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Expert Opinion on Therapeutic Targets Volume 6, 2002 - Issue 1
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Review

The bacterial cell wall as a source of antibacterial targets

David W Green Cubist Pharmaceuticals, Inc., 65 Hayden Ave., Lexington, MA 02421, USA. [email protected]
Pages 1-20 | Published online: 25 Feb 2005

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  • ••Excellent description of developingglycopeptides from vancomycin that inhibit transglycosylation rather than transpeptidation.
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  • ••Great review of the enzyme mechanismsusing phosphoenolpyruvate in biosynthesis.
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  • •Good example of how structure-function studies can be used to explain mechanisms of resistance at a molecular level.
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  • •Good example of how protein structure can be used to identify differences among target enzymes in developing antibacterial agents with broad spectrum.
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Websites

  • http://www.bact.wisc.edu/Bact303/ Structure Online textbook of bacteriology: structure and function of prokaryotic cells.
  • http://www.ncbi.nlm.nih.gov/entrezi query.fcgi?db=Protein Entrez protein data base.
  • http://www.rcsb.orglpdb/index.html Protein data base.

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