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Key Paper Evaluation

Targeting tumour necrosis factor-α in corticosteroid-dependent asthma

HOWARTH PH, BABU KS, ARSHAD HS et al.: Tumour necrosis factor (TNF-alpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax (2005) 60(12):1012-1018.

Pages 471-473 | Published online: 17 May 2006

Bibliography

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  • RUSSO C, POLOSA R: TNF-alpha as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritis. Clin. Sci. (Lond) (2005) 109(2):135-142.
  • AMRANI Y, CHEN H, PANETTIERI RA, Jr.: Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma? Respir. Res. (2000) 1(1):49-53.
  • GOSSET P, TSICOPOULOS A, WALLAERT B et al.: Increased secretion of tumor necrosis factor alpha and interleukin-6 by alveolar macrophages consecutive to the development of the late asthmatic reaction. J. Allergy Clin. Immunol. (1991) 88(4):561-571.
  • OHKAWARA Y, LEI XF, STAMPFLI MR et al.: Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation. Am. J. Respir. Cell Mol. Biol. (1997) 16(5):510-520.
  • THOMAS PS, HEYWOOD G: Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma. Thorax (2002) 57(9):774-778.
  • HOWARTH PH, BABU KS, ARSHAD HS et al.: Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax (2005) 60(12):1012-1018.
  • BODEY KJ, SEMPER AE, REDINGTON AE et al.: Cytokine profiles of BAL T cells and T-cell clones obtained from human asthmatic airways after local allergen challenge. Allergy (1999) 54(10):1083-1093.
  • WILSON SJ, WALLIN A, DELLA-CIOPPA G, SANDSTROM T, HOLGATE ST: Effects of budesonide and formoterol on NF-kappaB, adhesion molecules, and cytokines in asthma. Am. J. Respir. Crit. Care Med. (2001) 164(6):1047-1052.

Website

  • www.ginasthma.org Workshop Report, Global Strategy for Asthma Management and Prevention (2005).

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