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Expert Opinion on Biological Therapy Volume 16, 2016 - Issue 1
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Reviews

Current and advancing treatments for metastatic colorectal cancer

Enrique Sanz-GarciaDepartment of Medical Oncology, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, 08035Barcelona, Spain
,
Julieta GrasselliDepartment of Medical Oncology, Vall d’Hebron Institute of Oncology, 08035Barcelona, Spain;Department of Medical Oncology, Instituto Català de Oncologia, 08907Barcelona, Spain
,
Guillem ArgilesDepartment of Medical Oncology, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, 08035Barcelona, Spain;Department of Medical Oncology, Vall d’Hebron Institute of Oncology, 08035Barcelona, Spain
,
M Elena ElezDepartment of Medical Oncology, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, 08035Barcelona, Spain;Department of Medical Oncology, Vall d’Hebron Institute of Oncology, 08035Barcelona, Spain
&
Josep TaberneroDepartment of Medical Oncology, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, 08035Barcelona, Spain;Department of Medical Oncology, Vall d’Hebron Institute of Oncology, 08035Barcelona, SpainCorrespondence[email protected]
Pages 93-110 | Published online: 07 Nov 2015

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** Pivotal trial of irinotecan and 5-FU in first-line metastatic CRC.

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** FOLFOXIRI is the best treatment for fit mCRC patients.

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** Irinotecan and bevacizumab combination is a good option in first-line mCRC.

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** Pivotal trial of bevacizumab and oxaliplatin in first-line mCRC.

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** FOLFOXIRI and bevacizumab is a good option for mCRC.

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* Bevacizumab improves results in second-line mCRC treatment in bevacizumab-naïve patients.

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** Pivotal trial of aflibercept in combination with FOLFIRI for second-line mCRC treatment.

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* Cetuximab improves results in first-line mCRC.

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** First paper to consider RAS as predictive of response to EGFR.

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** No differences between initiation with antiEGFR or bevacizumab in KRAS WT mCRC.

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  • Stintzing S, Jung A, Rossius L, et al. Mutations within the EGFR signaling pathway: influence on efficacy in FIRE-3–A randomized phase III study of FOLFIRI plus cetuximab or bevacizumab as first-line treatment for wild-type (WT) KRAS (exon 2) metastatic colorectal cancer (mCRC) patients. Ann Oncol. 2014;32(3_suppl):445.
  • Lenz H, Niedzwiecki D, Innocenti F, et al. CALGB/SWOG 80405: phase III trial of irinotecan/5-FU/Leucovorin (FOLFIRI) or oxaliplatin/5-FU/Leucovorin (mFOLFOX6) with Bevacizumab (BV) or Cetuximab (CET) for patients (pts) with expanded RAS analyses untreated metastatic adenocarcinoma of the colon. Ann Oncol. 2014;25(suppl_4):mdu438.13.
  • Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med. 2009;360(6):563–572.
  • Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol. 2009;27(5):672–680.
  • Grothey A, Van Cutsem E, Sobrero A, et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013;381(9863):303–312.

** Pivotal trial of regorafenib in refractory mCRC.

  • Kim TW, Xu R, Yau TCC, et al. CONCUR: a randomized, placebo-controlled phase 3 study of regorafenib (REG) monotherapy in Asian patients with previously treated metastatic colorectal cancer (mCRC). Ann Oncol. 2014;25(suppl_4):iv168a–169.
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** Pivotal trial of regorafenib in refractory mCRC.

  • Pietrantonio F, Petrelli B, Coinu A, et al. Predictive role of BRAF mutations in patients with advanced colorectal cancer receiving cetuximab and panitumumab: a meta-analysis. Eur J Cancer. 2015;51(5):587–594.
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