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Review

Targeting systemic inflammation: novel therapies for the treatment of chronic obstructive pulmonary disease

, MD, , MD, , PhD & , MD, PhD
Pages 1273-1286 | Published online: 02 Oct 2007

Bibliography

  • AGUSTI A: Chronic obstructive pulmonary disease: a systemic disease. Proc. Am. Thorac. Soc. (2006) 3:478-481.
  • GAN WQ, MAN SF, SENTHILSELVAN A, SIN DD: Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax (2004) 59:574-580.
  • WOUTERS EF: Chronic obstructive pulmonary disease. 5. Systemic effects of COPD. Thorax (2002) 57:1067-1070.
  • AGUSTI AG, NOGUERA A, SAULEDA J, SALA E, PONS J, BUSQUETS X: Systemic effects of chronic obstructive pulmonary disease. Eur. Respir. J. (2003) 21:347-360.
  • FOGARTY AW, JONES S, BRITTON JR, LEWIS SA, MCKEEVER TM: Systemic inflammation and decline in lung function in a general population: a prospective study. Thorax (2007) 62:515-520.
  • THYAGARAJAN B, JACOBS DR, APOSTOL GG, SMITH LJ, LEWIS CE, WILLIAMS OD: Plasma fibrinogen and lung function: the CARDIA study. Int. J. Epidemiol. (2006) 35:1001-1008.
  • DAHL M, VESTBO J, LANGE P, BOJESEN SE, TYBJAERG-HANSEN A, NORDESTGAARD BG: C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. (2007) 175:250-255.
  • CELLI BR, MACNEE W, AGUSTI AG et al.: Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur. Respir. J. (2004) 23:932-946.
  • VAN EEDEN SF, HOGG JC: The response of human bone marrow to chronic cigarette smoking. Eur. Respir. J. (2000) 15:915-921.
  • NOGUERA A, BATLE S, MIRALLES C et al.: Enhanced neutrophil response in chronic obstructive pulmonary disease. Thorax (2001) 56:432-437.
  • GUSTAFSSON A, ASMAN B, BERGSTROM K: Cigarette smoking as an aggravating factor in inflammatory tissue-destructive diseases. Increase in TNF-α priming of peripheral neutrophils measured as generation of oxygen radicals. Int. J. Clin. Lab. Res. (2000) 30:187-190.
  • GAN WQ, MAN SF, SIN DD: The interactions between cigarette smoking and reduced lung function on systemic inflammation. Chest (2005) 127:558-664.
  • ANDELID K, BAKE B, RAK S, LINDEN A, ROSENGREN A, EKBERG-JANSSON A: Myeloperoxidase as a marker of increasing systemic inflammation in smokers without severe airway symptoms. Respir. Med. (2007) 101:888-895.
  • TØNNESEN P, CARROZZI L, FAGERSTROM KO et al.: Smoking cessation in patients with respiratory diseases: a high priority, integral component of therapy. Eur. Respir. J. (2007) 29:390-417.
  • RUTGERS SR, POSTMA DS, TEN HACKEN NH et al.: Ongoing airway inflammation in patients with COPD who do not currently smoke. Thorax (2000) 55:12-18.
  • TURATO G, DI STEFANO A, MAESTRELLI P et al.: Effect of smoking cessation on airway inflammation in chronic bronchitis. Am. J. Respir. Crit. Care Med. (1995) 152:1262-1267.
  • PATEL SA, CHOI AM, ZHANG Y et al.: Systemic biomarker pattern in different chronic obstructive pulmonary disease phenotypes independent of smoking status. Proc. Am. Thorac. Soc. (2006) 3:551 (Abstract).
  • VASSILAKOPOULOS T, ROUSSOS C, ZAKYNTHINOS S: The immune response to resistive breathing. Eur. Respir. J. (2004) 24:1033-1043.
  • VASSILAKOPOULOS T, ROUSSOS C, ZAKYNTHINOS S: Is loaded breathing an inflammatory stimulus? Curr. Opin. Crit. Care (2005) 11:1-9.
  • XU X, ZHOU J, YANG Q, FANG L, XIE Q, SHEN Y: An in vitro rat diaphragmatic fatigue model induced by combined hypoxic and hypercapnic acidosis and the effect of salmeterol. Pharmacol. Res. (2006) 3:171-176.
  • CARBO N, LOPEZ-SORIANO J, TARRAGO T et al.: Comparative effects of β2-adrenergic agonists on muscle waste associated with tumour growth. Cancer Lett. (1997) 115:113-118.
  • HARCOURT LJ, SCHERTZER JD, RYALL JG, LYNCH GS: Low dose formoterol administration improves muscle function in dystrophic mdx mice without increasing fatigue. Neuromuscul. Disord. (2007) 17:47-55.
  • VAN DER HEIJDEN HF, HEUNKS LM, FOLGERING H, VAN HERWAARDEN CL, DEKHUIJZEN PN: β2-Adrenoceptor agonists reduce the decline of rat diaphragm twitch force during severe hypoxia. Am. J. Physiol. (1999) 276:L474-L480.
  • KISSEL JT, MCDERMOTT MP, MENDELL JR et al.: Randomized, double-blind, placebo-controlled trial of albuterol in facioscapulohumeral dystrophy. Neurology (2001) 57:1434-1440.
  • KIM YS, SAINZ RD: β-Adrenergic agonists and hypertrophy of skeletal muscles. Life Sci. (1992) 50:397-407.
  • RAJAB P, FOX J, RIAZ S, TOMLINSON D, BALL D, GREENHAFF PL: Skeletal muscle myosin heavy chain isoforms and energy metabolism after clenbuterol treatment in the rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2000) 279:R1076-R1081.
  • RYALL JG, SILLENCE MN, LYNCH GS: Systemic administration of β2-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses. Br. J. Pharmacol. (2006) 147:587-595.
  • MOLENAAR P, CHEN L, PARSONAGE WA: Cardiac implications for the use of β2-adrenoceptor agonists for the management of muscle wasting. Br. J. Pharmacol. (2006) 147:583-586.
  • CAZZOLA M, MATERA MG, DONNER CF: Inhaled β2-adrenoceptor agonists: cardiovascular safety in patients with obstructive lung disease. Drugs (2005) 65:1595-1610.
  • BARNES PJ: Effect of β-agonists on inflammatory cells. J. Allergy Clin. Immunol. (1999) 104:S10-S17.
  • JOHNSON M, RENNARD S: Alternative mechanisms for long-acting β2-adrenergic agonists in COPD. Chest (2001) 120:258-270.
  • BOWDEN JJ, SULAKVELIDZE I, MCDONALD DM: Inhibition of neutrophil and eosinophil adhesion to venules of rat trachea by β2-adrenergic agonist formoterol. J. Appl. Physiol. (1994) 77:397-405.
  • YOSHIMURA T, KURITA C, NAGAO T et al.: Inhibition of TNF-α and interleukin-1-β production by β-adrenoceptor agonists from lipopolysaccharide-stimulated human peripheral blood mononuclear cells. Pharmacology (1997) 4:144-152.
  • OTTONELLO L, MORONE P, DAPINO P, DALLEGRI F: Inhibitory effect of salmeterol on the respiratory burst of adherent human neutrophils. Clin. Exp. Immunol. (1996) 106:97-102.
  • KAWASHIMA K, FUJII T: The lymphocytic cholinergic system and its biological function. Life Sci. (2003) 72:2101-2109.
  • PAVLOV VA, TRACEY KJ: Controlling inflammation: the cholinergic anti-inflammatory pathway. Biochem. Soc. Trans. (2006) 34:1037-1040.
  • WESSLER I, KILBINGER H, BITTINGER F, UNGER R, KIRKPATRICK CJ: The non-neuronal cholinergic system in humans: expression, function and pathophysiology. Life Sci. (2003) 72:2055-2061.
  • BARNES PJ, STOCKLEY RA: COPD: current therapeutic interventions and future approaches. Eur. Respir. J. (2005) 25:1084-1106.
  • KOYAMA S, RENNARD SI, ROBBINS RA: Acetylcholine stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity. Am. J. Physiol. (1992) 262:L466-L471.
  • KOYAMA S, SATO E, NOMURA H, KUBO K, NAGAI S, IZUMI T: Acetylcholine and substance P stimulate bronchial epithelial cells to release eosinophil chemotactic activity. J. Appl. Physiol. (1998) 84:1528-1534.
  • KLAPPROTH H, RACKE K, WESSLER I: Acetylcholine and nicotine stimulate the release of granulocyte-macrophage colony stimulating factor from cultured human bronchial epithelial cells. Naunyn Schmiedebergs Arch. Pharmacol. (1998) 357:472-475.
  • PROSKOCIL BJ, SEKHON HS, JIA Y et al.: Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Endocrinology (2004) 145:2498-2506.
  • GOSENS R, ZAAGSMA J, MEURS H, HALAYKO AJ: Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir. Res. (2006) 7:73.
  • CELLI B, ZUWALLACK R, WANG S, KESTEN S: Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes. Chest (2003) 124:1743-1748.
  • O'DONNELL DE, FLÜGE T, GERKEN F et al.: Effects of tiotropium on lung hyperinflation, dyspnea and exercise tolerance in patients with COPD. Eur. Respir. J. (2004) 23:832-840.
  • FERGUSON GT: Why does the lung hyperinflate? Proc. Am. Thorac. Soc. (2006) 3:176-179.
  • SALPETER SR, BUCKLEY NS, SALPETER EE: Meta-analysis: anticholinergics, but not β-agonists, reduce severe exacerbations and respiratory mortality in COPD. J. Gen. Intern. Med. (2006) 21:1011-1019.
  • BARNES PJ: Theophylline for COPD. Thorax (2006) 61:742-744.
  • ITO K, LIM S, CARAMORI G et al.: A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease gene expression. Proc. Natl. Acad. Sci. USA (2002) 99:8921-8926.
  • BARNES PJ: Targeting histone deacetylase 2 in chronic obstructive pulmonary disease treatment. Expert Opin. Ther. Targets (2005) 9:1111-1121.
  • BARNES PJ: Reduced histone deacetylase in COPD: clinical implications. Chest (2006) 129:151-155.
  • COSIO BG, TSAPROUNI L, ITO K, JAZRAWI E, ADCOCK IM, BARNES PJ: Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J. Exp. Med. (2004) 200:689-695.
  • WASSERMAN SI: The mast cell and theophylline in asthma. Am. J. Med. (1985) 20:22-25.
  • PAUWELS RA: New aspects of the therapeutic potential of theophylline in asthma. J. Allergy Clin. Immunol. (1989) 83:548-553.
  • KRAFT M, TORVIK JA, TRUDEAU JB, WENZEL SE, MARTIN RJ: Theophylline: potential antiinflammatory effects in nocturnal asthma. J. Allergy Clin. Immunol. (1996) 97:1242-1246.
  • SOSLAU G, BRODSKY I, PARKER J: Occupancy of P2 purinoceptors with unique properties modulates the function of human platelets. Biochim. Biophys. Acta (1993) 1177:199-207.
  • KOBAYASHI M, NASUHARA Y, BETSUYAKU T et al.: Effect of low-dose theophylline on airway inflammation in COPD. Respirology (2004) 9:249-254.
  • IIBOSHI H, ASHITANI J, KATOH S et al.: Long-term treatment with theophylline reduces neutrophils, interleukin-8 and TNF-α in the sputum of patients with chronic obstructive pulmonary disease. Pulm. Pharmacol. Ther. (2007) 20:46-51.
  • GAN WQ, MAN SF, SIN DD: Effects of inhaled corticosteroids on sputum cell counts in stable chronic obstructive pulmonary disease: a systematic review and a meta-analysis. BMC Pulm. Med. (2005) 5:3.
  • SIN DD, LACY P, YORK E, MAN SF: Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. (2004) 170:760-765.
  • PINTO-PLATA VM, MULLEROVA H, TOSO JF et al.: C-reactive protein in patients with COPD, control smokers, and nonsmokers. Thorax (2006) 61:23-28.
  • VAN SNICK J: Interleukin-6: an overview. Annu. Rev. Immunol. (1990) 8:253-278.
  • LIBBY P, RIDKER PM: Inflammation and atherosclerosis: role of C-reactive protein in risk assessment. Am. J. Med. (2004) 116:S9-S16.
  • DANESH J, WHEELER JG, HIRSCHFIELD GM et al.: C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N. Engl. J. Med. (2004) 350:1387-1397.
  • SIN DD, MAN SF: Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation (2003) 107:1514-1519.
  • LÖFDAHL C-G, POSTMA DS, PRIDE NB, BOE J, THORÉN A: Possible protection by inhaled budesonide against ischaemic cardiac events in mild COPD. Eur. Respir. J. (2007) 29(6):1115-1119.
  • HUIART L, ERNST P, RANOUIL X, SUISSA S: Low-dose inhaled corticosteroids and the risk of acute myocardial infarction in COPD. Eur. Respir. J. (2005) 25:634-639.
  • SIN DD, WU L, ANDERSON JA et al.: Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease. Thorax (2005) 60:992-997.
  • CALVERLEY PM, ANDERSON JA, CELLI B et al.: Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N. Engl. J. Med. (2007) 356:775-789.
  • WEI L, MACDONALD TM, WALKER BR: Taking glucocorticoids by prescription is associated with subsequent cardiovascular disease. Ann. Intern. Med. (2004) 141:764-770.
  • BARNES NC, QIU YS, PAVORD ID et al.: Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease. Am. J. Respir. Crit. Care Med. (2006) 173:736-743.
  • PERNG DW, WU CC, SU KC, LEE YC, PERNG RP, TAO CW: Inhaled fluticasone and salmeterol suppress eosinophilic airway inflammation in chronic obstructive pulmonary disease: relations with lung function and bronchodilator reversibility. Lung (2006) 184:217-222.
  • SIN DD, MAN SF, MARCINIUK DD et al.: Can inhaled fluticasone alone or in combination with salmeterol reduce systemic inflammation in chronic obstructive pulmonary disease? Study protocol for a randomized controlled trial [NCT00120978]. BMC Pulm. Med. (2006) 6:3.
  • SORIANO JB, VESTBO J, PRIDE NB, KIRI V, MADEN C, MAIER WC: Survival in COPD patients after regular use of fluticasone propionate and salmeterol in general practice. Eur. Respir. J. (2002) 20:819-825.
  • BURNEY P, SUISSA S, SORIANO JB et al.: The pharmacoepidemiology of COPD: recent advances and methodological discussion. Eur. Respir. J. (2003) 22(Suppl. 43):S1-S44.
  • MATERA MG, CAZZOLA M: New anti-inflammatory approaches in COPD. Drug Discov. Today Ther. Strat. (2004) 1:335-343.
  • CULPITT SV, ROGERS DF, SHAH P et al.: Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. (2003) 167:24-31.
  • BARNES PJ: New molecular targets for the treatment of neutrophilic diseases. J. Allergy Clin. Immunol. (2007) 119:1055-1062.
  • DONNELLY LE, BARNES PJ: Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease. Trends Pharmacol. Sci. (2006) 27:546-453.
  • MAHLER DA, HUANG S, TABRIZI M, BELL GM: Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot study. Chest (2004) 126:926-934.
  • BUKHTIYAROVA M, NORTHROP K, CHAI X, CASPER D, KARPUSAS M, SPRINGMAN E: Improved expression, purification, and crystallization of p38a MAP kinase. Protein Exp. Purif. (2004) 37:154-161.
  • ZHANG J, SHEN B, LIN A: Novel strategies for inhibition of the p38 MAPK pathway. Trends Pharmacol. Sci. (2007) 28:286-295.
  • KUMAR S, BOEHM J, LEE JC: p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat. Rev. Drug Discov. (2003) 2:717-726.
  • VAN DER VAART H, KOETER GH, POSTMA DS, KAUFFMAN HF, TEN HACKEN NH: First study of infliximab treatment in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. (2005) 172:465-469.
  • RENNARD SI, FOGARTY C, KELSEN S et al.: The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. (2007) 175:926-934.
  • BOSWELL-SMITH V, CAZZOLA M, PAGE CP: Are phosphodiesterase 4 inhibitors just more theophylline? J. Allergy Clin. Immunol. (2006) 117:1237-1243.
  • SOUNESS JE, ALDOUS D, SARGENT C: Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors. Immunopharmacology (2000) 47:127-162.
  • RABE KF, BATEMAN ED, O'DONNELL D, WITTE S, BREDENBROKER D, BETHKE TD: Roflumilast – an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. Lancet (2005) 366:563-571.
  • RENNARD SI, SCHACHTER N, STREK M, RICKARD K, AMIT O: Cilomilast for COPD: results of a 6-month, placebo-controlled study of a potent, selective inhibitor of phosphodiesterase 4. Chest (2006) 129:56-66.
  • OUAGUED M, MARTIN-CHOULY CA, BRINCHAULT G et al.: The novel phosphodiesterase 4 inhibitor, CI-1044, inhibits LPS-induced TNF-α production in whole blood from COPD patients. Pulm. Pharmacol. Ther. (2005) 18:49-54.
  • MCCLUSKIE K, KLEIN U, LINNEVERS C et al.: Phosphodiesterase type 4 inhibitors cause proinflammatory effects in vivo. J. Pharmacol. Exp. Ther. (2006) 319:468-476.
  • GIEMBYCZ MA: Life after PDE4: overcoming adverse events with dual-specificity phosphodiesterase inhibitors. Curr. Opin. Pharmacol. (2005) 5:238-244.
  • TYRRELL DJ, HORNE AP, HOLME KR, PREUSS JM, PAGE CP: Heparin in inflammation: potential therapeutic applications beyond anticoagulation. Adv. Pharmacol. (1999) 46:151-208.
  • LEVER R, PAGE CP: Novel drug development opportunities for heparin. Nat. Rev. Drug Discov. (2002) 1:140-148.
  • PAGE CP: One explanation of the asthma paradox: inhibition of natural anti-inflammatory mechanism by β2-agonists. Lancet (1991) 337:717-720.
  • WALSH RL, DILLON TJ, SCICCHITANO R, MCLENNAN G: Heparin and heparan sulphate are inhibitors of human leucocyte elastase. Clin. Sci. (1991) 81:341-346.
  • BROWN RA, LEVER R, JONES NA, PAGE CP: Effects of heparin and related molecules upon neutrophil aggregation and elastase release in vitro. Br. J. Pharmacol. (2003) 139:845-853.
  • LEDOUX D, MERCIRIS D, BARRITAULT D, CARUELLE JP: Heparin-like dextran derivatives as well as glycosaminoglycans inhibit the enzymatic activity of human cathepsin G. FEBS Lett. (2003) 537:23-29.
  • LEVER R, HOULT JR, PAGE CP: The effects of heparin and related molecules upon the adhesion of polymorphonuclear leukocytes to vascular endothelium in vitro. Br. J. Pharmacol. (2000) 129:533-540.
  • JONES H, PAUL W, PAGE CP: The effects of heparin and related molecules on vascular permeability and neutrophil accumulation in rabbit skin. Br. J. Pharmacol. (2002) 135:469-479.
  • BROWN RA, ALLEGRA L, MATERA MG, PAGE CP, CAZZOLA M: Additional clinical benefit of enoxaparin in COPD patients receiving salmeterol and fluticasone propionate in combination. Pulm. Pharmacol. Ther. (2006) 19:419-424.
  • FRYER A, HUANG YC, RAO G et al.: Selective O-desulfation produces nonanticoagulant heparin that retains pharmacological activity in the lung. J. Pharmacol. Exp. Ther. (1997) 282:208-219.
  • BAVINGTON CD, LEVER R, MULLOY B et al.: Anti-adhesive glycoproteins in echinoderm mucus secretions. Comp. Biochem. Physiol. B Biochem. Mol. Biol. (2004) 139:607-617.
  • RABINOVICH RA, ARDITE E, TROOSTERS T et al.: Reduced muscle redox capacity after endurance training in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. (2001) 164:1114-1118.
  • SAEY D, MICHAUD A, COUILLARD A et al.: Exercise-induced quadriceps oxidative stress and peripheral muscle dysfunction in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. (2003) 167:1664-1669.
  • AGUSTI AG: COPD, a multicomponent disease: implications for management. Respir. Med. (2005) 99:670-682.
  • KIRKHAM P, RAHMAN I: Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy. Pharmacol. Ther. (2006) 111:476-494.
  • SADOWSKA AM, MANUEL-Y-KEENOY B, DE BACKER WA: Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review. Pulm. Pharmacol. Ther. (2007) 20:9-22.
  • DAVIS WB, PACHT ER: Extracellular antioxidant defenses. In: The Lung: Scientific Foundations (2nd Edition). Crystal RG, West JB, Weibel ER, Barnes PJ (Eds), Philadelphia, Lippincott-Raven (1997):2271-2278.
  • DECRAMER M, RUTTEN-VAN MOLKEN M, DEKHUIJZEN PN et al.: Effects of NAC on outcome of COPD. The bronchitis randomized on NAC cost-utility study (BRONCHUS). Lancet (2005) 365:1552-1560.
  • VAN HELVOORT HA, HEIJDRA YF, HEUNKS LM et al.: Supplemental oxygen prevents exercise-induced oxidative stress in muscle-wasted patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. (2006) 173:1122-1129.
  • LAROSA JC, HE J, VUPPUTURI S: Effect of statins on risk of coronary disease. A meta-analysis of randomized controlled trials. JAMA (1999) 282:2340-2346.
  • RIDKER PM, CANNON CP, MORROW D et al.: C-reactive protein levels and outcomes after statin therapy. N. Engl. J. Med. (2005) 352:20-28.
  • FERRO D, PARROTTO S, BASILI S, ALESSANDRI C, VIOLI F: Simvastatin inhibits the monocyte expression of proinflammatory cytokinesin patients with hypercholesterolemia. J. Am. Coll. Cardiol. (2000) 36:427-431.
  • HEINRICH PC, CASTELL JV, ANDUS T: Interleukin-6 and the acute phase response. Biochem. J. (1990) 265:621-636.
  • HOTHERSALL E, MCSHARRY C, THOMSON NC: Potential therapeutic role for statins in respiratory disease. Thorax (2006) 61:729-734.
  • JACOBSON JR, BARNARD JW, GRIGORYEV DN, MA SF, TUDER RM, GARCIA JG: Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. (2005) 288:L1026-L1032.
  • LEE JH, LEE DS, KIM EK et al.: Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am. J. Respir. Crit. Care Med. (2005) 172:987-993.
  • LEE SD, LEE JH, KIM EK, CHOI KH, OH YM, SHIM TS: Effects of simvastatin on cigarette smoking-induced structural and functional changes in rat lungs. Chest (2005) 128:S574 (Abstract).
  • TAKAHASHI S, NAKAMURA H, FURUUCHI M et al.: Simvastatin suppresses the development of elastase-induced emphysema in mice (abstract). Proc. Am. Thor. Soc. (2005) 2:A135 (Abstract).
  • YOUNIS WG, CHBEIR EA, DAHER NN, DERNAIKA TA, KINASEWITZ GT, KEDDISSI JI: Statins protect smokers from lung disease. Chest (2006) 130:S180 (Abstract).
  • ALEXEEFF SE, LITONJUA AA, SPARROW D, VOKONAS PS, SCHWARTZ J: Statin use reduces decline in lung function: VA normative anging study. Am. J. Respir. Crit. Care Med. (2007) [Epub ahead of print].
  • MORIMOTO K, JANSSEN WJ, FESSLER MB et al.: Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease. J. Immunol. (2006) 176:7657-7665.
  • HENSON PM, BRATTON DL, FADOK VA: Apoptotic cell removal. Curr. Biol. (2001) 11:R795-R805.
  • ODAKA C, MIZUOCHI T, YANG J, DING A: Murine macrophages produce secretory leukocyte protease inhibitor during clearance of apoptotic cells: implications for resolution of the inflammatory response. J. Immunol. (2003) 171:1507-1514.
  • MORIMOTO K, AMANO H, SONODA F et al.: Alveolar macrophages that phagocytose apoptotic neutrophils produce hepatocyte growth factor during bacterial pneumonia in mice. Am. J. Respir. Cell Mol. Biol. (2001) 24:608-615.
  • GOLPON HA, FADOK VA, TARASEVICIENE-STEWART L et al.: Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth. FASEB J. (2004) 18:1716-1718.
  • MANCINI GB, ETMINAN M, ZHANG B, LEVESQUE LE, FITZGERALD JM, BROPHY JM: Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease. J. Am. Coll. Cardiol. (2006) 47:2554-2560.
  • SOYSETH V, BREKKE PH, SMITH P, OMLAND T: Statin use is associated with reduced mortality in chronic obstructive pulmonary disease. Eur. Respir. J. (2007) 29:279-283.
  • FROST FJ, PETERSEN H, TOLLESTRUP K, SKIPPER B: Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins. Chest (2007) 131:1006-1012.
  • VIERECK V, GRUNDKER C, BLASCHKE S et al.: Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts. J. Cell. Biochem. (2005) 96:1244-1253.
  • FERDER L, INSERRA F, MARTINEZ-MALDONADO M: Inflammation and the metabolic syndrome: role of angiotensin II and oxidative stress. Curr. Hypertens. Rep. (2006) 8:191-198.
  • KANAZAWA H, HIRATA K, YOSHIKAWA J: Effects of captopril administration on pulmonary hemodynamics and tissue oxygenation during exercise in ACE gene subtypes in COPD patients: a preliminary study. Thorax (2003) 58:629-631.
  • ANKER SD, NEGASSA A, COATS AJ et al.: Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study. Lancet (2003) 361:1077-1083.
  • SHOUP R, DALSKY G, WARNER S et al.: Body composition and health-related quality of life in patients with obstructive airways disease. Eur. Respir. J. (1997) 10:1576-1580.
  • POEHLMAN ET, SCHEFFERS J, GOTTLIEB SS, FISHER ML, VAITEKEVICIUS P: Increased resting metabolic rate in patients with congestive heart failure. Ann. Intern. Med. (1994) 121:860-862.
  • ANKER SD, SWAN JW, VOLTERRANI M et al.: The influence of muscle mass, strength, fatiguability, and blood flow on exercise capacity in cachectic and non-cachectic patients with chronic heart failure. Eur. Heart J. (1997) 18:259-269.
  • DOEHNER W, RAUCHHAUS M, FLOREA VG et al.: Uric acid in cachectic and noncachectic patients with chronic heart failure: relationship to leg vascular resistance. Am. Heart J. (2001) 141:792-799.
  • HORNIG B, ARAKAWA N, DREXLER H: Effect of ACE inhibition on endothelial dysfunction in patients with chronic heart failure. Eur. Heart J. (1998) 19(Suppl. G):G48-G53.
  • SWEDBERG K, ENEROTH P, KJEKSHUS J, WILHELMSEN L: Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS trial study group. Circulation (1990) 82:1730-1736.
  • FRANCIS GS, COHN JN, JOHNSON G, RECTOR TS, GOLDMAN S, SIMON A: Plasma norepinephrine, plasma renin activity, and congestive heart failure: relations to survival and the effects of therapy in V-HeFT II. Circulation (1993) 87(6 Suppl.):VI40-VI48.
  • ANDREAS S, HERRMANN-LINGEN C, RAUPACH T et al.: Angiotensin II blockers in obstructive pulmonary disease: a randomised controlled trial. Eur. Respir. J. (2006) 27:972-979.
  • REMELS AH, SCHRAUWEN P, BROEKHUIZEN R et al.: Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD. Eur. Respir. J. (2007) 30:245-252.
  • HARRIS SG, PHIPPS RP: Induction of apoptosis in mouse T cells upon peroxisome proliferator-activated receptor γ (PPAR-γ) binding. Adv. Exp. Med. Biol. (2002) 507:421-425.
  • PATEL HJ, BELVISI MG, BISHOP-BAILEY D, YACOUB MH, MITCHELL JA: Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. J. Immunol. (2003) 170:2663-2669.
  • BIRRELL MA, PATEL HJ, MCCLUSKIE K et al.: PPAR-γ agonists as therapy for diseases involving airway neutrophilia. Eur. Respir. J. (2004) 24:18-23.
  • SPEARS M, MCSHARRY C, THOMSON NC: Peroxisome proliferator-activated receptor-γ agonists as potential anti-inflammatory agents in asthma and chronic obstructive pulmonary disease. Clin. Exp. Allergy (2006) 36:1494-1504.
  • PFUTZNER A, SCHNEIDER CA, FORST T: Pioglitazone: an antidiabetic drug with cardiovascular therapeutic effects. Expert. Rev. Cardiovasc. Ther. (2006) 4:445-459.

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