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Meeting Report

Second Annual GPCRs: From Orphan to Blockbuster

Pages 495-498 | Published online: 25 Feb 2005

Bibliography

  • BOCKAERT J, PIN J: Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO (1999) 18:1723.
  • DREWS J: Drug discovery: a historical perspective. Science (2000) 287:1960–1964.
  • HOPKINS AL, GROOM CR: The druggable genome. Nat. Rev Drug Discov. (2002) 1:727–730.
  • KLABUNDE T, HESSLER G: Drug design strategies for targeting G-protein-coupled receptors. Chembiochem. (2002) 3:928–944.
  • KENAKIN T: Efficacy as a vector: the relative prevalence and paucity of inverse agonism. Mol. Pharmacol. (2004) 65:2.
  • KENAKIN T: Inverse, protean, and ligand-selective agonism: matters of receptor conformation. FASEB (2001) 15:598.
  • GBAHOU F, ROULEAU A, MORISSET S et al: Protean agonism at histamine H3 receptors in vitro and in vivo. Proc. Natl. Acad. Sci. USA (2003) 100:11086.
  • MADABUSHI S, GROSS A, PHILIPPI A, MENG E, WENSEL T, LICHTARGE O: Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions. Biol. Chem. (2004) 279:8126.
  • EDWARDS B, OPREA T, PROSSNITZ E, SKLAR L: Flow cytometry for high-throughput, high-content screening. Curr. Opin. Chem. Biol. (2004) 8:392.
  • KENAKIN T: Ligand-selective receptor conformations revisited: the promise and the problem. Trends Pharmacol. Sci. (2003) 24:346–354.
  • BRINK CB, HARVEY BH, BODENSTEIN J, VENTER DP, OLIVER DW: Recent advances in drug action and therapeutics: relevance of novel concepts in G-protein-coupled receptor and signal transduction pharmacology. Br. J. Clin. Pharmacol. (2004) 57:373–387.
  • HERMANS E: Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors. Pharmacol. Ther. (2003) 99:25–44.
  • TUNARU S, KERO J, SCHAUB A et al.:PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat. Med. (2003) 9:352.
  • SWAMINATH G, XIANG Y, LEE T, STEENHUIS J, PARNOT C, KOBILKA B: Sequential binding of agonists to the 32 adrenoceptor. Kinetic evidence for intermediate conformational states. J. Biol. Chem. (2004) 279:686.
  • AVLANI V, MAY L, SEXTON P, CHRISTOPOULOS A: Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors. J. Pharmacol. Exp. Ther. (2004) 308:1062.
  • WATSON C, CHEN G, IRVING P, WAY J,CHEN W, KENAKIN T: The use of stimulus-biased assay systems to detect agonist-specific receptor active states: implications for the trafficking of receptor stimulus by agonists. Mol. Pharmacol. (2000) 58:1230.
  • MCLATCHIE L, FRASER N, MAIN M et al.: RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature (1998) 393:333
  • JIMONET P, JAGER R: Strategies for designing GPCR-focused libraries and screening sets. Curr. Opin. Drug Discov. Dev. (2004) 7:325.
  • SEMINARA SB, MESSAGER S, CHATZIDAKI EE et al.: The GPR54 gene as a regulator of puberty. N. Engl. J. Med. (2003) 349:1614.
  • LEE DK, NGUYEN T, LYNCH KR et al.: Discovery and mapping of ten novel G protein-coupled receptor genes. Gene (2001) 275:83.

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