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Emerging Therapeutic Targets Volume 2, 1998 - Issue 1
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Miscellaneous

An improved blood substitute

Jan Simoni Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, Texas 79430, USA. Tel: +1 806 743 2370 (Extn. 240); Fax: +1 806 743 2113; [email protected]
,
Grace Simoni Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, Texas 79430, USA. Tel: +1 806 743 2370 (Extn. 240); Fax: +1 806 743 2113; [email protected]
,
Shelley Weinstock Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, Texas 79430, USA. Tel: +1 806 743 2370 (Extn. 240); Fax: +1 806 743 2113; [email protected]
,
Charles Lox Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, Texas 79430, USA. Tel: +1 806 743 2370 (Extn. 240); Fax: +1 806 743 2113; [email protected]
&
Mario Feola Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, Texas 79430, USA. Tel: +1 806 743 2370 (Extn. 240); Fax: +1 806 743 2113; [email protected]
Pages 85-91 | Published online: 25 Feb 2005

Reference

  • CHANG TMS: Past, present and future perspectives on the 40th anniversary of hemoglobin based red blood cell substitutes. Artif. Cells Blood Substit. Immobil.Biotechnol. (1996) 24:ix-xxiv.
  • HESS JR: Blood substitutes. Semin. Hematol. (1996) 33:369-378.
  • WINSLOW RM: Hemoglobin-Based Red Cell Substitutes. Baltimore, John HopkinsUniversity Press (1992).
  • KASPER SM et al.: Effect of a hemoglobin-based oxygen carrier (HBOC-201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilation for elective surgery. Anesth. Analg. (1996) 83:921-927.
  • SWAM SK et al.: Pharmacologic profile of diaspirin cross-linked hemoglobin in hemodialysis patients. Am. J. Kidney Dis. (1995) 26:918-923.
  • VIELE MK et al.: Recombinant human hemoglobin does not affect renal function in humans: analysis of safety and pharmacokinetics. Anesthesiology (1997) 86:848-858.
  • SIMONI J et al.: An improved blood substitute. In vivo evaluation of its hemodynamic effects. ASAIO J. (1996) 42:M773–M782.
  • SIMONI J et al.: An improved blood substitute. In vivo evaluation of its renal effects. ASAIO J. (1997) 43:M714–M725.
  • SIMONI J et al.: Cytokines and PAF release from human monocytes and macrophages: effect of hemoglobin and contaminants. Artif. Cells Blood Substit. Immobil. Biotechnot (1994) 22:525–534.
  • SIMONI J et al.: Reaction of human endothelial cells to bovine hemoglobin solution and tumor necrosis factor. Artif. Cells Blood Substit. Immobil. Biotechnol. (1994) 22:777–787.
  • SIMONI J et al.: Evidence for the direct inhibition of endothelin-1 secretion by hemoglobin in human endothelial cells. ASAIO J. (1995) 41:M641–M651.
  • SIMONI J et al.: Modified Hb solution with desired pharmacological properties, does not activate the transcription factor NF-kappa B in human vascular endothelial cells. Artif. Cells Blood Substit. Immobil. Biotechnot (1997) 25:193–210.
  • SIMONI J et al.: Expression of adhesion molecules and von Willebrand factor in human coronary artery endothelial cells incubated with differently modified hemoglobin solutions. Artif. Cells Blood Substit. Immobil. Biotechnol. (1997) 25:211–225.
  • SIMONI J et al: Investigation into the Hb-mediated inflammatory reactions and the attenuation of such effects. Shock (1997) 7:27–28.

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