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Expert Opinion on Therapeutic Targets Volume 5, 2001 - Issue 3
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Miscellaneous

The Type III secretion system of Gram-negative bacteria: a potential therapeutic target?

Simone Müller Université Catholique de Louvain, 74 Avenue Hippocrate, UCL 74.49, B-1200 Brussels, Belgium. [email protected]
,
Mario F Feldman Université Catholique de Louvain, 74 Avenue Hippocrate, UCL 74.49, B-1200 Brussels, Belgium. [email protected]
&
Guy R Cornelis Université Catholique de Louvain, 74 Avenue Hippocrate, UCL 74.49, B-1200 Brussels, Belgium. [email protected]
Pages 327-339 | Published online: 25 Feb 2005

Bibliography

  • GREENWOOD D: Resistance to antimicrobial agents: a personal view. j Med. Microbial (1998) 47:751–755.
  • BONOMO RA: Multiple antibiotic-resistant bacteria in long-term-care facilities: An emerging problem in the practice of infectious diseases. Clin. Infect. Dis. (2000) 31:1414–1422.
  • PHILPOTT DJ, EDGEWORTH JD, SANSONETTI PJ: The pathogenesis of Shigella llexrieri infection: lessons from in vitro and in vivo studies. Phil Trans. R. Soc. Lorid. B. (2000) 355:575–586.
  • BRAUN L, COSSART P: Interaction between Listeria moriocytogeries and host mammalian cells. Microbes. Infect. (2000) 2:803–811.
  • FINLAY BB, FALKOW S: Common themes in microbial pathogenicity revisited. MMBR (1997) 61:136–169.
  • SALMOND GPC, REEVES PJ: Membrane traffic wardens and protein secretion in Gram-negative bacteria. Trends Biochem. Se (1993) 18:7–12.
  • VAN GIJSEGEM F, GENIN S, BOUCHER C: Conservation of secretion pathways for pathogenicity determinants of plants and animal bacteria. Trends Microbial (1993) 1:175–180.
  • DANESEPN, SILHAVY TJ: Targeting and assembly of periplasmic and outer-membrane proteins in Escherichia coil. Ann. Rev Genet. (1998) 32:59–94.
  • FATH MJ, KOLTER R: ABC transporter: bacterial exporters. Microbial Rev (1993) 57:995–1017.
  • THANASSI DG, HULTGREN SJ: Multiple pathways allow protein secretion across the bacterial outer membrane. Curr. Opiri. Cell Biol. (2000) 12:420–430.
  • RUSSEL M: Macromolecular assembly and secretion across the bacterial cell envelope: Type II protein secretion systems. j Mal Biol. (1998) 279:485–499.
  • PUGSLEY AP: The complete general secretory pathway. Microbial Rev (1993) 57:50–108.
  • CORNELIS GR, VAN GIJSEGEM F: Assembly and function of Type III secretion systems. Ann. Rev Microbial (2000) 54:735–774.
  • ••A complete review about Type III in Gramnegative bacteria and plants.
  • BACKERT S, ZISKA E, BRINKMANN V et al.: Translocation of the Helicobacter pylori CagA protein in gastric cells by a Type IV secretion apparatus. Cell. Microbial (2000) 2:155–164.
  • CHRISTIE PJ, VOGEL JP: Bacterial Type IV secretion: conjugation systems adapted to deliver effector molecules to host cells. Trends Microbial. (2000) 8:354–360.
  • HENDERSON IR, NAVARRO-GARCIA F NATARO JP: The great escape: structure and function of the autotransporter proteins. Trends Microbial. (1998) 6:370–378.
  • CORNELIS GR, BOLAND A, BOYD AP et al.: The virulence plasmid of Yersinia, an antihost genome. 11/licrobial Mal Biol. Rev (1998) 62:1315–1352.
  • •A thorough review about Type III in Yersinia.
  • GALAN JE: Interactions of Salmonella with host cells: encounters of the closest kind. Proc. Natl. Acad. Li. USA (1998) 95:14006–14008.
  • •A thorough review about Type III in Salmonella.
  • VAN NHIEU GT, SANSONETTI PJ: Mechanism of Shigella entry into epithelial cells. Curr. Opin. Microbial (1999) 2:51–55.
  • •A thorough review about Type III in Shigella.
  • JARVIS KG. GIRON JA, JERSE AE, MC DANIEL TK, DONNENBERG M.S, KAPER JB: Enteropathogenic Escherichia coil contains a putative Type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation. Proc. Natl. Acad. Sci. USA (1995) 92:7996–8000.
  • FRANK DW: The exoenzyme S regulon of Pseudomorias aerugiriosa. Mal. Microbial (1997) 26:621–629.
  • YAHR TL, GORANSON J, FRANK DW: Exoenzyme S of Pseudomorias aerugiriosa is secreted by a Type III pathway. Mal Microbial (1996) 22:991–1003.
  • YUK MH, HARVILL ET, MILLER JF: The BygAS virulence control system regulates Type III secretion in Bordetella brarichiseptica. Mal Microbial (1998) 28:945–959.
  • KERR JR, RIGG GP, MATTHEWS RC,BURNIE JP: The Bpel locus encodes Type III secretion machinery in Bordetella pertussis. Microb. Pathog. (1999) 27:349–367.
  • YUK MH, HARVILL ET, COTTER PA, MILLER JF: Modulation of host immune responses, induction of apoptosis and inhibition of NF-kappaB activation by the Bordetella Type III secretion system. Mal Microbial (2000) 35:991–1004.
  • WINSTANLEY C, HALES BA, HART CA: Evidence for the presence in Burkholderia pseudomalleii of a Type III secretion system-associated gene cluster. Med. 11/licrobial (1999) 48:649–656.
  • WINSTANLEY C, HART CA: Presence of Type III secretion genes in Burkholderia pseudomalled correlates with Ara phenotypes. j Chia. Microbial (2000) 38:883–885.
  • HSIA RC, PANNEKOEK Y, INGEROWSKI E, BAVOLI PM: Type III secretion genes identify a putative virulence locus of Chlamydia. Mal 11/licrobial (1997) 25:351–359.
  • HUECK CJ: Type III protein secretion systems in bacterial pathogens of animals and plants. Microbial Mal Biol. Rev (1998) 62:379–433.
  • ••A extensive review of Type III secretion.
  • CORNELIS GR: Type III secretion: a bacterial device for close combat with cells of their eukaryotic host. Phil. Trans. R. Soc. Land. B. (2000) 355:681–693.
  • GROISMAN EA, BLANC-POTARD A, UCHIYA K: Pathogenicity islands and the evolution of Salmonella virulence. In: Pathogenicity islands and other mobile virulence elements. Koper JB, Hacker J (Eds.), American Society For Microbiology, Washington, DC (1999):127–150.
  • JONES BD, FALKOW S: Salmonellosis: host immune response and bacterial virulence determinants. Ann. Rev Irnmurial (1996) 14:533–561.
  • GOOSNEY DL, GRUENHEID S, FINLAY BB: Gut feelings: enteropathogenic Feat interactions with the host. Ann. Rev Cell Dev. Biol. (2000) 16:173–189.
  • •A complete review about Type III in EPEC.
  • LEVINE MM, EDELMAN R: Enteropathogenic Escherichia coli of classic serotypes associated with infant diarrhea: epidemiology and pathogenesis. Epidemial Rev(1984) 6:31–51.
  • KNAPP B, HUNDT E, LENZ U et al: A recombinant hybrid outer membrane protein for vaccination against Pseudomorias aerugiriosa. Vaccine (1999) 17:1663–1666.
  • DENISE-MICE KS, PRICE BM, BAKER NR, GALLOWAY D: Analysis of immunization with DNA encoding Pseudomorias aerugiriosa exotoxin A. FEMS Immunology and Medical Microbiology (2000) 27:147–154.
  • HORAN TC, WHITE JW, JARVIS WR et al.: Nosocomial infection surveillance. MMWR (1986) 35:17–29.
  • MULLER M, HILDEBRANDT A: Nucleotide sequences of the 23S RNA genes from Bordetella pertussis, B. parapertussis, B. brarichiseptica and B. avium, and their implications for phylogenetic analysis. Nucleic Acids Res. (1993) 21:3320.
  • HEWLETT EL: Bordetella species. In: Principles and Practice of Infectious Diseases (Edition 3) Mandell GL, Douglas Jr. RG, Bennett JE (Eds.). Churchill Livingstone, New York (1995):2078–2084.
  • CULLINANE LC, ALLEY MR, MARSHALL RB MANKTELOW BW: Bordetella pertussis from lambs. NZ Vet J. (1987) 55:175.
  • PORTER JF, CONNOR K, DONACHIE W: Isolation and characterization of Bordetella parapertussis-like bacteria from ovine lungs. 11/licrobial (1994) 140:255–261.
  • GOODNOW RA: Biology of Bordetella brarichiseptica. Microbial Rev (1980) 44:722–738.
  • WOODS DE, DESHAZER D, MOORE RA: Current studies on the pathogenesis of melioidosis. Microbes. Infect. (1999) 2:157–162.
  • WYRICK PB: Intracellular survival by Chlamydia. Cell Microbial. (2000) 4:275–282.
  • SUBTIL A, PARSOT C, DAUTRY-VARSAT A: Secretion of predicted, Inc. proteins of Chlamydia prieumaniae by a heterologous Type III machinery. Mal. Microbial. (2001) 39:792–800.
  • FIELDS KA, PLANO GV, STRALEY SC: A low Ca2+ response (LCR) secretion (ysc) locus lies within the krBregion of the LCR plasmid in Yersinia pestis. J. Bacteria (1994) 176: 569–579.
  • PAYNE PL, STRALEY SC: Ysc0 of Yersinia pestis is a mobile core component of the Yop secretion system. J. Bacteria (1998) 180:3882–3890.
  • DAY JB, PLANO GV: The Yersinia pestis YscY protein binds directly to YscX, a secreted component of the Type III secretion machinery. J. Bacteria (2000) 182:1834–1843.
  • STAINIER I, BLEVES S, JOSENHANS C et al.: YscP, a Ye/sulfa protein required for Yop secretion that is surface exposed, and released in low Ca2+. Mal. APerabial. (2000) 37:1005–1018.
  • ALLAOUI A, SCHULTE R, CORNELIS GR: Mutational analysis of the Ye/sulfa enterocalatica virC operon: characterisation of yscE, C,L J Krequired for Yop secretion and yscHencoding YopR. Mal. Microbial. (1995) 18:343–355.
  • PLANO GV, STRALEY SC: Mutations in yscC, yscD, and yseC prevent high-level expression and secretion of V antigen and Yops in Yersinia pestis. J. Bacteria (1995) 177:3843–3854.
  • ALLAOUI A, WOESTYN S, SLUITERS C, CORNELIS GR: YscU, a Yersinia enterocalitica inner membrane protein involved in Yops secretion. J. Bacteria (1994) 176:4534–4542.
  • SORY MP CORNELIS GR: Translocationof the hybrid YopE-adenylate cyclase from Yersinia enterocalitica into Hela cells. Mal. Microbial. (1994) 14:583–594.
  • PLANO GV, STRALEY SC: Multiple effects of kr Vmutations in Yersinia pestis. Bacterial. (1993) 175:3536–3545.
  • KUBORI T, MATSUSHIMA Y, NAKAMURA D et al.: Supramolecular structure of the Salmonella nphimurium Type III protein secretion system. Science (1998) 280:602–605.
  • ••First report of visualisation of Type IIIsecretion apparatus in Salmonella.
  • BLOCKER A, JOUIHRI N, LARQUET E et al.: Structure and composition of the Shigella flexile/I 'needle complex', a part of its Type III secreton. Mal. Microbial. (2001) 39:652–663.
  • HOICZYK E, BLOBEL G: Polymerization eukaryotic cells. Proc. Nati Acad. Sri. USA (2001) 98:4669–4674.
  • KOSTER MW, BITTER W, DE COCK H et al.: The outer membrane component, YscC, of the Yop secretion machinery of Yersinia enterocolitica forms a ring shaped multimeric complex. Mol. Microbiol. (1997) 26:789–798.
  • SARKER MR, SORY MP, BOYD AP, IRIARTE M, CORNELIS GR: LcrG is required for efficient internalization of Yersinia Yop effector proteins into eukaryotic cells. Infect. Immun. (1998) 66:2976–2979.
  • FORSBERG A, VIITANEN AM, SKURNIK M, WOLF-WATZ H: The surface-located YopN protein is involved in calcium signal transduction in Yersinia pseudatuberculasis: Mal. A/Perch:fa (1991) 5:977–986.
  • IRIARTE M, SORY MP, BOLAND A et al.: TyeA, a protein involved in control of Yop release ad in translocation of Ye/sulfa Yop effectors. EMBO J. (1998) 17:1907–1918.
  • YAHR TL, MENDE-MUELLER LM, FRIESE MB, FRANK DW: Identification of Type III secreted products of the Pseudamonas aeruginosa exoenzyme S regulon.j Bacteria (1997) 179:7165–7168.
  • ROSQVIST R, FORSBERG A, WOLF-WATZ H: Intracellular targeting of the YersinfaYopE cytotoxin in mammalian cells induces actin microfilament disruption. Infect. Immun. (1991) 59:4562–4569.
  • HAKANSSON S, BERGMANN T, VANOOTEGHEM JC, CORNELIS G, WOLF-WATZ H: YopB and YopD constitute a novel class of Ye/sulfa Yop proteins. Infect. Immun. (1993) 61:71–80.
  • HAKANASSON S, SCHESSER K, PERSSON C et al.: The yopB protein of Yersirtia preudotubercuksis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact dependent membrane disrupting activity. EMBO J. (1996) 15:5812–5823.
  • NEYT C, CORNELIS GR: Insertion of a Yop translocation pore into the macrophage plasma membrane by Yersinia enterocalitica: requirement for translocators YopB and YopD, but not for LcrG. Mal. APerabial. (1999) 33:971–981.
  • HOLSTROM A, OLSSON J, CHEREPANOV P et al.: LcrV is a channel size-determining component of the Yop effector translocon of Yersinia. Mal. APerabial. (2001) 3:620–632.
  • PETTERSON J, HOLSTROM A, HILL J et al.: The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation. Mal. Microbial. (1999) 32:961–976.
  • SARKER MR; NEYT C; STAINIER I; CORNELIS GR: The Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and YopD. I Bacteria (1998) 180:1207–1214.
  • LEE VT, TAM C, SCHNEEWIND O: LcrV, a substrate for Ye/sulfa enterocalitica Type III secretion, is required for toxin targeting into the cytosol of HeLa cells. j Biol. Chem. (2000) 275: 36869–36875.
  • HOLMSTROM A, PETTERSON J, ROSQVIST R: YopK of Yersinia preudatuberculasis controls translocation of Yop effectors across the eukaryotic cell membrane. Mal. Microbial. (1997) 24:73–91.
  • IRIARTE M, CORNELIS GR: YopT, a new YersinfaYop effector protein, affects the cytoskeleton of host cells. Mal. Microbial. (1998) 29:915–929.
  • ORTH K, PALMER LE, BAO ZQ et al.:Inhibition of the mitogen-activated protein kinase superfamily by a Yersinia effector. Science (1999) 285:1920–1923.
  • GALYOV EE, HAKANSSON S, FORSBERG A, WOLF-WATZ H: A secreted protein kinase of Yersinia preudatuberculasis is an indispensable virulence determinant. Nature (1993) 361:730–732.
  • SKRZYPEK E, COWAN C, STRALEY SC: Targeting of the Yersinia pestisYopM protein into HeLa cells and intracellular trafficking to the nucleus. Mal. Microbial. (1998) 5:1051–1065.
  • ANDERSON DM, SCHNEEWIND O: A mRNA signal for the Type III secretion of Yop proteins by Yersinia enterocalitica. Science (1997) 278:1140–1143.
  • LLOYD SA, NORMAN M, ROSQVIST R, WOLF-WATZ H: Yersinia YopE is targeted for Type III secretion by N-terminal, not mRNA, signals. Mal. Microbial (2001) 39:520–531
  • MICHIELS T, WATTIAU P, BRASSEUR R, RUYSSCHAERT JM, CORNELIS GR: Secretion of Yop proteins by Yersinia. Infect. Immun. (1990) 58:2840–2849.
  • MENARD AT, SANSONETTI PJ, PARSOT C: The secretion of Shigella flexneri invasins is induced by the epithelial cell and controlled by IpaB and IpaC. EMBO J. (1994) 13:5293–5302.
  • BAHRANI FK, SANSONETTI PJ, PARSOT C: Secretion of Ipa proteins by Shigella flexneri: inducing molecules and kinetics of activation. Infect. Immun. (1997) 65:4005–4010.
  • KOMORIYA K, SHIBANO N, HIGANO T, AZUMA N, YAMAGUCHI S, AIZAWA S-I: Flagellar proteins and Type III-exported virulence factors are the predominant proteins secreted into the culture media of Salmonella Othimurium. Mal 11/licrobial (1999) 34:767–779.
  • HALLER JC, CALSON S, PEDERSON KJ, PIERSON DE: A chromosomally encoded Type III secretion pathway in Yersinia enterocalitica is important in virulence. Mal. Microbial (2000) 36:1436–1446.
  • SHEA JE, HENSEL M, GLEESON C, HOLDEN D: Identification of a virulence locus encoding a second Type III secretion system in Salmonella typhimurium. Proc. Nati Acad. Sri (1996) 93:2593–2597.
  • HENSEL M, SHEA JE, RAUPACH B et al.: Functional analysis of ssa J and the ssaK/ Uoperon, 13 genes encoding components of the Type III secretion apparatus of Salmonella pathogenicity island 2. Mal Microbial (1997) 24:155–167.
  • OCHMANN H, SONCINI FC, SOLOMON E GROISMAN E: Identification of a pathogenicity island required for Salmonella survival in host cells. Proc. Natl. Acad. Sri. (1996) 93:7800–7804.
  • BOURDET-SICARD R, RODIGER M, JOCKUSCH BM, GOUNON E SANSONETTI PJ, TRAN VAN NHIEU G: Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerisation. (1999) EMBO J. 18: 5853–5862.
  • NIEBUHR K, SANSONETTI PJ: Invasion of epithelial cells by bacterial pathogens: the paradigm of Shigella.In: Subcellular Biochemistry (Volume 3) Bacterial Invasion into eukaryatic cells. Cfischläger T, Hacker J (Eds.), Kluwer Academic/Plenum Press, New York (2000):251–287.
  • HENSEL M, SHEA JE, GLEESON C, JONES MD, DALTON E, HOLDEN DW: Simultaneous identification of bacterial virulence genes by negative selection. Science (1995) 269:400–403.
  • HENSEL M, SHEA JE, WATERMAN ST et al.: Genes encoding putative effector proteins of the Type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages. Mal Microbial. (1998) 30:163–174.
  • SHEA JE, HENSEL M, GLEESON C, HOLDEN DW: Identification of a virulence locus encoding a second Type III secretion system in Salmonella typhimurium. Proc. Natl. Acad. Sri. (1996) 93:2593–2597.
  • GUY RL, GONIAS LA, STEIN MA: Aggregation of host endosomes by Salmonella requires 5PI2 translocation of SseFG and involves SpyR and the fms-aroE intragenic region. Mal 11/licrobial (2000) 37:1417–1435.
  • FRANKEL G, PHILLIPS AD, ROSENSHINE I et al.: Enteropathogenic and enterohaemorrhagic Escherichia coil: more subversive elements. Mal 11/licrobial (1998) 30:911–921.
  • KENNY B, JEPSON M: Targeting of an enteropathogenic Escherichia coil (EPEC) effector protein to host mitochondria. Cell Microbial. (2000) 2:579–590.
  • CRANE JK, MCNAMARA BP, DONNENBERG MS: Role of EspF in host cell death induced by enteropathogenic Escherichia coli Cell Microbial. (2001) 3:197–211.
  • TAMANO K, AIZAWA S-I, KATAYAMA E et al.: Supramolecular structure of the Shigella Type /II secretion machinery: the needle part is changeable in length and essential for delivery of effectors. EMBO (2000) 19:3876–3887.
  • NICHOLS BA, SETZER PY, PANG F, DAWSON CR: New view of the surface projections of Chlamydia trachomatis. Bacterial. (1985) 164:344–349.
  • MATSUMOTO A: Electron microscopic observations of surface projections on Chlarnydia psittacireticulate bodies. J. Bacterial. (1982) 150:358–364.
  • EBEL F, PODZADEL T, ROHDE M et al.: Initial binding of Shiga toxin-producing Escherichia coil to host cells and subsequent induction of actin rearrangements depend on filamentous EspA-containing surface appendages. Mal Microbial (1998) 30:147–161.
  • KNUTTON S, ROSENSHINE I, PALLEN MJ et al.:A novel EspA-associated surface organelle of enteropathogenic Escherichia coil involved in protein translocation into epithelial cells. EMBO (1998) 17:2166–2176.
  • WARAWA J, FINLAY BB, KENNY B: Type III secretion-dependent hemolytic activity of enteropathogenic Escherichia coil. Infect. Immun. (1999) 67:5538–5540.
  • SHAW RK, DANIELL S, EBEL F, FRANKEL G, KNUTTON S: EspA filament-mediated protein translocation into red blood cells. Cell. Microbial. (2001) 3:213–222.
  • GENIN S, BOUCHER CA: A superfamily of proteins involved in different secretion pathways in Gram-negative bacteria: modular structure and specificity of the N-terminal domain. Mal Gen. Cenci. (1994) 243:112–118.
  • MICHIELS T, VANOOTEGHEM JC, LAMBERT DE ROUVROIT CL et al.: Analysis of virC, an operon involved in the secretion of Yop proteins by Ye/sulfa enterocalitica. J. Bacterial (1991) 173:4994–5009.
  • KIMBROUGH TG, MILLER SI: Contribution of Salmonella typhimurium Type III secretion components to needle complex formation. PNAS (2000) 97:11008–11013.
  • CRAGO AM, KORONIKOS V: Salmonella InvG forms a ring-like multimer that requires the InvH lipoprotein for outer membrane localisation. Mal Microbial (1998) 30:47–56.
  • WOESTYN S, ALLAOUI A, WATTIAU P, CORNELIS GR: YscN, the putative energizer of the Yersinia Yop secretion machinery. J. Bacterial (1994) 176:1561–1569.
  • FAN M, MACNAB RIVI: Enzymatic characterization of FliI. An ATPase involved in the assembly of Salmonella typhimurium. J. Biol. Chem. (1996) 57:31981–31988.
  • SUKHAN A, KUBORI T, WILSON J, GALAN JE: Genetic analysis of assembly of the Salmonella elite/Ica serovar typhimurium Type III secretion-associated needle complex. J. Bacteria (2001) 183:1159–1167.
  • WATTIAU P, CORNELIS GR: SycE, a chaperone-like protein of Yersinia enterocalitica involved in the secretion of YopE. Mal Microbial. (1993) 1:123–131.
  • BENNETT JC, HUGHES C: From flagellum assembly to virulence: the extended family of Type III export chaperones. Trends Microbial (2000) 5:202–204.
  • WOESTYN S, SORY MP, BOLAND A, LEQUENNE O, CORNELIS GR: The cytosolic SycE and SycH chaperones of Yersinia protect the region of YopE and YopH involved in translocation across eukaryotic cell membranes. Mal. Microbial. (1996) 6:1261–1271.
  • NEYT C, CORNELIS GC: Role of SycD, the chaperone of the Yersinia Yop translocators YopB and YopD. Microbial (1999) 31:143–56.
  • DAY JB, GULLER I, PLANO GV: Yersinia pestis YscG protein is a Syc-like chaperone that directly binds YscE. Infect. Immun (2000) 11:6466–6471.
  • MENARD R, SANSONETTI PJ, PARSOT C, VASLON T: Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. Ikxneri. Cell (1994) 79:515–525.
  • CHENG LW, SCHNEEWIND O: Yersinia enterocalitica Type III secretion. On the role of SycE in targeting YopE into HeLa cells. Biol. Chem. (1999) 274:22102–22108.
  • BOYD AP, LAMBERMONT I, CORNELIS GR: Competition between the Yops of Yersinia enterocalitica for delivery into eukaryotic cells: role of the SycE chaperone binding domain of YopE. Bacterial (2000) 17:4811–4821.
  • GALAN JE: Interaction of Salmonella with host cells through the centisome 63 Type III secretion system. Curr. Opin. Microbial (1999) 1:46–50.
  • WAINWRIGHT J, KAPER JB: EspB and EspD require a specific chaperone for proper secretion from enteropathogenic Escherichia coil. Mal Microbial (1998) 27:1247–1260.
  • KOBE B, DEISENHOFER: Proteins with leucine-rich repeats. Curr. Opin. Struct. Biol. (1995) 5:409–416.
  • FERNENDEZ-PRADA CM, HOOVER DL, TALL BD, HARTMANN AB, KOPELOWITZ J, VENKATESAN MM: Shigella flexile/1 IpaH (7.8) facilitates escape of virulent bacteria from the endocytic vacuoles of mouse and human macrophages. Infect. Immun. (2000) 68:3608–3619.
  • MIAO EA, SCHERER CA, TSOLIS RM et al.: Salmonella typhimutium leucine-rich repeat proteins are targeted to the SPI 1 and SPI 2 Type III secretion systems. Mal Microbial (1999) 34:850–864.
  • AKTORIES K, SCHMIDT G, JUST I: Rho GTPases as targets of bacterial protein toxins. Biol. Chem. (2000) 381:421–426.
  • FU YX, GALAN JE: A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion. Nature (1999) 401:293–297.
  • KANIGA K, URALIL J, BLISKA JB, GALAN JE: A secreted tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella itphimurium. Mal Microbial (1996) 21:633–641.
  • SCHESSER K, DUKUZUMUREMYI JM, CILIO C et al.: The Salmonella YopJ-homologue AvrA does not posses YopJ-like activity. Microb. Pathog. (2000) 28:59–70.
  • HARDT WD, GALAN JE: A secreted Salmonella protein with homology to an avirulent determinant of plant pathogenic bacteria. PNAS (1997) 18:9887–9892.
  • BURROWS TW, BACON GA: The effects of loss of different virulence determinants on the virulence and immunogenicity of strains of Pasteurella pestis. Br. I Exp. Pathol. (1958) 39:278–291.
  • UNE T, BRUBAKER RR: Roles of V antigen in promoting virulence and immunity in Yersinia. j Irrimurial. (1984) 133:2226–2230.
  • MOTIN VL, NAKAJIMA R, SMIRNOV GB, BRUBAKER RR: Passive immunization to Yersiniae mediated by anti-recombinant V antigen and protein A-V fusion peptide. Infect. Immun. (1984) 62:4192–4201.
  • ANDERSON GW, LEARY SEC, WILLIAMSON D et al.: Recombinant V antigen protects mice against pneumonic and bubonic plaque caused by Fl-capsule-positive and -negative strains of Yersinia pestis. Infect. Immun. (1996) 64:4580–4585.
  • SAWA T, YAHR T, OHARA L et al: Active and passive immunisation with the Pseudamonas V antigen protects against Type III intoxication and lung injury. Nature Med. (1999) 5:392–398.
  • ••Interesting example of immunisation and protection using proteins of Type III secretion systems.
  • LI Y, FREY E, MACKENZIE AM, FINLAY BB: Human response to Escherichia coil 0157:H7 infection: antibodies to secreted virulence factors. Infect. Immun. (2000) 68:5090–5095.
  • TURBYFILL KR, HARTMAN AB, OAKS EV: Isolation and characterisation of a Shigella flextieri invasin complex subunit vaccine. Infect. Immun. (2000) 68:6624–6632.
  • LEARY SE, GRIFFIN KF, GALYOV EE et al.: Yersinia outer proteins (YOPS) E, K and N are antigenic but non-protective compared to V antigen, in a murine model of bubonic plague. Microb. Pathog. (1999) 3:159–169.
  • ANDREWS ST, STRACHAN ST, BENNER GE et al.: Protective efficacy of recombinant Yersinia outer proteins against bubonic plaque caused by encapsulated and nonencapsulated Yersinia pestis. Infect. Immun. (1999) 67:1533–1537.
  • ROSSMANN H, SHAMS H, POBLETE F, FU Y, GALAN JE, DONIS RO: Delivery of epitopes by the Salmonella Type III secretion system for vaccine development. Science (1998) 281:565–568.
  • ••Interesting example of use of Type IIIsecretion systems mediated delivery of epitopes for vaccine development.
  • VAN DEN EYNDE BJ, BOON T: Tumor antigens recognized by T lymphocytes. Int. Clin. Lab. Res. (1997) 27:81–86.
  • FORSLUND KONO, NORDQVIST K: The melanoma antigen genes - any clues to their function in normal tissues? Exp. Cell. Res. (2001) 265:185–194.
  • SCHULER-THURNER B, DIECKMANN D, KEIKAVOUSSI P et al.: MAGE-3 and influenza-matrix peptide-specific cytotoxic T cells are inducible in terminal stage HLA-A2.1+ melanoma patients by mature monocyte-derived dendritic cells. j Irnmunal (2000) 165:3492–3496.
  • MACKENSEN A, HERBST B, CHEN JL et al: Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells. Int. Cancer (2000) 86:385–392.
  • CHAUX P, LUITEN R, DEMOTTE N et al.: Identification of five MAGE-Al epitopes recognized by cytolytic T lymphocytes obtained by in vitro stimulation with dendritic cells transduced with M4 GE-Al. j brununol. (1999) 163:2928–2936.
  • DUFFOUR M-T, CHAUX P, LURQUIN C, CORNELIS G, BOON T, VAN DER BRUGGEN P: A MAGE-A4 peptide presented by HLA-A2 is recognized by cytolytic T lymphocytes. Eur. j Immunol. (1999) 29:3329–3337.

Websites

  • http: //www.who.int/vaccines-diseases/ diseases/Shigella.htm World Health Organisation website gives a summary of state of play with regards to Shigella infection worldwide Affiliation

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