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Expert Opinion on Therapeutic Targets Volume 10, 2006 - Issue 4
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Key Paper Evaluation

Phosphoinositide 3-kinase-γ as a target in rheumatoid arthritis and systemic lupus

CAMPS M, RÜCKLE T, JI H et al.: Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat. Med. (2005) 11:936-943, and BARBER DF, BARTOLOMÉ A, HERNANDEZ C et al.: PI3Kg inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat. Med. (2005) 11:933-935.

Sheila A Doggrell Charles Darwin University, School of Science, Casuarina, NT 0811, Australia. [email protected]
Pages 627-630 | Published online: 18 Jul 2006

Bibliography

  • SASAKI T, IRIE-SASAKI J, JONES RG et al.: Function of PI3Kγ in thymocyte development, T-cell activation, and neutrophil migration. Science (2000) 287:1040-1045.
  • DEL PRETE A, VERMI W, DANDER E et al.: Defective dendritic cell migration and activation of adaptive immunity in PI3Kγ-deficient mice. EMBO (2004) 23:3505-3515.
  • HIRSCH E, KATANAEV VL, GARLANDA C et al.: Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation. Science (2000) 287:1049-1053.
  • LAFFARGUE M, CALVEZ R, FINAN P et al.: Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function. Immunity (2002) 16:441-451.
  • CAMPS M, RÜCKLE T, JI H et al.: Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat. Med. (2005) 11:936-943.
  • BARBER DF, BARTOLOMÉ A, HERNANDEZ C et al.: PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat. Med. (2005) 11:933-935.
  • NICULESCU F, NGUYEN P, NICULESCU T, RUS H, RUS V, VIA CS: Pathogenic T cells in murine lupus exhibit spontaneous signaling through phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. Arthritis Rheum. (2003) 48:1071-1079.
  • BORLADO LR, REDONO C, ALVAREZ B et al.: Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo. FASEB J. (2000) 14:895-903.
  • JACKSON SF, SCHOENWAELDER SM: Type I phosphoinositide 3-kinases – potential antithrombotic targets? Cell. Mol. Life Sci. (2006) Epub ahead of print.
  • BARBER DF, BARTOLOMÉ A, HERMANDEZ C et al.: Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion. J. Immunol. (2006) 176:589-593.

Websites

  • http://www.emedicine.com/emerg/topic48.htm Arthritis, rheumatoid (2006).
  • http://www.emedicine.com/emerg/topic564.htm Systemic lupus erythematosus (2006).

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