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Editorial

Fatalities in natalizumab treatment – a ‘no go’ for leukocyte recirculation approaches?

, &
Pages 489-499 | Published online: 18 Jul 2006

Bibliography

  • BARON JL, MADRI JA, RUDDLE NH, HASHIM G, JANEWAY CA Jr: Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. (1993) 177:57-68.
  • BERLIN C, BERG EL, BRISKIN MJ et al.: Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell (1993) 74:185-195.
  • ELICES MJ, OSBORN L, TAKADA Y et al.: VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell (1990) 60:577-584.
  • MUNOZ M, SERRADOR J, NIETO M, LUQUE A, SANCHEZ-MADRID F, TEIXIDO J: A novel region of the alpha4 integrin subunit with a modulatory role in VLA-4-mediated cell adhesion to fibronectin. Biochem. J. (1997) 327(Pt 3):727-733.
  • WAYNER EA, GARCIA-PARDO A, HUMPHRIES MJ, MCDONALD JA, CARTER WG: Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. J. Cell Biol. (1989) 109:1321-1330.
  • BERLIN C, BERG EL, BRISKIN MJ et al.: Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell (1993) 74:185-195.
  • LOBB RR, HEMLER ME: The pathophysiologic role of alpha 4 integrins in vivo. J. Clin. Invest. (1994) 94:1722-1728.
  • YANG XD, KARIN N, TISCH R, STEINMAN L, MCDEVITT HO: Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors. Proc. Natl. Acad. Sci. USA (1993) 90:10494-10498.
  • KULIDJIAN AA, INMAN R, ISSEKUTZ TB: Rodent models of lymphocyte migration. Semin. Immunol. (1999) 11:85-93.
  • RICE GP, HARTUNG HP, CALABRESI PA: Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale. Neurology (2005) 64:1336-1342.
  • SIMMONS DL: Anti-adhesion therapies. Curr. Opin. Pharmacol. (2005) 5:398-404.
  • POLMAN CH, O’CONNOR PW, HAVRDOVA E et al.: A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. (2006) 354:899-910.
  • RUDICK RA, STUART WH, CALABRESI PA et al.: Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N. Engl. J. Med. (2006) 354:911-923.
  • KLEINSCHMIDT-DEMASTERS BK, TYLER KL: Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N. Engl. J. Med. (2005) 353:369-374.
  • LANGER-GOULD A, ATLAS SW, GREEN AJ, BOLLEN AW, PELLETIER D: Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N. Engl. J. Med. (2005) 353:375-381.
  • VAN ASSCHE G, VAN RANST M, SCIOT R et al.: Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn’s disease. N. Engl.J. Med. (2005) 353:362-368.
  • YOUSRY TA, MAJOR EO, RYSCHKEWITSCH C et al.: Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N. Engl. J. Med. (2006) 354:924-933.
  • ASTROM KE, MANCALL EL, RICHARDSON EP Jr: Progressive multifocal leuko-encephalopathy; a hitherto unrecognized complication of chronic lymphatic leukaemia and Hodgkin’s disease. Brain (1958) 81:93-111.
  • PADGETT BL, WALKER DL: Virologic and serologic studies of progressive multifocal leukoencephalopathy. Prog. Clin. Biol. Res. (1983) 105:107-117.
  • MONACO MC, JENSEN PN, HOU J, DURHAM LC, MAJOR EO: Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection. J. Virol. (1998) 72:9918-9923.
  • DU PASQUIER RA, SCHMITZ JE, JEAN-JACQUES J et al.: Detection of JC virus-specific cytotoxic T lymphocytes in healthy individuals. J. Virol. (2004) 78:10206-10210.
  • DU PASQUIER RA, CLARK KW, SMITH PS et al.: JCV-specific cellular immune response correlates with a favorable clinical outcome in HIV-infected individuals with progressive multifocal leukoencephalopathy. J. Neurovirol. (2001) 7:318-322.
  • DU PASQUIER RA, KURODA MJ, ZHENG Y, JEAN-JACQUES J, LETVIN NL, KORALNIK IJ: A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy. Brain (2004) 127:1970-1978.
  • WEBER F, GOLDMANN C, KRAMER M et al.: Cellular and humoral immune response in progressive multifocal leukoencephalopathy. Ann. Neurol. (2001) 49:636-642.
  • WEBER T, TREBST C, FRYE S et al.: Analysis of the systemic and intrathecal humoral immune response in progressive multifocal leukoencephalopathy. J. Infect. Dis. (1997) 176:250-254.
  • WEI G, LIU CK, ATWOOD WJ: JC virus binds to primary human glial cells, tonsillar stromal cells, and B-lymphocytes, but not to T lymphocytes. J. Neurovirol. (2000) 6:127-136.
  • DU PASQUIER RA, COREY S, MARGOLIN DH et al.: Productive infection of cerebellar granule cell neurons by JC virus in an HIV+ individual. Neurology (2003) 61:775-782.
  • LIU CK, WEI G, ATWOOD WJ: Infection of glial cells by the human polyomavirus JC is mediated by an N-linked glycoprotein containing terminal alpha(2-6)-linked sialic acids. J. Virol. (1998) 72:4643-4649.
  • ELPHICK GF, QUERBES W, JORDAN JA et al.: The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science (2004) 306:1380-1383.
  • KORALNIK IJ, DU PASQUIER RA, LETVIN NL: JC virus-specific cytotoxic T lymphocytes in individuals with progressive multifocal leukoencephalopathy. J. Virol. (2001) 75:3483-3487.
  • MONACO MC, ATWOOD WJ, GRAVELL M, TORNATORE CS, MAJOR EO: JC virus infection of hematopoietic progenitor cells, primary B lymphocytes, and tonsillar stromal cells: implications for viral latency. J. Virol. (1996) 70:7004-7012.
  • GALLIA GL, HOUFF SA, MAJOR EO, KHALILI K: Review: JC virus infection of lymphocytes-revisited. J. Infect. Dis. (1997) 176:1603-1609.
  • WEI G, LIU CK, ATWOOD WJ: JC virus binds to primary human glial cells, tonsillar stromal cells, and B-lymphocytes, but not to T lymphocytes. J. Neurovirol. (2000) 6:127-136.
  • MONACO MC, ATWOOD WJ, GRAVELL M, TORNATORE CS, MAJOR EO: JC virus infection of hematopoietic progenitor cells, primary B lymphocytes, and tonsillar stromal cells: implications for viral latency. J. Virol. (1996) 70:7004-7012.
  • ATWOOD WJ, AMEMIYA K, TRAUB R, HARMS J, MAJOR EO: Interaction of the human polyomavirus, JCV, with human B-lymphocytes. Virology (1992) 190:716-723.
  • DAVIDSON I, FROMENTAL C, AUGEREAU P, WILDEMAN A, ZENKE M, CHAMBON P: Cell-type specific protein binding to the enhancer of simian virus 40 in nuclear extracts. Nature (1986) 323:544-548.
  • JENSEN PN, MAJOR EO: Viral variant nucleotide sequences help expose leukocytic positioning in the JC virus pathway to the CNS. J. Leukoc. Biol. (1999) 65:428-438.
  • ATWOOD WJ, AMEMIYA K, TRAUB R, HARMS J, MAJOR EO: Interaction of the human polyomavirus, JCV, with human B-lymphocytes. Virology (1992) 190:716-723.
  • HOUFF SA, MAJOR EO, KATZ DA et al.: Involvement of JC virus-infected mononuclear cells from the bone marrow and spleen in the pathogenesis of progressive multifocal leukoencephalopathy. N. Engl. J. Med. (1988) 318:301-305.
  • ELICES MJ, OSBORN L, TAKADA Y et al.: VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell (1990) 60:577-584.
  • CUNNINGHAM SA, RODRIGUEZ JM, ARRATE MP, TRAN TM, BROCK TA: JAM2 interacts with alpha4beta1. Facilitation by JAM3. J. Biol. Chem. (2002) 277:27589-27592.
  • STEFFEN BJ, BUTCHER EC, ENGELHARDT B: Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. Am. J. Pathol. (1994) 145:189-201.
  • YEDNOCK TA, CANNON C, FRITZ LC, SANCHEZ-MADRID F, STEINMAN L, KARIN N: Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature (1992) 356:63-66.
  • ISSEKUTZ TB: Inhibition of in vivo lymphocyte migration to inflammation and homing to lymphoid tissues by the TA-2 monoclonal antibody. A likely role for VLA-4 in vivo. J. Immunol. (1991) 147:4178-4184.
  • ISSEKUTZ TB, MIYASAKA M, ISSEKUTZ AC: Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation. J. Exp. Med. (1996) 183:2175-2184.
  • ISSEKUTZ AC, ISSEKUTZ TB: Monocyte migration to arthritis in the rat utilizes both CD11/CD18 and very late activation antigen 4 integrin mechanisms. J. Exp. Med. (1995) 181:1197-1203.
  • ISSEKUTZ TB, ISSEKUTZ AC: T lymphocyte migration to arthritic joints and dermal inflammation in the rat: differing migration patterns and the involvement of VLA-4. Clin. Immunol. Immunopathol. (1991) 61:436-447.
  • BARON JL, MADRI JA, RUDDLE NH, HASHIM G, JANEWAY CA Jr: Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. (1993) 177:57-68.
  • KENT SJ, KARLIK SJ, CANNON C, HINES DK, YEDNOCK TA, FRITZ LC, HORNER HC: A monoclonal antibody to alpha 4 integrin suppresses and reverses active experimental allergic encephalomyelitis. J. Neuroimmunol. (1995) 58:1-10.
  • YEDNOCK TA, CANNON C, FRITZ LC, SANCHEZ-MADRID F, STEINMAN L, KARIN N: Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature (1992) 356:63-66.
  • ENGELHARDT B, LASCHINGER M, SCHULZ M, SAMULOWITZ U, VESTWEBER D, HOCH G: The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin. J. Clin. Invest. (1998) 102:2096-2105.
  • PODOLSKY DK, LOBB R, KING N et al.: Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody. J. Clin. Invest. (1993) 92:372-380.
  • CHISHOLM PL, WILLIAMS CA, LOBB RR: Monoclonal antibodies to the integrin alpha-4 subunit inhibit the murine contact hypersensitivity response. Eur. J. Immunol. (1993) 23:682-688.
  • YANG XD, MICHIE SA, TISCH R, KARIN N, STEINMAN L, MCDEVITT HO: A predominant role of integrin alpha 4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice. Proc. Natl. Acad. Sci. USA (1994) 91:12604-12608.
  • BURKLY LC, JAKUBOWSKI A, HATTORI M: Protection against adoptive transfer of autoimmune diabetes mediated through very late antigen-4 integrin. Diabetes (1994) 43:529-534.
  • BARON JL, REICH EP, VISINTIN I, JANEWAY CA Jr: The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1. J. Clin. Invest. (1994) 93:1700-1708.
  • POLMAN CH, O’CONNOR PW, HAVRDOVA E et al.: A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. (2006) 354:899-910.
  • RUDICK RA, STUART WH, CALABRESI PA et al.: Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N. Engl. J. Med. (2006) 354:911-923.
  • GONZALEZ-AMARO R, MITTELBRUNN M, SANCHEZ-MADRID F: Therapeutic anti-integrin (alpha4 and alphaL) monoclonal antibodies: two-edged swords? Immunology (2005) 116:289-296.
  • PUIG-KROGER A, SANZ-RODRIGUEZ F, LONGO N et al.: Maturation-dependent expression and function of the CD49d integrin on monocyte-derived human dendritic cells. J. Immunol. (2000) 165:4338-4345.
  • FREEDMAN AS, MUNRO JM, RICE GE et al.: Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110. Science (1990) 249:1030-1033.
  • RICE GE, MUNRO JM, CORLESS C, BEVILACQUA MP: Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues. Am. J. Pathol. (1991) 138:385-393.
  • MITTELBRUNN M, MOLINA A, ESCRIBESE MM et al.: VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses. Proc. Natl. Acad. Sci. USA (2004) 101:11058-11063.
  • NOJIMA Y, HUMPHRIES MJ, MOULD AP et al.: VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin. J. Exp. Med. (1990) 172:1185-1192.
  • MITTELBRUNN M, MOLINA A, ESCRIBESE MM et al.: VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses. Proc. Natl. Acad. Sci. USA (2004) 101:11058-11063.
  • SUZUKI J, ISOBE M, IZAWA A et al.: Differential Th1 and Th2 cell regulation of murine cardiac allograft acceptance by blocking cell adhesion of ICAM-1/LFA-1 and VCAM-1/VLA-4. Transpl. Immunol. (1999) 7:65-72.
  • SCHLEGEL PG, VAYSBURD M, CHEN Y, BUTCHER EC, CHAO NJ: Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers. J. Immunol. (1995) 155:3856-3865.
  • RODRIGUES M, NUSSENZWEIG RS, ROMERO P, ZAVALA F: The in vivo cytotoxic activity of CD8+ T cell clones correlates with their levels of expression of adhesion molecules. J. Exp. Med. (1992) 175:895-905.
  • WILLIAMS DA, RIOS M, STEPHENS C, PATEL VP: Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions. Nature (1991) 352:438-441.
  • PAPAYANNOPOULOU T, CRADDOCK C, NAKAMOTO B, PRIESTLEY GV, WOLF NS: The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen. Proc. Natl. Acad. Sci. USA (1995) 92:9647-9651.
  • OOSTENDORP RA, DORMER P: VLA-4-mediated interactions between normal human hematopoietic progenitors and stromal cells. Leuk. Lymphoma (1997) 24:423-435.
  • RYAN DH, NUCCIE BL, ABBOUD CN, WINSLOW JM: Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells. J. Clin. Invest. (1991) 88:995-1004.
  • YANG JT, RAYBURN H, HYNES RO: Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development (1995) 121:549-560.
  • FASSLER R, PFAFF M, MURPHY J et al.: Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts. J. Cell Biol. (1995) 128:979-988.
  • FASSLER R, MEYER M: Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev. (1995) 9:1896-1908.
  • STEPHENS LE, SUTHERLAND AE, KLIMANSKAYA IV et al.: Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev. (1995) 9:1883-1895.
  • GURTNER GC, DAVIS V, Li H, MCCOY MJ, SHARPE A, CYBULSKY MI: Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes Dev. (1995) 9:1-14.
  • KWEE L, BALDWIN HS, SHEN HM et al.: Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development (1995) 121:489-503.
  • GEORGE EL, GEORGES-LABOUESSE EN, PATEL-KING RS, RAYBURN H, HYNES RO: Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development (1993) 119:1079-1091.
  • MIYAKE K, WEISSMAN IL, GREENBERGER JS, KINCADE PW: Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis. J. Exp. Med. (1991) 173:599-607.
  • MIYAKE K, MEDINA K, ISHIHARA K, KIMOTO M, AUERBACH R, KINCADE PW: A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture. J. Cell Biol. (1991) 114:557-565.
  • RYAN DH: Adherence of normal and neoplastic human B cell precursors to the bone marrow microenvironment. Blood Cells (1993) 19:225-241.
  • RYAN DH, NUCCIE BL, ABBOUD CN, WINSLOW JM: Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells. J. Clin. Invest. (1991) 88:995-1004.
  • RYAN DH, NUCCIE BL, ABBOUD CN: Inhibition of human bone marrow lymphoid progenitor colonies by antibodies to VLA integrins. J. Immunol. (1992) 149:3759-3764.
  • PAPAYANNOPOULOU T, NAKAMOTO B: Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin. Proc. Natl. Acad. Sci. USA (1993) 90:9374-9378.
  • CRADDOCK CF, NAKAMOTO B, ANDREWS RG, PRIESTLEY GV, PAPAYANNOPOULOU T: Antibodies to VLA4 integrin mobilize long-term repopulating cells and augment cytokine-induced mobilization in primates and mice. Blood (1997) 90:4779-4788.
  • PAPAYANNOPOULOU T: Mechanisms of stem-/progenitor-cell mobilization: the anti-VLA-4 paradigm. Semin. Hematol. (2000) 37:11-18.
  • LU TT, CYSTER JG: Integrin-mediated long-term B cell retention in the splenic marginal zone. Science (2002) 297:409-412.
  • RANSOHOFF RM: Natalizumab and PML. Nat. Neurosci. (2005) 8:1275.
  • MEZEY E, CHANDROSS KJ, HARTA G, MAKI RA, MCKERCHER SR: Turning blood into brain: cells bearing neuronal antigenW generated in vivo from bone marrow. Science (2000) 290:1779-1782.
  • YAMADA M, KUBO H, KOBAYASHI S et al.: Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. J. Immunol. (2004) 172:1266-1272.
  • MALEK S, KAPLAN E, WANG JF et al.: Successful implantation of intravenously administered stem cells correlates with severity of inflammation in murine myocarditis. Pflugers Arch. (2006) Epub ahead of print.
  • ZERNECKE A, WEBER C: Inflammatory mediators in atherosclerotic vascular disease. Basic Res. Cardiol. (2005) 100:93-101.
  • SUBRAMANIAN S, BOURDETTE DN, CORLESS C, VANDENBARK AA, OFFNER H, JONES RE: T lymphocytes promote the development of bone marrow-derived APC in the central nervous system. J. Immunol. (2001) 166:370-376.
  • MEZEY E, KEY S, VOGELSANG G, SZALAYOVA I, LANGE GD, CRAIN B: Transplanted bone marrow generates new neurons in human brains. Proc. Natl. Acad. Sci. USA (2003) 100:1364-1369.
  • SEHMI R, DORMAN S, BAATJES A et al.: Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation. Immunology (2003) 109:536-546.
  • LI J, SAITO H, CRAWFORD L, INMAN MD, CYR MM, DENBURG JA: Haemopoietic mechanisms in murine allergic upper and lower airway inflammation. Immunology (2005) 114:386-396.
  • SERGEJEVA S, MALMHALL C, LOTVALL J, PULLERITS T: Increased number of CD34+ cells in nasal mucosa of allergic rhinitis patients: inhibition by a local corticosteroid. Clin. Exp. Allergy (2005) 35:34-38.
  • ZERNECKE A, WEBER C: Inflammatory mediators in atherosclerotic vascular disease. Basic Res. Cardiol. (2005) 100:93-101.
  • KOLLET O, SHIVTIEL S, CHEN YQ et al.: HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver. J. Clin. Invest. (2003) 112:160-169.
  • THEISE ND, NIMMAKAYALU M, GARDNER R et al.: Liver from bone marrow in humans. Hepatology (2000) 32:11-16.
  • KORBLING M, ESTROV Z: Adult stem cells for tissue repair – a new therapeutic concept? N. Engl. J. Med. (2003) 349:570-582.
  • MEZEY E, CHANDROSS KJ, HARTA G, MAKI RA, MCKERCHER SR: Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science (2000) 290:1779-1782.
  • LEBWOHL M, TYRING SK, HAMILTON TK et al.: A novel targeted T-cell modulator, efalizumab, for plaque psoriasis. N. Engl. J. Med. (2003) 349:2004-2013.
  • WESTHOVENS R, HOUSSIAU F, JOLY J et al.: A Phase I study assessing the safety, clinical response, and pharmacokinetics of an experimental infliximab formulation for subcutaneous or intramuscular administration in patients with rheumatoid arthritis. J. Rheumatol. (2006) 33:847-853.
  • POLMAN CH, O’CONNOR PW, HAVRDOVA E et al.: A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. (2006) 354:899-910.
  • RUDICK RA, STUART WH, CALABRESI PA et al.: Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N. Engl. J. Med. (2006) 354:911-923.
  • VOLLMER TL, PHILLIPS JT, GOODMAN AD et al.: An open-label safety and drug interaction study of natalizumab (Antegren) in combination with interferon-beta (Avonex) in patients with multiple sclerosis. Mult. Scler. (2004) 10:511-520.
  • KLEINSCHMIDT-DEMASTERS BK, TYLER KL: Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N. Engl. J. Med. (2005) 353:369-374.
  • SHITRIT D, LEV N, BAR-GIL-SHITRIT A, KRAMER MR: Progressive multifocal leukoencephalopathy in transplant recipients. Transpl. Int. (2005) 17:658-665.
  • LEBWOHL M, TYRING SK, HAMILTON TK et al.: A novel targeted T-cell modulator, efalizumab, for plaque psoriasis. N. Engl. J. Med. (2003) 349:2004-2013.
  • JENSES PN, MAJOR EO: Viral variant nucleotide sequences help expose leukocytic positioning in the JC virus pathway to the CNS. J. Leukoc. Biol. (1999) 65:428-438.

Websites

  • www.fda.gov US Food and Drug Administration (2006).
  • www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4208B1_02_01Biogenbriefingmaterial.pdf Natalizumab: advisory committee briefing document (2006).

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