et al. Magnetic resonance tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord. J Neurosci Res 2004;76(2):232-43
   PubMed Web of Science ®Google Scholar
• Horák D, Babič M, Jendelová P, et al. The effect of different magnetic nanoparticle coatings on the efficiency of stem cell labeling J Magn Magn Mater. 2009;321(10):1539-47
   Google Scholar
• Sykova E, Jendelova P. In vivo tracking of stem cells in brain and spinal cord injury. Prog Brain Res 2007;161:367-83
   PubMed Web of Science ®Google Scholar
• Kneipp M, Turner J, Hambauer S, et al. Functional real-time optoacoustic imaging of middle cerebral artery occlusion in mice. PLoS One 2014;9(4):e96118
   Google Scholar
• Low SW, Teo K, Lwin S, et al. Improvement in cerebral hemodynamic parameters and outcomes after superficial temporal artery-middle cerebral artery bypass in patients with severe stenoocclusive disease of the intracranial internal carotid or middle cerebral arteries. J Neurosurg 2015;1-8
   Web of Science ®Google Scholar
• Aswendt M, Adamczak J, Tennstaedt A. A review of novel optical imaging strategies of the stroke pathology and stem cell therapy in stroke. Front Cell Neurosci 2014;8:226
   PubMed Web of Science ®Google Scholar
• Vandeputte C, Reumers V, Aelvoet SA, et al. Bioluminescence imaging of stroke-induced endogenous neural stem cell response. Neurobiol Dis 2014;69:144-55
   PubMed Web of Science ®Google Scholar