IL-17A-producing CD8⁺T cells as therapeutic targets in autoimmunity

Bibliography

• So T, Lee SW, Croft M. Immune regulation and control of regulatory T cells by OX40 and 4-1BB. Cytokine Growth Factor Rev 2008;19:253-62
   PubMed Web of Science ®Google Scholar
• Denic A, Wootla B, Rodriguez M. CD8(+) T cells in multiple sclerosis. Expert Opin Ther Targets 2013;17:1053-66
   PubMed Web of Science ®Google Scholar
• Gill D, Tan PH. Induction of pathogenic cytotoxic T lymphocyte tolerance by dendritic cells: a novel therapeutic target. Expert Opin Ther Targets 2010;14:797-824
   PubMed Web of Science ®Google Scholar
• Liang Y, Xu WD, Peng H, et al. SOCS signaling in autoimmune diseases: molecular mechanisms and therapeutic implications. Eur J Immunol 2014;44:1265-75
   PubMed Web of Science ®Google Scholar
• Liang Y, Zhu Y, Xia Y, et al. Therapeutic potential of tyrosine kinase 2 in autoimmunity. Expert Opin Ther Targets 2014;18:571-80
   PubMed Web of Science ®Google Scholar
• Liang Y, Pan HF, Ye DQ. Therapeutic potential of STAT4 in autoimmunity. Expert Opin Ther Targets 2014;18:945-60
   Google Scholar
• Mosmann TR, Li L, Sad S. Functions of CD8 T-cell subsets secreting different cytokine patterns. Semin Immunol 1997;9:87-92
   PubMedGoogle Scholar
• Cerwenka A, Morgan TM, Harmsen AG, et al. Migration kinetics and final destination of type 1 and type 2 CD8 effector cells predict protection against pulmonary virus infection. J Exp Med 1999;189:423-34
   PubMed Web of Science ®Google Scholar
• Cho BA, Sim JH, Park JA, et al. Characterization of effector memory CD8+ T cells in the synovial fluid of rheumatoid arthritis. J Clin Immunol 2012;32:709-20
   PubMedGoogle Scholar
• Berner B, Akça D, Jung T, et al. Analysis of Th1 and Th2 cytokines expressing CD4+ and CD8+ T cells in rheumatoid arthritis by flow cytometry. J Rheumatol 2000;27:1128-35
   PubMed Web of Science ®Google Scholar
• Mei FJ, Osoegawa M, Ochi H, et al. Long-term favorable response to interferon beta-1b is linked to cytokine deviation toward the Th2 and TC2 sides in Japanese patients with multiple sclerosis. J Neurol Sci 2006;246:71-7
   PubMedGoogle Scholar
• Glenn JD, Smith MD, Calabresi PA, et al. mesenchymal stem cells differentially modulate effector CD8+ T Cell subsets and exacerbate experimental autoimmune encephalomyelitis. Stem Cells 2014;32:2744-55
   PubMed Web of Science ®Google Scholar
• Frisullo G, Plantone D, Marti A, et al. Type 1 immune response in progressive multiple sclerosis. J Neuroimmunol 2012;249:112-16
   PubMedGoogle Scholar
• Vizler C, Bercovici N, Heurtier A, et al. Relative diabetogenic properties of islet-specific TC1 and TC2 cells in immunocompetent hosts. J Immunol 2000;165:6314-21
   PubMedGoogle Scholar
• Audia S, Samson M, Mahévas M, et al. Preferential splenic CD8(+) T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia. Blood 2013;122:2477-86
   PubMed Web of Science ®Google Scholar
• Dong Z, Du L, Xu X, et al. Aberrant expression of circulating Th17, Th1 and TC1 cells in patients with active and inactive ulcerative colitis. Int J Mol Med 2013;31:989-97
   PubMedGoogle Scholar
• Sjöberg V, Sandström O, Hedberg M, et al. Intestinal T-cell responses in celiac disease - impact of celiac disease associated bacteria. PLoS One 2013;8:e53414
   Google Scholar
• Kudo T, Nagata S, Aoyagi Y, et al. Polarized production of T-helper cell type 1 cells in Peyer’s patches in Crohn’s disease. Digestion 2004;70:214-25
   PubMedGoogle Scholar
• Gunderson AJ, Mohammed J, Horvath FJ, et al. CD8(+) T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ. J Invest Dermatol 2013;133:955-63
   PubMedGoogle Scholar
• Kanai Y, Satoh T, Igawa K, et al. Impaired expression of Tim-3 on Th17 and Th1 cells in psoriasis. Acta Derm Venereol 2012;92:367-71
   PubMed Web of Science ®Google Scholar
• Tonel G, Conrad C. Interplay between keratinocytes and immune cells--recent insights into psoriasis pathogenesis. Int J Biochem Cell Biol 2009;41:963-8
   PubMed Web of Science ®Google Scholar
• Liu SJ, Tsai JP, Shen CR, et al. Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6. J Leukoc Biol 2007;82:354-60
   PubMed Web of Science ®Google Scholar
• Yen HR, Harris TJ, Wada S, et al. TC17 CD8 T cells: functional plasticity and subset diversity. J Immunol 2009;183:7161-8
   PubMed Web of Science ®Google Scholar
• Hamada H, Garcia-Hernandez Mde L, Reome JB, et al. TC17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol 2009;182:3469-81
   PubMed Web of Science ®Google Scholar
• Kondo T, Takata H, Matsuki F, et al. Cutting edge: phenotypic characterization and differentiation of human CD8+ T cells producing IL-17. J Immunol 2009;182:1794-8
   PubMed Web of Science ®Google Scholar
• Shabgah AG, Fattahi E, Shahneh FZ. Interleukin-17 in human inflammatory diseases. Postepy Dermatol Alergol 2014;31:256
   PubMed Web of Science ®Google Scholar
• Lønnberg AS, Zachariae C, Skov L. Targeting of interleukin-17 in the treatment of psoriasis. Clin Cosmet Investig Dermatol 2014;7:251-9
   PubMedGoogle Scholar
• Ortega C, Fernández S, Estévez OA, et al. IL-17 producing T cells in celiac disease: angels or devils? Int Rev Immunol 2013;32:534-43
   PubMed Web of Science ®Google Scholar
• Fitzpatrick LR. Inhibition of IL-17 as a pharmacological approach for IBD. Int Rev Immunol 2013;32:544-55
   PubMed Web of Science ®Google Scholar
• Fossiez F, Banchereau J, Murray R, et al. Interleukin-17. Int Rev Immunol 1998;16:541-51
   PubMedGoogle Scholar
• Huber M, Heink S, Pagenstecher A, et al. IL-17A secretion by CD8+T cells supports Th17-mediated autoimmune encephalomyelitis. J Clin Invest 2013;123:247-60
   PubMed Web of Science ®Google Scholar
• Huber M, Heink S, Grothe H, et al. A Th17-like developmental process leads to CD8(+) TC17 cells with reduced cytotoxic activity. Eur J Immunol 2009;39:1716-25
   PubMed Web of Science ®Google Scholar
• Ciric B, El-behi M, Cabrera R, et al. IL-23 drives pathogenic IL-17-producing CD8+ T cells. J Immunol 2009;182:5296-305
   PubMed Web of Science ®Google Scholar
• Res PC, Piskin G, de Boer OJ, et al. Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis. PLoS One 2010;5:e14108
   PubMed Web of Science ®Google Scholar
• Henriques A, Gomes V, Duarte C, et al. Distribution and functional plasticity of peripheral blood Th(c)17 and Th(c)1 in rheumatoid arthritis. Rheumatol Int 2013;33:2093-9
   PubMed Web of Science ®Google Scholar
• Henriques A, Inês L, Couto M, et al. Frequency and functional activity of Th17, TC17 and other T-cell subsets in systemic lupus erythematosus. Cell Immunol 2010;264:97-103
   PubMed Web of Science ®Google Scholar
• Tajima M, Wakita D, Satoh T, et al. IL-17/IFN-γ double producing CD8+ T (TC17/IFN-γ) cells: a novel cytotoxic T-cell subset converted from TC17 cells by IL-12. Int Immunol 2011;23:751-9
   PubMed Web of Science ®Google Scholar
• Saxena A, Desbois S, Carrié N, et al. TC17 CD8+ T cells potentiate Th1-mediated autoimmune diabetes in a mouse model. J Immunol 2012;189:3140-9
   PubMed Web of Science ®Google Scholar
• Curtis MM, Way SS, Wilson CB. IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons. J Immunol 2009;183:381-7
   PubMed Web of Science ®Google Scholar
• Vanden Eijnden S, Goriely S, De Wit D, et al. IL-23up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive TCellsin human. Eur J Immunol 2005;35:469-75
   PubMed Web of Science ®Google Scholar
• Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003;198:1875-86
   PubMed Web of Science ®Google Scholar
• Dwivedi VP, Tousif S, Bhattacharya D, et al. Transforming growth factor-β protein inversely regulates in vivo differentiation of interleukin-17 (IL-17)-producing CD4+ and CD8+ T cells. J Biol Chem 2012;287:2943-7
   PubMed Web of Science ®Google Scholar
• Satoh T, Tajima M, Wakita D, et al. The development of IL-17/IFN-γ-double producing CTLs from TC17 cells is driven by epigenetic suppression of Socs3 gene promoter. Eur J Immunol 2012;42:2329-42
   PubMed Web of Science ®Google Scholar
• Morishima N, Mizoguchi I, Okumura M, et al. A pivotal role for interleukin-27 in CD8+ T cell functions and generation of cytotoxic T lymphocytes. J Biomed Biotechnol 2010;2010:605483
   PubMed Web of Science ®Google Scholar
• Stumhofer JS, Laurence A, Wilson EH, et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 2006;7:937-45
   PubMed Web of Science ®Google Scholar
• Tsai JP, Lee MH, Hsu SC, et al. CD4+ T cells disarm or delete cytotoxic T lymphocytes under IL-17-polarizing conditions. J Immunol 2012;189:1671-9
   PubMed Web of Science ®Google Scholar
• Rubino SJ, Geddes K, Magalhaes JG, et al. Constitutive induction of intestinal TC17 cells in the absence of hematopoietic cell-specific MHC class II expression. Eur J Immunol 2013;43(11):2896-906
   PubMed Web of Science ®Google Scholar
• Intlekofer AM,Banerjee A,Takemoto N,et al. Anomaloustype 17 response to viral infection by CD8 +T cells lacking T-bet and eomesodermin. Science 2008;321(5887):408-11
   PubMed Web of Science ®Google Scholar
• Zhu Y, Ju S, Chen E, et al. T-bet and eomesodermin are required for T cell-mediated antitumor immune responses. J Immunol 2010;185(6):3174-83
   PubMed Web of Science ®Google Scholar
• Burrell BE, Csencsits K, Lu G, et al. CD8 + Th17 mediate costimulation blockade-resistan t allograft rejection in T-bet-deficient mice. J Immunol 2008;181(6):3906-14
   PubMed Web of Science ®Google Scholar
• Yu L, Yang F, Jiang L, et al. Exosomes with membrane-associated TGF-β1 from gene-modified dendritic cells inhibit murine EAE independently of MHC restriction. Eur J Immunol 2013;43:2461-72
   PubMed Web of Science ®Google Scholar
• Arocena AR, Onofrio LI, Pellegrini AV, et al. Myeloid-derived suppressor cells are key players in the resolution of inflammation during a model of acute infection. Eur J Immunol 2014;44:184-94
   PubMedGoogle Scholar
• Stürner KH, Verse N, Yousef S, et al. Boswellic acids reduce Th17 differentiation via blockade of IL-1β-mediated IRAK1 signaling. Eur J Immunol 2014;44:1200-12
   PubMed Web of Science ®Google Scholar
• Thomas RM, Sai H, Wells AD. Conserved intergenic elements and DNA methylation cooperate to regulate transcription at the il17 locus. J Biol Chem 2012;287:25049-59
   PubMed Web of Science ®Google Scholar
• Yu CR, Dambuza IM, Lee YJ, et al. STAT3 regulates proliferation and survival of CD8+ T cells: enhances effector responses to HSV-1 infection, and inhibits IL-10+ regulatory CD8+ T cells in autoimmune uveitis. Mediators Inflamm 2013;2013:359674
   PubMed Web of Science ®Google Scholar
• Linney E, Donerly S, Mackey L, et al. The negative side of retinoic acid receptors. Neurotoxicol Teratol 2011;33:631-40
   PubMedGoogle Scholar
• Eberl G. Development and evolution of RORγt+ cells in a microbe’s world. Immunol Rev 2012;245:177-88
   PubMedGoogle Scholar
• Yang Y, Xu J, Niu Y, et al. T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17. J Immunol 2008;181:8700-10
   Google Scholar
• Ysebrant de Lendonck L, Tonon S, Nguyen M, et al. Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes. Proc Natl Acad Sci USA 2013;110:E3189-97
   Google Scholar
• Pick J, Arra A, Lingel H, et al. CTLA-4 (CD152) enhances the TC17 differentiation program. Eur J Immunol 2014;44:2139-52
   PubMedGoogle Scholar
• Hayes MD, Ovcinnikovs V, Smith AG, et al. The aryl hydrocarbon receptor: differential contribution to T helper 17 and T cytotoxic 17 cell development. PLoS One 2014;9:e106955
   PubMed Web of Science ®Google Scholar
• Fitzgerald DC, O’Brien K, Young A, et al. Interferon regulatory factor (IRF) 3 is critical for the development of experimental autoimmune encephalomyelitis. J Neuroinflammation 2014;11:130
   PubMedGoogle Scholar
• Silva JL, Rezende-Oliveira K, da Silva MV, et al. IL-17-expressing CD4+ and CD8+ T lymphocytes in human toxoplasmosis. Mediators Inflamm 2014;2014:573825
   PubMed Web of Science ®Google Scholar
• El-Behi M, Dai H, Magalhaes JG, et al. Committed TC17 cells are phenotypically and functionally resistant to the effects of IL-27. Eur J Immunol 2014;44:3003-14
   PubMedGoogle Scholar
• Jiang G, Ma S, Wei Y, et al. The prevalence and distribution of Th17 and TC17 cells in patients with thyroid tumor. Immunol Lett 2014;162(1 Pt A):68-73
   Google Scholar
• Huber M, Lohoff M. IRF4 at the crossroads of effector T-cell fate decision. Eur J Immunol 2014;44:1886-95
   PubMed Web of Science ®Google Scholar
• Cheuk S, Wikén M, Blomqvist L, et al. Epidermal Th22 and TC17 cells form a localized disease memory in clinically healed psoriasis. J Immunol 2014;192:3111-20
   PubMed Web of Science ®Google Scholar
• Zhang Y, Hou F, Liu X, et al. TC17 cells in patients with uterine cervical cancer. PLoS One 2014;9:e86812
   PubMed Web of Science ®Google Scholar
• Duan MC, Tang HJ, Zhong XN, et al. Persistence of Th17/TC17 cell expression upon smoking cessation in mice with cigarette smoke-induced emphysema. Clin Dev Immunol 2013;2013:350727
   PubMedGoogle Scholar
• Zhang W, Hou F, Zhang Y, et al. Changes of Th17/TC17 and Th17/Treg cells in endometrial carcinoma. Gynecol Oncol 2014;132:599-605
   Google Scholar
• Faghih Z, Rezaeifard S, Safaei A, et al. IL-17 and IL-4 producing CD8+ T cells in tumor draining lymph nodes of breast cancer patients: positive association with tumor progression. Iran J Immunol 2013;10:193-204
   PubMedGoogle Scholar
• Khowawisetsut L, Pattanapanyasat K, Onlamoon N, et al. Relationships between IL-17(+) subsets, Tregs and pDCs that distinguish among SIV infected elite controllers, low, medium and high viral load rhesus macaques. PLoS One 2013;8:e61264
   Google Scholar
• Kumawat AK, Strid H, Tysk C, et al. Microscopic colitis patients demonstrate a mixed Th17/TC17 and Th1/TC1 mucosal cytokine profile. Mol Immunol 2013;55:355-64
   PubMedGoogle Scholar
• Lopes A, Machado D, Pedreiro S, et al. Different frequencies of TC17/TC1 and Th17/Th1 cells in chronic spontaneous urticaria. Int Arch Allergy Immunol 2013;161:155-62
   PubMedGoogle Scholar
• Yu Y, Cho HI, Wang D, et al. Adoptive transfer of TC1 or TC17 cells elicits antitumor immunity against established melanoma through distinct mechanisms. J Immunol 2013;190:1873-81
   PubMed Web of Science ®Google Scholar
• Hamada H, Bassity E, Flies A, et al. Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection. J Immunol 2013;190:296-306
   PubMedGoogle Scholar
• Gaardbo JC, Hartling HJ, Thorsteinsson K, et al. CD3+CD8+CD161high TC17 cells are depleted in HIV-infection. AIDS 2013;27:659-62
   PubMedGoogle Scholar
• Nanjappa SG, Heninger E, Wüthrich M, et al. TC17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells. PLoS Pathog 2012;8:e1002771
   PubMed Web of Science ®Google Scholar
• Girolomoni G, Mrowietz U, Paul C. Psoriasis: rationale for targeting interleukin-17. Br J Dermatol 2012;167:717-24
   PubMed Web of Science ®Google Scholar
• Zhuang Y, Peng LS, Zhao YL, et al. CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer. Gastroenterology 2012;143:951-62
   PubMed Web of Science ®Google Scholar
• McArthur MA, Sztein MB. Heterogeneity of multifunctional IL-17 a producing S. typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization. PLoS One 2012;7(6):e38408
   Google Scholar
• Zou Q, Hu Y, Xue J, et al. Use of praziquantel as an adjuvant enhances protection and TC-17 responses to killed H5N1 virus vaccine in mice. PLoS One 2012;7:e34865
   Google Scholar
• Hu Y, Ma DX, Shan NN, et al. Increased number of TC17 and correlation with Th17 cells in patients with immune thrombocytopenia. PLoS One 2011;6(10):e26522
   PubMed Web of Science ®Google Scholar
• Peelen E, Thewissen M, Knippenberg S, et al. Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators. J Neuroimmunol 2013;258:77-84
   PubMed Web of Science ®Google Scholar
• Tzartos JS, Friese MA, Craner MJ, et al. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol 2008;172:146-55
   PubMed Web of Science ®Google Scholar
• Rodeghiero F, Michel M, Gernsheimer T, et al. Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group. Blood 2013;121:2596-606
   PubMed Web of Science ®Google Scholar
• Hu Y, Ma DX, Shan NN, et al. Increased number of TC17 and correlation with Th17 cells in patients with immune thrombocytopenia. PLoS One 2011;6(10):e26522
   PubMed Web of Science ®Google Scholar
• Yaochite JN, Caliari-Oliveira C, Davanso MR, et al. Dynamic changes of the Th17/TC17 and regulatory T cell populations interfere in the experimental autoimmune diabetes pathogenesis. Immunobiology 2013;218:338-52
   PubMedGoogle Scholar
• Xu X, Zheng S, Yang F, et al. Increased Th22 cells are independently associated with Th17 cells in type 1 diabetes. Endocrine 2013;46(1):90-8
   PubMedGoogle Scholar
• Eysteinsdóttir JH, Sigurgeirsson B, Ólafsson JH, et al. The role of Th17/TC17 peripheral blood T cells in psoriasis and their positive therapeutic response. Scand J Immunol 2013;78:529-37
   PubMed Web of Science ®Google Scholar
• Kryczek I, Bruce AT, Gudjonsson JE, et al. Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol 2008;181:4733-41
   PubMed Web of Science ®Google Scholar
• Menon B, Gullick NJ, Walter GJ, et al. IL-17+CD8+ T-cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression. Arthritis Rheumatol 2014;66(5):1272-81
   PubMed Web of Science ®Google Scholar
• Tajima M, Wakita D, Noguchi D, et al. IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells. J Exp Med 2008;205:1019-27
   PubMed Web of Science ®Google Scholar
• Shen F, Gaffen SL. Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy. Cytokine 2008;41:92-104
   PubMed Web of Science ®Google Scholar
• Mitra A, Fallen RS, Lima HC. Cytokine-based therapy in psoriasis. Clin Rev Allergy Immunol 2013;44:173-82
   PubMed Web of Science ®Google Scholar
• Zhao XY, Xu LL, Lu SY, et al. IL-17-producing T cells contribute to acute graft-versus-host disease in patients undergoing unmanipulated blood and marrow transplantation. Eur J Immunol 2011;41:514-26
   PubMed Web of Science ®Google Scholar
• Skepner J, Ramesh R, Trocha M, et al. Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo. J Immunol 2014;192:2564-75
   PubMed Web of Science ®Google Scholar
• Pantelyushin S, Haak S, Ingold B, et al. Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice. J Clin Invest 2012;122:2252-6
   PubMed Web of Science ®Google Scholar