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- •An objective discussion of the various hypotheses and forms of evidence as explanations for the present worldwide explosion in allergy.
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- •This paper endorses earlier studies regarding the 'protective effect' of a farm environment for the development of allergies.
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- •The first use of an adjuvant for AV.
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- ••This paper illustrated the importance of theTh2 to Thl switch in AV.
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- •Resurrection of the blocking antibody theory.
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- •The first attempt to produce newer and safer forms of allergens, termed allergoids, by chemical modification.
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- •An interesting and scientifically elegant approach to AV.
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- •Early studies on peptides for immunotherapy.
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- •A short but useful review on T cell-reactive peptides in immunotherapy.
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- ••A study supporting the use of non-IgE-reactive T cell epitope-containing peptides for vaccination.
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- •Interesting studies of the Thl-inducing properties of bacterial ISSs.
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- ••An important review of the production and properties of a clinically acceptable Thl adjuvant.
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- •This paper details evidence for cellular mechanisms (including activation of TLR2 and TLR4) by which MPL induces host cell activation.
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- •This is an interesting study showing that tyrosine and MPL can act synergistically to produce a Thl response with model antigens.
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- ••A very important clinical study showinghow incorporation of a Thl adjuvant can reduce the number of injections required to obtain efficacy.
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- •Confirmation of the efficacy and safety of a Thl adjuvanted allergy vaccine. AV may reduce the progression of allergic disease in children.
- MAILLARD I, ADLER SH, PEAR WS: Notch and the immune system. Immunity (2003) 19(6):781–791.
- ••A novel and very interesting approach tospecific immunomodulation.
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- ••A landmark paper providing ratification ofAV as a mainstream method of treating allergy.
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- •A very thorough statistical analysis of controlled sublingual immunotherapy studies concludes that the treatment may be safe and efficacious.
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- •Provides good evidence of MPL inducing a Thl adjuvant effect.
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- •Provides good evidence of MPL inducing a Thl adjuvant effect.
- VON BAEHR V, SCHERF HP, HERMES A: Allergoid-specific cellular immune response as a possible marker for immunological M vitro effects of immunotherapy. Allergy (2001) 56\(Suppl. 68):91.
- •A publication supporting the use of allergoids, but with rather complex methodology.
- PUGGIONI F, FRANCIS JN, DURHAM SR: Monophosphoryl lipid A: M vitro effects on human T cell proliferation and cytokine production. Allergy Clin. Immunol (2003) 111(Pt 2):333.
- •Support for Thl adjuvants from a prestigious group. Patent
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