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Emerging Therapeutic Targets Volume 2, 1998 - Issue 1
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Miscellaneous

Inhibition of mammalian small heat shock protein 25 (HSP25) kinase (MAPKAP kinase-2)

Rainer Benndorf University of Michigan Medical School,Department of Anatomy and Cell Biology, Medical Sciences II, 1335 Cathrine Street, Ann Arbor, MI 48109, USA. Tel: +1313 763 951; Fax: +1313 763 1166; [email protected]
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Richard R Ransom University of Michigan Medical School,Department of Anatomy and Cell Biology, Medical Sciences II, 1335 Cathrine Street, Ann Arbor, MI 48109, USA. Tel: +1313 763 951; Fax: +1313 763 1166; [email protected]
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Robert R Gilmont University of Michigan Medical School,Department of Anatomy and Cell Biology, Medical Sciences II, 1335 Cathrine Street, Ann Arbor, MI 48109, USA. Tel: +1313 763 951; Fax: +1313 763 1166; [email protected]
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Katrin Hayess University of Michigan Medical School,Department of Anatomy and Cell Biology, Medical Sciences II, 1335 Cathrine Street, Ann Arbor, MI 48109, USA. Tel: +1313 763 951; Fax: +1313 763 1166; [email protected]
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Micheal J Welsh University of Michigan Medical School,Department of Anatomy and Cell Biology, Medical Sciences II, 1335 Cathrine Street, Ann Arbor, MI 48109, USA. Tel: +1313 763 951; Fax: +1313 763 1166; [email protected]
Pages 147-149 | Published online: 25 Feb 2005

Reference

  • MIRON T et al.: Characterization of an inhibitor of actin polymerization in vinculin-rich fraction of turkey gizzard smooth muscle. Eur, J. Biochem, (1988) 178:543.
  • MIRON T et al.: A 25kD inhibitor of actin polymerization is a low molecular mass heat shock protein. J. Cell Blot (1991) 114:255.
  • BENNDORF R et al.: Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity. I. Blot Chem, (1994) 269:20780.
  • BITAR KN et al.: Hsp27 is a mediator of smooth muscle contraction in response to bombesin. Biochem. Biophys. Res. Comm. (1991) 181:1192.
  • ARRIGO AP: Tumor necrosis factor induces the rapid phosphorylation of the mammalian heat shock protein hsp28. Mot Cell, Biol. (1990) 10:1276.
  • HORVATH CJ et al.: Recombinant tumor necrosis factor increases pulmonary vascular permeability independent of neutrophils. Proc. Natl. Acad. Sci. USA (1988) 85:9219.
  • MENDELSOHN ME et al.: The 29-kDa proteins phosphorylated in thrombin-activated human platelets are forms of the oestrogen receptor-related 27-kDa heat shock protein. Proc. Natl. Acad. Sci, USA (1991) 88:11212.
  • HUOT J et al.: Hsp27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress. Cancer Res, (1996) 56:273.
  • TANIGAWA S et al.: Differential tissue expression and phosphorylation of hsp27 in [PS treated rats. Mol. Biol. Cell (1997) 8:366a. Abstract 2133.
  • GILMONT RR et al.: Ischemia-reperfusion activates a kinase responsible for the phosphorylation of HSP 27. 41st Meeting of the Plastic Surgery Research Council. St. Louis, MO (June, 1996).
  • HAYESS K et al.: Effect of protein kinase inhibitors on activity of mammalian small heat shock protein (H5P25) kinase. Biochem. Pharmacot (1997) 53:1239.

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