Expert Opinion on Therapeutic Targets, Volume 10, Issue 4 (2006)

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Expert Opinion on Therapeutic Targets, Volume 10, Issue 4 (2006)

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Editorial

Article
Chemical genetic analysis of signal transduction pathways
Anja Jaeschke & Roger J Davis
Pages: 485-488
Published online: 18 Jul 2006
AbstractforChemical genetic analysis of signal transduction pathways | Full Text | References | PDF (50.6 KB)
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Article
Fatalities in natalizumab treatment – a ‘no go’ for leukocyte recirculation approaches?
Yi-Yang Yvonne Li, H Daniel Perez & Thomas M Zollner
Pages: 489-499
Published online: 18 Jul 2006
AbstractforFatalities in natalizumab treatment – a ‘no go’ for leukocyte recirculation approaches? | Full Text | References | PDF (189.9 KB)
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Interview

Article
Inhibiting angiogenesis: interview with Dr Jean Plouët
Emma Quigley
Pages: 501-503
Published online: 18 Jul 2006
AbstractforInhibiting angiogenesis: interview with Dr Jean Plouët | Full Text | PDF (53.5 KB)
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Free Access

Review

Article
Targeting protein aggregation in neurodegeneration – lessons from polyglutamine disorders
Patrick Weydt & Albert R La Spada
Pages: 505-513
Published online: 18 Jul 2006
AbstractforTargeting protein aggregation in neurodegeneration – lessons from polyglutamine disorders | Full Text | References | PDF (134.4 KB)
  • 136 Views
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Article
Targeting the dopamine D2 receptor in schizophrenia
Philip Seeman
Pages: 515-531
Published online: 18 Jul 2006
AbstractforTargeting the dopamine D2 receptor in schizophrenia | Full Text | References | PDF (263.8 KB)
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Article
Targeting invading macrophage- derived PGE2, IL-6 and calcitonin gene-related peptide in injured nerve to treat neuropathic pain
Weiya Ma & Rémi Quirion
Pages: 533-546
Published online: 18 Jul 2006
AbstractforTargeting invading macrophage- derived PGE2, IL-6 and calcitonin gene-related peptide in injured nerve to treat neuropathic pain | Full Text | References | PDF (432.9 KB)
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Article
Pharmacological targets in the treatment of abdominal aortic aneurysms
Michel P Bergoeing, Robert W Thompson & John A Curci
Pages: 547-559
Published online: 18 Jul 2006
AbstractforPharmacological targets in the treatment of abdominal aortic aneurysms | Full Text | References | PDF (147.3 KB)
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Article
High-density lipoproteins: a therapeutic target for atherosclerotic cardiovascular disease
Monica Gomaraschi, Laura Calabresi & Guido Franceschini
Pages: 561-572
Published online: 18 Jul 2006
AbstractforHigh-density lipoproteins: a therapeutic target for atherosclerotic cardiovascular disease | Full Text | References | PDF (342.1 KB)
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Article
Targeting adiponectin for cardioprotection
Noriyuki Ouchi, Rei Shibata & Kenneth Walsh
Pages: 573-581
Published online: 18 Jul 2006
AbstractforTargeting adiponectin for cardioprotection | Full Text | References | PDF (117.3 KB)
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Article
The role of hypoxia inducible factor-1 in cell metabolism – a possible target in cancer therapy
Rachida S Bel Aiba, Elitsa Y Dimova, Agnes Görlach & Thomas Kietzmann
Pages: 583-599
Published online: 18 Jul 2006
AbstractforThe role of hypoxia inducible factor-1 in cell metabolism – a possible target in cancer therapy | Full Text | References | PDF (200.9 KB)
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Article
Possible drug targets for celiac disease
Carmen Gianfrani, Salvatore Auricchio & Riccardo Troncone
Pages: 601-611
Published online: 18 Jul 2006
AbstractforPossible drug targets for celiac disease | Full Text | References | PDF (137.3 KB)
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Technology Evaluation

Article
Alternative isoform discrimination by the next generation of expression profiling microarrays
Matthew P Pando, Vinayaka Kotraiah, Kevin McGowan, Laurent Bracco & Richard Einstein
Pages: 613-625
Published online: 18 Jul 2006
AbstractforAlternative isoform discrimination by the next generation of expression profiling microarrays | Full Text | References | PDF (227.9 KB)
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Key Paper Evaluation

Article
Phosphoinositide 3-kinase-γ as a target in rheumatoid arthritis and systemic lupus
CAMPS M, RÜCKLE T, JI H et al.: Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat. Med. (2005) 11:936-943, and BARBER DF, BARTOLOMÉ A, HERNANDEZ C et al.: PI3Kg inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat. Med. (2005) 11:933-935.
Sheila A Doggrell
Pages: 627-630
Published online: 18 Jul 2006
AbstractforPhosphoinositide 3-kinase-γ as a target in rheumatoid arthritis and systemic lupus | Full Text | References | PDF (63.3 KB)
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