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Volume 10, Issue 4

Expert Opinion on Therapeutic Targets

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Expert Opinion on Therapeutic Targets, Volume 10, Issue 4 (2006)

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Expert Opinion on Therapeutic Targets, Volume 10, Issue 4 (2006)

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Editorial

Article

Chemical genetic analysis of signal transduction pathways

Anja Jaeschke & Roger J Davis

Pages: 485-488

Published online: 18 Jul 2006

AbstractforChemical genetic analysis of signal transduction pathways | Full Text | References | PDF (50.6 KB)

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Article

Fatalities in natalizumab treatment – a ‘no go’ for leukocyte recirculation approaches?

Yi-Yang Yvonne Li, H Daniel Perez & Thomas M Zollner

Pages: 489-499

Published online: 18 Jul 2006

AbstractforFatalities in natalizumab treatment – a ‘no go’ for leukocyte recirculation approaches? | Full Text | References | PDF (189.9 KB)

56 Views
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Interview

Article

Inhibiting angiogenesis: interview with Dr Jean Plouët

Emma Quigley

Pages: 501-503

Published online: 18 Jul 2006

AbstractforInhibiting angiogenesis: interview with Dr Jean Plouët | Full Text | PDF (53.5 KB)

322 Views
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Free Access

Review

Article

Targeting protein aggregation in neurodegeneration – lessons from polyglutamine disorders

Patrick Weydt & Albert R La Spada

Pages: 505-513

Published online: 18 Jul 2006

AbstractforTargeting protein aggregation in neurodegeneration – lessons from polyglutamine disorders | Full Text | References | PDF (134.4 KB)

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Article

Targeting the dopamine D₂ receptor in schizophrenia

Philip Seeman

Pages: 515-531

Published online: 18 Jul 2006

AbstractforTargeting the dopamine D₂ receptor in schizophrenia | Full Text | References | PDF (263.8 KB)

1656 Views
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Article

Targeting invading macrophage- derived PGE₂, IL-6 and calcitonin gene-related peptide in injured nerve to treat neuropathic pain

Weiya Ma & Rémi Quirion

Pages: 533-546

Published online: 18 Jul 2006

AbstractforTargeting invading macrophage- derived PGE₂, IL-6 and calcitonin gene-related peptide in injured nerve to treat neuropathic pain | Full Text | References | PDF (432.9 KB)

260 Views
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Article

Pharmacological targets in the treatment of abdominal aortic aneurysms

Michel P Bergoeing, Robert W Thompson & John A Curci

Pages: 547-559

Published online: 18 Jul 2006

AbstractforPharmacological targets in the treatment of abdominal aortic aneurysms | Full Text | References | PDF (147.3 KB)

108 Views
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Article

High-density lipoproteins: a therapeutic target for atherosclerotic cardiovascular disease

Monica Gomaraschi, Laura Calabresi & Guido Franceschini

Pages: 561-572

Published online: 18 Jul 2006

AbstractforHigh-density lipoproteins: a therapeutic target for atherosclerotic cardiovascular disease | Full Text | References | PDF (342.1 KB)

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Article

Targeting adiponectin for cardioprotection

Noriyuki Ouchi, Rei Shibata & Kenneth Walsh

Pages: 573-581

Published online: 18 Jul 2006

AbstractforTargeting adiponectin for cardioprotection | Full Text | References | PDF (117.3 KB)

109 Views
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Article

The role of hypoxia inducible factor-1 in cell metabolism – a possible target in cancer therapy

Rachida S Bel Aiba, Elitsa Y Dimova, Agnes Görlach & Thomas Kietzmann

Pages: 583-599

Published online: 18 Jul 2006

AbstractforThe role of hypoxia inducible factor-1 in cell metabolism – a possible target in cancer therapy | Full Text | References | PDF (200.9 KB)

124 Views
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Article

Possible drug targets for celiac disease

Carmen Gianfrani, Salvatore Auricchio & Riccardo Troncone

Pages: 601-611

Published online: 18 Jul 2006

AbstractforPossible drug targets for celiac disease | Full Text | References | PDF (137.3 KB)

72 Views
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Technology Evaluation

Article

Alternative isoform discrimination by the next generation of expression profiling microarrays

Matthew P Pando, Vinayaka Kotraiah, Kevin McGowan, Laurent Bracco & Richard Einstein

Pages: 613-625

Published online: 18 Jul 2006

AbstractforAlternative isoform discrimination by the next generation of expression profiling microarrays | Full Text | References | PDF (227.9 KB)

35 Views
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Key Paper Evaluation

Article

Phosphoinositide 3-kinase-γ as a target in rheumatoid arthritis and systemic lupus

CAMPS M, RÜCKLE T, JI H et al.: Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat. Med. (2005) 11:936-943, and BARBER DF, BARTOLOMÉ A, HERNANDEZ C et al.: PI3Kg inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat. Med. (2005) 11:933-935.

Sheila A Doggrell

Pages: 627-630

Published online: 18 Jul 2006

AbstractforPhosphoinositide 3-kinase-γ as a target in rheumatoid arthritis and systemic lupus | Full Text | References | PDF (63.3 KB)

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