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Review

Recombinant antibodies for cancer diagnosis and therapy

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Pages 305-318 | Published online: 03 Mar 2005

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  • •An important observation which suggests that high affinity can also be a limitation for tumour targeting and particularly for tumour penetration.
  • http://www.fda.gov/cber/efoi/approve.htm US Food and Drug Administration product approval information.
  • •This and the following websites are useful with regards to recombinant antibodies, scFv fragments and libraries.
  • http://www.lymphoma.com/ For latest product releases and treatment strategies.
  • http://www.leukemia-lymphoma.org For latest product releases and treatment strategies.
  • http://www.path.cam.ac.uld- mrc7/ humanisation/antibodies.html List of humanised antibodies.
  • http://www.mgen.uni-heidelberg.de/SD/ SDscFvSite.html Antibody structures.
  • http://www.mrc-cpe.cam.ac.uk/vbase-ok.php?menu=901 Vbase; human antibody sequences.
  • http://www.antibodyresource.com Antibody resource links.
  • http://www.rubic.rdg.ac.uld— andrew/ bioinf.org/abs/index5.htmlSACS- summary of antibody crystal structures and related antibody resource links.
  • http://www.morphosys.com HuCAL scFv library.
  • http://www.cambridgeantibody.com CAT scFv library.
  • http://www.dyax.com Dyax Fab library.
  • http://www.bioinvent.com BioInvent Ab library.
  • http://www.biosite.com Triage TM diagnostics platform.
  • http://www.zyomyx.comProtein Profiling BiochipTM array platform.
  • http://www.perkinelmer.com HydrogelTM immobilised antibody platform.

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