Advanced search
Publication Cover
Expert Opinion on Therapeutic Targets Volume 10, 2006 - Issue 4
Submit an article Journal homepage
31
Views
2
CrossRef citations to date
0
Altmetric
Editorial

Chemical genetic analysis of signal transduction pathways

Anja Jaeschke Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA. [email protected]
&
Roger J Davis Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA. [email protected]
Pages 485-488 | Published online: 18 Jul 2006

Bibliography

  • BISHOP AC, UBERSAX JA, PETSCH DT et al.: A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature (2000) 407(6802):395-401.
  • BISHOP AC, BUZKO O, SHOKAT KM: Magic bullets for protein kinases. Trends Cell Biol. (2001) 11(4):167-172.
  • BISHOP AC, SHOKAT KM: Acquisition of inhibitor-sensitive protein kinases through protein design. Pharmacol. Ther. (1999) 82(2-3):337-346.
  • KNIGHT ZA, SHOKAT KM: Features of selective kinase inhibitors. Chem. Biol. (2005) 12(6):621-637.
  • ALAIMO PJ, KNIGHT ZA, SHOKAT KM: Targeting the gatekeeper residue in phosphoinositide 3-kinases. Bioorg. Med. Chem. (2005) 13(8):2825-2836.
  • COHEN MS, ZHANG C, SHOKAT KM, TAUNTON J: Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science (2005) 308(5726):1318-1321.
  • ZHANG C, KENSKI DM, PAULSON JL et al.: A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases. Nat. Methods (2005) 2(6):435-441.
  • PAPA FR, ZHANG C, SHOKAT K, WALTER P: Bypassing a kinase activity with an ATP-competitive drug. Science (2003) 302(5650): 1533-1537.
  • ABELIOVICH H, ZHANG C, DUNN WA Jr, SHOKAT KM, KLIONSKY DJ: Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol. Biol. Cell (2003) 14(2):477-490.
  • WEISS EL, BISHOP AC, SHOKAT KM, DRUBIN DG: Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p. Nat. Cell Biol. (2000) 2(10):677-685.
  • SREENIVASAN A, BISHOP AC, SHOKAT KM, KELLOGG DR: Specific inhibition of Elm1 kinase activity reveals functions required for early G1 events. Mol. Cell Biol. (2003) 23(17):6327-6337.
  • CARROLL AS, BISHOP AC, DERISI JL, SHOKAT KM, O’SHEA EK: Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response. Proc. Natl. Acad. Sci. USA (2001) 98(22):12578-12583.
  • VENTURA JJ, HUBNER A, ZHANG C, FLAVELL RA, SHOKAT KM, DAVIS RJ: Chemical genetic analysis of the time course of signal transduction by JNK. Mol. Cell (2006) 21(5):701-710.
  • EBLEN ST, KUMAR NV, SHAH K et al.: Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. J. Biol. Chem. (2003) 278(17):14926-14935.
  • HABELHAH H, SHAH K, HUANG L, BURLINGAME AL, SHOKAT KM, RONAI Z: Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue. J. Biol. Chem. (2001) 276(21):18090-18095.
  • FAN QW, SPECHT KM, ZHANG C, GOLDENBERG DD, SHOKAT KM, WEISS WA: Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. Cancer Res. (2003) 63(24):8930-8938.
  • FAN QW, ZHANG C, SHOKAT KM, WEISS WA: Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling. Curr. Biol. (2002) 12(16):1386-1394.
  • WONG S, WITTE ON: The BCR-ABL story: bench to bedside and back. Ann. Rev. Immunol. (2004) 22:247-306.
  • WONG S, MCLAUGHLIN J, CHENG D, ZHANG C, SHOKAT KM, WITTE ON: Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations. Proc. Natl. Acad. Sci. USA (2004) 101(50):17456-17461.
  • KUNG C, SHOKAT KM: Small-molecule kinase-inhibitor target assessment. Chembiochem (2005) 6(3):523-526.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.