Pharmacological targets in the treatment of abdominal aortic aneurysms

Bibliography

• ALCORN HG, WOLFSON SK Jr, SUTTON-TYRRELL K, KULLER LH, O’LEARY D: Risk factors for abdominal aortic aneurysms in older adults enrolled in The Cardiovascular Health Study. Arterioscler. Thromb. Vasc. Biol. (1996) 16(8):963-970.
   PubMed Web of Science ®Google Scholar
• WILMINK TB, QUICK CR, DAY NE: The association between cigarette smoking and abdominal aortic aneurysms. J. Vasc. Surg. (1999) 30(6):1099-1105.
   PubMed Web of Science ®Google Scholar
• LEDERLE FA, NELSON DB, JOSEPH AM: Smokers’ relative risk for aortic aneurysm compared with other smoking-related diseases: a systematic review. J. Vasc. Surg. (2003) 38(2):329-334.
   PubMed Web of Science ®Google Scholar
• WANHAINEN A, BERGQVIST D, BOMAN K et al.: Risk factors associated with abdominal aortic aneurysm: a population-based study with historical and current data. J. Vasc. Surg. (2005) 41(3):390-396.
   PubMed Web of Science ®Google Scholar
• LEDERLE FA, JOHNSON GR, WILSON SE et al.: Prevalence and associations of abdominal aortic aneurysm detected through screening. Aneurysm Detection and Management (ADAM) Veterans Affairs Cooperative Study Group. Ann. Intern. Med. (1997) 126(6):441-449.
   PubMed Web of Science ®Google Scholar
• LEDERLE FA, JOHNSON GR, WILSON SE et al.: Relationship of age, gender, race, and body size to infrarenal aortic diameter. The Aneurysm Detection and Management (ADAM) Veterans Affairs Cooperative Study Investigators. J. Vasc. Surg. (1997) 26(4):595-601.
   PubMed Web of Science ®Google Scholar
• ASHTON HA, BUXTON MJ, DAY NE et al.: The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial. Lancet (2002) 360(9345):1531-1539.
   PubMed Web of Science ®Google Scholar
• BREWSTER DC, CRONENWETT JL, HALLETT JW Jr et al.: Guidelines for the treatment of abdominal aortic aneurysms. Report of a subcommittee of the Joint Council of the American Association for Vascular Surgery and Society for Vascular Surgery. J. Vasc. Surg. (2003) 37(5):1106-1117.
   PubMed Web of Science ®Google Scholar
• LEDERLE FA, WILSON SE, JOHNSON GR et al.: Immediate repair compared with surveillance of small abdominal aortic aneurysms [see comment]. N. Engl. J. Med. (2002) 346(19):1437-1444.
   PubMed Web of Science ®Google Scholar
• THOMPSON MM: Controlling the expansion of abdominal aortic aneurysms. Br. J. Surg. (2003) 90(8):897-898.
   PubMed Web of Science ®Google Scholar
• POWELL JT, BRADY AR: Detection, management, and prospects for the medical treatment of small abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. (2004) 24(2):241-245.
   PubMed Web of Science ®Google Scholar
• LEDERLE FA, WILSON SE, JOHNSON GR et al.: immediate repair compared with surveillance of small abdominal aortic aneurysms. N. Engl. J. Med. (2002) 346(19):1437-1444.
   PubMed Web of Science ®Google Scholar
• THE UNITED KINGDOM SMALL ANEURYSM TRIAL P: Long-term outcomes of immediate repair compared with surveillance of small abdominal aortic aneurysms. N. Engl. J. Med. (2002) 346(19):1445-1452.
   PubMed Web of Science ®Google Scholar
• ELKOURI S, GLOVICZKI P, MCKUSICK MA et al.: Perioperative complications and early outcome after endovascular and open surgical repair of abdominal aortic aneurysms. J. Vasc. Surg. (2004) 39(3):497-505.
   PubMed Web of Science ®Google Scholar
• ELKOURI S, GLOVICZKI P, MCKUSICK MA et al.: Endovascular repair of abdominal aortic aneurysms: initial experience with 100 consecutive patients. Mayo. Clin. Proc. (2003) 78(10):1234-1242.
   PubMed Web of Science ®Google Scholar
• HAYTER CL, BRADSHAW SR, ALLEN RJ, GUDUGUNTLA M, HARDMAN DT: Follow-up costs increase the cost disparity between endovascular and open abdominal aortic aneurysm repair. J. Vasc. Surg. (2005) 42(5):912-918.
   PubMed Web of Science ®Google Scholar
• HANCE KA, TATARIA M, ZIPORIN SJ, LEE JK, THOMPSON RW: Monocyte chemotactic activity in human abdominal aortic aneurysms: role of elastin degradation peptides and the 67-kD cell surface elastin receptor. J. Vasc. Surg. (2002) 35(2):254-261.
   PubMed Web of Science ®Google Scholar
• GRIGORYANTS V, HANNAWA KK, PEARCE CG et al.: Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic aneurysms. J. Vasc. Surg. (2005) 41(1):108-114.
   PubMed Web of Science ®Google Scholar
• OCANA E, BOHORQUEZ JC, PEREZ-REQUENA J, BRIEVA JA, RODRIGUEZ C: Characterisation of T and B lymphocytes infiltrating abdominal aortic aneurysms. Atherosclerosis (2003) 170(1):39-48.
   PubMed Web of Science ®Google Scholar
• HOLMES DR, LIAO S, PARKS WC, THOMPSON RW: Medial neovascularization in abdominal aortic aneurysms: a histopathologic marker of aneurysmal degeneration with pathophysiologic implications. J. Vasc. Surg. (1995) 21(5):761-771; discussion 771-762.
   PubMed Web of Science ®Google Scholar
• ELIASON JL, HANNAWA KK, AILAWADI G et al.: Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation. Circulation (2005) 112(2):232-240.
   PubMed Web of Science ®Google Scholar
• HENDERSON EL, GENG Y-J, SUKHOVA GK et al.: Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms. Circulation (1999) 99(1):96-104.
   PubMed Web of Science ®Google Scholar
• LOPEZ-CANDALES A, HOLMES DR, LIAO S et al.: Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms. Am. J. Pathol. (1997) 150(3):993-1007.
   PubMed Web of Science ®Google Scholar
• CAMPA JS, GREENHALGH RM, POWELL JT: Elastin degradation in abdominal aortic aneurysms. Atherosclerosis (1987) 65(1-2):13-21.
   PubMed Web of Science ®Google Scholar
• DAUGHERTY A, CASSIS LA: Mouse models of abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. (2004) 24(3):429-434.
   PubMed Web of Science ®Google Scholar
• AILAWADI G, ELIASON JL, UPCHURCH GR Jr: Current concepts in the pathogenesis of abdominal aortic aneurysm. J. Vasc. Surg. (2003) 38(3):584-588.
   PubMed Web of Science ®Google Scholar
• THOMPSON RW, GERAGHTY PJ, LEE JK: Abdominal aortic aneurysms: basic mechanisms and clinical implications. Curr. Probl. Surg. (2002) 39(2):110-230.
   PubMed Web of Science ®Google Scholar
• HANNAWA KK, ELIASON JL, WOODRUM DT et al.: L-selectin-mediated neutrophil recruitment in experimental rodent aneurysm formation. Circulation (2005) 112(2):241-247.
   PubMed Web of Science ®Google Scholar
• PYO R, LEE JK, SHIPLEY JM et al.: Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J. Clin. Invest. (2000) 105(11):1641-1649.
   PubMed Web of Science ®Google Scholar
• LONGO GM, XIONG W, GREINER TC et al.: Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms. J. Clin. Invest. (2002) 110(5):625-632.
   PubMed Web of Science ®Google Scholar
• GACKO M, CHYCZEWSKI L: Activity and localization of cathepsin B, D and G in aortic aneurysm. Int. Surg. (1997) 82(4):398-402.
   PubMed Web of Science ®Google Scholar
• GACKO M, GLOWINSKI S: Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus. Clin. Chem. Lab. Med. (1998) 36(7):449-452.
   PubMed Web of Science ®Google Scholar
• GACKO M, CHYCZEWSKI L, CHROSTEK L: Distribution, activity and concentration of cathepsin B and cystatin C in the wall of aortic aneurysm. Pol. J. Pathol. (1999) 50(2):83-86.
   PubMedGoogle Scholar
• LIU J, SUKHOVA GK, YANG JT et al.: Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells. Atherosclerosis (2006) 184(2):302-311.
   PubMed Web of Science ®Google Scholar
• SUKHOVA GK, SHI G-P, SIMON DI, CHAPMAN HA, LIBBY P: Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J. Clin. Invest. (1998) 102(3):576-583.
   PubMed Web of Science ®Google Scholar
• JEAN-CLAUDE J, NEWMAN KM, LI H, GREGORY AK, TILSON MD: Possible key role for plasmin in the pathogenesis of abdominal aortic aneurysms. Surgery (1994) 116(2):472-478.
   PubMed Web of Science ®Google Scholar
• NEWMAN KM, JEAN-CLAUDE J, LI H et al.: Cellular localization of matrix metalloproteinases in the abdominal aortic aneurysm wall. J. Vasc. Surg. (1994) 20(5):814-820.
   PubMed Web of Science ®Google Scholar
• REILLY JM, SICARD GA, LUCORE CL: Abnormal expression of plasminogen activators in aortic aneurysmal and occlusive disease. J. Vasc. Surg. (1994) 19(5):865-872.
   PubMed Web of Science ®Google Scholar
• LOUWRENS HD, KWAAN HC, PEARCE WH, YAO JS, VERRUSIO E: Plasminogen activator and plasminogen activator inhibitor expression by normal and aneurysmal human aortic smooth muscle cells in culture. Eur. J. Vasc. Endovasc. Surg. (1995) 10(3):289-293.
   PubMed Web of Science ®Google Scholar
• SCHNEIDERMAN J, BORDIN GM, ENGELBERG I et al.: Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion. J. Clin. Invest. (1995) 96(1):639-645.
   PubMed Web of Science ®Google Scholar
• SHIREMAN PK, MCCARTHY WJ, PEARCE WH et al.: Elevations of tissue-type plasminogen activator and differential expression of urokinase-type plasminogen activator in diseased aorta. J. Vasc. Surg. (1997) 25(1):157-164.
   PubMed Web of Science ®Google Scholar
• SATTA J, JUVONEN T, HAUKIPURO K, JUVONEN M, KAIRALUOMA MI: Increased turnover of collagen in abdominal aortic aneurysms, demonstrated by measuring the concentration of the aminoterminal propeptide of Type III procollagen in peripheral and aortal blood samples. J. Vasc. Surg. (1995) 22(2):155-160.
   PubMed Web of Science ®Google Scholar
• HUFFMAN MD, CURCI JA, MOORE G et al.: Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms. Surgery (2000) 128(3):429-438.
   PubMed Web of Science ®Google Scholar
• DAVIS EC: Stability of elastin in the developing mouse aorta: a quantitative radioautographic study. Histochemistry (1993) 100(1):17-26.
   PubMedGoogle Scholar
• DUBICK MA, RUCKER RB, CROSS CE, LAST JA: Elastin metabolism in rodent lung. Biochim. Biophys. Acta (1981) 672(3):303-306.
   PubMed Web of Science ®Google Scholar
• KEELEY FW, JOHNSON DJ: Measurement of the absolute synthesis of soluble and insoluble elastin by chick aortic tissue. Can. J. Biochem. Cell. Biol. (1983) 61(10):1079-1084.
   PubMedGoogle Scholar
• DOBRIN PB, BAKER WH, GLEY WC: Elastolytic and collagenolytic studies of arteries. Implications for the mechanical properties of aneurysms. Arch. Surg. (1984) 119(4):405-409.
   PubMed Web of Science ®Google Scholar
• DOBRIN PB, ANIDJAR S: Pathophysiology of arterial aneurysms. Arch. Mal. Coeur Vaiss. (1991) 84(Spec. No 3):57-62.
   PubMedGoogle Scholar
• DOBRIN PB, BAUMGARTNER N, ANIDJAR S, CHEJFEC G, MRKVICKA R: Inflammatory aspects of experimental aneurysms. Effect of methylprednisolone and cyclosporine. Ann. N Y Acad. Sci. (1996) 800:74-88.
   PubMed Web of Science ®Google Scholar
• SATTA J, HAUKIPURO K, KAIRALUOMA MI, JUVONEN T: Aminoterminal propeptide of Type III procollagen in the follow-up of patients with abdominal aortic aneurysms. J. Vasc. Surg. (1997) 25(5):909-915.
   PubMed Web of Science ®Google Scholar
• BUSUTTIL RW, ABOU-ZAMZAM AM, MACHLEDER HI: Collagenase activity of the human aorta. A comparison of patients with and without abdominal aortic aneurysms. Arch. Surg. (1980) 115(11):1373-1378.
   PubMedGoogle Scholar
• VERSCHUREN L, LINDEMAN JH, VAN BOCKEL JH et al.: Up-regulation and coexpression of MIF and matrix metalloproteinases in human abdominal aortic aneurysms. Antioxid. Redox Signal. (2005) 7(9-10):1195-1202.
   PubMed Web of Science ®Google Scholar
• PAN JH, LINDHOLT JS, SUKHOVA GK et al.: Macrophage migration inhibitory factor is associated with aneurysmal expansion. J. Vasc. Surg. (2003) 37(3):628-635.
   PubMed Web of Science ®Google Scholar
• REILLY JM, MIRALLES M, WESTER WN, SICARD GA: Differential expression of prostaglandin E2 and interleukin-6 in occlusive and aneurysmal aortic disease. Surgery (1999) 126(4):624-627; discussion 627-628.
   PubMed Web of Science ®Google Scholar
• NEWMAN KM, JEAN-CLAUDE J, LI H, RAMEY WG, TILSON MD: Cytokines that activate proteolysis are increased in abdominal aortic aneurysms. Circulation (1994) 90(5 Pt 2):II224-II227.
   PubMedGoogle Scholar
• KOCH AE, KUNKEL SL, PEARCE WH et al.: Enhanced production of the chemotactic cytokines interleukin-8 and monocyte chemoattractant protein-1 in human abdominal aortic aneurysms. Am. J. Pathol. (1993) 142(5):1423-1431.
   PubMed Web of Science ®Google Scholar
• JONES KG, BRULL DJ, BROWN LC et al.: Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation (2001) 103(18):2260-2265.
   PubMed Web of Science ®Google Scholar
• TRESKA V, TOPOLCAN O, PECEN L: Cytokines as plasma markers of abdominal aortic aneurysm. Clin. Chem. Lab. Med. (2000) 38(11):1161-1164.
   PubMed Web of Science ®Google Scholar
• DAVIS VA, PERSIDSKAIA RN, BACA-REGEN LM et al.: Cytokine pattern in aneurysmal and occlusive disease of the aorta. J. Surg. Res. (2001) 101(2):152-156.
   PubMed Web of Science ®Google Scholar
• SCHONBECK U, SUKHOVA GK, GERDES N, LIBBY P: T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm. Am. J. Pathol. (2002) 161(2):499-506.
   PubMed Web of Science ®Google Scholar
• BAYSTON T, RAMESSUR S, REISE J, JONES KG, POWELL JT: Prostaglandin E2 receptors in abdominal aortic aneurysm and human aortic smooth muscle cells. J. Vasc. Surg. (2003) 38(2):354-359.
   PubMed Web of Science ®Google Scholar
• WALTON LJ, FRANKLIN IJ, BAYSTON T et al.: Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms: implications for smooth muscle cell viability, inflammatory processes, and the expansion of abdominal aortic aneurysms. Circulation (1999) 100(1):48-54.
   PubMedGoogle Scholar
• HOLMES DR, WESTER W, THOMPSON RW, REILLY JM: Prostaglandin E2 synthesis and cyclooxygenase expression in abdominal aortic aneurysms. J. Vasc. Surg. (1997) 25(5):810-815.
   PubMed Web of Science ®Google Scholar
• BROPHY C, TILSON JE, TILSON MD: Propranolol delays the formation of aneurysms in the male blotchy mouse. J. Surg. Res. (1988) 44(6):687-689.
   PubMed Web of Science ®Google Scholar
• LEACH SD, TOOLE AL, STERN H, DENATALE RW, TILSON MD: Effect of beta-adrenergic blockade on the growth rate of abdominal aortic aneurysms. Arch. Surg. (1988) 123(5):606-609.
   PubMedGoogle Scholar
• GADOWSKI GR, PILCHER DB, RICCI MA: Abdominal aortic aneurysm expansion rate: effect of size and beta-adrenergic blockade. J. Vasc. Surg. (1994) 19(4):727-731.
   PubMed Web of Science ®Google Scholar
• PROPANOLOL ANEURYSM TRIAL I: Propranolol for small abdominal aortic aneurysms: results of a randomized trial. J. Vasc. Surg. (2002) 35(1):72-79.
   PubMed Web of Science ®Google Scholar
• WILMINK ABM, HUBBARD CSSF, DAY NE, QUICK CRG: Effect of propanolol on the expansion of abdominal aortic aneurysms: a randomized study. Br. J. Surg. (2000) 87(4):499.
   Google Scholar
• LINDHOLT JS, HENNEBERG EW, JUUL S, FASTING H: Impaired results of a randomised double blinded clinical trial of propranolol versus placebo on the expansion rate of small abdominal aortic aneurysms. Int. Angiol. (1999) 18(1):52-57.
   PubMed Web of Science ®Google Scholar
• SLAIBY JM, RICCI MA, GADOWSKI GR, HENDLEY ED, PILCHER DB: Expansion of aortic aneurysms is reduced by propranolol in a hypertensive rat model. J. Vasc. Surg. (1994) 20(2):178-183.
   PubMed Web of Science ®Google Scholar
• WOJTOWICZ-PRAGA SM, DICKSON RB, HAWKINS MJ: Matrix metalloproteinase inhibitors. Investig. New Drugs (1997) 15(1):61-75.
   PubMed Web of Science ®Google Scholar
• BIGATEL DA, ELMORE JR, CAREY DJ et al.: The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms. J. Vasc. Surg. (1999) 29(1):130-138; discussion 138-139.
   PubMed Web of Science ®Google Scholar
• MOORE G, LIAO S, CURCI JA et al.: Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908). J. Vasc. Surg. (1999) 29(3):522-532.
   PubMed Web of Science ®Google Scholar
• GOLUB LM, LEE HM, LEHRER G et al.: Minocycline reduces gingival collagenolytic activity during diabetes. Preliminary observations and a proposed new mechanism of action. J. Periodontal Res. (1983) 18(5):516-526.
   PubMed Web of Science ®Google Scholar
• GOLUB LM, LEE HM, RYAN ME et al.: Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv. Dent. Res. (1998) 12(2):12-26.
   PubMedGoogle Scholar
• PETRINEC D, LIAO S, HOLMES DR et al.: Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase. J. Vasc. Surg. (1996) 23(2):336-346.
   PubMed Web of Science ®Google Scholar
• MANNING MW, CASSIS LA, DAUGHERTY A: Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. (2003) 23(3):483-488.
   PubMed Web of Science ®Google Scholar
• KAITO K, URAYAMA H, WATANABE G: Doxycycline treatment in a model of early abdominal aortic aneurysm. Surg. Today (2003) 33(6):426-433.
   PubMed Web of Science ®Google Scholar
• CURCI JA, PETRINEC D, LIAO S, GOLUB LM, THOMPSON RW: Pharmacologic suppression of experimental abdominal aortic aneurysms: acomparison of doxycycline and four chemically modified tetracyclines. J. Vasc. Surg. (1998) 28(6):1082-1093.
   PubMed Web of Science ®Google Scholar
• PRALL AK, LONGO GM, MAYHAN WG et al.: Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice. J. Vasc. Surg. (2002) 35(5):923-929.
   PubMed Web of Science ®Google Scholar
• FRANKLIN IJ, HARLEY SL, GREENHALGH RM, POWELL JT: Uptake of tetracycline by aortic aneurysm wall and its effect on inflammation and proteolysis. Br. J. Surg. (1999) 86(6):771-775.
   PubMed Web of Science ®Google Scholar
• CURCI JA, MAO D, BOHNER DG et al.: Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms. J. Vasc. Surg. (2000) 31(2):325-342.
   PubMed Web of Science ®Google Scholar
• MOSORIN M, JUVONEN J, BIANCARI F et al.: Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study.[see comment]. J. Vasc. Surg. (2001) 34(4):606-610.
   PubMed Web of Science ®Google Scholar
• BAXTER BT, PEARCE WH, WALTKE EA et al.: Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study. J. Vasc. Surg. (2002) 36(1):1-12.
   PubMed Web of Science ®Google Scholar
• ALLAIRE E, FOROUGH R, CLOWES M, STARCHER B, CLOWES AW: Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model. J. Clin. Invest. (1998) 102(7):1413-1420.
   PubMed Web of Science ®Google Scholar
• MIRALLES M, WESTER W, SICARD GA, THOMPSON R, REILLY JM: Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase. J. Vasc. Surg. (1999) 29(5):884-892; discussion 892-883.
   PubMed Web of Science ®Google Scholar
• HOLMES DR, PETRINEC D, WESTER W, THOMPSON RW, REILLY JM: Indomethacin prevents elastase-induced abdominal aortic aneurysms in the rat. J. Surg. Res. (1996) 63(1):305-309.
   PubMed Web of Science ®Google Scholar
• KING VL, TRIVEDI D, GITLIN JM, LOFTIN CD: Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. Arterioscler. Thromb. Vasc. Biol. (2006) Epub ahead of print.
   Google Scholar
• DAVIES MG, FULTON GJ, HAGEN PO: Clinical biology of nitric oxide. Br. J. Surg. (1995) 82(12):1598-1610.
   PubMed Web of Science ®Google Scholar
• JOHANNING JM, ARMSTRONG PJ, FRANKLIN DP et al.: Nitric oxide in experimental aneurysm formation: early events and consequences of nitric oxide inhibition. Ann. Vasc. Surg. (2002) 16(1):65-72.
   PubMed Web of Science ®Google Scholar
• JOHANNING JM, FRANKLIN DP, HAN DC, CAREY DJ, ELMORE JR: Inhibition of inducible nitric oxide synthase limits nitric oxide production and experimental aneurysm expansion. J. Vasc. Surg. (2001) 33(3):579-586.
   PubMed Web of Science ®Google Scholar
• LEE JK, BORHANI M, ENNIS TL, UPCHURCH GR Jr, THOMPSON RW: Experimental abdominal aortic aneurysms in mice lacking expression of inducible nitric oxide synthase. Arterioscler. Thromb. Vasc. Biol. (2001) 21(9):1393-1401.
   PubMed Web of Science ®Google Scholar
• KUHLENCORDT PJ, GYURKO R, HAN F et al.: Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice. Circulation (2001) 104(4):448-454.
   PubMed Web of Science ®Google Scholar
• LAWRENCE DM, SINGH RS, FRANKLIN DP, CAREY DJ, ELMORE JR: Rapamycin suppresses experimental aortic aneurysm growth. J. Vasc. Surg. (2004) 40(2):334-338.
   PubMed Web of Science ®Google Scholar
• WOODS TC, MARKS AR: Drug-eluting stents. Ann. Rev. Med. (2004) 55(1):169-178.
   PubMed Web of Science ®Google Scholar
• PUNITHAVATHI D, VENKATESAN N, BABU M: Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats. Br. J. Pharmacol. (2000) 131(2):169-172.
   PubMed Web of Science ®Google Scholar
• LECLERCQ IA, FARRELL GC, SEMPOUX C, PENA AD, HORSMANS Y: Curcumin inhibits NF-[kappa]B activation and reduces the severity of experimental steatohepatitis in mice. J. Hepatol. (2004) 41(6):926-934.
   PubMed Web of Science ®Google Scholar
• CHAN MM, HUANG HI, FENTON MR, FONG D: In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem. Pharmacol. (1998) 55(12):1955-1962.
   PubMed Web of Science ®Google Scholar
• PARODI FE, MAO D, ENNIS TL, PAGANO MB, THOMPSON RW: Oral administration of diferuloylmethane (curcumin) suppresses proinflammatory cytokines and destructive connective tissue remodeling in experimental abdominal aortic aneurysms. Ann. Vasc. Surg. (2006) 20:360-368.
   PubMed Web of Science ®Google Scholar
• MILLER FJ Jr, SHARP WJ, FANG X et al.: Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling. Arterioscler. Thromb. Vasc. Biol. (2002) 22(4):560-565.
   PubMed Web of Science ®Google Scholar
• YAJIMA N, MASUDA M, MIYAZAKI M et al.: Oxidative stress is involved in the development of experimental abdominal aortic aneurysm: a study of the transcription profile with complementary DNA microarray. J. Vasc. Surg. (2002) 36(2):379-385.
   PubMed Web of Science ®Google Scholar
• SINGH U, DEVARAJ S, JIALAL I: Vitamin E, oxidative stress, and inflammation. Ann. Rev. Nutr. (2005) 25:151-174.
   PubMed Web of Science ®Google Scholar
• GAVRILA D, LI WG, MCCORMICK ML et al.: Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. (2005) 25(8):1671-1677.
   PubMed Web of Science ®Google Scholar
• NAKAHASHI TK, HOSHINA K, TSAO PS et al.: Flow loading induces macrophage antioxidative gene expression in experimental aneurysms. Arterioscler. Thromb. Vasc. Biol. (2002) 22(12):2017-2022.
   PubMed Web of Science ®Google Scholar
• TORNWALL ME, VIRTAMO J, HAUKKA JK, ALBANES D, HUTTUNEN JK: Alpha-tocopherol (vitamin E) and beta-carotene supplementation does not affect the risk for large abdominal aortic aneurysm in a controlled trial. Atherosclerosis (2001) 157(1):167-173.
   PubMed Web of Science ®Google Scholar
• PARODI FE, MAO D, ENNIS TL, BARTOLI MA, THOMPSON RW: Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB. J. Vasc. Surg. (2005) 41(3):479-489.
   PubMed Web of Science ®Google Scholar
• CHAKRABORTI S, MANDAL M, DAS S, MANDAL A, CHAKRABORTI T: Regulation of matrix metalloproteinases: an overview. Mol. Cell. Biochem. (2003) 253(1–2):269-285.
   PubMed Web of Science ®Google Scholar
• YOSHIMURA K, AOKI H, IKEDA Y et al.: Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nat. Med. (2005) 11(12):1330-1338.
   PubMed Web of Science ®Google Scholar
• AILAWADI G, ELIASON JL, ROELOFS KJ et al.: Gender differences in experimental aortic aneurysm formation. Arterioscler. Thromb. Vasc. Biol. (2004) 24(11):2116-2122.
   PubMed Web of Science ®Google Scholar
• MARTIN-MCNULTY B, THAM DM, DA CUNHA V et al.: 17{beta}-estradiol attenuates development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. (2003) 23(9):1627-1632.
   PubMed Web of Science ®Google Scholar
• HENRIQUES TA, HUANG J, D’SOUZA SS, DAUGHERTY A, CASSIS LA: Orchidectomy, but not ovariectomy, regulates angiotensin II-induced vascular diseases in apolipoprotein E-deficient mice. Endocrinology (2004) 145(8):3866-3872.
   PubMed Web of Science ®Google Scholar
• MIKKOLA TS, CLARKSON TB: Estrogen replacement therapy, atherosclerosis, and vascular function. Cardiovasc. Res. (2002) 53(3):605-619.
   PubMed Web of Science ®Google Scholar
• BROWN NJ, VAUGHAN DE: Angiotensin-converting enzyme inhibitors. Circulation (1998) 97(14):1411-1420.
   PubMed Web of Science ®Google Scholar
• CHRYSANT SG: Vascular remodeling: the role of angiotensin-converting enzyme inhibitors. Am. Heart J. (1998) 135(2 Suppl. 1):S21-S30.
   Google Scholar
• NISHIMOTO M, TAKAI S, FUKUMOTO H et al.: Increased local angiotensin II formation in aneurysmal aorta. Life Sci. (2002) 71(18):2195-2205.
   PubMed Web of Science ®Google Scholar
• TSUNEMI K, TAKAI S, NISHIMOTO M et al.: Possible roles of angiotensin II-forming enzymes, angiotensin converting enzyme and chymase-like enzyme, in the human aneurysmal aorta. Hypertens. Res. (2002) 25(6):817-822.
   PubMed Web of Science ®Google Scholar
• LIAO S, MIRALLES M, KELLEY BJ et al.: Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors. J. Vasc. Surg. (2001) 33(5):1057-1064.
   PubMed Web of Science ®Google Scholar
• LIAO JK: Clinical implications for statin pleiotropy. Curr. Opin. Lipidol. (2005) 16(6):624-629.
   PubMed Web of Science ®Google Scholar
• RIKITAKE Y, LIAO JK: Rho GTPases, statins, and nitric oxide. Circ. Res. (2005) 97(12):1232-1235.
   PubMed Web of Science ®Google Scholar
• NICHOLLS SJ, CUTRI B, WORTHLEY SG et al.: Impact of short-term administration of high-density lipoproteins and atorvastatin on atherosclerosis in rabbits. Arterioscler. Thromb. Vasc. Biol. (2005) 25(11):2416-2421.
   PubMed Web of Science ®Google Scholar
• HARTUNG D, SARAI M, PETROV A et al.: Resolution of apoptosis in atherosclerotic plaque by dietary modification and statin therapy. J. Nucl. Med. (2005) 46(12):2051-2056.
   PubMed Web of Science ®Google Scholar
• WILSON WR, EVANS J, BELL PR, THOMPSON MM: HMG-CoA reductase inhibitors (statins) decrease MMP-3 and MMP-9 concentrations in abdominal aortic aneurysms. Eur. J. Vasc. Endovasc. Surg. (2005) 30(3):259-262.
   PubMed Web of Science ®Google Scholar
• NAGASHIMA H, AOKA Y, SAKOMURA Y et al.: A 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, cerivastatin, suppresses production of matrix metalloproteinase-9 in human abdominal aortic aneurysm wall. J. Vasc. Surg. (2002) 36(1):158-163.
   PubMed Web of Science ®Google Scholar
• STEINMETZ EF, BUCKLEY C, SHAMES ML et al.: Treatment with simvastatin suppresses the development of experimental abdominal aortic aneurysms in normal and hypercholesterolemic mice. Ann. Surg. (2005) 241(1):92-101.
   PubMed Web of Science ®Google Scholar
• KALYANASUNDARAM A, ELMORE JR, MANAZER JR et al.: Simvastatin suppresses experimental aortic aneurysm expansion. J. Vasc. Surg. (2006) 43(1):117-124.
   PubMed Web of Science ®Google Scholar
• SCHOUTEN O, VAN LAANEN JHH, BOERSMA E et al.: Statins are associated with a reduced infrarenal abdominal aortic aneurysm growth. Eur. J. Vasc. Endovasc. Surg. (2006) 32(1):21-26.
   PubMed Web of Science ®Google Scholar