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Review

Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes

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Pages 1265-1274 | Published online: 09 Sep 2008

Bibliography

  • Doble BW, Patel S, Wood GA, et al. Functional redundancy of GSK-3α and GSK-3β in Wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev Cell 2007;12:957-71
  • Grimes CA, Jope RS. The multifaceted roles of glycogen synthase kinase 3β in cellular signaling. Prog Neurobiol 2001;65:391-426
  • Woodgett JR. Molecular cloning and expression of glycogen synthase kinase-3/Factor A. EMBO J 1990;9:2431-8
  • Frame S, Cohen P, Biondi RM. A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol Cell 2001;7:1321-7
  • Mukai F, Ishiguro K, Sano Y, Fujita SC. Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3β. J Neurochem 2002;81:1073-83
  • Hoeflich KP, Luo J, Rubie EA, et al. Requirement for glycogen synthase kinase-3β in cell survival and NF-kB activation. Nature 2000;406:86-90
  • Macaulay K, Doble BW, Patel S, et al. Glycogen synthase kinase 3α-specific regulation of murine hepatic glycogen metabolism. Cell Metab 2007;6:329-37
  • Cross DA, Alessi DR, Cohen P, et al. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995;378:785-89
  • Foster FM, Traer CJ, Abraham SM, Fry MJ. The phosphoinositide (PI) 3-kinase family. J Cell Sci 2003;116:3037-40
  • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098-01
  • Jope RS, Johnson GV. The glamour and gloom of glycogen synthase kinase-3. 2004;29:95-102
  • Doble BW, Woodgett JR. GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 2003;116:1175-86
  • Nagafuchi A, Takeichi M. Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin. Cell Reg 1989;1:37-44
  • Van Noort M, Clevers H. TCF transcription factors, mediators of Wnt-signaling in development and cancer. Dev Biol 2002;244:1-8
  • Salahshor S, Woodgett JR. The links between axin and carcinogenesis. J Clin Pathol 2005;58:225-36
  • Amit S, Hatzubai A, Birman Y, et al. Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev 2002;16:1066-76
  • Aberle H, Bauer A, Stappert J, et al. β-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 1997;16:3797-804
  • Hart MJ, de los Santos R, Albert IN, et al. Downregulation of β-catenin by human axin and its association with the APC tumor suppressor, β-catenin and GSK3β. Curr Biol 1998;8:573-81
  • Polakis P. Wnt signaling and cancer. Genes Dev 2000;14:1837-51
  • Fiol CJ, Mahrenholz AM, Wang Y, et al. Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3. J Biol Chem 1987;262:14042-8
  • Roach PJ. Multisite and hierarchal protein phosphorylation. J Biol Chem 1991;266:14139-42
  • Roach PJ. Glycogen and its metabolism. Curr Mol Med 2002;2:101-20
  • Embi N, Rylatt DB, Cohen P. Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur J Biochem 1980;107:519-27
  • Brady MJ, Saltiel AR. The role of protein phosphatase-1 in insulin action. Recent Prog Horm Res 2001;56:157-73
  • Kaidanovich-Beilin O, Eldar-Finkelman H. Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle. J Pharmacol Exp Ther 2006;316:17-24
  • Nikoulina SE, Ciaraldi TP, Carter L, et al. Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished phosphatidylinositol 3-kinase activation. J Clin Endocrinol Metab 2001;86:4307-14
  • Eldar-Finkelman H, Argast GM, Foord O, et al. Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells. Proc Natl Acad Sci USA 1997;93:10228-33
  • Kelley DE, Mandarino LJ. Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus. J Clin Invest 1990;86:1999-2007
  • Hojlund K, Staehr P, Hansen BF, et al. Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes. Diabetes 2003;52:1393-402
  • Gaster M, Brusgaard K, Handberg A, et al. The primary defect in glycogen synthase activity is not based on increased glycogen synthase kinase-3α activity in diabetic myotubes. Biochem Biophys Res Commun 2004;319:1235-40
  • Ryves WJ, Harwood AJ. Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. Biochem Biophys Res Commun 2001;280:720-5
  • Furnsinn C, Noe C, Herdlicka R, et al. More marked stimulation by lithium than insulin of the glycogenic pathway in rat skeletal muscle. Am J Physiol 1997;273:E514-20
  • Tabata I, Schluter J, Gulve EA, Holloszy JO. Lithium increases susceptibility of muscle glucose transport to stimulation by various agents. Diabetes 1994;43:903-7
  • Cheng K, Creacy S, Larner J. ‘Insulin-like’ effects of lithium ion on isolated rat adipocytes. II. Specific activation of glycogen synthase. Mol Cell Biochem 1983;56:183-9
  • MacAulay K, Hajduch E, Blair AS, et al. Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase. Eur J Biochem 2003;270:3829-38
  • Orena SJ, Torchia AJ, Garofalo RS. Inhibition of glycogen-synthase kinase 3 stimulates glycogen synthase and glucose transport by distinct mechanisms in 3T3-L1 adipocytes. J Biol Chem 2000;275:15765-72
  • Henriksen EJ, Kinnick TR, Teachey MK, et al. Modulation of muscle insulin resistance by selective inhibition of GSK-3 in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab 2003;284:E892-900
  • Henriksen EJ, Teachey MK. Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty rats. Metabolism 2007;56:931-8
  • Bain J, Plater L, Elliott M, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 2007;408:297-315
  • Nikoulina SE, Ciaraldi TP, Mudaliar S, et al. Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle. Diabetes 2002;51:2190-8
  • Ring DB, Johnson KW, Henriksen EJ, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 2003;52:588-95
  • Dokken BB, Henriksen EJ. Chronic selective glycogen synthase kinase-3 inhibition enhances glucose disposal and muscle insulin action in prediabetic obese Zucker rats. Am J Physiol Endocrinol Metab 2006;291:E207-13
  • Dokken BB, Sloniger JA, Henriksen EJ. Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in pre-diabetic insulin-resistant rat skeletal muscle. Am J Physiol Endocrinol Metab 2005;288:E1188-94
  • Summers SA, Kao AW, Kohn AD, et al. The role of glycogen synthase kinase 3β in insulin-stimulated glucose metabolism. J Biol Chem 1999;274:17934-40
  • McManus EJ, Sakamoto K, Armit LJ, et al. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J 2005;24:1571-83
  • Patel S, Doble BW, MacAulay K, et al. Tissue-specific role of glycogen synthase kinase-3β in insulin action. Mol Cell Biol 2008; In press
  • Cline GW, Johnson K, Regittnig W, et al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes 2002;51:2903-10
  • Rao R, Hao CM, Redha R, et al. Glycogen synthase kinase 3 inhibition improves insulin-stimulated glucose metabolism but not hypertension in high-fat-fed C57BL/6J mice. Diabetologia 2007;50:452-60
  • Pearce NJ, Arch JR, Clapham JC, et al. Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3β on a muscle-specific promoter. Metabolism 2004;53:1322-30
  • Bouskila M,Hirshman MF, et al. Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle. Am J Physiol Endocrinol Metab. 2008;294:E28-35
  • Leloir LF, Olavarria JM, Goldemberg SH, Carminatti H. Biosynthesis of glycogen from uridine diphosphate glucose. Arch Biochem Biophys 1959;81:508-20
  • Halse R, Bonavaud SM, Armstrong JL, et al. Control of glycogen synthesis by glucose, glycogen, and insulin in cultured human muscle cells. Diabetes 2001;50:720-6
  • Kelsall IR, Munro S, Hallyburton I, et al., The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drug. FEBS Lett 2007;581:4749-53
  • O'Brien RM, Granner DK. PEPCK gene as model of inhibitory effects of insulin on gene transcription. Diabetes Care 1990;13:327-39
  • Sutherland C, O'Brien RM, Granner DK. New connections in the regulation of PEPCK gene expression by insulin. Philos Trans R Soc Lond B Biol Sci 1996;351:191-9
  • Foster JD, Pederson BA, Nordlie RC. Glucose-6-phosphatase structure, regulation, and function: an update. Proc Soc Exp Biol Med 1997;215:314-32
  • Patel S, Lipina C. Sutherland C. Different mechanisms are used by insulin to repress three genes that contain a homologous thymine-rich insulin response element. FEBS Lett 2003;549:72-6
  • Lochhead PA, Coghlan M, Rice SQ, Sutherland C. Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression. Diabetes 2001;50:937-46
  • Finlay D, Patel S, Dickson LM, et al. Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element. BMC Mol Biol 2004;5:15. Published online 6 September 2004, doi:10.1186/1471-2199-5-15
  • Lipina C, et al. Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3. Biochem J 2005;392:633-9
  • Liberman Z, Eldar-Finkelman H. Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling. J Biol Chem 2005;280:4422-8
  • Eldar-Finkelman H, Krebs EG. Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action. Proc Natl Acad Sci USA 1997;94:9660-4
  • Nikoulina SE, Ciaraldi TP, Abrams-Carter L, et al. Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes: role of chronic hyperinsulinemia and hyperglycemia. Diabetes 1997;46:1017-24
  • Bruning JC, Winnay J, Bonner-Weir S, et al. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 1997;88:561-72
  • White MF. Regulating insulin signaling and β-cell function through IRS proteins. Can J Physiol Pharmacol 2006;84:725-37
  • Tanabe K, Liu Z, Patel S, et al. Genetic deficiency of glycogen synthase kinase-3β corrects diabetes in mouse models of insulin resistance. PLoS Biol. 2008;6:e37. Published online 19 February 2008, doi:10.1371/journal.pbio.0060037
  • Ruel L, Bourouis M, Heitzler P, et al. Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch. Nature 1993;362:557-560

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