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Key Paper Evaluation

Crizotinib for EML4-ALK positive lung adenocarcinoma: a hope for the advanced disease?

Evaluation of Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010;363(18):1693–703

, MD PhD
Pages 351-353 | Published online: 05 Jan 2011

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  • Kwak EL, Camidge DR, Clark J, Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066. J Clin Oncol (Meeting Abstracts) 2009;27(15S): abstract 3509
  • Mok TS, Wu YL, Thongprasert S, Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361(10):947-57
  • Soda M, Choi YL, Enomoto M, Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007;448(7153):561-6
  • Soda M, Takada S, Takeuchi K, A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci USA 2008;105(50):19893-7

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